Questions tagged [cancer]

A malignant group of uncontrollably dividing cells that form a tumour. Questions regarding (proto)oncogenes and tumour-suppressor genes should also use this tag.

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36 views

Could we tell that cancerous cells behave that way because-of their genetic machinery is work in a “primitive” way like Amoeba?

Amoeba sp. is unicellular, so can't form a tissue. It need not go through any apoptosis. It just continuously get doubled. Could we compare them with cancer-cells? or in-reverse, could we tell ...
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Have there been any measurements on the genomic differences between cancer cell DNA and healthy cell DNA?

I'm loooking for simple stats like the average number of base pair differences to normal cells, average diversity between different cancer cells, etc.
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Why not surgically resect the tumor before CAR-T cell therapy? Won't that be more efficient?

If CAR-T cell therapies suffer from tumor antigenic escape, why not just resect the tumor via surgery, leaving behind a small number of cancerous cells, and then wipe them out with CAR-T cells? The ...
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125 views

Find Mutations Frequencies by Cancer Type

Is there somewhere that has mutation frequencies by cancer type? So if I were looking at CML, AML, or even more generally at something like leukemia. Is there some database that would contain mutation ...
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Pharmacological inhibition of Ras

I was reading this review and came by this: Direct pharmacologic inhibition of RAS has been a major challenge. Interference with the nucleotide-binding pocket of the protein seems to be far ...
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Why is RAS undruggable?

Why can't mutated RAS get inactivated by GTPase? Why don't we have any inhibitors for RAS-GTP binding? Why is RAS undruggable? How can mutated RAS be inactivated? I had been researching on the topic ...
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379 views

Clonality of tumour cells

Does all cancer cells come from a single clone of cells or are there evidences of polyclonal cancer cells too?
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How does carcinoma enter into blood or lymphatic vessels?

When carcinoma begins to metastasize, it enters into blood vessel or lymphatic vessel to migrate to the site of metastasis. In that case, although I think breaking down the basement membrane is ...
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1answer
719 views

What's the difference between the *types* of tissue dissociation enzymes?

I'm trying to dissociate a tumor, and most protocols like NCI/NIH recommend a 10X triple enzyme digestion stock consisting of: collagenase type IV, DNase I type IV and hyaluronidase type V in HBSS. ...
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Estimate of total number of oncogenic mutations

So there are a number of ways point mutations can hyperactivate or inactivate genes. But realistically there are only some small number of point mutations ever observed for a particular gene in ...
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60 views

Sources of Mutations [closed]

I'm looking for a reference that gives some information quantifying sources of mutations that occur within cells. These can be general, but I'm interested in some percentage of mutations caused by ...
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80 views

Can telomere length maintenance be an answer to increased life span of human beings?

Telomere shortening may prevent the development of cancer in human aged cells by limiting the number of cell divisions. However, shortening of telomeres impairs immune function and thus might also ...
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do cancer cells respond to EM fields?

Do cancer cells respond to electromagnetic fields? If so, can someone please provide reliable information as to how they behave in such fields? Do you suppose the growth rate to be affected in any way ...
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786 views

What is the mechanism of cytokine release syndrome in CAR T cells?

CAR T cell administration results in cytokine release syndrome (CRS). But what is the mechanism that induces the CRS in CART therapy? Also, what factors correlate with CRS severity? CAR structure? Or ...
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458 views

Can cancerous cells reach the Hayflick limit?

This may be a stupid question, but I've been wondering. Each time a cell divides, the telomeres on the chromosomes shorten. If this goes on for long enough, the chromosomes will no longer have ...
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304 views

The mechanism of cancer metastasis

Generally, EMT, Epithelial to Mesenchymal Transition is thought to be involved in the mechanism in which cancer cells metastasize in the early stage. EMT is an process in which epithelial cells ...
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How is signalling disturbed in trophoblastic cancer cells?

