Questions tagged [cell-signaling]

Tag for questions related to the process of cells receiving a stimulus from its environment, or from itself (autocrine signaling), and responding as a result of the stimulus.

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6
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4answers
439 views

Exocytosis of mast cell secretory granules

I've been doing a bit of reading about mast cell degranulation and have become thoroughly lost while trying to understand how the secretory granules are actually secreted. I understand that there are ...
3
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1answer
537 views

How do GPCRs transmit a signal across the plasma membrane?

How do G-coupled protein receptors (GPCR) transmit signals through the plasma membrane? Links containing information about this and pictures will be very helpful.
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1answer
855 views

Why can't intermediate filaments be used as tracks by motor proteins?

A motor protein like kinesin-1 cannot use an IF as a track because it lacks polarity. Can someone elaborate on this answer?
1
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1answer
399 views

Transverse diffusion of lipids in red blood cells

The membrane of a human erythrocyte has polarity: Phosphatidylethanolamine and phosphatidylserine are predominantly on the inner side. Phosphatidylcholine and sphingomyelin are predominantly on the ...
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1answer
312 views

What is a phospho-protein binding domain?

Is this just a domain that binds proteins that have been phosphorylated? And it mediates signalling between an activated/phosphorylated protein? How is this significant with BRCA1?
4
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2answers
507 views

Signaling through G protein Coupled Receptors?

There are two different cell lines but we do not know that these cell lines have Gs or Gi proteins, associated with their G-protein coupled receptors. If we wants to know about this. Can we design a ...
4
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1answer
269 views

Amino acid profile of GPCRs

You are studying cellular signalling through a newly identified GPCR. Specifically you’re working on a pair of newly identified GPCRs, GPCR-A and GPCR-B. Each binds the same small ligand, but ...
4
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1answer
982 views

Significance of lipids in biological membranes…?

Membranes are specifically designed by lipids to maintain internal hydrophilic environment in narrow range.There are hydrophobic amino acids among naturally occurring 20 amino acids and as well as ...
0
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1answer
64 views

Bilayer synthesis? [closed]

If we want to design a bilayer from Myristic acid (14 carbon fatty acid). The average bond length between C-C is 1.5 A. What will be average thickness of the membrane? Edited to include the OP ...
2
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1answer
111 views

Structure of biological membranes?

Integral membrane proteins have functional asymmetry i.e. they have two different domains of proteins performing different functions. these proteins have Tyr and Trp amino acid residues at the ...
5
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2answers
21k views

Explanation of the terms “downstream signaling” and “upstream signaling”

In molecular biology, what's the meaning of the terms "downstream signaling" and "upstream signaling"? What's the difference between them?
6
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1answer
453 views

Models of quorum sensing for multi-agent systems

Quorum sensing is a system of stimulus and responses correlated to population density that is used by bacteria to coordinate gene-expression. I am looking for a simple computational/mathematical model ...
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0answers
21 views

histamine inter-cellular and cytoplasmic binding site

I noticed that HRH (histamine receptor) has an inter-cellular and cytoplasmic binding site of anti-histamines which are equal in binding energy. Does anyone know what is the function of the well ...
2
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1answer
148 views

Autophagy in eukaryotic cells

What is autophagy? How and under which circumstances is it used by the cell? I believe The reason for autophagy is some kind of recycling, am I right? But why does it occur in infections?
7
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1answer
2k views

Cat purring: What are some possible underlying mechanisms behind purring and bone remodeling and formation?

http://www.scientificamerican.com/article.cfm?id=why-do-cats-purr The article above says that cats purr mostly when they're wounded or under duress. They hypothesis that cats purring leads to ...
3
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1answer
358 views

How do axon terminals report to the soma?

It is important to bear in mind that the distance between a neuron's axon terminal and its soma can be extensive, up to about 1m in the human body. The fastest transport along the axon is 400mm/day (...
6
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2answers
1k views

Question about cell signaling pathways (RTK, Jak-Stat, SMAD, etc)

I am in an embryology course right now and we've just started covering cell-cell communication in development. We were talking about the roles of the various cadherins and their discoveries but we got ...

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