Questions tagged [cancer]

A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

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Why aren't purine analogs effective in non-hematological malignancies?

FDA has approved many purine analogs e.g. thioguanine, cladribine, pentostatin, mercaptopurine for various forms of leukemia and lymphoma, but none for non-hematological malignancies. What makes non-...
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70 views

Why are smaller mammals more prone to cancer and tumors

especially rats and mice usually develop cancer and tumors very fast, reducing their life expectancy. From an evolutionary point of view, how come that these mammals are so prone to cancer and tumors ...
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Why might long telomeres be selected for in laboratory mice?

In a recent episode of The Portal, Eric Weinstein sits down with his brother Bret Weinstein to discuss Bret's Reserve-Capacity Hypothesis. It's an incredible story of scientific discovery and and ...
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47 views

Circulating Tumor Cell vs Circulating Tumor DNA

I'm a little confused about the wording of these two phrases and under which context the epithelial-mesenchymal transition occurs. For example: Is it the circulating tumor cell that releases the ...
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Does anyone know any statistics about the rate of cell division of malignant cells?

I've tried to look online to find some statistical data about the rate of growth of any type of cancerous cells, but haven't been able to find any. Would anyone know an appropriate time period for a ...
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Is it safe to work with HeLa cells?

Hela cells are infected with HPV. So is it safe to work with them? What are the safety precautions?
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What determines new neuron/astrocyte survival?

I'm asking because I noticed that supplements like tumeric and Reserval cause apoptosis in cancer cells specifically. And my question is basically how does the body know which ones are cancer cells? I ...
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Are all carcinogens mutagens?

I assume that all carcinogens must be mutagens, but I've read that this is not the case. However, I can't find any good examples or an explanation of why it is not the case. How can a non-mutagenic ...
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KRAS gene and K-Ras Mutations

This question pertains to the KRAS wikipedia page, and I just want to double check and clarify my own understanding of how this mutation works in cancer. It states: K-Ras protein acts like a ...
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58 views

A question about cancer antigens and their mechanism [closed]

Can you name the most common antigen that cancer cells in general can't live without?
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Which sample type is more proper for whole genome sequencing in AML patients? Peripheral blood or bone marrow?

I intend to perform whole genome sequencing in AML patients in order to find genomic abnormalities, particularly translocation and gene fusions. However, I am not sure whether it is better to obtain ...
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86 views

How do tumor cells 'gravitate' towards each other?

In a popular article it is mentioned that in centrifugal experiments with cancer cells that When subjected to microgravity-conditions, the cancer cells were unable to sense each other and therefore ...
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Can primary tumor cells grow in 2D culture? [closed]

Is it possible to expand primary tumor cells in 2D culture? Are they adherent cells? Do you have any experience especially with culturing non-small cell lung cancer in 2D? Thank you.
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Could tumor cells have normal genomic profiles?

I have thawed primary tumor cells and performed FACS. They were EpCAM positive cells. Then, I expanded them as organoids in 3D and did another FACS analysis. Again, they were EpCAM positive. I also ...
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Can a drug induce specific mechanism of resistance in tumors?

For example, can a drug that targets a given protein induce overexpression of that protein or increase the copy number of the gene coding that protein? I strongly suspect that antineoplastic ...
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How to deal with water insoluble drug for drug release experiment?

I am doing drug release experiment of Rapamycin which is loaded in micelles. the release medium is PBS with acidic and basic pH with tween 80. the questions are: Rapamycin is water insoluble, can the ...
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35 views

Is p53 a cyclin dependent kinase? [closed]

I've been reading some research papers about p53 and associated tumour suppressor proteins, such as p21. I see them referred to and associated with cyclin-dependent kinases. Is p53,p63 et cetera part ...
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What is the substance that tumors release that stimulates growth of blood vessels but suppresses its release from other tumors?

I'm currently in high school and I am working on a cancer research project. My project consists of a cancer, and different ways to treat it. I have a set of benign tumor and I was thinking of ...
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57 views

Where does the number 67 in the nuclear protein/antigen Ki-67 come from? Why not 66 or 68?

I have read in in the original paper that in the year 1983 a research group in Kiel, Germany (that's where the Ki- in the name comes from) developed monoclonal mouse antibodies against Hodgkin ...
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How do mutations and protein synthesis link to cancer?

How do mutations and protein synthesis link to cancer? I know that a mutation in DNA can cause the triplet code on the mRNA to change so different amini acids are made and a different order means a ...
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What does “radiographic progression” mean in cancer?

I tried looking up the definition of the term "radiographic progression" using Google and medical dictionary, etc., but I couldn't find its meaning anywhere. All research articles that I found just ...
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Are tumor-associated antigens unique to cancerous cells?

Are tumor-associated antigens found only on the membrane of cancerous cells or just over-expressed on the membrane of carcinogenic cells? In other words, are these antigens also found on healthy ...
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44 views

Non-coding DNA as a protection to deleterious mutations

We know that most part of our genome (at least 75 percent) is non-coding DNA. Can it be a way to protect the organism from mutations in important genes, such as the ones which control cellular cycle, ...
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42 views

Which chemokines are being produced by melanocytes?

I am looking into Vitiligo it's an autoimmune disease that results in apoptosis of melanocytes due to misfolded protein accumulation. It also dramatically increases breast cancer rates (600 times) ...
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Does anyone know a good pancreatic-cancer metastasis cell line?

Researching about pancreatic cancer. We have mostly "main-tumor" cell lines in our lab, and I´m currently looking for cell lines originating from metastases (liver, lung, etc.). Does anyone know a ...
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How to troubleshoot in vitro formaldehyde fixation for nucleosomes?

