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Questions tagged [cholesterol]

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4
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2answers
687 views

Are there differences in cell membrane cholesterol levels between cell types?

With different cell types, and cell functions, are there distinct levels of cholesterol in each cell type's cell membrane, or do all cell types have a similar amount of cholesterol? I am assuming ...
4
votes
1answer
4k views

How does cholesterol affect the fluidity of a plasma membrane?

I was previously taught that cholesterol affects the fluidity of a plasma membrane. At high temperatures, cholesterol decreases fluidity and at low temperatures cholesterol increases fluidity. The ...
3
votes
1answer
94 views

Why do high cholesterol levels result in a buildup of fat in blood vessels?

As is well known, high levels of cholesterol can lead to a buildup of fat in blood vessels, which can lead to them being constricted which makes it more difficult for blood to pass through. In fact, ...
3
votes
0answers
194 views

What is the function of CETP?

I read up that CETP transfers cholesterol from HDL, which collected it from tissues, to VLDL. This VLDL is then sent back to the tissues, ultimately forming LDL internalised by cells. What is the ...
2
votes
1answer
56 views

How can low cholesterol cause mortality?

I am studying processes 1. stroke, 2. heart disease, and 3. cancer, and their mechanisms associated with low cholesterol which is a result of lowering cholesterol especially in elderly, Low ...
2
votes
0answers
17 views

Is there a relationship between HDL-C and LDL-C?

For a gentle introduction to cholesterol and its functions, see a great answer on SE Biology Whenever I read about how to deal with cholesterol level, the rule is to keep a low LDL fraction, ad a ...
2
votes
1answer
72 views

How does LDL leave the circulatory system and enter the interstitial fluid to deliver cholesterol to cells?

I have read that small molecules like oxygen and carbon dioxide diffuse through the capillaries, but larger structures can't fit through. This answer indicates that some proteins go through via ...
2
votes
0answers
31 views

Is the amount of cholesterol the body produces affected by how much cholesterol you take in with food?

In the past I've been told multiple times that if you don't eat foods containing cholesterol, your body will increase its production of cholesterol to balance out the lack of nutritional cholesterol. ...
2
votes
0answers
58 views

What is the rationale behind reverse cholesterol transport?

Reverse cholesterol transport is transport of cholesterol from the tissues back to liver/VLDL. My question is why do the tissues have this extra cholesterol in the first place? Why would you ...
2
votes
0answers
72 views

Is there a way to quantify in vivo cholesterol transport rates?

I have always had trouble grasping the physiology of lipoprotein cholesterol transport. The "standard" description found in the literature is that liver synthesizes cholesterol which is carried in "...
2
votes
0answers
439 views

How much energy would it cost to synthesize all cholesterol requirements de novo?

Imagine a scenario in which some person is unable to absorb any dietary cholesterol because of some intestinal mutation (for example). Thus, they have no cholesterol available from their diet for ...
1
vote
2answers
1k views

What are the good and bad cholesterol ?

I have question about cholesterol, as I know we can get cholesterol using vegetables and meat, so what is good and what is bad ?
1
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0answers
141 views

What is the actual function of HDLs and CETP?

I know that HDLs collect cholesterol from peripheral tissues and transport it back to the liver using SRB1 - Reverse cholesterol transport and dumping it in bile. So the tissue is producing some extra ...
0
votes
0answers
93 views

How does the body differentiate between sources of good and bad cholesterol?

I keep hearing "good cholesterol, bad cholesterol" everywhere, and how certain food sources of cholesterol raise LDL and certain other raise HDL. I don't understand how any food can increase ...