Questions tagged [calcium]

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Why calcitriol inhibits PTH synthesis

Calcitriol increases the calcium concentration of the blood and so does PTH. But calcitriol inhibits the synthesis of PTH. Why? Why would it inhibit something that would help it to increase the ...
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Performing histology on undecalcified tissue

Performing histology on tissue containing calcification - without performing decalcification of the tissue - is a challenging problem. There are currently a few methods to overcome these challenges ...
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What benefit do cardiomyocytes accrue by requiring calcium induced calcium release (relative to skeletal myocytes)?

According to 2 sources I've read, in contrast to skeletal myocytes, cardiac myocytes need calcium to diffuse in to result in contraction. One source says that they need large amounts of calcium to ...
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How do the maximum rates of calcium pumping compare between the calcium ATPases SERCA and PMCA

Two important Calcium ATPases found within cells are the Sarcoplasmic reticulum Ca2+ ATPase (SERCA) and the Plasma membrane Ca2+ ATPase (PMCA). Both use ATP to help maintain resting calcium ...
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How is Vitamin D deficiency linked to multiple sclerosis? [closed]

Numbness and tingling in various parts of the body can be linked to the deficiency if vitamin D in one's diet. Also, multiple sclerosis has Vitamin D deficiency as one of its risk factors. How exactly ...
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At what calcium concentration does the Sodium-Calcium Exchanger (NCX) "turn on"?

I am interested in the comparison between the Plasma Membrane Calcium ATPase (PMCA) and the Sodium-Calcium Exchanger (NCX) which are two pumps on the plasma membrane of cells that serve to move ...
2 votes
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What are "inactive" cells during Ca2+ imaging of neurons?

I am reading this paper, and have found the following Figure (Extended Data Figure 5) where they show maps of active cells in the amygdala as imaged with a miniscope and GCaMP6m: Legend: Using the ...
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Turning off the IP3 cascade

After PIP2 has been converted into IP3 and DAG by phospholipase C (PLC), some of the IP3 opens calcium channels in the endoplasmic reticulum and calcium ions can enter the cytoplasm. However, it is ...
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1 answer
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Why does hypocalcaemia cause increased muscle contraction?

Calcium is needed for muscle contraction, so how does hypocalcaemia cause increased sustained contraction?
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1 answer
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Where do the Ca ions that causes neurotransmitter release from synaptic bouton, come from?

I hope the information you share will help clarify the following doubts and gaps in my knowledge: Where do the Calcium ions in the influx (which then triggers the neurotransmitter vesicles) come from?...
2 votes
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What is the role of increased cytosolic calcium concentration after firing, in neuronal cell bodies?

I've come across several studies in which scientists were investigating various questions related to neural activity by focusing on neuronal cell bodies using Calcium imaging. As this article suggests ...
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How does coffee cause calcium loss in our body?

Recently on radio a doctor advices to reduce the consumption of coffee as it leads to calcium loss(as my mother described). My initial response was: How could such thing be possible? What kind of ...
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1 vote
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What causes a tendinopathy to calcify?

I read in this 2012 research paper {1}: The aetiopathogenesis of CT [calcific tendinopathy] is still controversial, but seems to be the result of an active cell-mediated process and a localized ...
2 votes
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How much does calcium reduce iron absorption?

Generally calcium inhibits the absorption of iron, but to what extent? One atom of calcium will not block 100% of iron absorption, that clearly isn't feasible. On the other hand, if someone ate 10 ...
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Scaling of Ca2+/biochemical signals with dendritic spine size?

I am looking for references that discuss the scaling of biochemical signals in dendritic spines with spine size/synaptic strength. A recent paper (Walker et al. 2017) reports attenuation of NMDA ...
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Calcium and nitric oxide: does a numerical relationship exist?

Currently, I am trying to understand how nitric oxide and calcium are related during the production of the former (I am not a biologist nor a chemist, so my knowledge about these topics is very poor). ...
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1 answer
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Calcium concentration in activated dendritic spines?

What are the typical calcium levels reached in single postsynaptic spines following activation of NMDA receptors by an EPSP or backpropagating spike? Everyone seems to refer to that one Neuron paper (...
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Can the calcification response of a marine organisms, at different pH conditions, be assessed by the calcium magnesium ratio?

Can the calcification response of a marine organisms, at different pH conditions, be assessed by the calcium magnesium ratio? the calcium magnesium ratio is a proxy of calcification?
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How to induce a steady increase in cyctoplasmic [Ca2+] in HEK293T cells? And is there any simple marker/method to confirm it?

We are trying to find out whether increase or decrease of cytoplasmic calcium concentration affects the interaction of two proteins, using co-IP in HEK293T cells as a readout. In different forums and ...
2 votes
1 answer
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Has anyone modelled calcium oscillations using Matlab software? [closed]

I have been trying to model calcium oscillations using MatLab, but I cannot obtain the oscillation. I created a function where I put all the equations and used ode15s to call the function. I have ...
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Effect of extremely hard water on marine life?

When researching water quality standards, I found that a minimum and maximum was set for water hardness. Several sources also state that water can in fact be too hard. The question is how does hard ...
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Which hormones/factors affect Calcium absorption in the small intestine and its regulation?

I think the question is very broad and cannot find precise mechanisms. I am not sure about the precise mechanisms of the regulation. I think they are at least Vitamin D, diffusion and specific ...