# Questions tagged [fst]

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### Calculate expected heterozygocity using Wright's F statistics (here, FIS)

I try to better understand Wright's F statistics. In general, there are many derivations and many interpretations, and in books, the parameters are called differently, that's why I am struggling. More ...
1 vote
205 views

### What precisely is the pairwise Fst calculated in GenAlEx 6.5?

A professor of population genetics informed me that there is not a unique notion of pairwise Fst scores in the literature. This information has made me more cautious about what may be implemented by a ...
• 1,045
1 vote
49 views

### Why is $H_{S}$ divided by $H_{T}$ in Wright's $F_{st}$ equation?

$F_{st} = H_{t}-\frac{H_{s}}{H_{T}}$, where $H_{T}$ stands for expected average heterozygosity in the meta population and $H_{S}$ stands for expected average heterozygosity in the sub-population. As I ...
• 11
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### Why is Fst/1-Fst used when calculating isolation by distance?

In population genetics a common analysis when considering the genetic structure of a population is to examine isolation by distance - the relationship between the genetic difference and the geographic ...
• 131
110 views

### Will Fst (inbreeding coefficient) always be a value close or at 0 in asexual populations?

FST is the average inbreeding coefficient of a total population. The equation is: $F_{ST} = \frac{Var(S)}{Var(T)}$ $Var(S)$ = variance in the frequency of the allele between different subpopulations, ...
• 41
390 views

### Fst genetic distance: Autosomal vs. mtDNA

As far as I'm aware, mtDNA is only inherited from the mother. Hence, if I compute Fst from autosomal SNPs, then I'll get the actual genetic distance between two human populations. If I compute the ...
238 views

### What test to apply to detect genomic signatures of selection?

I would like to ask you for your sugestions for selecting a test to detect signatures of selection in the following mouse model: We have three groups: animals exhibiting trait A, trait B and controls....
• 185
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### Calculating pairwise Fst from allele frequencies

I am trying to refresh my memory on population genetics for a project, and I'm having some trouble. Assume I have genetic data on 3 populations with 5 individuals in each of a given species, with the ...
• 41
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### How could one calculate the gene flow between two populations?

Imagine there are two populations X and Y, and for each population you have the genotypes of each individual in that population (e.g. Aa, AA, aa, etc.), but for multiple loci (e.g. AABb). How could ...
• 3,577
1k views

### Software to calculate Fst from sequence data

I'm looking for a software to calculate Fst from 3 loci DNA data of individuals from a metapopulation. I don't have any prior on the population structure (have no idea of the number of subpopulations ...
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