Questions tagged [cancer]

A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

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61 views

How can cancer preventing genes from animals be transferred to humans? [closed]

I recently read this non-peer reviewed article that states that the prevalence of cancer in crocodiles or elephants is really low, much lower than humans. It is said below A team of researchers in ...
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537 views

What is the first recorded unambiguous case of childhood cancer? [closed]

I can't seem to find any references to childhood cancer going far back. I am asking for the first verifiable instance of childhood cancer.
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Online resource for downloading gene variant data?

I have a long list of gene variations. For example, Here are 4 of them: CBL Q249E TERT H412Y SF3B1 R625H EGFR L747_T751delinsP The first term identifies the gene, the second identifies the ...
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622 views

Why does asbestos cause cancer?

We are probably all familiar with the dangers of asbestos in your rooftop or in various pieces of old equipment as it has been shown that the microscopic asbestos particles reach our lungs and can ...
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22 views

Estimation of cases with dominant inheritance

I am reading [1] and I didn't understand this passage: All bilateral cases should be counted as hereditary because the proportion of affected offspring closely approximates the 50% expected with ...
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1answer
192 views

Can DNA methylation induce breast cancer? [closed]

What is the role of DNA methylation in breast cancer? DNA methylation is a process by which methyl groups are added to the DNA molecule. In the September 2015 paper The Role of Methylation in Breast ...
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what is the word origin of myelo- as in myelofibrosis or myeloma?

what is the word origin of myelo- as in myelofibrosis or myeloma? I know that these are plasma cancers originating in the bone marrow.
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368 views

Why are childhood cancers less frequent than infant or adult?

According to data provided by Cancer Research UK, the lowest rate of cancer incidence by age occurs between 5 and 15 years. Infants have a higher rate, and the odds of an adult developing cancer ...
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1answer
100 views

white blood cells and cancer cells transport through lymphatic vessels

It is a well-known fact that both of these cells can reach the lymphatic vessels from interstitial space. How does it do so physically? Are there any mathematical models describing this process? It ...
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257 views

What is “multiple” myeloma?

Multiple myeloma, commonly referred to as myeloma, is a cancer of the plasma cells found in the bone marrow.(source) Is there any significance in calling myeloma as "MULTIPLE" myeloma?
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80 views

Detecting cancer in the hyperplasia phase using image processing and SEM

I was wondering if it possible or have someone tried before to use SEM or some other spectroscopy to detect an cancer evolvement in its hyperplasia phase: It sounds like a good way to do it? I guess ...
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334 views

How do I find samples/patients in TCGA (the cancer genome atlas) that had radiation therapy?

I want to correlate the expression of a gene (for sample the KRAS gene) with survival and if the patient received radiation therapy using any suitable TCGA (the cancer genome atlas) dataset. However, ...
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What is the best solvent for Mutagen X?

Many solvents can be used for mutagen X (3-chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one), however, long-term stability is not specified. Which would be the best solvent for long-term storage? ...
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59 views

What's the difference between constitutional samples and tumor samples?

I think the tumor samples have two copies of the chromosomes. But for constitutional samples, do they only have one copy of the chromosomes?
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367 views

If bortezomib, a cancer drug, inhibits cell proteasomes, wouldn't resulting protein aggregate in normal cells further increase the risk of cancer?

Bortezomib is an anti-cancer drug that inhibits the proteasomes of cancer cells, allowing proteins that stop cell growth to fold and perform their function. However, wouldn't bortezomib also affect ...
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1answer
105 views

Does an increase in cancer cell traction forces increase metastasis of the cancer cells?

I am not very familiar with biology, but I have read some articles about cell traction forces lately, where the cells are cancer cells. I found this very interesting, so I thought it might be nice to ...
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106 views

Copy number regulation & CNV

I have some genes which showed copy number loss between two groups. Now I want to see the copy number regulation of those genes. I really don't know about this concept. Can anyone please tell me ...
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553 views

Clonal and subclonal mutations in cancer

Likely this will sound as a silly question, but I don't know whom to ask. Ok, here it goes. McGranahan et al link found that tumors with high clonal antigen load are more likely to respond to the ...
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Can a regulator genes be more highly expressed when it has more places to bind?

I am doing some research on small cell lung cancer and, from what I have found, many tumors show high levels of ASCL1, which is a regulator for neuroendocrine cell differentiation. However, no papers ...
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414 views

What is meant by “genes at the trunk of the evolutionary tree”?

Recently I went through a paper about hepatocellular carcinoma in which they talked about trunk genes (p. 26, second paragraph): Branching tumor evolution complicates efforts to implement ...
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77 views

How are oncogenes targeted for therapy?

How would oncogenes be targeted for therapy and are there any examples of existing therapies for such cancers if the gene was upregulated (i) as a result of copy number variation and (ii) due to ...
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2answers
680 views

How to combine gene set enrichment analysis with hierarchical clustering?

I would like to find out how to combine gene set enrichment analysis with hierarchical clustering. The motivation for this combination is that potentially too many gene-set symbols for leukemia may ...
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1answer
5k views

Can vitamin B17 cure cancer?

I have heard that a 'vitamin B17' can cure cancer, but that the medical industry never talks about it, since making it legal would cause them loss of billions. But I have never found a reliable report ...
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How can I download histological slide from Cancer Digital Slide Archive

Could you tell me if it possible and how to download images data from http://cancer.digitalslidearchive.net ? Thank you.
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247 views

Which are the most important carcinogens in tobacco smoke?

I am researching the neoplastic effects of tobacco smoke and would like to measure a set of key molecules in the saliva of several study subjects after they have smoked. Which are the most relevant ...
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1answer
207 views

What really causes cancer? [closed]

A lot of things are claimed to cause cancer, eating red meat, eggs, smoking, using phones, deodorant, breathing. Surely these can't all actually significantly contribute to the development of cancer. ...
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225 views

What's the difference between proliferation and diffusion when talking about changes in tumor density?

