Questions tagged [coronavirus]

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7
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0answers
141 views

How does a virus stick to a non-biological surface?

Recent events has triggered an renewed interest in understanding how a virus is able to stay on a surface. For sake of argument, let's assume we are dealing with a Corona-type virus. One can then ...
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118 views

Why is the SARS-CoV-2 target receptor ACE2 not endocytosed when bound physiologically?

The COVID-19 coronavirus SARS-CoV-2 enters cells by receptor-mediated endocytosis. See, e.g. here. Why doesn’t the enzyme ACE2 — SARS-CoV-2’s target receptor — undergo endocytosis when bound by its ...
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75 views

Why there is no ELISA for SARS-CoV-2?

As far as I know, SARS-CoV-2 tests currently used worldwide are real-time RT-PCR. Why there is no ELISA for SARS-CoV-2? Compared to PCRs, ELISA is: Way cheaper; Way faster; Does not require trained ...
4
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140 views

How was 2019-nCoV (Wuhan coronavirus) identified so quickly?

It seems that from the first few cases to identifying 2019-nCoV as a new disease happened very quickly. How were they able to identify this as a new disease and not an outbreak of a previously known ...
3
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1answer
61 views

Do mRNA vaccines cause transfected cells to be killed by cytotoxic T cells?

Based on my research on how mRNA vaccines (specifically for COVID-19) work: An mRNA sequence, that contains the sequence of the coronavirus spike protein, is absorbed by some cells. These cells now ...
3
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1answer
43 views

How does the immune system distinguish between a TH1 and a TH2 response?

Hello and thanks for taking the time to read my post. I know that naive T-Cells (T0) can be induced to become mature T-Helper cells (TH1 or TH2) by induction with either IL2 or IL4. IL2+ TH0 -> TH1 ...
2
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61 views

Are SARS-CoV-2 virus particles really able to travel through filopodia and “emerge from the tips”?

Watching the new University of California San Francisco video Coronavirus forces cells to produce tentacle-like structures that infect neighboring cells I saw The growths spread out, and ...
2
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37 views

How do we know that the “original animal exposure event” of a human to the Covid-19 virus occurred between October and December 2019?

In a Yale med page (interview) on Covid-19 from January it is said that The molecular dating of the virus genomes indicates that the original animal exposure event happened sometime between late ...
2
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101 views

T-cell “exhaustion” in patients with Covid-19

Following up on my previously asked question, which asks how COVID infects T-cells in immune system. Here's a study that shows that recovered covid patients have "exausted t-cells". To quote: T ...
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23 views

Would symptoms differ from eating virus contaminated food versus breathing in virus?

Would symptoms differ from eating virus contaminated food versus breathing in virus? The COVID-19 causes respiratory symptoms and I guess that is because people are breathing in virus droplets in ...
2
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56 views

L strain of SARS-CoV-2?

Early in the epidemic, Chinese researchers (Jian Lu, et al,) reported in the National Science Review earlier this month that there was an aggressive more virulent L strain compared to the older S ...
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62 views

Could blood transfusions from COVID19 surviver be worth researching as a possible form of treatment

As a general viral immunology question (rather than seeking personal medical advice). Would a blood transfusion from a COVID19 surviver to a sufferer be worth researching as a possible form of ...
2
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159 views

Paper shows 2 hours of high humidity and hot temperatures kills corona virus, does this stop the spread of the virus?

I found this paper (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863430/) which says these corona virus strains live for months at 4 degrees C, 20% relative humidity. But at 40 degrees C and 80% ...
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73 views

Why is half dose of Oxford's vaccine of covid more effective than full dose?

I recently read in a newspaper that the half dose of the Oxford's vaccine is 90% effective while the full dose is only 62% effective. Why is this the case ?
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29 views

Is there a survey on whether people have gained or lost weight as a consequence of lockdown?

