Questions tagged [forward-genetics]

Start with a phenotype, and try to figure out the genotype that causes it. GWAS, linkage disequilibrium mapping, etc.

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How can a YAC be screened against a cDNA library and a cosmid library of genomic DNA to find a gene?

I am reading fw2.2: A Quantitative Trait Locus Key to the Evolution of Tomato Fruit Size (doi: 10.1126/science.289.5476.85). The authors are trying to find the gene that makes tomatoes bigger. As far ...