Questions tagged [gene]

The basic unit of heredity which encodes for some function RNA or protein product.

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18
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4answers
4k views

Do all humans have an identical nucleotide sequence for certain proteins, e.g haemoglobin?

All humans have the same sort of proteins in our bodies. Take haemoglobin for example. Is the gene coding for haemoglobin in my body identical to everyone else's gene or is there slight variations ...
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What is the average number of alleles per gene we have today?

Yesterday I was making some calculations, and I started to wonder the average number of alleles per gene the human species have today. The best question would be how many mutations per base or how ...
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Consider gene is countable, can anyone give a concrete example of “a gene”?

gene is a countable noun but people always say genes, so what is A gene? for instance, Each chromosome contains many genes, so, which part of the chromosome of Escherichia coli could be ...
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1answer
181 views

haplotype data for 1000 Genomes

I need to get haplotype data for HapMap or 1000 Genomes for CEU, MKK, TSI, CHB and JPT for ± 1 Mb at LCT gene. I'm quite new in the area. Actually I don't know the meaning of "± 1 Mb". From which ...
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3answers
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What does the gene name “lexA” stand for?

It is an important gene expressed in E. coli that represses the SOS response and also the expression of lambda lytic phase genes. UV light and damage to DNA is responsible for its breakdown and hence ...
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Need help in identifying and understanding the origin of an expression variant

We usually denote the origin of a mutation as either somatic or germline. This information is usually available in certain databases such as CIVIC, ClinVar, COSMIC etc. But when we come to variants ...
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1answer
44 views

Gene frequency — database/site

Is there any free database when one can check the gene frequency in a healthy population? For example I would like to check it for genes like BIN1, CLU or CR1. On the English Wikipedia I found a gene ...
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1answer
37 views

Do human genes get affected by irregular sleep and other factors

I'm new here so please go easy on me. Do our genes-the ones that carry our appearance, intelligence and other traits get destroyed or lost due to irregular sleep, excessive body heat, smoking, ...
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1answer
57 views

Where can I find DNA decryption research? [closed]

What is the name of the science that studies the mathematics of DNA? Where can I learn about maths, statistics, types of code, numbers, patterns and graphs for genes and information found in DNA?
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1answer
71 views

Emergence of novel protein interactions by mutation of amino acids

Are there any examples of proteins that, without coming from a recent duplication event, underwent a mutation(s) that caused it to have a novel interaction with a new ligand, substrate, other protein ...
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Why eyebrow growth stopped after it has specific length?

When comparing with hair that grow forever after we cut it, why eyebrow not. what gene measure current length of eyebrow so it stop to grow after specific length.
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1answer
925 views

What is the length of gene when calculating TPM (transcripts per million)

What is the length of gene when calculating TPM (transcripts per million)? Assume I have a dataset matrix with k rows(each row is a gene) and n columns (each column is a sample), is there any way I ...
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2answers
894 views

Why can't this be 1st meiotic division non-disjunction as well?

The child has gotten 2 "sick" chromosomes from his dad and 1 healthy from his mom, leaving it with trisomy 13. I can see how this can happen in the second meiotic division of the father but I can ...
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1answer
3k views

Please explain what a gene isoform is in lay terms?

I am a physicist by training, however I am now doing computational biology research. I know what genes, DNA, proteins, enzymes, introns and exons are. I sort of understand how DNA is used to create ...
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5answers
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Do men and women have the same number of genes?

As far as I know, humans have 23 pairs of chromosomes, each one which contains a particular amount of genes. But in the "last" pair, men have a XY pair chromosome, and women have a XX pair chromosome. ...
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1answer
31 views

What is the difference between Regulatory Gene and Modifier Gene?

If both controls the expression of another gene by physically or genetically interacting with the target gene, which attributes make "Regulatory gene" different from "Modifier gene" or vice-versa?
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Is there a known mutation of an insertion type that prevents being infected by a virus?

Recently there was big news about the mutation CCR5 delta 32, that prevents HIV from infecting white blood cells, that was a deletion type of a mutation. Do we know of an insertion type of mutation ...
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Does the law of independent assortment apply to homologous chromosomes or alleles, or both?

My textbook is giving me two definitions 1st def: "random orientation of homologous chromosomes at the metaphase plate in meiosis 1." 2nd def: "alleles for one gene separate into gametes ...
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2answers
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What does curated gene mean? [closed]

I see in databases "curated" or "not curated" for genes. What does that mean?
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1answer
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What does Ercc1-/- / DAT-Cre+ mean?

I really need to know what Ercc1-/- / DAT-Cre+ mean. I think the 1st part means that the mice don't have the Ercc1 gene (knockout). But what about DAT-Cre+? This question arised from reading the ...
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1answer
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How can inbreeding be used for selecting mutations?

I understand that inbreeding, after a number of generations of crossing genetically related individuals eventually yields homozygotes, however I can't seem to understand how it can be used for ...
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2answers
105 views

If bacteria with recombinant DNA molecules do not survive in gene cloning, how they can be grown into a colony after being isolated?

This is as far as my understanding of gene cloning goes. Let's say that the plasimd (vector) in the bacteria contains an ampicillin resistence gene. Through restriction enzymes, the ampicillin ...
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1answer
36 views

Identifying statistically significant gene rich and gene poor regions

I am just wondering If there any adapted way of Identifying significant gene rich and gene poor regions in each chromosome for a given genome say mm10?
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What does ubiquitination between 2 genes mean?

I have come across the Hedgehog signaling pathway. In this pathway, the genes Cul3 and ptc have an interaction of ubiquitination (The information is available from the KGML file). What does this ...
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Genes and Intelligence

Assuming that intelligence has a genetic component, • do we know which genes contribute to it? and, if so, • can we predict intelligence from genomic analysis?
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Can Tajima's D and other population genetic tools be used to copare Arabidopsis ecotypes?

