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A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

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1answer
58 views

Can oral baking soda effect tumor cells in mice

Could anyone explain me please, how exactly (according to research article in Cell journal) adding the baking soda in drinking water can influence the acidity of tumor cells? What about homeostasis ...
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0answers
9 views

EJ138 bladder cancer cell line

My question is about EJ138 bladder cancer cell line. Is there any mutation in this cell line, esp in TP53 gene?
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1answer
34 views

Why telomere shortening slowing down cancer?

I am reading Alternative Lengthening of Telomeres in Mammalian Cells, about how telomeres linked to human cancers. Due to the end-replication problem,5,6 the ends of linear chromosomes shorten ...
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0answers
14 views

Why is CLL B-Cell leukemia t(12;21) more responsive to chemotherapy?

Chronic Lympoid Leukemia targeting B-Cell (with the particular translocation mutation on chromosome 12 and 21) is known to be more responsive to chemotherapy. Is there a known molecular mechanism for ...
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2answers
96 views

Can you eat cancer cells without risk?

Afaik GMO products are not a real risk to health of course if they do not contain toxins. But how about cancer cells? Like say rhabdomyosarcoma which is more or less a muscle cancer found also in ...
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0answers
15 views

How does latency in carcinogenisis differ from the effect of chance?

Most chemically induced cancers seem to have a long latency between exposure to the carcinogen and expression of the disease. Mesothelioma typically 30-40 years, bladder cancer about 20 years, for ...
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0answers
19 views

What are the normal IC50 values for doxorubicin at 48h and 72h?

Different IC50 values are reported in papers for the U937, K562 cell lines and PBMC and all of them are given on ng ml. I do not understand well, why these values change too much, even if the ...
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1answer
76 views

Can a plasmid cause cancer? [closed]

Can a plasmid cause cancer? According to wikipedia, plasmids are normally present in bacteria They (plasmids) are normally present in bacteria , and sometimes in eukaryotic organisms such as yeast [...
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1answer
128 views

Why are only few cigarette smokers prone to cancer?

It's tacit that only a few populace of smokers get cancer. What spares the others from it or what specifically cause cancer in those populace? See this Washington Post Article
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0answers
15 views

Prerequisites for Weinberg's “Biology of Cancer” [duplicate]

I'm a PhD mathematician who recently became interested in mathematical biology, specifically cancer modeling, and I figured I should educate myself a little better on the biology. So, I picked up "...
2
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1answer
57 views

Is a large tumor is more likely to develop hypoxic regions?

It is known that cancerous tumors in humans can develop hypoxic regions where no blood nor oxygen arrive to some volume of its cells, creating a dead lump inside or around the tumor. See Wikipedia - ...
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1answer
51 views

is glyphosate cancerogenic?

I'm trying to understand if glyphosate is cancerogenic. The information in internet is very confusing. There are many ecological oriented websites which claim it's cancerogenic which I suppose they ...
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1answer
28 views

What is the meaning of “Rb is in the active state”?

I am reading about cyclins, cdks and Rb (Retinoblastoma) and some of the terminology is not clear to me. I understand that when CDK phosphorylates Rb, it disconnects from E2F, and E2F can act as a ...
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1answer
39 views

Does a certain tumor type being invasive mean that it is highly metastatic?

Does a certain tumor type being invasive mean that it is highly metastatic? Thanks
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2answers
76 views

Distinction between primary and secondary tumor

How can a primary tumor be distinguished from a secondary tumor? I tried finding it on the internet but it only said that they are found by means of immunohistology but I couldn't understand how....
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0answers
45 views

Can metabolically inactive cells still replicate? pertaining to mitochondria specifically

If some drug acts on mitochondrial enzymes (probably dehydrogenases) and inhibits their activity; could cell still replicate or undergo mitosis via some other means? Is Cell proliferation possible ...
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0answers
20 views

What is(are) the mechanism(s) that stop cells from fusing in vivo?

