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Questions tagged [fat-metabolism]

The set of biochemical processes involved in the creation and utilization of lipids.

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When consuming carbohydrates and fats together, why are the fats caloric?

If I understand things, and I most likely don't: mammals primarily use carbohydrates to produce metabolic energy when there are sufficient carbohydrates to do so. The use of fats for fuel requires ...
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Where does weight go when you lose it? [duplicate]

When one loses weight, where does the lost poundage (I assume comprised mainly of fat) go? Is it urinated out? Defecated out? If a combination of both, does the percentage of each differ depending on ...
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How does body fat leave your body?

So I know that it’s not from tears or sweat because they are composed of mainly water and sodium, it’s not from going poo or pee as poo and pee are made of the parts of food that supply your body with ...
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Lipids that are not found in human body

I know that human body contains FA some of which are essential and the other is not depending on the ability of the body to synthesize them in a sufficient amount, but I need a reference of the lipids ...
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What is the source of the fat in adipose tissue?

I have heard the opinion that all of it comes from de novo lipogenesis of carbohydrates, but I'm skeptical. Is there evidence either way - either that dietary fat definitely gets stored in the adipose ...
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Why do humans lose subcutaneous fat from the extremities with age?

Why does fat tissue die and shrink on the hands, knees, and lower legs of most people as they age, even when they are overweight? In most people, their bone definition becomes much more visible around ...
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117 views

Why do humans lose subcutaneous fat tissue with age?

Why exactly do humans lose subcutaneous fat tissue with age? It appears that we either lose fat cell volume or we might actually be losing the number of fat cells with age. One hypothesis is that as ...
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How would a medication cause a one to maintain a different weight?

This isn’t really a medical question, I’m just really curious about this. I was maintaining weight A and then started taking a medication that brought me to weight B. While on the medication, I ...
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CETP inhibitors and LDL levels

While CETP inhibitors effectively reduce LDL, they also paradoxically increase the frequency of adverse cardiovascular events (angina, revascularization, myocardial infarction, heart failure, and ...
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76 views

When you lose weight, how does the mass exit your body?

As a thought experiment, consider the case of Angus Barbiery, who allegedly lost almost 200kg in about a year by not eating at all, save for necessary nutrients provided as supplements. My question ...
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What happens to lipoprotein lipase after a sugar only diet?

Insulin increases the activity of lipoprotein lipase thay allows cells to take in lipids from chylomicrons in the blood. If a person takes a sugar only meal like drinking coke, insulin is released. ...
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Does humans' subcutaneous fat increase with lower temperatures?

Is there a study on the dependence of the natural amount of subcutaneous fat and environment temperature? Is there a genetic difference in fat storing across human populations?
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Why are fatty acids consisting of even number of carbons predominant?

Most of the fatty acids in animal biology consist of even number of carbons in its parent chain. What property of such fatty acids cause the biological systems to prefer them over the odd counterparts?...
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How short chain fatty acids directly enter blood vessels?

Long chain fatty acids enter lymph and then get drained into blood vessels. But why short chain fatty acids don't go this pathway? Is it related with solubility?
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Extra-mitochondrial conversion of Acyl Carnitine to Acyl CoA

Normally fatty acids in the form of acyl CoA are converted to acyl carnitine in a reaction catalysed by carnitine palmitoyltransferase I (CPT1), which is also known as carnitine acyltransferase I. ...
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Why does the amount of adipose tissue contribute the most to the total body water amount in humans?

I don't quite get this concept. An obese individual will have a greater fat content in their body, and thus will have 45% water in their bodies (for example), versus a slim person that will have 75% ...
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Is dietary fat directly stored in adipose tissue or is it immediately metabolized?

I know that fat goes to adipose tissue and even sugar gets converted to fat and goes to adipose tissue, but what happens to fat (unsalted cow milk butter) I just ate? Will it give me energy now, or ...
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370 views

How are micelles formed from the byproducts of emulsification in fat digestion?

It is known that fat droplets are made into emulsion droplets via the addition of bile salts. It is then said that the emulsion droplets are made into micelles through some sort of lipase, which can ...
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Breathing faster to lose (more) weight?

I understand that when the human body loses weight, the vast majority of that weight is lost as $CO_2$ (and a small bit is lost as water). I expect the predominant way $CO_2$ exits the body is through ...
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After fat is burned from one part of the body, is fat moved around the body?

If you go running, for example, and burn fat from your legs, does your body send fat from other parts of the body to that area? If so, why would it do this?
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How can grass-fed livestock generate fat?

How can herbivorous cattle get fat? These animals eat only grassy substances, think of cattle, buffalo, goats etc. For example, wheat grass contains 0% fat, and its nutritional value is limited to ...
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Is the amount of cholesterol the body produces affected by how much cholesterol you take in with food?

In the past I've been told multiple times that if you don't eat foods containing cholesterol, your body will increase its production of cholesterol to balance out the lack of nutritional cholesterol. ...
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How does the body determine where to deposit fat reserves?

People's bodies store fat in similar areas, but often there are subtle differences in which areas are first or slightly more effected. This seems to also be apparent with morbidity, where certain ...
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Is palmitic acid really that dangerous?

According to Wikipedia, "Palmitic acid is the most common saturated fatty acid found in animals, plants and microorganisms. It is also the first fatty acid produced during fatty acid synthesis and is ...
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Why is glycerol kinase absent from adipocytes but present in the liver?

Why don't adipocytes have the enzyme, glycerol kinase? Wouldn’t it be more efficient for them to utilise glycerol present to synthesize triglycerides than to get it from the liver? So what is the ...
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Is there such substances that body can only send to storage (as fat)?

