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Questions tagged [autoimmune]

Questions pertaining to the production of an immune response to self tissues/molecules.

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Has any work been done on using induced chimerism before birth to avoid tissue rejection?

See this question for a fuller description of the idea behind the question. I've only ever found one reference to this idea (in Xeno: The Promise of Transplanting Animal Organs into Humans By David K....
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Could bone marrow transplants be used to prevent tissue rejection of trans-species organs?

So the immune system doesn't calibrate (for want of a better euphemism) to recognize it's own cells until fairly well along in fetal development & the major components of the immune system (...
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Is there a organ or type of cell that makes Nagalase?

Schindler disease / Kanzaki disease is being described as alpha-N-acetylgalactosaminidase deficiency. So then, which organ or cell(s) produce this alpha-N-acetylgalactosaminidase (Nagalase) ?
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MHC-II molecules and Erythrocytes

I am doing an essay which focuses on the MHC Class II deficiency and hemolytic anaemia, however I cannot seem to figure out why the deficiency of MHC-II would cause hemolytic anaemia, I could only ...
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How can autoimmunity be selective?

Vitiligo is a skin disorder where the pigment disappears. More on Wikipedia. This is believed to be caused by autoimmunity and has made me interested in autoimmunity in general. I am still very much ...
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1answer
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Where happens MHCII coordination to a self-peptide, and what happens if the bond would be irreversible?

MHC-II proteins are presenting antigens on the surface of cells with lysosomal activities where they eventually might get transported off by some T-cell receptor-anti-gens, as far as I understand (pls ...
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2answers
269 views

How exactly does a prion cause disease?

During my study of the immune system, I came across 2 very contrasting explanation as to how prions work. Firstly, scientific American pointed out this: link here: "A major breakthrough ...
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T1D autoimmunity causes' possibilities

As far as I've learned about T1D, the prevalence of the disease and autoimmune disorders in general over the past 5 decades intrigued me to the point it made me wonder if it's really a genetic ...
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1answer
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What goes wrong in the immune system that leads to autoimmune diseases

As far as I understood so far, B and T cells are produced in the bone marrow, and during their maturing process in the bone marrow or Thymus, the are "programmed" to react to certain proteins. It is ...
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1answer
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How do B and T cells work incorrectly in a person with Systemic Lupus Erythematosus?

Systemic lupus erythematosus is an autoimmune disease in which the body's immune system attacks healthy cells. How exactly do B and T cells attack these cells they mistake for pathogens?
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“Treatment” of allergy.

Is there any treatment for allergy? I am not saying about solutions like epi-pen which reduce the symptoms. Is there any way to modify our immunity so that it does not identify the allergens? Can we ...
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Where are epitopes located on HLA molecules?

Normally HLA molecules present cellular and extra cellular proteins to the immune system; presumably the proteins in this case are where antibody /t-cells etc bind. But when an organ is transplanted ...
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How is the antigen against which autoantibodies are formed, identified?

Say we suspect some new autoimmune disorder in a patient, and we collect blood for serology. How are self antibodies differentiated from normal ones in the collected sample? Once they are identified, ...
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2answers
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How are Thyroid Stimulating Ab destroying thyroid tissues?

I was reading about Graves' disease, which is an autoimmune disorder. I read a few books, including Endocrinology by Hadley and Levine, and websites where they mentioned that the antibody named TSAb (...
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1answer
83 views

Is it possible to transfer acquired hemophilia with breast milk?

There is a transplacental form of acquired hemophilia: http://www.jpeds.com/article/S0022-3476%2895%2970132-X/abstract This disease is caused by polyclonal immunoglobulins (IgG1 and IgG4) against the ...
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1answer
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Does atrophy of the thymus not effect T-cell selection and tolerance?

The thymus atrophies as age progresses. Does the T cell selection (which happens in the thymus) continue to take place? This doubt came into my mind because in the cadaver we dissected, the thymus was ...
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1answer
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Do the antibodies in a patient suffering from Hashimoto's, attack the thyroid hormones or the thyroid gland (or both?)?

If oral thyroid hormone supplement is administered, is the attack stopped or does it just create an excess of thyroid hormones so that even after a lot of it is destroyed by the antibodies, there is ...
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Can Allergy and Auto-immune diseases be the signs of hyper-vigilant immune system?

