Questions tagged [gene]

The basic unit of heredity which encodes for some function RNA or protein product.

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29 views

If the AraC protein was a gene repressor when it binds arabinose, would there be high or low transcription levels when arabinose is present?

If the AraC protein were to function as a gene repressor when it binds arabinose, would there be high or low transcription levels when arabinose is present?
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Is it possible to fuse DNA from two sperms and can a baby be born from that?

If this is possible, then isn't there going to be a chance to have a YY child?
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How often are diseases caused by more than a single mutation of a gene?

Many genetic diseases are caused by mutations in a gene and often, it is a single nucleotide polymorphism (SNP) that has dramatic consequences (e.g. the E6V hemoglobin mutation in sickle cell disease)....
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Is there any way siblings could be related more than 3/4th siblings, but less than full siblings?

I couldn’t find anything on Wikipedia. 3/4th siblings are 37.5% related while full siblings are 50% related. Is there anything in between?
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Can one mouse gene have multiple human orthologs?

I was trying to map a mouse gene: Arfgap1 to it's human ortholog. Uniprot shows there are two human orthologs of this gene: https://www.uniprot.org/uniprot/?query=yourlist:...
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What is targeted gene disruption?

I am a bit confused about what targeted gene disruption means. I was reading this article in which they compare the Pyrococcus Furiosus genome with a genetically tractable strain P. Furiosus variant ...
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What are the causes of gene amplification in archaea?

I was studying this article about Genome Sequencing of a Genetically Tractable Pyrococcus furiosus Strain Reveals a Highly Dynamic Genome in order to try to extrapolate some features that could ...
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117 views

What is the map unit between the genes?

While doing some biology I came across this question: The following tables present results of plant crosses involving two linked genes: S is a seed-color gene, and L is a plant-height gene. Each gene ...
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58 views

What is the probability of having a son with blood type O? [closed]

So I was solving some biology questions, and this question left me confused. The response is supposed to be 22% according to the answers, but all the methods that I used did not lead me to it. I ...
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50 views

Genomic library preparation: Why does the restriction enzyme not cut into the gene?

I am currently trying to understand creating a genomic library more profoundly. In most textbooks I read (as well as wikipedia), they mentioned that the genomic library is created by isolating the DNA ...
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103 views

Can a strand not be synthesised in 5' -> 3' direction?

I've been solving some biology questions, and according to one of them ( I have the responses too) the following phrase is false: "Both strands are always synthesised in the 5' to 3' direction.&...
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What is a good book to start with if I'm interested in Gene clustering analysis?

As a beginner, I would like to learn more about gene clustering analysis, namely discovering groups of correlated genes potentially coregulated or associated to some conditions or finding patterns in ...
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276 views

How do gene locations change during crossing over events?

Suppose you have two variants from the same species, which have slightly different chromosomes I's to each other. Genes may be in slightly different positions on the chromosome, and the lengths of the ...
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Why is the start of my coding sequence ATG and not TAC?

I am engineering a set of genetic sequences and have come across a surprisingly basic point of confusion that seems to have fallen through the cracks regarding coding sequences. The standard start ...
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149 views

What is the difference between non-coding and intergenic regions?

The initial question was about understanding what is in the downstream of a gene in a eukaryotic organism. I understand that this region is located 3' of a gene, and therefore I would expect to find ...
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109 views

Deviation from Hardy Weinberg equilibrium (HWE)

I have a set of 10 genes, each gene contains around 15 SNPs. I have tested the deviation from Hardy Weinberg equilibrium (HWE) for all SNPs. All of the SNPs didn't deviate from HWE, except 5 SNPs in ...
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102 views

Is there a term for the opposite of intergenic?

I am looking for a term that describes DNA regions that overlap genes, i.e., non-intergenic DNA regions. For example, say I am writing a paper about DNA-binding sites (i.e., DNA sequences that ...
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62 views

Should I consider one or two DNA chains to find how many nucleotides are in a gene?

I am trying to solve an exercise. How many nucleotides does a gene contain if information about 287 amino acids is encoded in it? What is the molecular mass and length of this gene? AFAIK, I have to ...
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78 views

What is the impact of selection on orthologous and paralogous genes? How would this impact differ in different regions of protein coding genes?

Since paralogs increase the size of the genome and provide more opportunity for the evolution of novel characteristics, would they be more prone to selection?
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What is the definition of gene, genotype and phenotype, pre and post DNA?

i know that the definition of gene is a unit of heredity, also a sequence of nucleotides in DNA that gets copied to RNA and then proteins. Genotype is the genetic composition of an individual ...
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Microarray experiment validation meaning

I have a quick question: what does microarray experiment validation mean ? I was reading a paper in which they say that the data of the experiment show that the 3 genes radB, dp1 and dp2 are co-...
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38 views

Is the mRNA produced constant during time?

I am doing a statistical data analysis of a dataset of P. Furiosus cells exposed to gamma radiation. For the samples exposed to gamma radiation, I have the values of mRNA produced over time. For the ...
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54 views

Is there a negative correlation between the mRNA produced by the cell and the time of extraction? [closed]

I am doing some data analysis about gene expression time series. When I plot mRNA produced by P. Furiosus cells irradiated by gamma radiation against the time of extraction, it seems that there is a ...
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1answer
80 views

Convert fasta to ascii?

Is there an algorithm or tool to convert a fasta sequence file (such as the file linked below) into an ascii file for the purpose of gene synthesis? https://www.rcsb.org/fasta/entry/6EQJ To the best ...
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What is the word for a group of genes inherited together?

