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Questions tagged [diabetes-mellitus]

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How is Gliclazide SR and Metformin SR a rational fixed dose combination? And should it be taken before or after meals? [on hold]

(Assuming the doses are right) since Gliclazide is a sulfonylurea which should be given before meals and metformin, a biguanide, which should be given after meals, isn't irrational due to different ...
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How do hypoparathyroidism, diabetes mellitus cause glossitis?

The page for the Merck Veterinary manual on Oral inflammation states that: Glossitis, an acute or chronic inflammation of the tongue, may be due to infectious (calicivirus, herpesvirus, ...
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What ailments used to be completely fatal (or nearly so) but, now modern medicine has a treatment or cure?

My brother was a Type 1 diabetic and back in high school I did a report on diabetes. One of the things that struck me was that before 1921, type 1 diabetes was basically 100% fatal. I was wondering ...
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1answer
116 views

Is it unusual for a child to be diagnosed with diabetes?

Recently, I came to know that a boy in my town who is 6 years old is diabetic and many people were shocked from this news.
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1answer
117 views

Why ketoacidosis is less common in patients of Noninsulin Dependent Diabetes Mellitus?

The other day my teacher said ketone bodies are mostly formed when insulin is less and NIDDM type diabetes mellitus has less chances to grow ketosis. https://medlineplus.gov/ency/article/000320.htm P. ...
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1answer
604 views

Mechanism by which hypokalemia reduces insulin secretion

Is there any known mechanism by which hypokalemia reduces insulin secretion? This video explains a mechanism, but its inherently wrong because ATP dependent K+ channels will allow movement of K+ from ...
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1answer
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Finding out the best concentration for my plant extract to be used as drug for diabetes

I am using plant extract of Ajuga parviflora and found out that it possess anti-diabetic properties by using alpha-amylase inhibitory assay. I used various concentration 250 µg/ml(29% inhibiton of ...
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1answer
47 views

What are some potential consequences for attempting to cure Type one Diabetes?

Type one diabetes has been in my family for a few generations. As a carrier and having a mother with the disorder, I've done a lot of research on it. As I am completing my High school Biology course, ...
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1answer
1k views

Renal threshold for glucose

Wikipedia in its article on 'Glycosuria' says that the renal threshold for glucose (RTG) reabsorption in the kidney is around 160-180 mg/dL. Beyond which the glucose starts to excrete in the urine. ...
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T1D autoimmunity causes' possibilities

As far as I've learned about T1D, the prevalence of the disease and autoimmune disorders in general over the past 5 decades intrigued me to the point it made me wonder if it's really a genetic ...
6
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1answer
671 views

Why do type 1 diabetics experience hypoglycemia?

I know that type 1 diabetics do not produce enough (possibly none) insulin since beta cells of pancreas are damaged and as far as I know glucagon is produced by alpha cells (which are healthy in ...
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2answers
394 views

Is diabetes (type 2) a genetic disease?

My friend's father has diabetes (who was diagnosed with diabetes long after my friend's birth). The doctor told the friend that he has more chances of getting diabetes than a normal person and he ...
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1answer
39 views

Why do polyneuropathies affect the extremities first?

Polyneuropathy is an anatomic pattern of nerve damage most commonly seen in Diabetes mellitus. To quote Robbin's Pathology, In most polyneuropathies, axons are affected in a length dependent ...
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Link between hypoglycemic events in Type 1 diabetics and clinical anxiety?

I recognize that the scientific community is aware that the chemical stress pathway is mediated by glucocorticoids. The pathway response initializes as a result of some sort of stress (potentially ...
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1answer
95 views

Diabetes Mellitus and renal failure?

I have studied that Diabetes Mellitus leads to kidney failure and that this is because of the damage to the blood vessels (especially the blood vessels in the kidney) due to high levels of blood ...
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1answer
236 views

Freestyle Libre's Glucose's Specificity and Accuracy?

I am studying the Continuous Glucose Monitoring devices i.e. glucose sensors with continuous monitoring. Here one good presentation about the topic. They are considering interstitial fluid in their ...
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3answers
8k views

What happens if a non-diabetic receives an injection of insulin?

If a person without diabetes or any diabetes-related issues receives an injection of insulin, what happens? Would the blood glucose level drop or does the body naturally compensate for the added ...
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0answers
32 views

Electrically facilitated active transport across a membrane

I'm trying to go back to school to do a PhD in control theory, specifically concerned with control of glucose. The glucose system can be controlled using two chemicals: insulin and glucagon. I was ...
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601 views

Can a brown recluse bite lead to diabetes?

Ok, I realize that this question may seem crazy at first glance. I would agree. Also, this does deal with a medical diagnosis, however, as I'm more concerned with the explanation behind it, I figured ...
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1answer
81 views

Can stress-induced cortisol reduce diabetes type I?

Let us consider a patient with type 1 diabetes. I think it would be safe to say that diabetes is an autoimmune disease. Now let us suppose this patient comes under stress. As far as I know, cortisol ...
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1answer
157 views

Do blood glucose “spikes” contribute to insulin resistance, or is prolonged elevation required?

There's increasing public discussion about the health risks of chronic insulin resistance* (IR). In many cases there's a focus on high glycemic index foods that "spike" your blood sugar, which implies ...
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1answer
131 views

How would real-time blood glucose monitoring work?

Is it possible to perform real-time blood glucose monitoring using a wearable non-invasive device (similar to a fitness band measuring heart rate)? I'm aware that there are some devices in the market ...
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1answer
4k views

Why basement membrane thickens in diabetes mellitus?

Untreated diabetes mellitus may lead to blindness and kidney failure because the basement membrane of small blood vessels in these organs thickens due to increased production of collagen and laminin. ...
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1answer
82 views

How do you express and detect GLP-1 receptors?

I am currently working with a peptide which is an analogue for glp-1, but during invitro studies am not able to detect for the presence of GLP1- receptors. The cell line used is Min-6. How do I detect ...
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1answer
76 views

When was it determined that Type 1 Diabetes is an autoimmune disease?

I just found out today that type 1 diabetes is an autoimmune disease. When was this discovered?
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1answer
122 views

Growth Hormone and diabetes

Growth hormone and insulin like growth factors are diabetogenic, so I assume that people with high growth hormone (say due to pituitary tumor) may be at high risk for diabetes. Has any correlation ...