Questions tagged [gene]

The basic unit of heredity which encodes for some function RNA or protein product.

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19
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4answers
4k views

Do all humans have an identical nucleotide sequence for certain proteins, e.g haemoglobin?

All humans have the same sort of proteins in our bodies. Take haemoglobin for example. Is the gene coding for haemoglobin in my body identical to everyone else's gene or is there slight variations ...
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5answers
10k views

Do men and women have the same number of genes?

As far as I know, humans have 23 pairs of chromosomes, each one which contains a particular amount of genes. But in the "last" pair, men have a XY pair chromosome, and women have a XX pair chromosome. ...
11
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3answers
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Is there any virus that contains both DNA and RNA in its genome?

It is known that viruses contain DNA or RNA- either one and not both. I came across a question: Which virus contains both DNA and RNA?
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2answers
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Why does human chromosome 19 have the second highest number of protein-coding genes?

While chromosome 19 only is the 19th largest autosomal chromosome, it contains 1440 protein-coding genes, and thus has the second highest number of protein-coding genes of any human chromosome. For ...
7
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2answers
1k views

Father with mutated mtDNA- why isn't his offspring at risk?

Mothers transmit their mitochondria (and therefore mtDNA) to their offspring and fathers don't. Lets assume that father had a mutation of the gene that encodes mtDNA, would then be his offspring at ...
7
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1answer
978 views

Whole Genome Sequencing vs Whole Exome Sequencing

I am working on a project where I want to discover causative genes for a certain disease I may have. I was wondering whether to get WGS or WES to perform this experiment:- I am looking at SNP's and ...
7
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1answer
135 views

Why aren't gene drives extremely common?

The ability for gene drives to sidestep the Mendelian mechanism and rapidly spread through populations (even if the gene is slightly fitness reducing) is extremely powerful. Why aren't normal ...
6
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4answers
631 views

Genes and Intelligence

Assuming that intelligence has a genetic component, • do we know which genes contribute to it? and, if so, • can we predict intelligence from genomic analysis?
6
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2answers
399 views

Which DNA elements belong to the definition of a gene?

I see a lot of different DNA elements mentioned as part of a gene (talking about eukaryotes): The length of DNA following the promoter is a gene and it contains the recipe for a protein. (video) ...
5
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1answer
120 views

Explain a gene network to a first year undergrad

I have an adjacency matrix with list of genes connected to each other which signifies the gene network. How do you get this information that one gene is connected to other in the first place. Is it ...
5
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1answer
75 views

How allele is related to trait that is more complex than two cases (ex. height)?

Recently I started to learn about evolution and genetics. Simple stuff at the beginning - some videos, some reading. So far, everything seems to be pretty simple and straightforward. I easily grasp ...
5
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1answer
1k views

What happens if there is a blood incompatibility during pregnancy?

There are possible combinations of blood types with the rH factors: Rh factors are genetically determined. A baby may have the blood type and Rh factor of either parent, or a combination of both ...
5
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1answer
2k views

What does it mean to “map the human genome”

I know some elementary chemistry and biology. I also think I know what a gene is (it's a sequence of DNA which encodes a particular protein). I also know that on a chromosome there are sections of DNA ...
5
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1answer
342 views

Can methylation of a promoter induce gene expression in some rare cases?

Can methylation of a promoter induce gene expression in some rare cases? I've read somewhere that methylation of an intron can induce gene expression (eg. Igf2). How is that even possible? Thank ...
5
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2answers
347 views

How do I know whether or not a nuclear gene is single copy?

As a part of a phylogenetic study, I need to find a nuclear gene that meets the following requirements: Single copy gene; Highly variable gene; Gene longer than 400 bps; Gene that gives information ...
5
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2answers
659 views

Animal gene in plants

Usually only microbes, specifically bacteria are used to express genes of other species for various functions. But, it is possible to try and express an animal gene into a plant. Bacteria like ...
4
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2answers
16k views

Stop codons and exons?

