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Questions tagged [differentiation]

Differentiation describes the process in the development from more general cell types into higher specialized cell types.

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2answers
195 views

What controls specific gene silencing during cell differentiation?

I am intrigued by the fact that all cells of our body use the same DNA. How do the cells differentiate during the post fertilisation divisions? I read about gene silencing, which can be an answer to ...
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15 views

Sex change in fishes

When in a flock/school of gold fishes, if male fishes are removed due to some reason and only female fishes remain. It is said that after sometime one of the female fish will turn into male and the ...
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1answer
22 views

What is the difference between differentiation and phenotype switching?

I am trying to model bone remodeling process and I wonder what is the difference between phenotype switching and differentiation. I am relatively inexperienced in biology. Please explain me with ...
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1answer
55 views

Are epigenetic modifications the most stable mechanisms for cell differentiation?

Wondering what the general take is on what are the molecular mechanisms that are mostly responsible for cell type differentiation stability; ie, for a cell's identity to actually become 'locked in' ...
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29 views

Difference in timescale of tissue movement vs cellular differentiation

I would like to better understand the difference in the timescales that cells seem to function. For example, how is it that muscle cells can move within seconds or less under stimuli such as hormones ...
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2answers
45 views

How does a cell identify itself?

In embryological development, undifferentiated cells developed into specific types. As far as I understand, a key differentiating factor is the regulation of gene expression via transcription factors....
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1answer
51 views

Why do stem cells injected into muscle become muscle cells?

In this article published in Science Daily, researchers injected teratoma-derived stem cells into mice with muscular dystrophy, and the stem cells regenerated 80% of the lost muscle. But what is the ...
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1answer
91 views

What is the relationship between induction of cell differentiation and DNA methylation status?

This may sound like a broad question to ask, but I am working on interpreting a review article for my epigenetics course and I'm having trouble reconciling two seemingly contradictory things this ...
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0answers
48 views

Homework: Diffrentiate between 2 toads

How to differentiate between 2 toads one of them result of artificial parthenogenesis and the other from renucleation? I answered that the toad resulting from artificial parthenogensis is identical ...
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1answer
22 views

B Cell Differentiation

During the differentiation of B cells in bone marrow, recombination occurs in light chain and heavy chain genes to produce a single type of functional gene which determines the type of light chain and ...
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0answers
129 views

How do cells become differentiated using epigenetics despite having the same genome?

How is epigenetics used in the differentiation of cells and is this the only thing that is used? I've seen that transcription factors play a role but are these simply proteins that initially write the ...
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36 views

What's the difference in roles of GATA-2 and BMI-1 in guiding Hematopietic cells?

I've discovered that hematopoietic cells become lineage-positive (Lin+) and go down the path of becoming lymphoblasts and myeloblasts, and that both BMI-1 and GATA-2 are transcription factors that ...
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1answer
114 views

In (human) zygote cell differentiation, do we know how the cells coordinating the process know their current position? [closed]

I've seen this question asked in a mature person -- e.g. lip cells will create more lip cells -- but how about in the developing zygote. I've seen neighboring cells help determine the type of the ...
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1answer
36 views

How does the cell cycle affect stem cell fate?

I keep reading about the stages of the cell cycle affecting stem cell fate, however I do not understand how. After all, any cell will have to pass through the whole of the cell cycle, and go through ...
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0answers
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In Vitro Meat Initial Production

I've gotten interested in the science behind in vitro meat, and I was wondering what would be necessary to create it. Would you initially need a primary culture, or an immortalized cell line? And how ...
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217 views

What's the difference between proliferation and diffusion when talking about changes in tumor density?

Cell proliferation and cell diffusion seem to be important quantities to estimate when trying to understand or measure tumor growth, but I don't really understand a) the difference between them or b) ...
5
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1answer
118 views

Spermatogenesis in humans - timing of phases and chromatin modifications

I'm interested in the timing of events during human spermatogenesis, ideally with some references I can build off of. Specifically, I am trying to pin down the number of days for: Spermatogenesis, ...
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1answer
31 views

differentially expressed genes of the treated with estradiol samples

I did differential analysis on samples treated (G1E-ER4) with estradiol (differentiation induced by estradiol) and control (G1E). The genes that I gor as differentially expressed in G1E-ER4 showed ...
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1answer
315 views

cell specialisation and their location

When we create new cells, how come they are of the 'right' type at the 'right' place? For example, when I make a new cell on my lips, it's obviously not the same as a new one in my kidneys. Is the ...
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1answer
40 views

Cell-type specific methylation profiles: original reference finding?

This is a general question, and a specific question. I'm looking for the original reference that first talked about how DNA methylation profiles are cell-type specific. This is specific, because I ...
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1answer
198 views

Bacterial Cell Problem

A microbiologist has discovered what she thinks are two new types of algae. The first cell (Organism 1) appears cubic and is approximately 1.5 μm long, 1.5 μm wide and 1.5 μm deep. The second (...
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857 views

DIfference between diversification and differentiation

In Adaptive dynamic : what is the difference between Ecological Differentiation and Ecological Divergence ?
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Where can I find a full genealogy of human cell types?

It is said on Wikipedia, that the precursor of blastocyst is a morula, and that the precursor of morula is a zygote. This gives us the part of genealogy tree of cell types. Unfortunately, no full ...