Questions tagged [gene]
The basic unit of heredity which encodes some functional RNA or protein.
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Should I consider one or two DNA chains to find how many nucleotides are in a gene?
I am trying to solve an exercise.
How many nucleotides does a gene contain if information about 287 amino acids is encoded in it? What is the molecular mass and length of this gene?
AFAIK, I have to ...
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What is the impact of selection on orthologous and paralogous genes? How would this impact differ in different regions of protein coding genes?
Since paralogs increase the size of the genome and provide more opportunity for the evolution of novel characteristics, would they be more prone to selection?
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What is the definition of gene, genotype and phenotype, pre and post DNA?
i know that the definition of gene is a unit of heredity, also a sequence of nucleotides in DNA that gets copied to RNA and then proteins. Genotype is the genetic composition of an individual ...
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Microarray experiment validation meaning
I have a quick question: what does microarray experiment validation mean ?
I was reading a paper in which they say that the data of the experiment show that the 3 genes radB, dp1 and dp2 are co-...
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Is the mRNA produced constant during time?
I am doing a statistical data analysis of a dataset of P. Furiosus cells exposed to gamma radiation.
For the samples exposed to gamma radiation, I have the values of mRNA produced over time. For the ...
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Is there a negative correlation between the mRNA produced by the cell and the time of extraction? [closed]
I am doing some data analysis about gene expression time series. When I plot mRNA produced by P. Furiosus cells irradiated by gamma radiation against the time of extraction, it seems that there is a ...
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Gene knockdown vs gene knockout vs knocksideways? [closed]
How are the techniques: Knock-sideways, knockout & knock-down different?
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Convert fasta to ascii?
Is there an algorithm or tool to convert a fasta sequence file (such as the file linked below) into an ascii file for the purpose of gene synthesis?
https://www.rcsb.org/fasta/entry/6EQJ
To the best ...
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What is the word for a group of genes inherited together?
I know the words haplotype and haplogroup, as well as genetic linkage, but...
I recently came across a new phrase describing genes which tend to be inherited as a group, and wrote it down, but now ...
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Clarification regarding a statement in "The Selfish Gene" by Richard Dawkins
In the third chapter of The Selfish Gene: Immortal coils, Dr.Dawkins makes the following statement while arguing for the case that ultimately "the gene" as he defines it is the unit of natural ...
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How does DNA shape a living organism? [closed]
I'm haven't studied biology so excuse me if I'm getting something wrong.
I'm trying to understand how the DNA from a sperm and egg cause the egg too multiply and form a perticular shape (shape of a ...
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Mutated and unmutated PCR product
If I have a mutated colony containing the fusion protein, mCherry instead of the stop codon TAA, and an unmutated colony which does not contain the protein. Why will the PCR products of the two ...
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which specific field to study to know more about genes and genomes [closed]
I recently got interested in specific subjects :
1.Evolution
2. DNA, genomes etc and its structure
3. Abiogenesis
I am a software engineer with good fundamental understanding in math & physics ...
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Where do biologists get information about mouse genes? [closed]
From this article https://ui.adsabs.harvard.edu/abs/2005Sci...308.1909S/abstract
“We created transgenic mice that overexpress human catalase localized in the peroxisome, nucleus, or mitochondria (...
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Open Reading Frames vs Coding Sequences (CDS), are they different?
The two terms confuse me for a long time. What is the difference between ORF and CDS. Some people say ORF could contain intron and CDS does not. The wikipedia definition of ORF does not contains ...
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How does new species come into existence?
The only reason for the creation of new species that I found from the internet is geographical isolation. Are there any more reasons?
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How do I identify and then isolate a Gene that codes for a particular observable phenotype
How do I identify and then isolate a Gene that codes for a particular observable phenotype. It is a novel bacteria and I do not know the gene sequence or the protein that it codes for.
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What are the implications/predictions of the selfish gene theory?
Are there any testable predictions or implications of the selfish gene theory? Or it is just interesting interpretation of the observations/experimental data? If this theory is not falsifiable and ...
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Genes where both a disabling mutation and copy number amplification cause different genetic diseases
I'm trying to make a list of such genes, because they must be tightly regulated. MeCP2 is one - it causes Rett Syndrome with a disabling mutation, but causes MeCP2 duplication syndrome if its copy ...
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What is an allele?
According to the entry for allele in Wikipedia:
“An allele is a variant form of a given gene, meaning it is one of two or more versions of a known mutation at the same place on a
chromosome.”
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What does it mean that the transcript is enriched?
I think I don't get the meaning of "enriched" in the context of genes.
What's the difference of gene being "enriched" and "expressed" in the cell?
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Can two proteins activate/inhibit the same gene at the same time?
Suppose there are two proteins inhibiting a particular gene. Its not necessary that both will inhibit the gene at the same time instance right?
So if one protein has already inhibited that gene before ...
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Study on Introns?
I am curious whether there has been a study done on the effects of removing introns. Specifically, what happens if you genetically edit a eukaryote genome to no longer contain introns? Or maybe just a ...
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Are any genes over a billion years old?
Are there any genes (for any organism) for which we can say with confidence that they are over a billion years old?
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Do all humans have an identical nucleotide sequence for certain proteins, e.g haemoglobin?
All humans have the same sort of proteins in our bodies. Take haemoglobin for example.
Is the gene coding for haemoglobin in my body identical to everyone else's gene or is there slight variations ...
