Questions tagged [covid]

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What is the nature of false negatives on Covid-19 Lateral Flow Tests?

Mainly the thing I'm trying to understand is "how do repeated LFT testing and PCR testing interact with false negatives". But I think the answer to that is a fairly direct function of what ...
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Validity of report of reverse-transcription of Covid-19 vaccine mRNA in cultured human liver tumor-derived cells

The following paper reports results suggesting that when Huh7 cells (severely karyotypically abnormal immortalized cells derived from a human liver tumor) were incubated with the Pfizer/BioNTech COVID-...
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0 votes
1 answer
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How is mRNA made in a lab

I'm not a biologist, but I think I have a sound layman's understanding of how mRNA vaccines are made. At least this is how it was explained to me: create some mRNA get it into a cell (with the lipid ...
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Does COVID interfere with internal respiration?

Siddiqi et al. wrote in January 2021, Pulmonary ECs [= endothelial cells, in this paper] have an important role in immune surveillance, maintaining alveolar integrity and ensuring appropriate oxygen ...
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Any evidence that getting a covid booster works for omicron?

I've been hearing colloquially that the booster helps for immunity to Omicron, but haven't actually found any evidence supporting this. Does anyone know of any studies that look at the efficacy of the ...
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14 votes
1 answer
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Was the Harcourt COVID-19 isolate paper ever published?

One very interesting paper concerning COVID-19 was the paper describing the first isolation of the virus by Harcourt et al. However, this paper as far as I can tell was only published as a preprint in ...
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2 votes
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Can a less fit strain of a virus impose over a fitter one? [closed]

According to this link, the Dominant Delta Variant may mutate itself into destruction. The Delta variant in Japan was highly transmissible and keeping other variants out. But as the mutations piled ...
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Can the SARS‑CoV‑2 virus mutate in people who have been fully vaccinated?

I am curious to know if the original SARS‑CoV‑2 virus, or any of its variants, can mutate in people who have been fully vaccinated. I am referring to those people who have received all the recommended ...
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COVID-19 exposure risk from passing joggers versus walkers

What is the COVID exposure risk from passing close by someone who is jogging relative to passing close by someone who is walking? The reason I ask is with regard to going out for exercise, or to run ...
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29 votes
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Are fully vaccinated people more likely to not get infected at all with COVID-19?

I've found some papers which describe that the viral shedding does not decrease during infection (for fully vaccinated people). But the overall shedding time does decrease. Therefore it is possible to ...
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4 votes
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Boost of Janssen COVID-19 Vaccine increasing Immune Response to Vector

I have been looking for published, or even pre-print, data that evaluates the serological response to a boost of the Janssen COVID-19 Vaccine against the adenoviral vector Ad26 rather than the ...
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CCTV cameras in Microbiology (Pathology) Laboratories

Isn't it highly beneficial to have CCTV cameras installed in all Microbiology Labs in the COVID-19 times? As the COVID vaccines are already developed, the research & development carried further in ...
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-1 votes
1 answer
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If you catch Covid-19 infection, does it need to become vaccinated after recovery?

When we catch a cold, influenza, or Covid-19, the body starts to produce antibody against them, So the body become immune for a period of time. That means one should not get them until the presence of ...
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2 answers
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How did we do the COVID PCR after its first appear?

I recently learned about the PCR testing and its idea of using primers to replicate the DNA or RNA. By this I assume that we need to know the sequencing of the DNA to make our primers. If that is true;...
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Why are more children being hospitalized with Covid-19?

I see that more children are being hospitalized with Covid-19. If I recall correctly, throughout the pandemic, researchers have thought that children were more resistant to the virus because they are ...
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Searching for a vaccine vs searching for poor genes in the covid-19 pandemic

I have only basic knowledge about biology. I have some propositions (may be wrong) and a question about the covid-19 pandemic. In 1918, the world had a similar pandemic, the Spanish Flu. Millions of ...
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Is there any chance that the COVID-19 virus could become more deadly by it interacting with the HIV virus?

I would like to know if there is any chance that the COVID-19 virus, or one of its variants, could become more deadly by interacting with the HIV virus. Let's say for example, that a person who has ...
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2 votes
2 answers
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delta coronavirus: Why isn't similar viral load in vaccinated people causing as severe adverse effects as in unvaccinated people?

In latest news, it is reported that: if vaccinated people get infected anyway, they have as much virus in their bodies as unvaccinated people. That means they're as likely to infect someone else as ...
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Has anyone tried the petri dish experiment with and without mask but at the side?

There are quite a few videos and experiments online that show the benefits of wearing a mask by holding a petri dish in front of their face while talking, singing, coughing etc., once with a mask and ...
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What's the difference between mRNA and inactive virus vaccine?

