Questions tagged [cancer]

A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

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What is a Archival Tumor Tissue ? For What Purpose is it collected?

Over the course of Conducting trials various tissue and tumor samples are collected from the patients. One such sample is the Archival Tumor Tissue. Could someone kindly clarify what is the meaning ...
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Why do BRAF mutations appear more in skin cutaneous melanoma?

When looking at the tissue expression of the BRAF protein it seems that BRAF is regularly expressed in almost all of the tissues. There is elevated expression in tissues like the Testis and the ...
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What part of the skin is damaged under sun exposure?

How exactly does extensive sun exposure lead to skin damage and increase cancer risk. In which part of the skin is the sun doing the most damage. Is it in the epidermis or beneath ? I would like to ...
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Do mutated c-sis oncogenes only affect cell growth?

Since c-sis regulates only cell growth, a mutation there should only lead to an out of control growth of the cell, but the cells would still be mature, since c-sis does not regulate the function or ...
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Can a hydra get cancer?

Because hydras have immune systems, telomerase activity, and Piwi-piRNA like cancer cells I wonder if they can get cancer?
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Why don't rates of cancer increase generation to generation?

As cells divide, they accumulate mutations that can sometimes cause cancer. Gametes have to divide like any other cell, and thus generation to generation mutations should accumulate in people's ...
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Can a dividing cell that skipped DNA replication become cancerous?

Let's assume that a cell fails to replicate its DNA during the S Phase of the cell cycle. Let's also assume that the appropriate CDKs are inactive (perhaps due to mutation or lack of cyclin proteins ...
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For a luekemia patient - how does the chemotherapy fixes the bone marrow to not produce immature cells

For ALL patient this link says 90% of the children are cured. It has high survival rate. From what I understand is that - luekemia is type of cancer where the immature cells does not turn into ...
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Fluoroquinolone mitochondrial and genomic DNA adduct

What could be possible consequences of covalent bond mitochondrial and genomic DNA adduct by Fluoroquinolones, our study was done by Fluoroquinolone Toxicity Study NFP. All 50+ participates who took ...
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Can a cancerous cell from outside cause cancer in a healthy person?

If a cancerous cell enters the body of a healthy person from someone else's blood or something, will that healthy person get cancer? In human beings.
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64 views

Chance of cancer as a function of smoking frequency

I was wondering if there is some kind of known relation between the chance of getting cancer and the frequency of smoking cigarettes. A quick Google search did not yield results. Would any of you ...
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54 views

What don't we know about cancer? [closed]

I was wondering, after decades of research what we do not know about Cancer yet as in what unanswered questions are still puzzling biologists about cancer? I have read that cancer research, in its ...
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can a bacterium cell become a cancer?

I don't mean if a bacterium can be the cause of cancer inside a human. But can actually a bacterium changes in the way as normal cells change into tumor cells? So gaining such characteristics of a ...
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Can mitochondria become cancerous?

Given that mitochondria have their own DNA and can replicate independently, can they ever become cancerous? For example, could a mutation in their DNA cause them to rapidly replicate, ultimately ...
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Can oral baking soda effect tumor cells in mice

Could anyone explain me please, how exactly (according to research article in Cell journal) adding the baking soda in drinking water can influence the acidity of tumor cells? What about homeostasis ...
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104 views

Why telomere shortening slowing down cancer?

I am reading Alternative Lengthening of Telomeres in Mammalian Cells, about how telomeres linked to human cancers. Due to the end-replication problem,5,6 the ends of linear chromosomes shorten ...
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Why is CLL B-Cell leukemia t(12;21) more responsive to chemotherapy?

Chronic Lympoid Leukemia targeting B-Cell (with the particular translocation mutation on chromosome 12 and 21) is known to be more responsive to chemotherapy. Is there a known molecular mechanism for ...
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Can you eat cancer cells without risk?

Afaik GMO products are not a real risk to health of course if they do not contain toxins. But how about cancer cells? Like say rhabdomyosarcoma which is more or less a muscle cancer found also in ...
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How does latency in carcinogenisis differ from the effect of chance?

Most chemically induced cancers seem to have a long latency between exposure to the carcinogen and expression of the disease. Mesothelioma typically 30-40 years, bladder cancer about 20 years, for ...
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137 views

Can a plasmid cause cancer? [closed]

Can a plasmid cause cancer? According to wikipedia, plasmids are normally present in bacteria They (plasmids) are normally present in bacteria , and sometimes in eukaryotic organisms such as yeast [...
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Why are only few cigarette smokers prone to cancer?

It's tacit that only a few populace of smokers get cancer. What spares the others from it or what specifically cause cancer in those populace? See this Washington Post Article
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Is a large tumor is more likely to develop hypoxic regions?

It is known that cancerous tumors in humans can develop hypoxic regions where no blood nor oxygen arrive to some volume of its cells, creating a dead lump inside or around the tumor. See Wikipedia - ...
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Is glyphosate carcinogenic?

I'm trying to understand if glyphosate is carcinogenic. The information in internet is very confusing. There are many ecological oriented websites which claim it's carcinogenic which I suppose they ...
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327 views

What is the meaning of “Rb is in the active state”?

I am reading about cyclins, cdks and Rb (Retinoblastoma) and some of the terminology is not clear to me. I understand that when CDK phosphorylates Rb, it disconnects from E2F, and E2F can act as a ...
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Does a certain tumor type being invasive mean that it is highly metastatic?