Trophoblastic cancer seems to be a form of growth that no longer responds to the neural signals which try to inhibit them. Can someone please explain whether experiments have been performed as to how ...
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86 views

How many co-expressed genes would be expected in a tissue?

I am working with gene expression microarrays of tumor tissues and I want to use a program to find the clusters of co-expressed genes in order to know if some particular genes are co-expressed with ...
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Cancer biology: Can tumors form from cells that are genetically identical to non-cancerous cells?

Can a tumor begin to form without any genetic mutations? I'm specifically interested in a tumor which could later lead to cancer.
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What are extracellular matrix pathways?

I was reading a research paper dealing with acute myeloid leukemia and the term "extracellular matrix pathway" came up. What does it mean? I found literature on extracellular matrix, but I'm not sure ...
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Do Tumor-Infiltrating T Cells Experience Any Prolonged Effects Due To Hypoxia After They Return To Normoxia?

Adoptive cell transfer (ACT) therapy using tumor-inflitrating lymphocytes (TIL) is at the cutting edge of immuno-oncology treatments involving metastatic melanoma and other indications (1). The idea ...
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61 views

How do normal cell division chance into a tumor forming cell division? [closed]

Or its better to say what happens at molecular level that tumors are formed? I tried normal google search and google books but couldn't find any appropriate explanation. I am trying to understand why ...
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155 views

How do cancers eventually lead to death / other debilitating symptoms? [closed]

With regards to people I know or have read about who live with cancer, most of their symptoms are results of chemotherapy, surgical interventions, etc., which have the goal of eradicating the cancer. ...
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Why are sarcomas rare compared to carcinomas?

A sarcoma (from the Greek σάρξ sarx meaning "flesh") is a cancer that arises from transformed cells of mesenchymal origin. Thus, malignant tumors made of cancellous bone, cartilage, fat, muscle, ...
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209 views

Why is chronic lymphocytic leukemia (CLL) most common leukemia in the West but so rare in Asia?

In "Advances in Chronic Lymphocytic Leukemia" (2013, Edited by Sami Malek), several times it is stated that CLL is very common in Western countries. However, it is quite rare in Asia. (I do not have ...
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196 views

Is metastatic cancer always lethal if uncured?

Can matastases spread in different parts of the body of an animal suffering from cancer grow in a limited way, such as not to cause much more harm that a benignant tumor in those parts of the body ...
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Has Staphylococcus aureus ever been used against cancer?

Treating inoperable tumors with bacteria appears to be very effective, albeit being toxic to the patient as well. Has (live attenuated) Staphylococcus aureus ever been used against cancer? If the ...
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Why does fever above 102 herald a cancer patient's death?

I was recently intrigued by a longtime hospice nurse's observation that her cancer patients die a different death than her Alzheimer's, multiple sclerosis, heart failure and COPD patients. She stated ...
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Measuring tumor heterogeneity [closed]

I would like to ask if there's any method (established or not) in order to quantify heterogeneity found in mutations occuring in primary neoplasms and metastatic lesions (either common or private) and ...
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160 views

How to construct tumor phylogenetic tree?

I would like to know if anyone has tried any software that constructs tumor evolution trees where the trunks represent the common mutations and the private alterations are noted on each branch. I can ...
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107 views

Does cancer cells come from same process as evolution? [duplicate]

Here is how I understand it: DNA replication is not 100% perfect and error can happen, this error can be good(evolution) or bad(cancer properties). But its not the only source of cancer cells - DNA ...
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1k views

Why do we have oncogenes? [closed]

Oncogene is a gene which in certain circumstances can transform a cell into a tumour cell. Everything we have has reason and meaning. Or there was some use in past. What's the reason for we have ...
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2answers
250 views

How to predict the effect of a non coding SNP variant on the expressed protein?

I am writing a paper for non coding SNPs on patients with metastatic breast cancer. Having used a specific gene panel (NGS) of approximately 60 genes, I'm currently running out of ideas on what to ...
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58 views

How do CD 8+ Tc cells reach the site of tumors?

