Questions tagged [dna-repair]

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Are highly-polyploid organisms more resistant to ionising-radiation-induced DNA damage?

Homologous recombination, although most famous for its use to mix together maternal and paternal alleles during meiosis, is most commonly used as a DNA-repair mechanism, allowing cells to repair ...
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Families within the UDG superfamily

Does anyone know how many families within UDG superfamily are there? My confusion arises as in the review Schormann, N., Ricciardi, R., & Chattopadhyay, D. (2014). Uracil‐DNA glycosylases—...
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Could you force meiosis in a cell that normally uses mitosis

I've read in the red queen something that suggests the DNA repair mechanisms are better in meiosis than they are in mitosis. I was wondering if occasionally we could force some of our cells that use ...
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How does repair take place on leading strand in Eukaryotes?

I am currently reading molecular biology of the gene by Watson to develop understanding for the mechanism of replication and repair. Under the topic mismatch repair of DNA they mentioned that ...
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Does the SMUG1 enzyme break single-stranded DNA?

The SMUG1 gene codes for the enzyme single-strand selective monofunctional uracil DNA glycosylase. This enzyme can remove uracil from single-strand (unpaired) DNA. (Uracil can occur in DNA due to ...
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In DNA repair, how is it determined which strand contains the error?

DNA replication is more accurate than transcription (or RNA replication) because mechanisms exist for proof-reading and repair of DNA, but not for RNA. Consider a segment of a DNA strand, AGTC. Its ...