Questions tagged [dna-repair]

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12
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2answers
3k views

Do spike-protein-based vaccines undermine the DNA repair system?

I ain't no biologist, but I came across a paper recently and tried to understand it: SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro My question: Is it a correct ...
2
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1answer
115 views

How does repair take place on leading strand in eukaryotes?

I am currently reading molecular biology of the gene by Watson to develop an understanding of the mechanism of replication and repair. Under the topic mismatch repair of DNA, they mentioned that ...
3
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0answers
162 views

Are highly-polyploid organisms more resistant to ionising-radiation-induced DNA damage?

Homologous recombination, although most famous for its use to mix together maternal and paternal alleles during meiosis, is most commonly used as a DNA-repair mechanism, allowing cells to repair ...
0
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0answers
43 views

Could you force meiosis in a cell that normally uses mitosis

I've read in the red queen something that suggests the DNA repair mechanisms are better in meiosis than they are in mitosis. I was wondering if occasionally we could force some of our cells that use ...
1
vote
1answer
51 views

Does the SMUG1 enzyme break single-stranded DNA?

The SMUG1 gene codes for the enzyme single-strand selective monofunctional uracil DNA glycosylase. This enzyme can remove uracil from single-strand (unpaired) DNA. (Uracil can occur in DNA due to ...
7
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4answers
1k views

In DNA repair, how is it determined which strand contains the error?

DNA replication is more accurate than transcription (or RNA replication) because mechanisms exist for proof-reading and repair of DNA, but not for RNA. Consider a segment of a DNA strand, AGTC. Its ...