I watched video with statement that there are such part of substance in potato chips which body can't use ("empty calories"), that they surely will be stored as fat. It was here on 12:23: https://...
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Rate of production of enzymes in human [closed]

In the metabolic pathways, each of the reaction needs an enzyme(protein) in order to occur successfully. Is there any quantitative measure that can be associated to this enzyme? Like synthesis rate of ...
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What would the presence of a hub metabolite in a metabolic pathway signify?

Say I have a metabolic pathway, consisting of multiple metabolites and reactions. On analyzing the pathway I find that among all the metabolite, one metabolite is the hub metabolite (hub metabolite is ...
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3k views

Can the human body create glucose out of fat?

I read conflicting views about whether or not the human body can create glucose out of fat. Can it?
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1k views

Fate of Acetyl CoA in well fed state?

When we have eaten well and take fat rich diet then in this condition Acetyl CoA produced from fatty acid breakdown will be gone to storage in adipose tissue or not? If it will go for storage then why ...
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Can lactate be created in ketosis?

After looking at Cori Cycle (from wikipedia) I have a question about how the lactate can be produced in ketosis. According to this article: in a low-glucose state, where the body senses that ...
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Does the body prioritise the use of available sugar before fat?

Let's say you eat a very unhealthy snack that contains 90% sugar and 10% fat. Would somatic cells not start using the fat for energy until all the sugar is used up? Does the body not use fat at all ...
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If chylomicrons can not get into the capillaries, how do they supply to tissues?

The transport of chylomicrons is into the lacteals mainly because they are too big to get into the capillaries and yet they later supply triglycerides in the extra hepatic tissue by traversing in the ...
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Can bacteria metabolize fatty acids for fuel?

I'm not a microbiologist, but rather a physiologist curious about microbial metabolism. Much like humans bacteria can utilize glucose, but when it comes to long chain, medium chain, or short chain ...
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What is the function of CETP?

I read up that CETP transfers cholesterol from HDL, which collected it from tissues, to VLDL. This VLDL is then sent back to the tissues, ultimately forming LDL internalised by cells. What is the ...
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What is the rationale behind reverse cholesterol transport?

Reverse cholesterol transport is transport of cholesterol from the tissues back to liver/VLDL. My question is why do the tissues have this extra cholesterol in the first place? Why would you ...
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291 views

How body loses more fat in CO2 form than in sweating form? [closed]

Yesterday, I saw TV Game Show. There is question like this: Body loses more fat in which form? It gave 4 options: 1) CO2 2) sweating 3) xxx 4) xyz sorry i didn't remember 3 & 4 options. ...
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What is the actual function of HDLs and CETP?

I know that HDLs collect cholesterol from peripheral tissues and transport it back to the liver using SRB1 - Reverse cholesterol transport and dumping it in bile. So the tissue is producing some extra ...
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Bodyweight loss vs calorie shortfall

I have read that 1g of pure fat has 9 Calories. If I dieted successfully in a way that did not cause me to loose muscle, and I had a cumulative calorie shortfall of 90,000 calories. Would that ...
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How much energy would it cost to synthesize all cholesterol requirements de novo?

Imagine a scenario in which some person is unable to absorb any dietary cholesterol because of some intestinal mutation (for example). Thus, they have no cholesterol available from their diet for ...
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134 views

Is there an evolutionary advantage for coconut oils to be rich in saturated fats?

I know that coconut oil is composed of multiple saturated fatty acids, but is there a reason why this would have increased the fitness of the coconut plant?
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194 views

Metabolic efficiency for fats and sugars

I am making an exercise for physics students about the first law of thermodynamics, burning heat and evaporation heat. So my idea is to use cycler which runs on fats and sugars where proportion ...
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380 views

What are the differences between carnitine forms?

I've heard of L-carnitine, acetyl L-carnitine and L-carnitine L-tartrate. What form(s) occur in meat? What form does the human body manufacture? Is L-carnitine just a shortened name for L-carnitine L-...
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Consumption of different type of energy when one is inactive

I'm wonder if there is any study done on this and what are the results? how much of each type of energy one's body(healthy normal person) uses when inactive(seating down) I know there are alot of ...
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What would happen if most the fat in your body was rapidly converted into energy in 2 minutes? [closed]

It all started out as an argument I had with my friend.He said that "it would be the equivalent of catching a fire and burning" But all I thought would happen is that you would now be very hyper ...
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480 views

What happens when we eat excess fat?

The fats in our body are stored in fat cells. When we over eat fats does the size of our fat cells increase, are more fat cells generated, or do we "throw out" excess fat?
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368 views

If eating 100% fat 2 times more worth the energy I spend during the day, will I store body fat?

So in theory, insulin hormone is the one that tells the body "eat more. don't burn body fat". Alongside with glucose blood level regulation and turning excessive glucose into liver (which later goes ...
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84 views

Why doesn't the body optimize how many fatty acids it burns?

Ketone bodies are produced due to an excess of fatty acids being burned (accumulation of acetyl-CoA) so my question is: Why doesn't the body simply regulate how many fats it burns so it doesn't have ...
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Cholesterol's role in lipid uptake [closed]

I'm studying the digestion of fats and I understand that our dietary fats mostly consist of triglycerides. We absorb the fats and eventually they end up in a muscle/adipose cell for storage (as ...
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438 views

Is there any disadvantage to having a really low adipocyte count in our times?

The key feature of adipocytes seems to be energy storage. Today humans in Western countries don't have to hunger and have therefore less need to store energy in fat cells. Do adipocytes have ...