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Questions tagged [cancer]

A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

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Why don't rates of cancer increase generation to generation?

As cells divide, they accumulate mutations that can sometimes cause cancer. Gametes have to divide like any other cell, and thus generation to generation mutations should accumulate in people's ...
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Can a dividing cell that skipped DNA replication become cancerous?

Let's assume that a cell fails to replicate its DNA during the S Phase of the cell cycle. Let's also assume that the appropriate CDKs are inactive (perhaps due to mutation or lack of cyclin proteins ...
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For a luekemia patient - how does the chemotherapy fixes the bone marrow to not produce immature cells

For ALL patient this link says 90% of the children are cured. It has high survival rate. From what I understand is that - luekemia is type of cancer where the immature cells does not turn into ...
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Fluoroquinolone mitochondrial and genomic DNA adduct

What could be possible consequences of covalent bond mitochondrial and genomic DNA adduct by Fluoroquinolones, our study was done by Fluoroquinolone Toxicity Study NFP. All 50+ participates who took ...
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3answers
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Can a cancerous cell from outside cause cancer in a healthy person?

If a cancerous cell enters the body of a healthy person from someone else's blood or something, will that healthy person get cancer? In human beings.
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1answer
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Chance of cancer as a function of smoking frequency

I was wondering if there is some kind of known relation between the chance of getting cancer and the frequency of smoking cigarettes. A quick Google search did not yield results. Would any of you ...
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1answer
41 views

What don't we know about cancer? [closed]

I was wondering, after decades of research what we do not know about Cancer yet as in what unanswered questions are still puzzling biologists about cancer? I have read that cancer research, in its ...
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3answers
125 views

can a bacterium cell become a cancer?

I don't mean if a bacterium can be the cause of cancer inside a human. But can actually a bacterium changes in the way as normal cells change into tumor cells? So gaining such characteristics of a ...
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19 views

What is oxygen used for in cancer cells other than respiration?

This question stems from a reflection I had on cancer cells: It is known that cancer cells switching from aerobic respiration to anaerobic metabolism. Hence, they should be able to survive in the ...
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1answer
162 views

Can mitochondria become cancerous?

Given that mitochondria have their own DNA and can replicate independently, can they ever become cancerous? For example, could a mutation in their DNA cause them to rapidly replicate, ultimately ...
2
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1answer
106 views

Can oral baking soda effect tumor cells in mice

Could anyone explain me please, how exactly (according to research article in Cell journal) adding the baking soda in drinking water can influence the acidity of tumor cells? What about homeostasis ...
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1answer
50 views

Why telomere shortening slowing down cancer?

I am reading Alternative Lengthening of Telomeres in Mammalian Cells, about how telomeres linked to human cancers. Due to the end-replication problem,5,6 the ends of linear chromosomes shorten ...
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Why is CLL B-Cell leukemia t(12;21) more responsive to chemotherapy?

Chronic Lympoid Leukemia targeting B-Cell (with the particular translocation mutation on chromosome 12 and 21) is known to be more responsive to chemotherapy. Is there a known molecular mechanism for ...
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2answers
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Can you eat cancer cells without risk?

Afaik GMO products are not a real risk to health of course if they do not contain toxins. But how about cancer cells? Like say rhabdomyosarcoma which is more or less a muscle cancer found also in ...
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0answers
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How does latency in carcinogenisis differ from the effect of chance?

Most chemically induced cancers seem to have a long latency between exposure to the carcinogen and expression of the disease. Mesothelioma typically 30-40 years, bladder cancer about 20 years, for ...
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What are the normal IC50 values for doxorubicin at 48h and 72h?

Different IC50 values are reported in papers for the U937, K562 cell lines and PBMC and all of them are given on ng ml. I do not understand well, why these values change too much, even if the ...
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1answer
96 views

Can a plasmid cause cancer? [closed]

Can a plasmid cause cancer? According to wikipedia, plasmids are normally present in bacteria They (plasmids) are normally present in bacteria , and sometimes in eukaryotic organisms such as yeast [...
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1answer
159 views

Why are only few cigarette smokers prone to cancer?

