Stack Exchange Network

Stack Exchange network consists of 175 Q&A communities including Stack Overflow, the largest, most trusted online community for developers to learn, share their knowledge, and build their careers.

Visit Stack Exchange

Questions tagged [genetic-linkage]

The tag has no usage guidance.

1
vote
0answers
12 views

How does a neutral allele change relative to a nearby allele under selection?

Suppose I'm looking at a gene being selected against (A) that's decreasing at a rate ($\Delta$P). If there's a nearby allele that is neutral (B) am I correct to assume that B will decrease with A at a ...
1
vote
0answers
51 views

Linkage disequilibrium D sign

Linkage disequilibrium D equals $D=x_{11}−p1⋅q1$ where: Haplotype Frequency $A_{1}B_{1} = x_{11}$ $A_{1}B_{2} = x_{12}$ $A_{2}B_{1} = x_{21}$ $A_{2}B_{2} ...
0
votes
0answers
15 views

Why is it more likely that EXACTLY one crossover will take place?

I'm studying genetic linkage and the recombination frequency calculation (that is estimated to be directly proportional to allele distance) consider that only one cross over will take place. I know ...
0
votes
0answers
64 views

Why do genetic testing companies (FTDNA,AncestryDNA,23andme) express DNA shared in centimorgans (cM) instead of in number of base pairs or in percent?

Expressing DNA shared in number of base pairs or in percent of total genome would be so much simpler and easier to understand for the customers. .
0
votes
0answers
96 views

Cis and trans linkage

Question: Two dominant non-allelic genes are 50map units apart, the linkage is: (A) Cis type (B) Trans Type (C) Complete (D) Absent/Incomplete My take: After a lot of ...
0
votes
0answers
83 views

Calculating gene separation -a genetics problem

I am really struggling with genetics. In particular, I have the following question Now I am OK with calculating the separation of genes in centrimorgans when I have data like so: But in the first ...
0
votes
0answers
477 views

Cut-off values for LD, LOD and D-prime as algorithmic input

I created an algorithm to generate SNPs for random people of different descents - based on HapMap data. While this works good, there is something else I want to take into consideration. So if a SNP ...