Allergy sufferers are much less likely to get some types of cancers. Theories regarding allergy - cancer link are mixed. Many say it is due to hyper-sensitive immune response. But the correlation ...
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2answers
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Cancer cells and their ability to avoid the immune system

Since cancer cell retain their ability to trigger the immune system from their pre-cancerous state and any condition that causes an auto-immune reaction in a specific area of the body will attack any ...
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1answer
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What is the attacking mechanism of RF on IgG?

Rheumatoid Factor (RF) attacks Fc portion of Immunoglobulin G (IgG), I want to know the underlying mechanism at molecular level. Also, what type of bond or attachment is made by RF and Fc portion of ...
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1answer
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Can stress-induced cortisol reduce diabetes type I?

Let us consider a patient with type 1 diabetes. I think it would be safe to say that diabetes is an autoimmune disease. Now let us suppose this patient comes under stress. As far as I know, cortisol ...
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Are there any auto-immune diseases caused by T cells not detaching from antigen presenting cells (APCs)?

By not detaching I'm referring to after they have formed an immunological synapse, if they don't ever detach.
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How does Celiac's Disease cause people to stop growing?

In all of the sites I've looked on, one of the symptoms of Celiac's Disease is the failure to grow in children. Why would an immune attack against gluten cause stunted growth? Celiac.org states: ...
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How does de-myelination occur in multiple sclerosis?

From what I understand, only the oligodendrocytes are affected in multiple sclerosis, and they are attacked by T cells which cross the blood-brain barrier. This leads me to two questions: How is the ...
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1answer
2k views

How do genetic chimeras with different blood types not die?

If a person is a chimera and has two different blood types in his veins, how does he not die? Shouldn't the immune system attack one of the blood types? In 1953 a human chimera was reported in the ...
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5answers
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Can your immune system's cells destroy you? (Critical thinking and Fictional sense)

In an imaginary sense, If you alone were replicated into 2 so that there should now be 2 of "you" (meaning you both have the same DNA). Then let's say one of you shrunk to the size of a bacteria, and ...
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Is this description of etiology of celiac disease correct?

There is a detailed and, to my inexpert eyes, plausible description of the etiology of celiac disease and other autoimmune disorders posted here: http://no-gluten.org/CeliacDisease.htm Is it is at ...
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Could transfusion of a different blood type cure blood-based cancers?

Different antigen detection triggers an immune system response that could perhaps stimulate mitochondria and such in killing cancer cells - something like chemo without the hair-loss?
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Do macrophages engulf mtDNA?

Let us assume that in a human body, a mitochondrial DNA is released to extracellular environment. We know that mtDNA inheritance is solely matrilineal. So the question is, If your mitochondrial DNA ...
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Why is there no way to remove an immune response?

We've known for a long time now how to "add a new entry to the database," as it were, of immune responses. It's called vaccination, and it's been one of the greatest success stories in the history of ...
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Is cancer a defect of the immune system? [closed]

Is cancer due to a defect in the immune system?
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1answer
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What is immunosuppression? Why would one use it? [closed]

What is immunosuppression? I know it is used in cancer patients, but why would one want to suppress the immune system? Do homeopathic physicians ever use immunosuppression, or do only allopathic ...
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1answer
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When was it determined that Type 1 Diabetes is an autoimmune disease?

I just found out today that type 1 diabetes is an autoimmune disease. When was this discovered?
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Autoimmunity and central tolerance

Where in the body are self antigens important? In terms of central tolerance and autoimmunity, but also in terms of T cell activation?
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How does Humira work when injected into patients with rheumatoid arthritis?

OK, I have rheumatoid arthritis and I've been injecting Humira 2 times a month for the last 8 months. As far as I know rheumatoid arthritis is simply an immune system disorder which makes the immune ...
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1answer
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A possible cause of autoimmunity

I read that Doherty and Zinkernagel found that MHC- heterozygotes present more antigens to the immune system than homozygotes; yet, the infected heterozygous mice in their experiment all died, ...
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Is there a link between autoimmune diseases and X-chromosome inactivation?

I was reading about the necessity of niche formations to adequate development of blood progenitors and this idea reminded me of the patchy inactivation of the X chromosome which followed that maybe, ...
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3answers
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Cell identification by Body Cells

How do the B-cells and T-cells recognize or distinguish a body cell from a foreign particle? I suspect something to do with this causes Auto Immune Disorders.
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Immunity during pregnancy

I have learnt that our immune system distinguishes self from non-self by using MHC. So a mother during pregnancy should also develop antibodies against the fetus as it is also a genetically different ...