Questions tagged [animal-models]
Animals used, for both practical and ethical reasons, to study biological systems and draw conclusions about homologous processes in other organisms, especially humans.
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How similar are mouse proteins (EGFR, KRAS, etc.) to humans’?
Mouse models are widely used to evaluate anticancer drugs. There are two types of mouse models: immunodeficient mice engrafted with human cancer cells (xenografts) and immunocompetent mice bearing ...
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Looking for a recommendation: Anatomical diagrams of animals commonly used in laboratory testing (potential surgical procedure emphasized)
I'm interested in either a book or a place to find well-drawn diagrams of animal anatomy. The emphasis if possible would be on anything which includes material related to the nervous system of ...
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Are organisms that are genetically modified with a deletion classified as "transgenic"?
Imagine you delete a genomic region in a zygote with a CRISPR plasmid to generate an F1 animal with a genomic deletion.
The animal should be considered transgenic because of the presence of the ...
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Database of unique attributes of biological model systems
I am interested in deviations from standard eukaryotic biological mechanisms:
Sperm chromatin lacks nucleosomes, and are instead highly condensed by protamines. (most eukaryotic chromatin has ...
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Animal models to study depression [closed]
Is there a non-invasive animal model to study the pathogenesis (i.e., the development of) depression?
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Is there any reliable data about the correlation between the size of a species and number of individuals that belong to it?
I'm curious to know if such a collection of data exists, so I could visualize it with a graph, and see how humans compare to other spieces of similar size.
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How to find a model organism's standard data about proteome size and genome size?
I want to know proteome size(the number of proteins not length) and genome size(length) of model organisms like Caenorhabditis elegans, Saccharomyces cerevisiae etc.
I found www.uiprot.org
and I made ...
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Why do we use mice in labs? [closed]
Why do we use mice in labs for experiments targeting humans ? Are they near humans biologically speaking ?
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Animal body size determination for abundance
Does an animal being small or large determine its abundance?
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“The rhesus macaque is pretty much the closest thing we have to humans” — why?
Vincent Munster (researcher at Oxford) states (in the context of testing vaccines for COVID-19):
The rhesus macaque is pretty much the closest thing we have to humans
I thought chimpanzees and ...
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When comparing oral infection v IV infection in mice, why would the CFU given be different volumes?
In the paper, orally infected mice are given 1x10^9 CFU of C. Rodentium and IV infected mice are given 5x10^7 CFU of the pathogen. Does anyone know if there is a generic reason for this? Thanks in ...
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natural characteristics of insects used as human disease model
In this paper [1], the author found that the autism-related genes are conserved between honey bee and human. Thus, this paper providing a means to further explore sociobiology theory. In my opinion, ...
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Interesting examples of models [closed]
I am studying the general use of models in biology in terms of methodology, applications, usefulness etc, and I would really appreciate any recommendations of some specific examples of models from any ...
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Amount of animals to use for animal trials [closed]
I am working on an independent research project involving animal models. I am unsure how to deterine how many animals (rats) to use for the project. The rats will be injected with different solutions ...
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Does using animal models for medical research also promote veterinary research on these animal types?
I have been reading about mouse models for studying inflammatory bowel diseases such as Crohn's disease and Ulverative Colitis. For example, according to this publication, a widely used mouse model ...
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Mice that have been reconstituted with geneX-transduced cells
I read this article in the following:
... Mice that have been reconstituted with geneX-transduced cells
Now, someone who is not familiar with animal sciences, what does this exactly mean? ...
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Can predator-prey relationship be an example of negative feedback?
Predators eat their prey, prey population decreases. This results in the predator population to decrease, so less prey are consumed which causes the prey population to increase.
Therefore, if the ...
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Are there organisms sensing conformations, which we humans can't sense directly? [closed]
Are there organisms which can sense the conformations, which we humans can't sense directly, i.e. without using any equipment?
If there are organisms which can sense conformations ("the shape or ...
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At what g force do bacteria start to pellet down a tube?
I am working with C. elegans and bacteria and I want to get rid of the bacteria they eat by centrifuging the worms without centrifuging the bacteria. I am using a g-force of 600 and the bacteria ...
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How to give a biological interpretation to this phase portrait?
Consider the following system and analyze its behavior.
$$\begin{array}{rl} \frac{dA}{dt} &= A \left( 2-\frac{A}{5000}-\frac{L}{100} \right)\\ \frac{dL}{dt} &= L \left(-\frac{1}{2}+\frac{A}{...
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Are Zebras white with black stripes, or black with white stripes?
I'm not sure it makes sense, but are zebras black or white below the surface?
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Can C. elegans be raised on Lactobacillus as the only food source?