For an experiment, I am trying to fix the mononucleosomes (100ng) using formaldehyde as crosslinking agent in HEPES buffer. I have been using 2% formaldehyde in a reaction buffer containing 1mM EDTA, ...
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54 views

Are these 2 procedures to fight cancer (cancer “vaccine”, and cancer drugs which can attack all tumours) related?

Last year appeared the new of a cancer "vaccine" (not a vaccine in the traditional sense) tested in animals for 4 types of cancer and which worked in 97% of the cases to eliminate already existent ...
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Explain to a layperson how cigarettes smoke might cause cancer

I have a very intelligent friend who is a light smoker, and also a Biology layperson. I wondered whether understanding exactly how cigarettes smoke can cause cancer, might encourage him to smoke less ...
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103 views

If we can make magic bullets that are basically artificial antibodies, why has a cure for cancer not yet been developed? [closed]

So protonsil and salvarsan 606 where both used as the first magic bullets in the modern period of medicine in the 1900s. However, if we can create artificial antibodies that target specific diseases ...
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what causes epigenetic dysregulation in cancer?

Do mutations in regulatory gene sequences lead to changes in epigenetic alterations in cancer, and if so which ones? I know abnormal hypermethylation of GCP islands occurs in promoters of tumour ...
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Weight of fresh vs frozen tumours

I have some mouse tumours that have been snap frozen in liquid nitrogen following an in vivo study, and I thought it might be interesting to also determine the weight of the tumours. I was wondering ...
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Need help in identifying and understanding the origin of an expression variant

We usually denote the origin of a mutation as either somatic or germline. This information is usually available in certain databases such as CIVIC, ClinVar, COSMIC etc. But when we come to variants ...
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Can radiation exposure cause cancer later in life even if no traces of radioactive material are present in the body anymore?

I had a long-lasting debate with a friend of mine about the Fukushima incident. The question that we tried to solve was if radiation or toxin exposure can cause cancer later in life even if no ...
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86 views

Are all fusion genes somatic in origin or can fusion genes be germline?

Fusion genes should have an origin.These are essentially hybrid genes that are translocated in its entirety. Eg. BCR-ABL, EML4-ALK are known to be implicated in cancer pathogenesis. Do these ...
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Why are babies rarely born with cancer?

Childhood cancer is fundamentally a disease of dysregulated development. Why does it rarely occur during the fetal period, a time of enormous growth and development?
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What is a Archival Tumor Tissue ? For What Purpose is it collected?

Over the course of Conducting trials various tissue and tumor samples are collected from the patients. One such sample is the Archival Tumor Tissue. Could someone kindly clarify what is the meaning ...
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Why do BRAF mutations appear more in skin cutaneous melanoma?

When looking at the tissue expression of the BRAF protein it seems that BRAF is regularly expressed in almost all of the tissues. There is elevated expression in tissues like the Testis and the ...
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What part of the skin is damaged under sun exposure?

How exactly does extensive sun exposure lead to skin damage and increase cancer risk. In which part of the skin is the sun doing the most damage. Is it in the epidermis or beneath ? I would like to ...
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1answer
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Do mutated c-sis oncogenes only affect cell growth?

Since c-sis regulates only cell growth, a mutation there should only lead to an out of control growth of the cell, but the cells would still be mature, since c-sis does not regulate the function or ...
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Can a hydra get cancer?

Because hydras have immune systems, telomerase activity, and Piwi-piRNA like cancer cells I wonder if they can get cancer?
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Why don't rates of cancer increase generation to generation?

As cells divide, they accumulate mutations that can sometimes cause cancer. Gametes have to divide like any other cell, and thus generation to generation mutations should accumulate in people's ...
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Can a dividing cell that skipped DNA replication become cancerous?

Let's assume that a cell fails to replicate its DNA during the S Phase of the cell cycle. Let's also assume that the appropriate CDKs are inactive (perhaps due to mutation or lack of cyclin proteins ...
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For a luekemia patient - how does the chemotherapy fixes the bone marrow to not produce immature cells

For ALL patient this link says 90% of the children are cured. It has high survival rate. From what I understand is that - luekemia is type of cancer where the immature cells does not turn into ...
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Fluoroquinolone mitochondrial and genomic DNA adduct

What could be possible consequences of covalent bond mitochondrial and genomic DNA adduct by Fluoroquinolones, our study was done by Fluoroquinolone Toxicity Study NFP. All 50+ participates who took ...
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Can a cancerous cell from outside cause cancer in a healthy person?

If a cancerous cell enters the body of a healthy person from someone else's blood or something, will that healthy person get cancer? In human beings.
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Chance of cancer as a function of smoking frequency

I was wondering if there is some kind of known relation between the chance of getting cancer and the frequency of smoking cigarettes. A quick Google search did not yield results. Would any of you ...
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What don't we know about cancer? [closed]

I was wondering, after decades of research what we do not know about Cancer yet as in what unanswered questions are still puzzling biologists about cancer? I have read that cancer research, in its ...
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314 views

can a bacterium cell become a cancer?

I don't mean if a bacterium can be the cause of cancer inside a human. But can actually a bacterium changes in the way as normal cells change into tumor cells? So gaining such characteristics of a ...
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279 views

Can mitochondria become cancerous?

Given that mitochondria have their own DNA and can replicate independently, can they ever become cancerous? For example, could a mutation in their DNA cause them to rapidly replicate, ultimately ...
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145 views

Can oral baking soda effect tumor cells in mice

Could anyone explain me please, how exactly (according to research article in Cell journal) adding the baking soda in drinking water can influence the acidity of tumor cells? What about homeostasis ...

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