I am currently investigating 2 genes in Arabidopsis taliana that are a product of a recent duplication even (observable from synteny and phylogenetic analysis). In addition to the molecular and ...
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1answer
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Are modern gene-editing techniques capable of creating genetically-superior versions of humans? [closed]

Can we alter the DNA in, say, a small-framed, low muscle mass male to those of elite bodybuilders? Can we alter the DNA sequence that stops balding and hair loss? How about the genes responsible for ...
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1answer
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Question: What is CINWntUp and CINnormL?

What is CINWntUp and CINnormL? I read a paper that uses this two things as classes but Im not sure what they represent. I imply that CIN is referring to Chromosomal instability but I don't know what ...
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1answer
145 views

Are androgenic-anabolic steroids a form of gene editing?

Is taking AAS a form of gene-editing? Steroids alter genes in some way since they allow people to build more muscle than what's naturally possible -- so they sort of "break" natural genetics somehow. ...
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1answer
4k views

Is the promoter region of a gene transcribed?

If the RNA polymerase attaches to the promoter region of the gene, would it form the initial mRNA portion soon after attachment by reading the promoter region? Or should it slide across the DNA then ...
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1answer
27 views

Gene expression: which allele is considered?

For human beings, we have two copies of each gene inherited from the parents. The question is, when referring to gene expression, which copy (or allele) is considered?
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1answer
114 views

Understanding different genetic terminology - Genotype vs SNP

I recently came across a study that refereed to variations in genes like this: IGF1 (CA)19/(CA)19, IGF1(CA)19/X, IGF1 X/X (From this study: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274549/) I ...
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Is there any way to tell if a gene is functional for an individual with only a reference sequence and the individual's sequence of the gene?

I have gene sequence of a ton of individuals within a subspecies from cdna and the ncbi IDed sequence as well. Is there any way to tell using just the sequence that the gene for an individual is non-...
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Is there any virus that contains both DNA and RNA in its genome?

It is known that viruses contain DNA or RNA- either one and not both. I came across a question: Which virus contains both DNA and RNA?
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1answer
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Confusion about a gene's description

I have a very basic biology question. I am reading the description of gene FAM166A here, and I have no idea what "sequence similarity 166" means. What does 166 stand for, what is this gene's sequence "...
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1answer
60 views

How do you define a gene list?

So I wrote in a chapter that I will be checking for publications with gene lists in them. I got a comment asking "How would you define a gene list and what criteria did I use". I know that gene lists ...
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Functional Difference between the Distal Promoter and Enhancer Region

According to the Wikipedia article on eukaryotic promoter regions, the distal promoter is: Anything further upstream (but not an enhancer or other regulatory region whose influence is positional/...
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1answer
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Query regarding KEGG KGML pathway files

With respect to the the Wnt pathway in KEGG, the KGML file of this pathway has description of each interaction between a pair of genes. These interactions are designated in the form: ...
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2answers
561 views

Do chromosomes change with time?

An offspring is 23 chromosomes of mother and 23 of father, if one of the mate learns say music after the birth of their first child— will their second offspring have better music skills than former? ...
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1answer
48 views

How to do a blast search for similar sequences?

Tried doing a Blast search for a PPO gene in an advocado genome: https://www.ncbi.nlm.nih.gov/blast/Blast.cgi?PAGE_TYPE=BlastSearch&PROG_DEFAULTS=on&BLAST_SPEC=OGP__3435__73885&DATABASE=...
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1answer
67 views

How to find a gene sequence?

So I need to learn how to find the sequence of a gene, polyphenoloxidase. Please do not do this for me. Tell me how to approach the problem. I have found : https://www.ncbi.nlm.nih.gov/gene and ...
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1answer
430 views

how many copies of tp53 (p53) gene do we have?

I just started studying biology so I almost have no knowledge. I learned about the tp53 gene and I just wanted to know how many copies of tp53 gene we have?
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Which gene regulatory network is the largest in human?

What is the maximum number of nodes involved in any gene regulatory network and which network is it, provided its from human?
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2answers
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Can gene-gene interactions result in gene expression?

I am building a project on Inferring Gene Regulatory Networks using ARACNE and PCA-CMI algorithms, and the input to these algorithms is taken from the DREAM3 challenge. The format of the input data ...
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1answer
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What is linkage?

If two genes are on the same chromosome, are they always “linked”? What if they are more than 50 cM apart? Then they would follow Mendalian pattern of inheritence. So are they still linked?
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How should I interpret for example AA result, when SNPedia only has CC/CT/TT listed? [closed]

I don't know how to properly formulate this question because I'm new to this, so please edit this if you can... For example when I would check SNPedia for rs gene, it would have listed CC/CT/TT genes,...
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2answers
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Isolating gene of interest from a large strand of DNA [closed]

I was always confused about this in class and never learned it fully. So say you have 10,000 bp of DNA and you just want to isolate 100bp of specific region(gene of interest) using restriction enzyme. ...
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1answer
51 views

Genetic modifications in humans to prevent disease [closed]

I was reading an article about "designer babies", which was about how before birth the DNA can be modified so to achieve certain features. Can a technique such as this also be used to prevent diseases,...
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1answer
157 views

Are mutations the cause of alleles?

For example, some leopards have a mutation which causes black fur. So Black fur and normal fur colour (orange-white) are both alternate forms of the same gene, right? So does that mean that mutations ...
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1answer
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Why HIV need integrase enzyme to integrate their DNA into host cell?

In gene transfer by microinjection, the gene of interest is injected into the nucleus of host cell without using integrase enzyme. So why does HIV need that enzyme? Why they not just place their DNA ...