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Questions tagged [dopamine]

Dopamine is a neuotransmitter which is secreted by dopamine-secreting neurons. It is released in the brain by nerve cells to send signals over the synaptic gap to other nerve cells.

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42 views

Number of dopaminergic neurons in VTA

Do you know an authoritative source for the approximate number of dopaminergc cells in the ventral tegmental area (VTA)? Ideally I would like to know this for mice, rats, as well as humans, but one ...
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19 views

Prolactin and Dopamine throughout orgasm?

Dopamine is also known as a prolactin-inhibiting hormone, which keeps prolactin levels in the body in check. However, during orgasm, dopamine is released to make the experience pleasurable. I know ...
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56 views

What is this type of diagram called and how to interpret?

I'm just starting a project on neuroscience for sixth form. I have had no teaching in this area so had to teach myself entirely. This is a "low-power image of a transverse section through the ...
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1answer
426 views

Why does excess dopamine activity in the pleasure centers results in less pleasure in schizophrenics?

According to the dopamine hypothesis of schizophrenia, there is an excess of dopamine in the mesolimbic pathway (nucleus accumbens), and this contributes to the positive symptoms of schizophrenia. I ...
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129 views

If I receive dopamine only from doing difficult things will I eventually enjoy them?

I've recently read a post from reddit about how dopamine affects our motivation. Author states: Dopamine is pleasure. Your brain craves more pleasure. You get too much pleasure and your brain ...
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1answer
80 views

Does cocaine bind competitively or non competitively to DAT?

I was just wondering whether cocaine, once reaching a synapse, binds to a DAT (Dopamine transporter) competitively or non competitively, or neither of them?
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51 views

Trying to understand a scientific text about neurons and dopamine

I'm in the process of reading https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1564381/ and I'm trying to understand how the predicting is done in the neuron. What I distilled so far: A cell gets an ...
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485 views

Can dopamine antagonists be used as dopamine upregulation?

Can dopamine antagonists such as Thorazine that are used to treat schizophrenia and bipolar be used to upregulate dopamine in the long term in healthy (non schizophrenic or bipolar) users to get a ...
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1answer
8k views

How long does it take for dopamine to reach normal levels after a significant drop?

The building block sequence for is: Phenylalanine << Tyrosine << L-Dopa << Dopamine. It’s produced only in a few, very specific regions: Substantia Nigra and the Ventral Tegmental ...
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104 views

Dopamine receptor count: Role and Measurement

Can the Dopamine (DA) receptor count take a significant drop over the course of life or does it stay constant? I read that low D2 (Dopamine receptor type 2) receptor count does not cause Parkinson's ...
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3answers
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Why is dopamine or a dopamine-receptor agonist not pumped into the brain of Parkinson patients?

I am aware that dopamine cannot cross the blood-brain barrier, but can't it be pumped inside the cerebrospinal fluid via some permanent tube implant? Wouldn't Parkinson patients chose that over ...
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1answer
524 views

Dopamine and other neurotransmitter release during music listening

I'm looking for any studies that show a positive curve in respects to music sessions in humans and neurotransmitter release (specifically dopamine, epinephrine, and serotonin.) Any direct links would ...
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24k views

What is the difference between tonic and phasic firing?

I am reading about dopamine, and I have realized that dopaminergic neurons can fire phasically or tonically. What is the difference between these two modes of firing?
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Prenatal hyperkinetic dysfunction and its effect on endurace

Do people with an hyperkinetic dysfuntion have a better endurance? Are they fitter in cause of their Dopamine-overdose or any other reason? I have a case, where someone does not do any sports, but ...
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1answer
193 views

What happens to human dopaminergic reward system once a teenager becomes adult?

I've recently heard a podcast which explained teenage impulsivity and novelty seeking in part by "Lowering the baseline dopamine activity in the reward system" "Increase in dopaminergic reward in ...
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86 views

DAT1 dopamine and cocaine binding

I've searched the internet for several minutes and I've looked at DAT but I'm having trouble finding the DAT binding location. Where (and to which aa) does dopamine and cocaine bind to hDAT1?