If we had a hypotheical gene called gene exampleGene and this gene had 5 exons, labeled A, B, C, D, and E in that order on the chromosome, could it be the case that the stop codon for this gene be on ...
4
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2answers
180 views

What determines the efficiency of electron production in photosynthetic bacteria?

Is there a specific gene involved, perhaps? Would one be able to genetically engineer a bacterium to oxidize water and generate electrons quicker? I am speaking about this biological problem in terms ...
4
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2answers
565 views

Gene and alleles

This is a multiple choice question: Consider a gene, ABC, which codes for an enzyme involved in the metabolism of sugars. There are two known alleles of this gene, ABC1 and ABC2. Which statement ...
4
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1answer
2k views

Where to download gene list of human genome?

I am looking for a place where I can download a full gene list of human genome. Either by HGNC symbol or ensemble ID as long as it is usable on the consensusPathdatabase. Up until this point I have ...
4
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1answer
278 views

How can human infants express chymosin with only a pseudogene at their disposal?

I read on the Wikipedia article about Chymosin http://en.m.wikipedia.org/wiki/Chymosin It stated that chymosin is produced by gastric chief cell in human infants. But it also stated that human only ...
4
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1answer
2k views

What is the difference between “physical interaction” and “genetic interaction”?

I searched sac1 in uniprot to know more about this gene. in interaction I selected this link and there I see that this gene has some "physical interactions" and "genetic interactions". I am wondering ...
4
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1answer
39 views

Can the same target gene be regulated differently by the same transcription factor under different conditions?

I'm very new in biology and doing more computational analysis. I'm confused with the type of interactions between Transcription Factors (TF) and target genes. Is it possible that the same ...
4
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2answers
86 views

How many co-expressed genes would be expected in a tissue?

I am working with gene expression microarrays of tumor tissues and I want to use a program to find the clusters of co-expressed genes in order to know if some particular genes are co-expressed with ...
3
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2answers
4k views

Interpretation of picture of human chromosomes

Does this picture show sister chromatids or homologous chromosomes? If they are homologous then what is YY? If they are sister chromatids then do homologous chromosomes ever appear like this (with the ...
3
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3answers
306 views

What does the gene name “lexA” stand for?

It is an important gene expressed in E. coli that represses the SOS response and also the expression of lambda lytic phase genes. UV light and damage to DNA is responsible for its breakdown and hence ...
3
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3answers
186 views

Single copy housekeeping genes

I am working on a tool for SNP calling in polyploid plants. To test my method, I need a list of housekeeping genes common in almost all plants. For my case, these genes must be single copy (ie each HK ...
3
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1answer
948 views

Is gene only the portion of a single strand which codes for a particular protein?

I know that gene is a segment of DNA that codes for a specific protein. But is it a segment of a single DNA molecule or a DNA duplex? The given image shows a section of a dsDNA. Source of image:...
3
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1answer
48 views

How to do a blast search for similar sequences?

Tried doing a Blast search for a PPO gene in an advocado genome: https://www.ncbi.nlm.nih.gov/blast/Blast.cgi?PAGE_TYPE=BlastSearch&PROG_DEFAULTS=on&BLAST_SPEC=OGP__3435__73885&DATABASE=...
3
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1answer
68 views

Is the term 'allele' specific to sexual populations?

I had always thought that 'allele' simply meant a variant of a gene and thus could be used in the context of either asexual or sexual populations. With it only being slightly less useful as a concept ...
3
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2answers
598 views

Do chromosomes change with time?

An offspring is 23 chromosomes of mother and 23 of father, if one of the mate learns say music after the birth of their first child— will their second offspring have better music skills than former? ...
3
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1answer
98 views

What is the attachment after this gene name, following the comma: SULF1,hCG18956?

What is this part mean: hCG18956? Is it an alternate naming convention for genes? I am trying to read in a list of gene names using R, but I don't have an extensive biology background. There are ...
3
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1answer
3k views

Please explain what a gene isoform is in lay terms?