It's tacit that only a few populace of smokers get cancer. What spares the others from it or what specifically cause cancer in those populace? See this Washington Post Article
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Prerequisites for Weinberg's “Biology of Cancer” [duplicate]

I'm a PhD mathematician who recently became interested in mathematical biology, specifically cancer modeling, and I figured I should educate myself a little better on the biology. So, I picked up "...
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1answer
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Is a large tumor is more likely to develop hypoxic regions?

It is known that cancerous tumors in humans can develop hypoxic regions where no blood nor oxygen arrive to some volume of its cells, creating a dead lump inside or around the tumor. See Wikipedia - ...
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2answers
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Is glyphosate carcinogenic?

I'm trying to understand if glyphosate is carcinogenic. The information in internet is very confusing. There are many ecological oriented websites which claim it's carcinogenic which I suppose they ...
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1answer
61 views

What is the meaning of “Rb is in the active state”?

I am reading about cyclins, cdks and Rb (Retinoblastoma) and some of the terminology is not clear to me. I understand that when CDK phosphorylates Rb, it disconnects from E2F, and E2F can act as a ...
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1answer
57 views

Does a certain tumor type being invasive mean that it is highly metastatic?

Does a certain tumor type being invasive mean that it is highly metastatic? Thanks
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2answers
176 views

Distinction between primary and secondary tumor

How can a primary tumor be distinguished from a secondary tumor? I tried finding it on the internet but it only said that they are found by means of immunohistology but I couldn't understand how....
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Can metabolically inactive cells still replicate? pertaining to mitochondria specifically

If some drug acts on mitochondrial enzymes (probably dehydrogenases) and inhibits their activity; could cell still replicate or undergo mitosis via some other means? Is Cell proliferation possible ...
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0answers
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What is(are) the mechanism(s) that stop cells from fusing in vivo?

I just learned about the phenomenon of 'cell fusion' in which two diploid somatic cells can combine into some aneuploid cell in vitro and proceed to proliferate in culture. Apparently this can even ...
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0answers
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could an organism have 100% cancer cells?=

for example could a simple multi-celular organisme have all the cells with cancer ? for example the cancer cells advance and replace the normal cells so the organism would be practically inmortal ...
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1answer
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Is it possible to make a cancer cell that doesn’t encode any neoantigens?

The cell still has mutations, but those mutations only occur in the noncoding sequences, such as promoters, which drives over expression of proto-oncogenes and downregulation of tumor suppressor genes....
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Cancer stem cell undergoes asymmetric divison?

Does cancer stem cell undergo asymmetric division to produce one cancer stem cell and one cancer cell? Is this the reason for heterogeneity found in cancer?
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Cancer Growth Time-Series

I am working on an exercise in developing mathematical models of tumour growth. So far, most of the models I have found in publications employ a qualitative approach to verification, stating that the ...
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1answer
72 views

What is the precise mechanism by which exercise reduces chance of cancer?

Sources like this: http://www.cancerresearchuk.org/about-cancer/causes-of-cancer/physical-activity-and-cancer/how-physical-activity-prevents-cancer point out that we can reduce our risk of some ...
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1answer
80 views

Which cancers are routinely treated with anti-angiogenic therapy? [closed]

I have been asked to discuss 2 of these cancers and how the therapy is used. I understand angiogenesis and its role in tumour progression, but need some help in explaining how the therapy is used.
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Can DNA Methylation data of different samples from Human Methylation 27 and 450 platforms be combined using common set of 25,978 CpG sites?