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Consider gene is countable, can anyone give a concrete example of "a gene"?
gene is a countable noun but people always say genes, so what is A gene?
for instance, Each chromosome contains many genes, so, which part of the chromosome of Escherichia coli could be ...
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haplotype data for 1000 Genomes
I need to get haplotype data for HapMap or 1000 Genomes for CEU, MKK, TSI, CHB and JPT for ± 1 Mb at LCT gene. I'm quite new in the area. Actually I don't know the meaning of "± 1 Mb". From which ...
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Gene frequency — database/site
Is there any free database when one can check the gene frequency in a healthy population? For example I would like to check it for genes like BIN1, CLU or CR1. On the English Wikipedia I found a gene ...
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Do human genes get affected by irregular sleep and other factors
I'm new here so please go easy on me.
Do our genes-the ones that carry our appearance, intelligence and other traits get destroyed or lost due to irregular sleep, excessive body heat, smoking, ...
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Where can I find DNA decryption research? [closed]
What is the name of the science that studies the mathematics of DNA?
Where can I learn about maths, statistics, types of code, numbers, patterns and graphs for genes and information found in DNA?
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Emergence of novel protein interactions by mutation of amino acids
Are there any examples of proteins that, without coming from a recent duplication event, underwent a mutation(s) that caused it to have a novel interaction with a new ligand, substrate, other protein ...
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What is the length of gene when calculating TPM (transcripts per million)
What is the length of gene when calculating TPM (transcripts per million)?
Assume I have a dataset matrix with k rows(each row is a gene) and n columns (each column is a sample), is there any way I ...
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Why can't this be 1st meiotic division non-disjunction as well?
The child has gotten 2 "sick" chromosomes from his dad and 1 healthy from his mom, leaving it with trisomy 13.
I can see how this can happen in the second meiotic division of the father but ...
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Please explain what a gene isoform is in lay terms?
I am a physicist by training, however I am now doing computational biology research. I know what genes, DNA, proteins, enzymes, introns and exons are. I sort of understand how DNA is used to create ...
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Do men and women have the same number of genes?
As far as I know, humans have 23 pairs of chromosomes, each one which contains a particular amount of genes. But in the "last" pair, men have a XY pair chromosome, and women have a XX pair chromosome. ...
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What is the difference between Regulatory Gene and Modifier Gene?
If both controls the expression of another gene by physically or genetically interacting with the target gene, which attributes make "Regulatory gene" different from "Modifier gene" or vice-versa?
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Is there a known mutation of an insertion type that prevents being infected by a virus?
Recently there was big news about the mutation CCR5 delta 32, that prevents HIV from infecting white blood cells, that was a deletion type of a mutation.
Do we know of an insertion type of mutation ...
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Does the law of independent assortment apply to homologous chromosomes or alleles, or both?
My textbook is giving me two definitions
1st def: "random orientation of homologous chromosomes at the metaphase plate in meiosis 1."
2nd def: "alleles for one gene separate into gametes ...
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What does curated gene mean? [closed]
I see in databases "curated" or "not curated" for genes. What does that mean?
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What does Ercc1-/- / DAT-Cre+ mean?
I really need to know what Ercc1-/- / DAT-Cre+ mean. I think the 1st part means that the mice don't have the Ercc1 gene (knockout). But what about DAT-Cre+?
This question arised from reading the ...
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How can inbreeding be used for selecting mutations?
I understand that inbreeding, after a number of generations of crossing genetically related individuals eventually yields homozygotes, however I can't seem to understand how it can be used for ...
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If bacteria with recombinant DNA molecules do not survive in gene cloning, how they can be grown into a colony after being isolated?
This is as far as my understanding of gene cloning goes. Let's say that the plasimd (vector) in the bacteria contains an ampicillin resistence gene. Through restriction enzymes, the ampicillin ...
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Identifying statistically significant gene rich and gene poor regions
I am just wondering If there any adapted way of Identifying significant gene rich and gene poor regions in each chromosome for a given genome say mm10?
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Genes and Intelligence
Assuming that intelligence has a genetic component,
• do we know which genes contribute to it?
and, if so,
• can we predict intelligence from genomic analysis?
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Can Tajima's D and other population genetic tools be used to copare Arabidopsis ecotypes?
I am currently investigating 2 genes in Arabidopsis taliana that are a product of a recent duplication even (observable from synteny and phylogenetic analysis). In addition to the molecular and ...
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Are modern gene-editing techniques capable of creating genetically-superior versions of humans? [closed]
Can we alter the DNA in, say, a small-framed, low muscle mass male to those of elite bodybuilders?
Can we alter the DNA sequence that stops balding and hair loss? How about the genes responsible for ...
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Question: What is CINWntUp and CINnormL?
What is CINWntUp and CINnormL?
I read a paper that uses this two things as classes but Im not sure what they represent. I imply that CIN is referring to Chromosomal instability but I don't know what ...
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Are androgenic-anabolic steroids a form of gene editing?
Is taking AAS a form of gene-editing? Steroids alter genes in some way since they allow people to build more muscle than what's naturally possible -- so they sort of "break" natural genetics somehow.
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Gene expression: which allele is considered?
For human beings, we have two copies of each gene inherited from the parents. The question is, when referring to gene expression, which copy (or allele) is considered?
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Understanding different genetic terminology - Genotype vs SNP
I recently came across a study that refereed to variations in genes like this:
IGF1 (CA)19/(CA)19, IGF1(CA)19/X, IGF1 X/X
(From this study: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274549/)
I ...