Stack Exchange Network

Stack Exchange network consists of 174 Q&A communities including Stack Overflow, the largest, most trusted online community for developers to learn, share their knowledge, and build their careers.

Visit Stack Exchange

Programmed cell death. It is designed to prevent old damaged cells from mutating into neoplastic (cancer) cells.

0
votes
0answers
15 views

Why we see apoptosis in differentiated/ undifferentiated cells during or after induction with chemical(s)?

My question is about cell conversion to another cell. It is not a bioinformatic que, but I thank to everyone who could answer this que. Why we see apoptosis in differentiated/ undifferentiated cells ...
3
votes
1answer
33 views

Flow cytometric counting of apoptotic adhering cells

I have been trying to measure rates of apoptosis in epithelial cells by marking apoptotic cells with annexin V conjugated with phycoerythrin (PE) and sorting using flow cytometry. Unfortunately, the ...
2
votes
1answer
56 views

What is going on with these buccal epithelial cells?

A pooled saliva sample from a 70 year old male. What is happening with these cells? Are these cells undergoing normal apoptosis? In the video, the cytoplasmic movement looks liquefied and jelly-...
0
votes
0answers
69 views

What's the difference between autolysis and apoptosis?

https://en.wikipedia.org/wiki/Autolysis_(biology) https://en.wikipedia.org/wiki/Apoptosis Both terms describe a very similar thing: cell self-desctruction. I've seen both terms applied to the ...
1
vote
0answers
36 views

Can Programmable Cell Death (PCD) be engineered in a bacterium like E. coli?

I am reading a paper which says : Messages not received after a certain time can be considered lost, as bacteria carrying them will suicide. I even read some paper which says about PCD like this, but ...
1
vote
0answers
36 views

Does a cell deprived of growth factor undergoes apoptosis or G0 stasis?

I can't seem to find a decisive answer on this topic on any of my textbooks. If a cell is deprived of growth factors does it: Activate apoptosis Go in G0 phase but keeps living? Thanks.
1
vote
0answers
33 views

Cell cycle arrest and apoptosis

Is cell cycle arrest needed for apoptosis to occur? I note that some of the factors that mediate cell cycle arrest induction (e.g. DNA damage) happen to be responsible for initiating apoptosis as well....
2
votes
0answers
95 views

How exactly apoptosis starts? [closed]

I read article about apoptosis on Wikipedia, but didn't understand, how exactly the organism learns that it is necessary to launch process of apoptosis in certain cell. In other words, on what signs ...
4
votes
1answer
165 views

Does apoptosis occur more at a particular time of day?

I am interested to know if apoptosis (programmed cell death) occurs more frequently during daytime or nighttime hours, e.g. if apoptosis is associated with a circadian rhythm. A simple search turned ...
1
vote
0answers
36 views

The properties of benign tumours

Do benign tumours have no functioning apoptosis mechanisms ? If so what stops benign tumours from excessive growth? Also can a benign tumour have a functioning apoptosis mechanism?
1
vote
0answers
141 views

Can a cell completely lose the ability to undergo apoptosis?

What I mean is - can a super-cancer cell completely lose the ability to kill itself, losing all apoptosis-related mechanisms and becoming eternally resistant to any drug that tries to induce apoptosis ...
0
votes
1answer
324 views

What specific mutations can cause an apoptosis mechanism to malfunction?

What specific mutations can cause the apoptosis mechanisms in a cell to malfunction? Are any such mutations 'reversible' , somehow or are they generally permanent? what kind of mutations can happen ...
1
vote
1answer
465 views

Choosing the best assay for my experiment? [closed]

Which of the following assays can be used to determine whether cell death specifically due to apoptosis has occurred in a given cell sample? Choose all that apply. WST-1 Assay Caspase Colorimetric ...
4
votes
1answer
22k views

What is the difference between intrinsic and extrinsic apoptosis?

Hello my Professor has been teaching about apoptosis and sometimes makes the distinction between extrinsic and intrinsic. I am not sure if I know for sure what this means. Does this just refer to ...
0
votes
0answers
61 views

Stem cells and if they can correct a lack of apoptosis

If a cell ,call it C1 has no functioning apoptosis mechanism could a stem cell somehow be 'induced' to be like C1 , at least have the same genome as C1. Then use this stem cell 'duplicate' to 'restart'...
1
vote
1answer
2k views

What is the present tense verb form of apoptosis?