I just learned about the phenomenon of 'cell fusion' in which two diploid somatic cells can combine into some aneuploid cell in vitro and proceed to proliferate in culture. Apparently this can even ...
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0answers
24 views

could an organism have 100% cancer cells?=

for example could a simple multi-celular organisme have all the cells with cancer ? for example the cancer cells advance and replace the normal cells so the organism would be practically inmortal ...
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1answer
47 views

Is it possible to make a cancer cell that doesn’t encode any neoantigens?

The cell still has mutations, but those mutations only occur in the noncoding sequences, such as promoters, which drives over expression of proto-oncogenes and downregulation of tumor suppressor genes....
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0answers
13 views

Cancer stem cell undergoes asymmetric divison?

Does cancer stem cell undergo asymmetric division to produce one cancer stem cell and one cancer cell? Is this the reason for heterogeneity found in cancer?
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0answers
22 views

Cancer Growth Time-Series

I am working on an exercise in developing mathematical models of tumour growth. So far, most of the models I have found in publications employ a qualitative approach to verification, stating that the ...
3
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1answer
59 views

What is the precise mechanism by which exercise reduces chance of cancer?

Sources like this: http://www.cancerresearchuk.org/about-cancer/causes-of-cancer/physical-activity-and-cancer/how-physical-activity-prevents-cancer point out that we can reduce our risk of some ...
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1answer
44 views

Which cancers are routinely treated with anti-angiogenic therapy? [closed]

I have been asked to discuss 2 of these cancers and how the therapy is used. I understand angiogenesis and its role in tumour progression, but need some help in explaining how the therapy is used.
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0answers
12 views

Can DNA Methylation data of different samples from Human Methylation 27 and 450 platforms be combined using common set of 25,978 CpG sites?

I am studying the Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) data set of TCGA. The DNA methylation datatype has 200 samples from Human Methylation 27 platform and 300 samples from Human Methylation ...
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1answer
50 views

Tumour cell injection into a mice [closed]

I am going to inject mice tumour cells into mice to create them tumours and I am wondering if I need to have special precautions for that, even they are cells from mice tumour I am afraid what can ...
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1answer
30 views

Can cancer cells transmit from one organism to another?

I know cancer cells are very resilient, so would it be possible for them to survive outside of the original organism for long enough to be absorbed by another? Furthermore, would that type of "...
0
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1answer
105 views

How long does it take for cancer to be detectable if it grows from a single cell? [closed]

Assuming cancer has its origins at a single malfunctioning cell, how long would it take for that cell to grow from the point at which it is malfunctioning enough so that it can be detected by the ...
5
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1answer
107 views

Are new blood vessels able to deliver oxygen to hypoxic tissue before the establishment of blood circulation?

Sprouting angiogenesis - the growth of new blood vessels from a preexisting vasculature - can be triggered by cells in hypoxia in order to re-stablish the oxygen and nutrients supply to the tissue. ...
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0answers
15 views

Does anyone know of a table/matrix that shows me relationships between cancer types?

Does anyone know of a table that links different cancers/can visually show me through a table or network whether the incidence of one cancer affects the incidence of a second cancer? I imagine the ...
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0answers
19 views

How is increase in breast cancer to rapid to be explained by genetics alone?

I have been told that if it was purely genetic it would take 25 years to pass from generation to the next, suggesting it is to do with the environment and epigenetics. How does it suggest it is to do ...
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0answers
8 views

Interleukins vs Interleukin Signal Transducer

Can someone explain what this difference is between an Interleukin and an interleukin signal transducer? Like the difference between IL6 and IL6ST.
2
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1answer
171 views

Can neurons become cancerous?

I've been reading about brain cancer lately, and something I've noticed is that the tumors seem to start in all tissues, except neural tissue. Am I missing something, or is there an explanation?
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2answers
23 views

CDK3 1 simple coding mutation/missense mutations (S106N) glioma

I found the below quotation in (Peyressatre, 2015) CDK3 1 simple coding mutation/missense mutations (S106N) glioma [135] The author has cited a database but not a paper. I want to find the ...
3
votes
3answers
128 views

Why is cancer more lethal than (hypothetical)infections?