Does a certain tumor type being invasive mean that it is highly metastatic?
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Distinction between primary and secondary tumor

How can a primary tumor be distinguished from a secondary tumor? I tried finding it on the internet but it only said that they are found by means of immunohistology but I couldn't understand how....
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What is(are) the mechanism(s) that stop cells from fusing in vivo?

I just learned about the phenomenon of 'cell fusion' in which two diploid somatic cells can combine into some aneuploid cell in vitro and proceed to proliferate in culture. Apparently this can even ...
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204 views

Is it possible to make a cancer cell that doesn’t encode any neoantigens?

The cell still has mutations, but those mutations only occur in the noncoding sequences, such as promoters, which drives over expression of proto-oncogenes and downregulation of tumor suppressor genes....
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What is the precise mechanism by which exercise reduces chance of cancer?

Sources like this: http://www.cancerresearchuk.org/about-cancer/causes-of-cancer/physical-activity-and-cancer/how-physical-activity-prevents-cancer point out that we can reduce our risk of some ...
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Which cancers are routinely treated with anti-angiogenic therapy? [closed]

I have been asked to discuss 2 of these cancers and how the therapy is used. I understand angiogenesis and its role in tumour progression, but need some help in explaining how the therapy is used.
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Tumour cell injection into a mice [closed]

I am going to inject mice tumour cells into mice to create them tumours and I am wondering if I need to have special precautions for that, even they are cells from mice tumour I am afraid what can ...
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41 views

Can cancer cells transmit from one organism to another?

I know cancer cells are very resilient, so would it be possible for them to survive outside of the original organism for long enough to be absorbed by another? Furthermore, would that type of "...
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384 views

How long does it take for cancer to be detectable if it grows from a single cell? [closed]

Assuming cancer has its origins at a single malfunctioning cell, how long would it take for that cell to grow from the point at which it is malfunctioning enough so that it can be detected by the ...
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130 views

Are new blood vessels able to deliver oxygen to hypoxic tissue before the establishment of blood circulation?

Sprouting angiogenesis - the growth of new blood vessels from a preexisting vasculature - can be triggered by cells in hypoxia in order to re-stablish the oxygen and nutrients supply to the tissue. ...
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915 views

Can neurons become cancerous?

I've been reading about brain cancer lately, and something I've noticed is that the tumors seem to start in all tissues, except neural tissue. Am I missing something, or is there an explanation?
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CDK3 1 simple coding mutation/missense mutations (S106N) glioma

I found the below quotation in (Peyressatre, 2015) CDK3 1 simple coding mutation/missense mutations (S106N) glioma [135] The author has cited a database but not a paper. I want to find the ...
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Why is cancer more lethal than (hypothetical)infections?

I am a computer science student and I'm interested in algorithmic aspects of cancer! Once I heard that there exist more bacteria in human body than our own cells, I wondered that why bacteria, which ...
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do tumour cells begin with abnormal characteristics?

At what point in the cell cycle do cells start to become tumorous? Do they have abnormal characteristics to begin with; if so what are they?
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Treatment validation on mouse models

I am struggling to set up a project proposal for validation of a known treatment for metastatic colorectal cancer in mouse models. I want to see how SNPs in patients contribute to their drug ...
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Embolism risk in cancer [closed]

Why is there an increased risk of embolism in any malignancy? I studied that malignancy is a risk factor for pulmonary embolism. Can someone explain me the exact mechanism under which malignancy ...
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2answers
2k views

Why are tumor suppressor genes recessive?

In my Intro. to Biochemistry course, we have been studying cancer. The professor has pointed out that tumor suppressor genes are "recessive" while proto-oncogenes are "dominant". Since only one ...
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Characterising mechanisms responsible for generating structural variants

I have a high-quality set of structural variant breakpoints from tumour/normal WGS data, and I am interested in digging into the various mechanisms that might be involved in each event. There are ...
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176 views

How medical studies induce cancer in lab animals?

To test the effectiveness of drugs, they are typically tested on animals. How cancer is induced in lab animals to test the effectiveness of cancer drugs?
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Which matched normal(s) to use when computing CNAs from exome data with a Read-Depth approach

I want to use a Read-Depth algorithm to call copy number alterations (CNAs) from Whole Exome Sequencing data (WES) of a specific tumor. I have a set of WES tumor samples, some of which also have the ...
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97 views

Are there foods which not only prevent but help fighting cancer?

I was reading a probably not to serious webpage and I found this quote " Certain types of vegetables, such as the cruciferous variety, are not only nutrient-dense but contain compounds that may ...
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57 views

Warburg effect in lung carcinoma, the logic?

Outside of 'purposefully' removing mitochondria to diffuse cytochrome C's apoptotic threat, I would assume that lung carcinomas, and their proximity to high oxygen levels, would have the lowest rate ...
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171 views

What is functional dissection?

Reading [1] I found the sentence: Consistently, functional dissection of mouse and human wild-type and mutant RAS isogenic leukemia cells demonstrated induction of methotrexate resistance but also ...
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52 views

Importance of germline and somatic genomic mutations to the purpose of treatment in cancer

Is there a hierarchy in the sets of genomic mutations (somatic and germline) to the purpose of treatment in cancer? Can they be considered at the same level in the context of targeted therapy or are ...
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97 views

Cancer and Evolution [duplicate]

Edit: just to clarify, I am asking what, if anything, the literature says can be gleaned about evolution by studying cancer, especially relating to how multicellularity evolved and the traits used to ...
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372 views

What is the definition of Mitotic Index?

Sometimes I find Mitotic Index defined as (i) the number of dividing cells over the number of non-dividing cells, other times as the (ii) the number of dividing cells over the total number of cells... ...

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