For example, if I want to say something along the lines of "this signaling pathway causes a cell to go through the process of apoptosis", but I want to shorten the phrase "go through the process of ...
3
votes
3answers
2k views

why do some cells in the body prefer necrosis to apoptosis as a means of cell death?

There are many programmed cell death pathways, but some cells show a greater preference for some over the other. I'm wondering as to why if necrosis is an inflammatory response that causes damage to ...
0
votes
2answers
513 views

What triggers programmed cell death in humans (from outside the cell)?

What triggers programmed cell death in humans? Is it decided by the brain (for the entire body)? Or is it a local decision of a cell by its environment? Something else? I realize that there might be ...
1
vote
1answer
95 views

About the apoptosis mechanisms in a cell

The apoptosis mechanisms in a cell are like a type of 'self-destruction mechanism': is this correct? As with any type of complex system with various necessary functions, if it has a set of self-...
3
votes
1answer
44 views

Regarding tumors and their developement

If certain cells or tissue in a specific part of the body are for some reason overworked; like the cases of severe acid reflux damaging the throat repeatedly and the cells in the throat having to do ...
2
votes
1answer
65 views

Regarding the apoptosis mechanisms in cells and cancer

If all the cells in a cancerous tumour had their apoptosis mechanisms 'turned back on' or reactivated or repaired by some 'yet to be discovered' process would this cause the tumour to 'self destruct' ...
0
votes
1answer
34 views

About artificially induced processes that would normally cause a cell to self-destruct

Are there certain biochemical processes that would normally cause a cell to self-destruct but if the cell being tested has apoptosis mechanisms that have malfunctioned or been 'turned off' the cell ...
1
vote
1answer
1k views

Apoptosis vs necroptosis

I understand that apoptosis and necroptosis share the same upper part of the pathway, but I cannot seem to distinguish when is each one activated? From my readings, it seems that when procaspases 8 or ...
2
votes
1answer
172 views

What's the meaning of this notation?

In Wang et al., the authors state on page 663 at the top that Furthermore, Bax-/- Bak-/- cells were completely resistant to paclitaxel-induced apoptosis. What's the meaning of the ...
1
vote
0answers
74 views

Cells with no apoptosis mechanism and their 'byproducts'

If a culture or sample of cells is such they all have no apoptosis mechanisms yet they have not been at present determined to be cancerous ; given such a cell culture is there a way to determine by ...
1
vote
0answers
94 views

Regarding benign tumors and what 'stops' them

Benign tumors can grow to dangerous size yet are they capable of metastisizing ; if not what stops this? Also with a benign tumor if you call its cells 'near' its edges its tumor 'cell wall' I was ...
0
votes
1answer
68 views

Regarding apoptosis and turning it 'back on'

Is there some chemical or chemicals or even special molecules that can be 'injected' into cancer cells that will turn any Apoptosis mechanisms 'back on'? Or maybe chemicals and/or molecules that ...
3
votes
1answer
48 views

Regarding apoptosis and inhibitors

If there is an apoptosis shut-off mechanism of any kind, one could call it a null-apoptosis mechanism. If this is possible, could there be a null-apoptosis inhibitor? Something that inhibits an ...
3
votes
2answers
8k views

What is Pan for in pan-caspase?

A simple question (I could not find it on internet): What is Pan for in pan-caspase? Is it any different from the term 'caspase' ?
7
votes
2answers
499 views

Can oncogenesis happen without apoptosis pathway being affected?

Has there ever been incidences of one or more cancerous cells having all it's cell-death pathways and apoptosis mechanisms intact and functional?
2
votes
2answers
123 views

About stem cells and Cancer

Do stem cells have an apoptosis mechanism and , if they do could this be used to repair the cell self-destruction pathways in a cancer cell?
1
vote
2answers
41 views

Concerning Apoptosis

What if cellular growth and repair is 'forced' to occur repeatedly in a region where it wouldn't normally happen , if the biological area was 'healthier'. Could this more aggressive cellular growth ...
3
votes
1answer
473 views

molecular indicators of apoptosis: clarification needed

I understand that DNA fragmentation is a molecular indicator of apoptosis. What distinguishes this as a hallmark of programmed cell death, versus one of necrosis?
1
vote
1answer
39 views

Do Fatty Acid Synthase Inhibitors Selectively induce Apoptosis in Cancer cells without inducing the same in healthy human cells?

Do Fatty Acid Synthase (FAS) Inhibitors (e.g. cerulenin) selectively induce apoptosis in cancer cells without inducing the same in healthy human cells?