If the techniques used in both vaccines are similar and if both use the spike protein approach, then how is the mRNA vaccine more effective than the other ones and more importantly how come it is also ...
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1 answer
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Does a vaccine reduce the contagion "efficiency"?

Note: I am specifically interested in the question in the context of COVID, but general information is welcome as well. If someone vaccinated still catches the COVID, is their capacity to infect ...
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Detection of primer dimer on RT-PCR?

I usually do RT-PCR test for covid-19. Curves for Patients and Positive CTRL mostly appeared at 20 to 25 Ct. Sometimes, there are some curves that emerge at the last 5 cycles. Some argue that they are ...
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3 votes
0 answers
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Do COVID-19 vaccines produce more spike protein than natural infection?

The SARS-CoV-2 spike protein has been shown to be harmful on its own. However, a news article quoted an "expert" as saying The spike protein components of the vaccine are not produced in ...
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7 votes
2 answers
427 views

Is the covid-19 vaccine-induced copy of the protein spike also damaging cells?

In recent scientific articles, it has been discovered how the spike protein not only is a respiratory disease but also damages blood vessels cells directly, and is connected with higher risk of ...
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How many mRNA strands are in a single dose of the COVID-19 vaccines?

I realize there are several different mRNA vaccines. I would be happy to know the ballpark figure for any of them. As a follow-up, is it known about what percentage of injected mRNA strands are ...
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SARS-CoV - relative size of the spike protein

I was given the task of determining the percentage of the S-protein of the SARS-CoV relative to the total of its proteins from the attached image. However, I have been given no explanation of the ...
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Is the stuffy environment due to using masks all day, helping in spread corona virus in people?

I came across a research that stated, the most disease ridden place in a toilet is actually the air dryer. The hot and moist microcosm that develops around the dryer due to frequent use helps in ...
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1 vote
1 answer
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Does the false positive covid-19 PCR % referred to by Surkova & Nikolayevskyy in The Lancet mean % of all tests, or % of positive tests?

In False-positive COVID-19 results: hidden problems and costs it is said: The current rate of operational false-positive swab tests in the UK is unknown; preliminary estimates show it could be ...
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Does stronger reaction to vaccine (fever, days of nausea) mean that an immune system would have reacted the same to the virus?

I have heard that the real danger of Covid-19 is the strong immune response. Is it more likely that a person's immune system would have reacted dangerously to the virus?
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16 votes
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Does vaccination lead to short-term secondary infection suceptibility?

For clarity, here is a summary of my question, per anongoodnurse's comment: Does a lower peripheral lymphocyte count resulting from recent immunization render us more susceptible to infection by other ...
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3 votes
2 answers
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Can the spike protein created by the Covid mRNA vaccines be created independently of the human body, and is there a higher cost to that?

How different in principle is using the bodies own mRNA to create the coronavirus spike protein differ from other methods of using genes to manufacture other drugs or proteins and is there a cost ...
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2 votes
1 answer
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Immunological factors for the cause of headaches following SAR-CoV-2/COVID vaccination

It is generally-accepted that headaches are a common side effect from receiving the COVID vaccine. Vaccine recipients with pre-existing immunity experience systemic side effects with a significantly ...
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4 votes
0 answers
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Why do the COVID vaccines contain the cationic lipids they do?

Why did Moderna & Pfizer specifically pick their SM-102 and ALC-0315 cationic lipids with tertiary amines, branched tails, long linker chains, and small hydroxyl head groups? Are the large tails ...
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9 votes
2 answers
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Do the primers used for Covid-19 test work with all new strains?

We keep reading news of new Sars-CoV-2 strains, some of them allegedly able to evade vaccine-induced Igs. That's not unexpected, specially for a single-stranded RNA virus. However, it seems to me that ...
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-5 votes
1 answer
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Will Covid-19 wipe out the Humanity that we know of?

As there are multiple variants of Coronavirus and every couple of weeks later there are new, deadly and highly contagious variants of COVID-19 virus emerging from the backdrop, I am just wondering is ...
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1 vote
0 answers
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How difficult is it to adapt an existing vaccine to a virus variant?

There is (at least in France) an ongoing discussion about the Astra-Zeneca vaccine which is perceived as "outdated" because of the prevalence of new variants (the vaccine was designed based ...
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4 votes
1 answer
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Can spike protein induced cell fusion be triggered by the mRNA vaccine?

The mRNA-based vaccines cannot lead to COVID-19 or its symptoms since they only lead to the production of the spike protein in the cell. However, the spike protein itself can lead to cell fusion: ...
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4 votes
1 answer
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How is SARS-CoV-2 'deactivated' for some Covid vaccines (for example Covaxin)? [closed]

Some Covid vaccines like Covaxin employ a 'Whole-Virion Inactivated Vero Cell'. How is the virion 'deactivated' for the vaccine?
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