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Questions tagged [extra-cellular-matrix]

Molecules secreted by cells to provide structural support and biochemical support.

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Signals triggering ECM formation

What signaling triggers the formation by the cells of extracellular matrix ? I assume the mechanism is connected to autocrine signaling or paracrine signaling. Or maybe also stiffness sensing. Could ...
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1answer
440 views

What do white blood cells do with FOREIGN white blood cells?

White blood cells or leukocytes are known to fight invaders, infections or basically anything foreign. They also contain DNA (while red blood cells don't). But what about foreign "white blood cells" ...
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How can one measure the effect of a stem cell's matrix on the progeny of that stem cell?

A number of recent papers that have used hydrogels to alter the ECM of mesenchymal stem cells to quicken their development to cells used specifically for cartilage or really any other type of cell. ...
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80 views

Estimating RPM to RCF in Methods from Older Papers

I'm attempting to replicate a cell biology method from a 1958 Laboratory Investigation paper. The protocol is for the isolation of an extracellular matrix protein, and a key step is a centrifugation ...
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Does trypsin strip flask coating?

Mammalian cell/tissue cultures sometimes require flasks coated with proteins. My uneducated guess is that these proteins mimic the ECM, perhaps the basal lamina, so finicky contact-dependent cells can ...
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1answer
376 views

Which cells are responsible for the extracellular matrix remodeling?

I am studying a case of tendinopathies induced by an alteration of how the extracellular matrix is being remodeled. From my understanding there has to be a careful balance of MMP (metallproteinases) ...