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Questions tagged [gene]

The basic unit of heredity which encodes for some function RNA or protein product.

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Gene frequency — database/site

Is there any free database when one can check the gene frequency in a healthy population? For example I would like to check it for genes like BIN1, CLU or CR1. On the English Wikipedia I found a gene ...
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Critical discussion: Gene expression and systems biology allows us to understand the control of complex traits

I'm having a bit of trouble tackling this question. Any help on what I should write about or the points I should mention would be much appreciated. I keep seeing articles about eQTL and QTL are these ...
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Why eyebrow growth stopped after it has specific length?

When comparing with hair that grow forever after we cut it, why eyebrow not. what gene measure current length of eyebrow so it stop to grow after specific length.
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Number of alleles' variations in a mushroom that has over 20,000 sexes

I am trying to understand the mating behavior of a particular species of fungi known as Schizophyllum commune, or the split-gill. I found a blog post that explains the mechanisms that define the ...
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Is there any technique can quickly expand one set of cell chromosomes?

Assume a cell type is very scarce while isolated out and hard to expand in vitro, and I wanna have more of its chromosomes, is there any technique , in vivo or in vitro or ex vitro, any would count, ...
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CRISPR Knock in

Using the CRISPR/Cas9 technology, it is possible that after inducing a DSB with the Cas9 endonuclease guided with an RNA designed by the user and using a template DNA, get a desired Knock-In (KI) by ...
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Does the law of independent assortment apply to homologous chromosomes or alleles, or both?

My textbook is giving me two definitions 1st def: "random orientation of homologous chromosomes at the metaphase plate in meiosis 1." 2nd def: "alleles for one gene separate into gametes ...
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Can Tajima's D and other population genetic tools be used to copare Arabidopsis ecotypes?

I am currently investigating 2 genes in Arabidopsis taliana that are a product of a recent duplication even (observable from synteny and phylogenetic analysis). In addition to the molecular and ...
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Functional Difference between the Distal Promoter and Enhancer Region

According to the Wikipedia article on eukaryotic promoter regions, the distal promoter is: Anything further upstream (but not an enhancer or other regulatory region whose influence is positional/...
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Which gene regulatory network is the largest in human?

What is the maximum number of nodes involved in any gene regulatory network and which network is it, provided its from human?
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Gene networks in insects

I am working on gene networks and I currently have the honey bee gene network to work with. What I am missing is a gene network that I could compare it with. Could you please guide me to a database/...
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135 views

Familial Hypercholesterolemia

Why does Familial Hypercholesterolemia shows autosomal dominant pattern? Let us take that there is mutation in LDL receptor gene, it is said that: The LDL receptor gene is located on the short arm ...
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What is the upper limit of number of SNP based mutation in any protein?

I want to know if there is any upper limit of, how many point mutation a protein can have because of disease or nsSNPs? The general studies only focus mostly on a single or double site mutation of any ...
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How to find name of the gene

Considering the kegg page, this page contains the description of the gene Edwardsiella tarda EIB202: ETAE_0074 . Now this gene has a name given in the page as : wabG. Now considering another gene 1 ...
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485 views

How to identify a pseudogene to a specific protein coding genes?

Pseudogenes are those sequences in the genome that bear similarity to specific protein coding genes, but nevertheless are unable to produce functional proteins due to existence of frameshifts, prema- ...
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GO term for orthologous gene IDs

I have a list of orthologous gene IDs from the first supplementary file in here. The gene IDs are of the following type: ...
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62 views

His Tag location in gene circuit

I am part of an undergraduate research group and we are trying to produce a protease in an E.coli gene circuit. We are not sure where to place the His tag in our circuit. The sequence is ...OmpA(gene)-...
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Immediate Early Genes during sleep

In Neuroscience 3rd ed by Bear et al. on page 607, immediate early genes are described as related to changing synaptic strength, yet have decreased expression during sleep. The explanation given is ...
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Is there a known mutation of an insertion type that prevents being infected by a virus?

Recently there was big news about the mutation CCR5 delta 32, that prevents HIV from infecting white blood cells, that was a deletion type of a mutation. Do we know of an insertion type of mutation ...
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What does ubiquitination between 2 genes mean?

I have come across the Hedgehog signaling pathway. In this pathway, the genes Cul3 and ptc have an interaction of ubiquitination (The information is available from the KGML file). What does this ...
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How many species have had their expression of Polyphenoloxidase reduced?

Polyphenol oxidase causes fruit to turn brown when cut. This is an undesirable trait therefore at least potatoes and artic apples have been genetically modified to reduce this browning. How many ...
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Difference between TRN and GRN

I am little bit confused about what is the difference between Transcriptional Regulatory Networks (TRNs) vs Gene Regulatory Networks (GRNs). As far as know, both involve interactions of transcription ...
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28 views

Gene networks for different tissues?

I currently work on gene networks and specifically, I analyze the brain gene regulatory network of an insect to understand its sexual behaviour. During a recent presentation, I got asked this question ...
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Organ secretions

If an animal secrets an enzyme from an organ that is entirely dedicated for the same secretion, can one or cannot one just use the gene coding for that protein to obtain the protein in vitro. How much ...
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minimum ratio of the shortest isoform to the longest one derived from one same parent gene

I want to know what is the minimum percentage of the shortest isoform/transcript to the longest one that derived from the same parent gene? Does it have organism specificity? What is the function of ...