I know the words haplotype and haplogroup, as well as genetic linkage, but... I recently came across a new phrase describing genes which tend to be inherited as a group, and wrote it down, but now ...
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Gene knockdown vs gene knockout vs knocksideways? [closed]

How are the techniques: Knock-sideways, knockout & knock-down different?
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Clarification regarding a statement in "The Selfish Gene" by Richard Dawkins

In the third chapter of The Selfish Gene: Immortal coils, Dr.Dawkins makes the following statement while arguing for the case that ultimately "the gene" as he defines it is the unit of natural ...
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How does DNA shape a living organism? [closed]

I'm haven't studied biology so excuse me if I'm getting something wrong. I'm trying to understand how the DNA from a sperm and egg cause the egg too multiply and form a perticular shape (shape of a ...
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Mutated and unmutated PCR product

If I have a mutated colony containing the fusion protein, mCherry instead of the stop codon TAA, and an unmutated colony which does not contain the protein. Why will the PCR products of the two ...
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which specific field to study to know more about genes and genomes [closed]

I recently got interested in specific subjects : 1.Evolution 2. DNA, genomes etc and its structure 3. Abiogenesis I am a software engineer with good fundamental understanding in math & physics ...
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Where do biologists get information about mouse genes? [closed]

From this article https://ui.adsabs.harvard.edu/abs/2005Sci...308.1909S/abstract “We created transgenic mice that overexpress human catalase localized in the peroxisome, nucleus, or mitochondria (...
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Can a gene be split between different genomic locations several kb appart? [closed]

Can you have exons and introns of the same gene separated by hundred of kb in a genome? If so, how is the full mRNA assembled in such distance? I'm working on plant mitochondria and I've seen an ...
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535 views

Open Reading Frames vs Coding Sequences (CDS), are they different?

The two terms confuse me for a long time. What is the difference between ORF and CDS. Some people say ORF could contain intron and CDS does not. The wikipedia definition of ORF does not contains ...
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How does new species come into existence?

The only reason for the creation of new species that I found from the internet is geographical isolation. Are there any more reasons?
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How do I identify and then isolate a Gene that codes for a particular observable phenotype

How do I identify and then isolate a Gene that codes for a particular observable phenotype. It is a novel bacteria and I do not know the gene sequence or the protein that it codes for.
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What are the implications/predictions of the selfish gene theory?

Are there any testable predictions or implications of the selfish gene theory? Or it is just interesting interpretation of the observations/experimental data? If this theory is not falsifiable and ...
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Genes where both a disabling mutation and copy number amplification cause different genetic diseases

I'm trying to make a list of such genes, because they must be tightly regulated. MeCP2 is one - it causes Rett Syndrome with a disabling mutation, but causes MeCP2 duplication syndrome if its copy ...
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What is an allele?

According to the entry for allele in Wikipedia: “An allele is a variant form of a given gene, meaning it is one of two or more versions of a known mutation at the same place on a chromosome.” ...
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What does it mean that the transcript is enriched?

I think I don't get the meaning of "enriched" in the context of genes. What's the difference of gene being "enriched" and "expressed" in the cell?
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Can two proteins activate/inhibit the same gene at the same time?

Suppose there are two proteins inhibiting a particular gene. Its not necessary that both will inhibit the gene at the same time instance right? So if one protein has already inhibited that gene before ...
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Study on Introns?

I am curious whether there has been a study done on the effects of removing introns. Specifically, what happens if you genetically edit a eukaryote genome to no longer contain introns? Or maybe just a ...
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Are any genes over a billion years old?

Are there any genes (for any organism) for which we can say with confidence that they are over a billion years old?
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Do all humans have an identical nucleotide sequence for certain proteins, e.g haemoglobin?

All humans have the same sort of proteins in our bodies. Take haemoglobin for example. Is the gene coding for haemoglobin in my body identical to everyone else's gene or is there slight variations ...
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Consider gene is countable, can anyone give a concrete example of "a gene"?

gene is a countable noun but people always say genes, so what is A gene? for instance, Each chromosome contains many genes, so, which part of the chromosome of Escherichia coli could be ...
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Do human genes get affected by irregular sleep and other factors

I'm new here so please go easy on me. Do our genes-the ones that carry our appearance, intelligence and other traits get destroyed or lost due to irregular sleep, excessive body heat, smoking, ...
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Where can I find DNA decryption research? [closed]

What is the name of the science that studies the mathematics of DNA? Where can I learn about maths, statistics, types of code, numbers, patterns and graphs for genes and information found in DNA?
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Emergence of novel protein interactions by mutation of amino acids

Are there any examples of proteins that, without coming from a recent duplication event, underwent a mutation(s) that caused it to have a novel interaction with a new ligand, substrate, other protein ...
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Why does eyebrow growth stop after it reaches a specific length?

When compared to hair that grows forever after we cut it, why do eyebrows stop growing? What genes measure current length of eyebrow to ensure it stops growing after a specific length?
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What is the difference between Regulatory Gene and Modifier Gene?

If both controls the expression of another gene by physically or genetically interacting with the target gene, which attributes make "Regulatory gene" different from "Modifier gene" or vice-versa?
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Is there a known mutation of an insertion type that prevents being infected by a virus?

Recently there was big news about the mutation CCR5 delta 32, that prevents HIV from infecting white blood cells, that was a deletion type of a mutation. Do we know of an insertion type of mutation ...