In normal humoral immunity, dendritic cells present antigens to the Th cells by arriving at the Lymph node. This is fine. But consider a tumor cell. How does the Tc cell sitting in the lymph node know ...
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69 views

The properties of benign tumours

Do benign tumours have no functioning apoptosis mechanisms ? If so what stops benign tumours from excessive growth? Also can a benign tumour have a functioning apoptosis mechanism?
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51 views

Pathogenesis of Cardiac Atypia?

I am studying the pathogenesis of atypia in cardiac cells where the etiology is most commonly irritation or infection and where the precancerous risk depends on the context of diagnosis. This fact ...
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111 views

Why is mRNA used as a biomarker for cancer over tRNA or rRNA?

I cannot find a clear explanation for why mRNA is used as cancer biomarker and not tRNA or rRNA. Is there something peculiar about mRNA which cannot be fulfilled by tRNA or rRNA?
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Can bacteria, viruses, and cancer cells be destroyed by resonance?

Radiotherapy has been used to treat cancer. Can the resonances by coordinated electromagnetic waves (and/or other forms of waves), of various frequencies, amplitudes and pulse rates, directed from ...
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47 views

Is there some research paper which focus on the influence of using cancer cell as experimental materials on experimental result? [closed]

Cancer cell is unstable cell and high variation, but there are many experiment use cancer cell as experimental materials. I always wonder how much influence can using cancer cell as experimental ...
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Why lactate inhibits growth (or enhances death rate)?

Extracellular lactate tends to inhibit cellular growth or enhance cell death. This happens in the vicinity of tumors and in cell cultures. See for example this reference: Ozturk, Sadettin S., Mark R....
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Escaping resource limitations during tumor evolution

In their discussion of the importance of r- and K-selection on tumors, Aktipis et al. (2013; figure 3) provide the following illustration of a hypothetical cancer growth curve: In it, you can see ...
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56 views

Where does the lactate produced by tumors go?

Tumors are known to burn glucose and secrete lactate (this is known as the Warburg effect). Where does this lactate go? Does it steadily accumulate in the neighborhood of the tumor? This doesn't ...
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912 views

In a tumor, why hypoxic regions have access to glucose?

The Warburg effect is ubiquitous in cancer. It consists of the upregulation of glucose uptake, glycolysis, and subsequent lactate secretion, sometimes by over 200 times, in cancer cells as compared to ...
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121 views

Whales and cancer [duplicate]

Do whales get less cancer than they should considering they have a lot more cells and tissue? If a lot of cancer formation is random because of mutations then shouldn't whales receive a lot of ...
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247 views

Do antioxidants interfere with chemotherapy?

Since most of the chemotherapy drugs kill cancer cells by damaging their DNAs by means of free radicals. So antioxidants, which will detoxify free radicals, should theoretically decrease the efficacy ...
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43 views

What are the determinants of tumor metastasis

Under what conditions do tumors migrate? Is it due to hostile microenvironment conditions, drug application, mutations, or other causes? Are there any migration probability values (I am doing an in ...
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98 views

Numbers in the names of tumor markers

In tumor markers such as CA 125, CA 19-9 and many other, CA stands for Carcinoma antigen, but what about the number?
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Where do I find microsatellite instability annotation for TCGA data

I have searched through the TCGA data portal but I was unable to find MSI annotation for TCGA Colon Adenocarcinoma (COAD) and Rectum Adenocarcinoma (READ) datasets. I am searching for the annotation ...
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175 views

Can Allergy and Auto-immune diseases be the signs of hyper-vigilant immune system?

Allergy sufferers are much less likely to get some types of cancers. Theories regarding allergy - cancer link are mixed. Many say it is due to hyper-sensitive immune response. But the correlation ...
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40k views

Is it possible to have cancer and normal blood count at the same time? [closed]

Does cancer always cause abnormal full blood count? I've read on the internet that some people who had advanced cancer, also had normal blood count. I can't find anything on the internet about this ...

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