Cell proliferation and cell diffusion seem to be important quantities to estimate when trying to understand or measure tumor growth, but I don't really understand a) the difference between them or b) ...
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Can HBV pseudotyped oncolytic viruses be used to treat hepatocellular carcinoma?

Chronic hepatitis B is the leading cause of hepatocellular carcinoma (HCC). Oncolytic virotherapy (OV) is an emerging tool to treat cancer. However, one challenge of OV is that our immune system may ...
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102 views

Database of cancer cells

I am looking for a database(or any kind of information source) of cancer cells, which has information about the speed of reproduction of these cells, how fast they grow, etc. So I could make my ...
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Isn't biological immortality strictly speaking impossible?

This question relates to both immortal cells such as cancers and organisms like the Hydra genus. Isn't it technically impossible for these "immortal" biological systems to live forever, even ...
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1answer
123 views

What if our whole body is made up of cancer cells? [closed]

Today I learnt in my biology class that cancer cells are immortal. That left me wondering what if our whole body is made up of cancer cells? Will that make us immortal? Is it possible or why is it ...
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1answer
95 views

How does translational immunotherapy work?

I skimmed an article on a recent experiment which suggested that it was effective to inject induced colon cancer tumors with an attenuated salmonella variant. According to the article, this stimulated ...
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406 views

Where do B cells produce antibodies?

I was recently at a Leukemia and Lymphoma Society conference where a particular oncologist lecturer claimed that all antibodies are created in the bone marrow (I won't mention his name, as he was a ...
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1answer
5k views

Difference between clonal and subclonal mutations

I'm a physicist writing a proposal that has to do with cancer as a disease driven by evolutionary selection. As far as I understand, all tumors start with a single precursor (single cell or group of ...
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Is blood donation risky for patients with MGUS?

Monoclonal gammopathy of unknown significance (MGUS) is often considered a pre-cancerous condition. Blood donors with MGUS are typically advised to discontinue blood donation as their blood may be ...
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170 views

Treatment of cancer

In treatment of cancer, radiation is given, but radiation can also be the cause of cancer. In the drugs of chemotherapy it is written that it is highly carcinogenic. Then why are such methods ...
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10k views

Is cancer caused by vitamin B17 deficiency?

I have read in an article on the internet that cancer is caused due to deficiency of vitamin B17 which has been removed from our diets long ago in the western food. But some people say that vitamin ...
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1answer
181 views

p53 gene in benign tumors

In a benign tumor, p53 gene does not work. I know that our cells constantly are mutating and the p53 fixes this. Hence, why does it take so long(or in some cases never) for a benign tumor to become a ...
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170 views

Does cell phone radiation promote longevity?

This preprint presents results from a 2-year National Toxicology Program study on the effects of cell-phone radiation in rats. On page 8 of the PDF, survival results are presented. The presentation of ...
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348 views

Molds associated with Aflatoxin?

I've been reading how some molds may be carcinogenic. In particular, molds associated with the fungus metabolite, Aflatoxin. Are the types of mold that produce this toxin, present in buildings/...
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59 views

Is it possible a cancer cell don't express any foreign antigens? [closed]

For example, there're tumor suppressor genes. Can we just delete them, without introducing neo-antigens? Would the resultant cells proliferate? If so, how do our immune system identify such cells?
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Which contributes more to cancer clearance, T cells or NK cells?

Both T cells and NK cells have cytotoxicity. However, most immunotherapy targets T cells rather than NK cells, such as CAR T and PD-1 inhibitor. Is it because T cells kills more cancer cells than NK ...
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2answers
68 views

If someone A has lung cancer

and the lung cancer has not spreaded to other parts of A, does transplant help to remove cancer? If someone B transplants a lung 'contaminated' by cancer, does B necessarily get cancer too? His body ...
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405 views

How is monoclonality or polyclonality determined?

I was reading up Kaposi sarcoma and Robbins Pathology says, ..many features suggest that KS is not a malignant tumor despite the ominous name ...spindle cells in many KS lesions are polyclonal or ...
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Do all tumors form the same way? [closed]

Do all tumors - both benign and malignant - form when proto-oncogenes and/or tumor suppressor genes experience mutations? Were all malignant tumors once benign?
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How do neuroblastoma cells divide? Is it via mitosis?

My name is Daniel and I'm 17 years old. I am currently designing a study to investigate compounds that potentially increase the replication of neural cells. I will be using neuroblastoma cells and ...
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1answer
80 views

Is it possible to induce erysipelas to treat cancer, under the condition that the patient is to be given antibiotics to control the erysipelas? [closed]

Dr.William Coley was one of the first to attempt fever therapy on cancer patients. He did this experiment: artificial erysipelas to treat cancer. Coley injected Streptococcus pyogenes directly into ...
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277 views

What is the mechanisms responsible for downregulation or loss of MHC-1 expression on the surface of cancer cells?

Downregulation or loss of MHC-1 expression on the surface of cancer cells generally have been thought to be involved in the mechanism of immune escape. It seems to be very attractive but I don't know ...
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27 views

Are there public records of results with laetrile treatment against cancer?

I'm looking for what the title says. This is based on the book by Edward Griffins. Is laetrile actually fatal because of its cyanide content? Or can it really help in this fight?
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199 views

Is there any disease in adult human, other-than cancer, which-is resulted from mutation?

On all environmental articles I read about 3 impacts of mutagens (say Cigarette/ Naphthalene/ EtBr/ Colchicine/ ionizing radiation/ whatever )... 1. direct effect on tissues, other than mutation, ...

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