I am a physicist by training, however I am now doing computational biology research. I know what genes, DNA, proteins, enzymes, introns and exons are. I sort of understand how DNA is used to create ...
3
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1answer
73 views

Emergence of novel protein interactions by mutation of amino acids

Are there any examples of proteins that, without coming from a recent duplication event, underwent a mutation(s) that caused it to have a novel interaction with a new ligand, substrate, other protein ...
3
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2answers
2k views

Why are tumor suppressor genes recessive?

In my Intro. to Biochemistry course, we have been studying cancer. The professor has pointed out that tumor suppressor genes are "recessive" while proto-oncogenes are "dominant". Since only one ...
3
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1answer
948 views

Are all phenotypes normally distributed

Reposting from the stats stackexchange. John Cook, in his blog https://www.johndcook.com/blog/2015/03/09/why-isnt-everything-normally-distributed/, writes that many aren't: Adult heights follow a ...
3
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1answer
56 views

Why HIV need integrase enzyme to integrate their DNA into host cell?

In gene transfer by microinjection, the gene of interest is injected into the nucleus of host cell without using integrase enzyme. So why does HIV need that enzyme? Why they not just place their DNA ...
2
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6answers
241 views

Which information can be obtained from a list of gene names?

Lets say I only have a list of gene names. I know they are up regulated and I know they are related to cancer. What information can I obtain from having only the names of genes? For example is there ...
2
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2answers
2k views

Genetic mutations and new alleles

Amongst silent, nonsense and missense genetic mutations, is the latter the only one that leads to the creation of new alleles? If we define alleles as a specific form of a gene, and a gene as a ...
2
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2answers
6k views

Are eukaroytic promoters located in the 5' UTR region?

I was wondering if promoter sequences are located on 5'UTR region in eukaryotic organisms?
2
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2answers
199 views

Sheep vs. Furry animals

Why can't we take the fur of a fox without killing or skinning it just like the sheep , what's the biological or chemical structure or even the trait which is on a sheep's body that separates wool ...
2
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1answer
81 views

Are any genes over a billion years old?

Are there any genes (for any organism) for which we can say with confidence that they are over a billion years old?
2
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1answer
643 views

Evolutionary elimination of recessive gene

As recessive gene is suppressed, why over millions of year of evolution have not wiped them away completely, why don't they just go extinct, as people with those genes go extinct?
2
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1answer
45 views

Confusion about a gene's description

I have a very basic biology question. I am reading the description of gene FAM166A here, and I have no idea what "sequence similarity 166" means. What does 166 stand for, what is this gene's sequence "...
2
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1answer
85 views

Can a gene be inactivated using CRISPR if it is not in the interspace of short palindromic repeats?

I have recently studied how CRISPR works but there is something that I do not understand at all. I have heard a lot of people claiming that with this method it is possible to modify any genome by ...
2
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2answers
2k views

Gene vs. Protein Expression Assays

Are the terms gene expression assays and protein expression assays used interchangeably in molecular biology? Or is it expected of you to differentiate between the two terms. For example, if I ...
2
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1answer
604 views

“bead” on a string theory of genetics, source?

Thomas Hunt Morgan was a pioneer in genetics and proposed the now false model of genes being "beads" on a string. These beads being indivisible and responsible for a single phenotype, if I understand ...
2
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1answer
66 views

Where to find gene manipulation video (or photos)

I hope Im not asking a dumb question! Where can i find video of gene manipulation in action under microscope? Like extracting a gene from a cell, fixing gene mutations, putting the gene in a vector, ...
2
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1answer
61 views

How do you define a gene list?

So I wrote in a chapter that I will be checking for publications with gene lists in them. I got a comment asking "How would you define a gene list and what criteria did I use". I know that gene lists ...
2
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1answer
4k views

Is the promoter region of a gene transcribed?

If the RNA polymerase attaches to the promoter region of the gene, would it form the initial mRNA portion soon after attachment by reading the promoter region? Or should it slide across the DNA then ...