I am studying the Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) data set of TCGA. The DNA methylation datatype has 200 samples from Human Methylation 27 platform and 300 samples from Human Methylation ...
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1answer
54 views

Tumour cell injection into a mice [closed]

I am going to inject mice tumour cells into mice to create them tumours and I am wondering if I need to have special precautions for that, even they are cells from mice tumour I am afraid what can ...
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1answer
36 views

Can cancer cells transmit from one organism to another?

I know cancer cells are very resilient, so would it be possible for them to survive outside of the original organism for long enough to be absorbed by another? Furthermore, would that type of "...
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1answer
242 views

How long does it take for cancer to be detectable if it grows from a single cell? [closed]

Assuming cancer has its origins at a single malfunctioning cell, how long would it take for that cell to grow from the point at which it is malfunctioning enough so that it can be detected by the ...
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1answer
112 views

Are new blood vessels able to deliver oxygen to hypoxic tissue before the establishment of blood circulation?

Sprouting angiogenesis - the growth of new blood vessels from a preexisting vasculature - can be triggered by cells in hypoxia in order to re-stablish the oxygen and nutrients supply to the tissue. ...
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Does anyone know of a table/matrix that shows me relationships between cancer types?

Does anyone know of a table that links different cancers/can visually show me through a table or network whether the incidence of one cancer affects the incidence of a second cancer? I imagine the ...
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0answers
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How is increase in breast cancer to rapid to be explained by genetics alone?

I have been told that if it was purely genetic it would take 25 years to pass from generation to the next, suggesting it is to do with the environment and epigenetics. How does it suggest it is to do ...
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1answer
336 views

Can neurons become cancerous?

I've been reading about brain cancer lately, and something I've noticed is that the tumors seem to start in all tissues, except neural tissue. Am I missing something, or is there an explanation?
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2answers
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CDK3 1 simple coding mutation/missense mutations (S106N) glioma

I found the below quotation in (Peyressatre, 2015) CDK3 1 simple coding mutation/missense mutations (S106N) glioma [135] The author has cited a database but not a paper. I want to find the ...
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3answers
140 views

Why is cancer more lethal than (hypothetical)infections?

I am a computer science student and I'm interested in algorithmic aspects of cancer! Once I heard that there exist more bacteria in human body than our own cells, I wondered that why bacteria, which ...
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3answers
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do tumour cells begin with abnormal characteristics?

At what point in the cell cycle do cells start to become tumorous? Do they have abnormal characteristics to begin with; if so what are they?
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Treatment validation on mouse models

I am struggling to set up a project proposal for validation of a known treatment for metastatic colorectal cancer in mouse models. I want to see how SNPs in patients contribute to their drug ...
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0answers
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Embolism risk in cancer [closed]

Why is there an increased risk of embolism in any malignancy? I studied that malignancy is a risk factor for pulmonary embolism. Can someone explain me the exact mechanism under which malignancy ...
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2answers
1k views

Why are tumor suppressor genes recessive?

In my Intro. to Biochemistry course, we have been studying cancer. The professor has pointed out that tumor suppressor genes are "recessive" while proto-oncogenes are "dominant". Since only one ...
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1answer
35 views

autophagy and cell division

I know that cell division goes on only if the cell receives the go-ahead signal. What happens to the cells that don' t receive the signal? (except those that stay in G0 ) I also want to know about the ...
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0answers
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Characterising mechanisms responsible for generating structural variants

I have a high-quality set of structural variant breakpoints from tumour/normal WGS data, and I am interested in digging into the various mechanisms that might be involved in each event. There are ...
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119 views

How medical studies induce cancer in lab animals?

To test the effectiveness of drugs, they are typically tested on animals. How cancer is induced in lab animals to test the effectiveness of cancer drugs?
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1answer
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Which matched normal(s) to use when computing CNAs from exome data with a Read-Depth approach

I want to use a Read-Depth algorithm to call copy number alterations (CNAs) from Whole Exome Sequencing data (WES) of a specific tumor. I have a set of WES tumor samples, some of which also have the ...