Questions tagged [cocaine]

An addictive narcotic stimulant derived from the coca plant. Cocaine functions by inhibiting the reuptake of neurotransmitters such as dopamine and serotonin.

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Does cocaine bind competitively or non competitively to DAT?

I was just wondering whether cocaine, once reaching a synapse, binds to a DAT (Dopamine transporter) competitively or non competitively, or neither of them?
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What is the physiological difference between snorting/swallowing cocaine

I know that mucosa inside the nose absorbs cocaine molecules when snorting cocaine, but what difference is there compared to swallowing? Also more cocaine administration equals more cocaine molecules ...
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What happens in the synapse when cocaine administration occurs in the human brain

As far as i know when you accept cocaine in your blood some cocaine molecules reach some synapses in your brain and fill some Reuptake tunnels preventing the cell to simply "do not know that fired ...
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DAT1 dopamine and cocaine binding

I've searched the internet for several minutes and I've looked at DAT but I'm having trouble finding the DAT binding location. Where (and to which aa) does dopamine and cocaine bind to hDAT1?
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