Questions tagged [diabetes-mellitus]
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32 questions
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Why doesn't the immune system ever destroy the glucagon-producing alpha cells in the pancreas? Why only insulin-making beta cells?
Our pancreas does multiple thing, yet I only ever hear of the beta cells in the Islets of Langerhans being annihilated.
Why is this?
Hmmmm.....
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Why does activity cause hypoglycaemia in diabetics?
(I'm from the UK so I'll be using mmol/L as units and taking <4.0 as hypoglycaemia.)
I remember being told that I should consume a small amount of sugar or reduce insulin dose sightly to increase ...
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How is an extreme insulin overdose counteracted
I just watched this comedy skit that went -
Trainee: I just gave him 10 of insulin
Doctor: 10 what?
Trainee: 10cc
Doctor: * look of terror *
As a diabetic myself I know that 10cc or 1000u is an insane ...
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Reason for sorbitol synthesis in human body
Sorbitol has been proved to be a major contributor to development of complications due to chronic diabetes.
It forms in retina, lens, kidneys, peripheral nerves, ovaries and seminal vesicles by the ...
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Why do some people accumulate more diglycerides in their muscle cells?
The scientist Gerald Shulman has experimentally found that young lean adults in their early twenties that are children to people with type 2 diabetes often show muscle insulin resistance. He found ...
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What terms or concepts are used to describe the morning metabolic phenomenon involving glucocorticoids, glucose, and blood pressure?
A recent conference report described using a vaccine-based strategy to blunt a surge of high blood pressure that occurs between 5 and 8 a.m. Apparently most heart attacks and strokes occur during ...
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How much does 10g of glucose raise the blood glucose level?
If you would calculate it:
~5 liters of blood = 50 deciliters
10g glucose = 10000 milligram
so the glucose level raises by 10000mg/50dl = 200mg/dl
However, it is known that ingesting 10g glucose ...
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What happens to glucose taken up by the liver in type 1 diabetes?
Type 1 diabetes is caused by insufficient insulin production.
Unlike in muscle and adipose tissue (GLUT4), glucose uptake by the liver is by GLUT2 and thus insulin-independent. Consequently, under ...
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Is Dioxin causing Diabetes Mellitus?
Today I was watching a show on Discovery Science (Everything You Need to Know About). In that show they were talking about toxins and venom.
In that they mentioned Dioxin and its effect. And suddenly ...
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Is it unusual for a child to be diagnosed with diabetes?
Recently, I came to know that a boy in my town who is 6 years old is diabetic and many people were shocked from this news.
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Why ketoacidosis is less common in patients of Noninsulin Dependent Diabetes Mellitus?
The other day my teacher said ketone bodies are mostly formed when insulin is less and NIDDM type diabetes mellitus has less chances to grow ketosis. https://medlineplus.gov/ency/article/000320.htm
P. ...
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Mechanism by which hypokalemia reduces insulin secretion
Is there any known mechanism by which hypokalemia reduces insulin secretion?
This video explains a mechanism, but its inherently wrong because ATP dependent K+ channels will allow movement of K+ from ...
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Finding out the best concentration for my plant extract to be used as drug for diabetes
I am using plant extract of Ajuga parviflora and found out that it possess anti-diabetic properties by using alpha-amylase inhibitory assay. I used various concentration 250 µg/ml(29% inhibiton of ...
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What are some potential consequences for attempting to cure Type one Diabetes?
Type one diabetes has been in my family for a few generations. As a carrier and having a mother with the disorder, I've done a lot of research on it. As I am completing my High school Biology course, ...
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Renal threshold for glucose
Wikipedia in its article on 'Glycosuria' says that the renal threshold for glucose (RTG) reabsorption in the kidney is around 160-180 mg/dL. Beyond which the glucose starts to excrete in the urine. ...
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T1D autoimmunity causes' possibilities
As far as I've learned about T1D, the prevalence of the disease and autoimmune disorders in general over the past 5 decades intrigued me to the point it made me wonder if it's really a genetic ...
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Why do type 1 diabetics experience hypoglycemia?
I know that type 1 diabetics do not produce enough (possibly none) insulin since beta cells of pancreas are damaged and as far as I know glucagon is produced by alpha cells (which are healthy in ...
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Is diabetes (type 2) a genetic disease?
My friend's father has diabetes (who was diagnosed with diabetes long after my friend's birth). The doctor told the friend that he has more chances of getting diabetes than a normal person and he ...
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Why do polyneuropathies affect the extremities first?
Polyneuropathy is an anatomic pattern of nerve damage most commonly seen in Diabetes mellitus.
To quote Robbin's Pathology,
In most polyneuropathies, axons are affected in a length dependent ...
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Link between hypoglycemic events in Type 1 diabetics and clinical anxiety?
I recognize that the scientific community is aware that the chemical stress pathway is mediated by glucocorticoids. The pathway response initializes as a result of some sort of stress (potentially ...
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Diabetes Mellitus and renal failure?
I have studied that Diabetes Mellitus leads to kidney failure and that this is because of the damage to the blood vessels (especially the blood vessels in the kidney) due to high levels of blood ...
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Freestyle Libre's Glucose's Specificity and Accuracy?
I am studying the Continuous Glucose Monitoring devices i.e. glucose sensors with continuous monitoring.
Here one good presentation about the topic.
They are considering interstitial fluid in their ...
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What happens if a non-diabetic receives an injection of insulin?
If a person without diabetes or any diabetes-related issues receives an injection of insulin, what happens? Would the blood glucose level drop or does the body naturally compensate for the added ...
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Electrically facilitated active transport across a membrane
I'm trying to go back to school to do a PhD in control theory, specifically concerned with control of glucose. The glucose system can be controlled using two chemicals: insulin and glucagon. I was ...
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Can a brown recluse bite lead to diabetes?
Ok, I realize that this question may seem crazy at first glance. I would agree. Also, this does deal with a medical diagnosis, however, as I'm more concerned with the explanation behind it, I figured ...
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Can stress-induced cortisol reduce diabetes type I?
Let us consider a patient with type 1 diabetes.
I think it would be safe to say that diabetes is an autoimmune disease. Now let us suppose this patient comes under stress. As far as I know, cortisol ...
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Do blood glucose "spikes" contribute to insulin resistance, or is prolonged elevation required?
There's increasing public discussion about the health risks of chronic insulin resistance* (IR). In many cases there's a focus on high glycemic index foods that "spike" your blood sugar, which implies ...
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How would real-time blood glucose monitoring work?
Is it possible to perform real-time blood glucose monitoring using a wearable non-invasive device (similar to a fitness band measuring heart rate)? I'm aware that there are some devices in the market ...
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Why basement membrane thickens in diabetes mellitus?
Untreated diabetes mellitus may lead to blindness and kidney failure because the basement membrane of small blood vessels in these organs thickens due to increased production of collagen and laminin.
...
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How do you express and detect GLP-1 receptors?
I am currently working with a peptide which is an analogue for glp-1, but during invitro studies am not able to detect for the presence of GLP1- receptors.
The cell line used is Min-6. How do I detect ...
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When was it determined that Type 1 Diabetes is an autoimmune disease?
I just found out today that type 1 diabetes is an autoimmune disease. When was this discovered?
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Growth Hormone and diabetes
Growth hormone and insulin like growth factors are diabetogenic, so I assume that people with high growth hormone (say due to pituitary tumor) may be at high risk for diabetes. Has any correlation ...
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