I'm interested in running some C. elegans experiments for educational purposes, but would like to avoid having to grow or handle E. coli. I was wondering if C. elegans need E. coli specifically, or ...
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About which cells in the human body do we know most? [closed]
Are there model cells (in the sense of model organisms) in the human body (other than E.coli) about which is known most (with respect to structure, function, metabolism, gene expression, ...) and to ...
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Why is Mus Musculus a good model organism? [closed]
I'm reading through a number of articles that use partial hepatectomy in Mus Musculus to study the mechanisms for liver regeneration (1, 2, 3). I have no doubt that a better understanding of ...
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How to watch a Zebrafish embryo in detail?
How much microscope zoom would I need to watch the development of a Zebrafish embryo in certain detail? Thanks guys!
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is this true to select 100 volume higher concentration of a drug test?
I am interested in knowing how to find/optimise the concentration needed for a drug effect in cell. and different organism
For example, if I use 1 micro molar for treating a cell. Should I use 10 nM ...
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Is it possible to establish a newer animal model completely based on Bioinformatics studies?
I wanted to know, if it is possible to prove a new organism as an animal model for any human disease by only Bioinformatics methods like NGS and Structural bioinformatics.
For Example, let's say ...
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How much does an experiment on monkeys cost?
Including legal fees, the paperwork, the housing, the food etc. (provided there is already a lab with biomedical lab equipment and space for the housing) for let's say the final testing phase of a ...
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Do only large birds float?
So, I've noticed a pattern in water fowl (here meaning birds who can take off and land on water, who float in the intervening time) tend to be larger birds.
The smallest I know of are gulls.
Are ...
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How many cells does the hermaphrodite version of Caenorhabditis elegans have? [closed]
Wikipedia states:
The male C. elegans, for example, has 1031 cells
How many cells does the female version have?
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Are there worms/snake traveling by rolling? (see youtube video) [closed]
Someone obtained this from a nature simulator : https://youtu.be/l-qOBi2tAnI
Is there any animals travelling like this?
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0.9% Saline or Ringer's Solution for in vivo work
A few of the labs where I currently work routinely use 0.9% saline for in vivo work (washing out debris during surgery, diluting substances for IP/IV/SC injections, etc.)
A few years ago I worked in ...
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Unknown animal - What could it be?
It's the first time I use this website and I really need help
because I'm totally stuck
Now I'm in school, but I'm trying to prepare for the Olympics
During the preparation, I found the issue on the ...
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What is the difference between conditional and inducible activation?
In the modern genetically modified animal models, there are not only constitutive mutations which start producing proteins already in the embryo, but also mutations which can be turned on later. I've ...
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Organ secretions
If an animal secrets an enzyme from an organ that is entirely dedicated for the same secretion, can one or cannot one just use the gene coding for that protein to obtain the protein in vitro. How much ...
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How good is the reproducibility of preclinical models?
Unofficially, biology researchers always complain how frequently fail to replicate results others have achieved. But of course, such failed experiments are underreported.
Is there data, or at least ...
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What motivates birds to make birdsong?
I was pondering the question "Why do humans make music?" and on an intuitive level, my answer was "because of the feelings it evokes of course!"
But I then wondered, what about songbirds? Does a ...
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What is the purpose of narwals' tusks?
I've heard that narwals can grow their tusks up to 16 ft long. What do they need the tusk for? Hunting? Comunication?
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DNA replacement: new species
This is a hypothetical question
What would happen if the DNA of a prokaryote was replaced with the one of a prokaryote of another species, would the cell structures change and adapt to the new DNA ...
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How do C. elegans manage nutrition?
If there is ample amount of food, do C. elegans worms know when to stop eating or do they store extra energy? Could they put this extra energy to use by moving faster or putting more eggs?
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What is the difference between a DPY-10, DPY-11, and DPY-13?
My TA mentioned these three mutations of C. elegans since we started working with the worms but seems to skip over what the differences are...
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Does isolation have any effect upon mouse behavior?
I work with a lot of mice. I don't do any behavioral analysis, I just inject DNA or RNA and do imaging assays. However, I have noticed some effect of isolation on mouse behavior. Normally, the mice ...
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What is an Ihh-/- mouse?
This one is too basic question:
I just came across $Ihh^{-/-}\ $ mouse. Is that means this mouse devoid of that gene Ihh. What is this sign called and are there other such representations?
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Which turtle species was on board the Iranian Space Agency launch in 2010?
They are seen briefly in this video:
https://www.youtube.com/watch?v=nZoNdf6hlII
The launch made international news, but there was no mention of the species.
Here's the entirety of Wikipedia's ...
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Is there a superterm combining "animal line" and "cell line" in disease models?
Biologists researching diseases will frequently use animal models. The way I understand it, there are species of animals, such as "mouse", and lines of mice, such as ...
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