I am not sure if this is the right forum for asking such a question. Moderators can of course close it if it isn't and please migrate it to relevant site. Is there a survey/study that statistically ...
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18 views

SARS-COV-2 detectability versus viability

This week (#47 of 2020) two meta-reviews were published in the Lancet. Ct values and infectivity of SARS-CoV-2 on surfaces, a brief review published on 19 November in The Lancet Infectious Diseases, ...
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46 views

RNA vaccination and Autoimmune Reactions

To my knowledge we do not have any robust experience with RNA vaccination. Most likely this will change in the near future as RNA vaccines against COVID are in the pipeline. The rationale behind this ...
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25 views

With the 5$ covid19 test - an antigen test - , would trials (most likely) be independent?

Actual question What would typically cause antigen tests to give a false positive or false negative and would these causes be typically independent (if we run the test twice it won't automatically ...
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40 views

Do person with strong immune system have less chance of surviving SARS-COV-2 attack?

In most of the cases dealing with SARS-COV-2 disease, the major mortality cause is due to cytokine storm in response to Corona-virus that also attack healthy organs causing multiple organ failure. ...
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33 views

Understand and reproduce withdrawn publication method - Blastp - covid19

I try to reproduce the method of this withdrawn paper. I know this paper has been debunked and withdrawn. I am curious to understand the details of the method used on it. I am a programmer and I don't ...
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45 views

How large a part of the corona-virus is coding?

If you find an example of a sequenced string of coronavirus it is about 30.000 long. Looking for example here https://nextstrain.org/ncov/europe you'll see that by far the largest part of this is ...
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23 views

What changes would allow cutting mRNA-based vaccine safety testing to 18 Months

I see a lot of skepticism among my fellow citizens following an interview that Bill Gates gave the BBC on the topic of Corona vaccines. The Gates foundation is funding several study ventures on Corona ...
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42 views

To what exten do children produce antibodies against covid-19?

Here in Sweden all kindergartens and schools up to the month of June the year people turn 16 remain open. In almost all other European country schools are closed. I do not really know why our schools ...
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22 views

Difference between infectivity and cell fusion abillity of Virus. (COVID 19)

I'm a computational chemist who have interest in COVID-19. As a physical chemist, I'm lack of basic knowledge for biology. What is the difference between 'infectivity' and 'membrane fusion activity'?...
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1answer
46 views

Are there COVID-19 citizen science projects to compare habits and outcomes?

I've seen some "citizen science" projects for coronavirus that are not really collaborations, but simply requests for processing time. Are there any "real" projects where people who have gotten their ...
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1answer
34 views

Sequence structure of antibodies

It is said that "When a virus or a pathogen enters the body, the immune-response produces Y-shaped proteins called antibodies to bind to the pathogen or virus". "Also it is possible to ...
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19 views

What is the physiological function of the CoV-2 targeted ACE2-Mas receptor pathway on lung/nasal epithelial cells?

CoV-2 targets ACE2 receptor on epithelial cells, pneumocytes, as well as nasal cells which seem to be cells of the nervous system (loss of smell is a symptom of Covid). ACE2-Receptor is rather well ...
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60 views

Biosafety Level 1 (BSL-1) surrogate viruses that show greatest similarity to SARS-CoV-2

I would like to know if there are any viruses that show high similarity to SARS-CoV-2 (particularly in terms of structure) that are very safe to use (i.e., classified as BSL-1). For example, an avian ...
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9 views

What does the decline of serum antibodies after infection mean for B cell immunity, exactly?

About a month ago there was a small media blip about a report in the New England Journal of Medicine that neutralizing antibodies to SARS-CoV-2 decline significantly within a matter of months. ...
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49 views

Testing a COVID-19 vaccine on a large sample space of population from different nationalities

I came across an article few days ago, while checking the number of canditates for vaccines about COVID-19 where Sinopharm's vaccine development's trial phase caught my eye. The article says that: In ...
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16 views

How are latence period and duration of infectiosity defined?

I assume that infectiosity of an individual is not a binary property but a quantity that grows and decays gradually, very much like the number of infected or infectious individuals in a population. ...
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73 views

For how long viruses survive in non-air moisture environments?

On the Internet there are plenty of information that viruses don't live long after they were exposed to air, after they starting to dry out. But it's hard to find an information on how long viruses ...
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17 views

Does coronavirus survives more on a surface if it's not exposed to air?

