Questions tagged [cell-cycle]

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During the cleavage cycle of a zygote what determines where the blastula starts folding?

If all of the cells divide from the same zygote it seems like they should all be the same. What causes one part of the clump of cells in a blastula to start folding over to form the mesoderm and ...
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66 views

Does a cell suspend or exit cell cycle at G0?

In an exam, there was one question which asked whether the cell exits or suspends cell cycle at G0 phase. I answered that it exits cell cycle but the official answer key says it suspends cell cycle. ...
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14 views

Length of cell cycle dependancy on nutrients, pressure, temperature or other factors

How is the duration of cell cycle influenced by the concentration in nutrients, mechanical constraint, temperature or other factors ? And can it change strongly ? Meaning there are 2 possibilities, ...
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46 views

Approximate Cell Doubling Time?

If I know it takes 12 min to occur in mitotic fibroblast cells and I count there are 32 dividing cells in the microscope slide out of a total population of 32034 cells, how do I calculate the ...
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47 views

When does DNA replicate actually?

I read on Wikipedia that when the cell enters prophase during mitosis , the DNA has already been duplicated , that is the DNA is replicated in the chromatin form , but here I see the picture which ...
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386 views

Confusion about the duration of different phases of the cell cycle such as G1, G2 & S

We all know that normally most of our cells (which are alive and have nuclei - except for cells such as "stem cells", "red blood cells", etc) spend most of their lives in interphase. But the ...
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90 views

Does meosis takes place in cell cycle?

Cell cycle is as follows- g1,s,g2,m( mitosis). Does this m stands for mitosis only or does this "m" stands for meosis also
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263 views

What is the meaning of “gap” in G1 phase?

The full form of G1 phase is Gap one phase. G1 os also called first gap phase. Is there any specific meaning of " gap" here ?
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186 views

What is the meaning of “Rb is in the active state”?

I am reading about cyclins, cdks and Rb (Retinoblastoma) and some of the terminology is not clear to me. I understand that when CDK phosphorylates Rb, it disconnects from E2F, and E2F can act as a ...
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1answer
39 views

Why don't cells double gene expression after S-Phase?

In the cell cycle (G1-S-G2-M), all of the DNA is replicated during the S or Synthesis stage. The cell may then spend some considerable time in the G2 phase before splitting in the M phase. Since there ...
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46 views

Crispr/CAS9 genome editing is actually processed at which phase of Cell cycle?

all, Is it only happens in certain phases, like S, G1,...or it can happen any time....or maybe, it has some perferences. Put it in another word, does it going to processe edit if the cell is not ...
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65 views

Cell cycle arrest and apoptosis

Is cell cycle arrest needed for apoptosis to occur? I note that some of the factors that mediate cell cycle arrest induction (e.g. DNA damage) happen to be responsible for initiating apoptosis as well....
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219 views

What determines the reversibility of cell of G0 phase in cell cycle?

From Weinberg's The Biology of Cancer: A cell that has been recently formed by mitosis must decide whether it will once again initiate a new round of active growth and division or retreat into non-...
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2k views

Is agriculture really a net contributor of greenhouse gases?

A lot of scientific studies and credible sources indicate that agriculture is one of the major contributors of greenhouse gases. The exact numbers seem to vary a lot, I've seen everything from 8% to ...
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1answer
277 views

Flow Cytometry to learn about Cell cycle

I am posting my Flow Cytometry data here again because I realize that there are many people who are willing to help me, and I can learn a lot from you guys. In this cell culture Lab, we use Cell U-...
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1answer
555 views

During interphase, is DNA wrapped around histones?

Are histone proteins present around DNA in the nucleus during all of interphase (including G1) or do histone proteins only form later on when chromosomes are condensing into chromatids? Thanks in ...
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36 views

How does the cell cycle affect stem cell fate?

I keep reading about the stages of the cell cycle affecting stem cell fate, however I do not understand how. After all, any cell will have to pass through the whole of the cell cycle, and go through ...
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674 views

Advantages and disadvantages of sporulation compared with competence in bacteria?

Why do bacteria have both of these mechanisms to deal with the same environmental stress: nutrient deprivation? In a culture exposed to this condition, often both competent cells and sporulated cells ...
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593 views

When does the kinetochore form?

According to Wikipedia, the outer plate... is assembled in the surface of the chromosomes when the nuclear envelope breaks down. However is makes not mention of when the inner portion of the ...
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326 views

MCQ - Events in the Mitotic cycle

The following question confused me at first However, I presumed that it must be in comparison to meiosis. In that case D would be correct. However, the correct answer is A. How can this be? I know ...
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3answers
10k views

Is there interphase between meiosis I and meiosis II?

Is there interphase between meiosis I and meiosis II? After 2 haploid cells are formed in meiosis I, do the cells go through a period of interphase (G1, S, G2) or do they go directly to meiosis II?
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172 views

Cell cycle-regulated genes and mRNA

I am a mathematician and my knowledge about biology is close to zero. I am reading a bioinformatics paper and I would like to understand a bit more about the biology task they are talking about. I ...
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551 views

In cell division, are daughter cells identical?

I understand that after a cell replicates, there will be two daughter cells instead of one. But wouldn't one of them be the old cell that created the second one? The old cell having gone through G0, ...
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1answer
9k views

Do human somatic cells have 46 chromosomes all the time?

As far as I know, a human somatic cell has the cell cycle: Interphase and Replication (mitosis). In interphase, the cell has 2 growth phases (G1 + G2) and a synthesis one (S phase being in between ...
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1k views

Contact Inhibition of Cell Division: Signaling Pathway

The following article refers to contact inhibition of cell division in epithelial cells, specifically MDCK cells: Collective and single cell behavior in epithelial contact inhibition. In their review ...
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192 views

Are both (partial) copies of DNA transcribed in S and G2 phases of cell cycle?

For a little less than half the cell cycle, a significant number of genes are represented twice (just before dividing). Does the cell differentiate between these DNA in any way or are transcription ...
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3k views

Alternatives to commercially available flow cytometric analysis software for use in cell cycle analysis?

I know that many labs use either FlowJo or FCS Express to plot and analyze their flow data. These seem like the two standards for most labs (and I have used FlowJo before). However, my current funding ...
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634 views

Is the nuclear envelope present in G1 of interphase?

Is the nuclear envelope present in G1 of interphase of eukaryotic cell? If so how does a method like Calcium mediated transfection get DNA past the nuclear envelope?
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210 views

Concentration of caffeine in physiologically relevant setting

Caffeine is known to overcome G2/M (and possibly other types of) cell cycle arrest through its effects on DNA repair machinery and is used as a positive control in studies of cell cycle arrest. In ...
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836 views

How many centrioles/basal bodies are there in multi-ciliated cells throughout the cell cycle?

I thought there were only two centrioles per cell, that convert to the basal body at some point during the cell cycle. I also thought there's one basal body per cilium, so I'm not clear on where the ...