I am a computer science student and I'm interested in algorithmic aspects of cancer! Once I heard that there exist more bacteria in human body than our own cells, I wondered that why bacteria, which ...
2
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3answers
68 views

do tumour cells begin with abnormal characteristics?

At what point in the cell cycle do cells start to become tumorous? Do they have abnormal characteristics to begin with; if so what are they?
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0answers
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Treatment validation on mouse models

I am struggling to set up a project proposal for validation of a known treatment for metastatic colorectal cancer in mouse models. I want to see how SNPs in patients contribute to their drug ...
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0answers
9 views

Embolism risk in cancer [closed]

Why is there an increased risk of embolism in any malignancy? I studied that malignancy is a risk factor for pulmonary embolism. Can someone explain me the exact mechanism under which malignancy ...
3
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2answers
530 views

Why are tumor suppressor genes recessive?

In my Intro. to Biochemistry course, we have been studying cancer. The professor has pointed out that tumor suppressor genes are "recessive" while proto-oncogenes are "dominant". Since only one ...
0
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1answer
29 views

autophagy and cell division

I know that cell division goes on only if the cell receives the go-ahead signal. What happens to the cells that don' t receive the signal? (except those that stay in G0 ) I also want to know about the ...
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0answers
20 views

Characterising mechanisms responsible for generating structural variants

I have a high-quality set of structural variant breakpoints from tumour/normal WGS data, and I am interested in digging into the various mechanisms that might be involved in each event. There are ...
0
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0answers
76 views

How medical studies induce cancer in lab animals?

To test the effectiveness of drugs, they are typically tested on animals. How cancer is induced in lab animals to test the effectiveness of cancer drugs?
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1answer
19 views

Which matched normal(s) to use when computing CNAs from exome data with a Read-Depth approach

I want to use a Read-Depth algorithm to call copy number alterations (CNAs) from Whole Exome Sequencing data (WES) of a specific tumor. I have a set of WES tumor samples, some of which also have the ...
0
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1answer
61 views

Are there foods which not only prevent but help fighting cancer?

I was reading a probably not to serious webpage and I found this quote " Certain types of vegetables, such as the cruciferous variety, are not only nutrient-dense but contain compounds that may ...
2
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1answer
44 views

Warburg effect in lung carcinoma, the logic?

Outside of 'purposefully' removing mitochondria to diffuse cytochrome C's apoptotic threat, I would assume that lung carcinomas, and their proximity to high oxygen levels, would have the lowest rate ...
2
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1answer
66 views

What is functional dissection?

Reading [1] I found the sentence: Consistently, functional dissection of mouse and human wild-type and mutant RAS isogenic leukemia cells demonstrated induction of methotrexate resistance but also ...
0
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1answer
35 views

Importance of germline and somatic genomic mutations to the purpose of treatment in cancer

Is there a hierarchy in the sets of genomic mutations (somatic and germline) to the purpose of treatment in cancer? Can they be considered at the same level in the context of targeted therapy or are ...
1
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1answer
81 views

Cancer and Evolution [duplicate]

Edit: just to clarify, I am asking what, if anything, the literature says can be gleaned about evolution by studying cancer, especially relating to how multicellularity evolved and the traits used to ...
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1answer
165 views

What is the definition of Mitotic Index?

Sometimes I find Mitotic Index defined as (i) the number of dividing cells over the number of non-dividing cells, other times as the (ii) the number of dividing cells over the total number of cells... ...
1
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1answer
51 views

How can cancer preventing genes from animals be transferred to humans? [closed]

I recently read this non-peer reviewed article that states that the prevalence of cancer in crocodiles or elephants is really low, much lower than humans. It is said below A team of researchers ...
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1answer
231 views

What is the first recorded unambiguous case of childhood cancer? [closed]

I can't seem to find any references to childhood cancer going far back. I am asking for the first verifiable instance of childhood cancer.