Coronavirus survives 72 and 24 hours on hard surfaces (steel, plastic etc) and soft surfaces ( clothes etc) respectively. Does this data change if the surface is not exposed to air? If yes, then by ...
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26 views

Who define the SARS-CoV-2 haplotypes?

If you look in this paper https://www.nejm.org/doi/full/10.1056/NEJMoa2006100 they work with several haplotypes of the virus. They claim that the definitions of the haplotypes come from GISAID/...
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Does the cell release the empty capsids?

The virus via the spike of the capsid connects to a receptor in a cell, then the DNA enters the cell wall. My question is what happens to the capsid - does it stay connected to the receptor or is ...
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31 views

Is it possible to force Sars-Cov-2 virus to mutate?

The title may definitely be a stupid question since I have no background in biology. I would like to know if the coronaviruses or any other can be manipulated artificially so that they stop spreading ...
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20 views

Is the receptor of SARS-CoV-like viruses in bats still unknown?

A fairly detailed 2012 review (Whittaker et al.) on the Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein noted that SARS-CoV-like viruses have been isolated in bats. In this ...
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14 views

Is the Alpaca-CoV still the closest known relative of HCoV-229E?

From a 2017 paper that suggests the more distant (and common) origin of both HCoV-229E and HCoV-NL63 is in African bat coronaviruses, I see that the closest virus most similar to HCoV-229E is Aplaca-...
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47 views

Does a longer exposure to covid-19 mean a higher viral load AND a worse infection?

I'm interested in knowing whether it's worse for someone to be exposed during a longer time to someone with covid-19 (coronavirus). Does it work that way? 1) Does that mean that I would get a higher ...
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26 views

Is anything known about the speed with which viruses spread geographically in R. affinis (or at least bats in general)?

RaTG13, which is the closest known relative of SARS-CoV-2 at full genome level, was sampled (just) in a R. affinis (bat) specimen in Yunnan Province... which is about 1,500 km away from Hubei, the ...
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43 views

What keeps a virus from spreading from one species to the other, when it can infect both?

I have read that there have been cases where animals (some tigers, also a dog) have been infected by Covid-19 through a human host. At the same time, I read that currently it is deemed unlikely that ...
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81 views

Can methanol be used to dissolve lipids and protein structure (disinfect Corona virus)?

According to my quick research, disinfecting an enveloped virus can be achieved by simply taking its lipid spikes and protein envelope apart. Therefore "anything that can dissolve fat and protein ...
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58 views

How does increased relative humidity change the airborne survival rate of coronavirus COVID-19?

I would like to make some HVAC recommendations in my community to assist in slowing the eventual spread of coronavirus COVID-19. Some recommendations are obvious like properly maintained HEPA ...
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80 views

Could total 2020 flu deaths be low due to Covid19 countermeasures?

A working assumption is that Covid19 countermeasures will also reduce seasonal flu transmission and mortality. Could this effect be so large that the 2020 total global deaths from both causes will be ...
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1answer
60 views

Virus viability on fabrics

According to the article How long do viruses live on surfaces: Plastic, stainless steel, fabric, and more: With fabrics, it's unclear how long viruses can last. But generally, they tend to last ...
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2answers
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How can I classify the 3 clades(S, G, V) of the coronavirus that are found on GISAID?

On GISAID they classified the corona using 4 clades(S, G, V, Other). I would like to know exactly how these genomes were classified for my research. So how do you classify a coronavirus genome as ...
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Could ACE become a target receptor of mutating Coronavirus as it is a homologue of ACE2?

ACE2 is the key target receptor of SARS-CoV-2 and considered a homologue of ACE. As homology of protein does not seem to imply exact and complete identity of protein, is it a possibility that SARS-...
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26 views

How long might it take for the coronavirus to develop insensitivity to vaccines?

How long would it take for the SARS-CoV-2 to evolve in such a way that the current vaccination does not protect against it?
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Do lipid nanoparticles used for mRNA delivery show any cell tropism?

New mRNA-vaccines like those developed against SARS-Covid-2 use lipid nano particles as vectors. Does this technique of encapsulating (no spike or similar antigen on the surface of the particle that ...