Questions tagged [genetics]

Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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40 views

How does new species come into existence?

The only reason for the creation of new species that I found from the internet is geographical isolation. Are there any more reasons?
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Whether de novo mutation can be inherited or not?

Think about the following scenario: A child is diagnosed as having long QT syndrome, an autosomal dominant disease. However, neither of his parents is affected. This may be due to a new mutation in ...
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Can the apparent drop in insect population be explained by local insects evolving to avoid traps?

In this widely reported Plos One article, it is stated that, after roughly 3 decades of placing Malaise traps in a set of predetermined locations (counting and replacing them regularly), a sharp ...
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DIY Biohacking? [closed]

I am a computer programmer, and while writing code is great for solving certain problems, programs easily become obsolete, and I want my input to humanity knowledge-base to be permanent. It might be a ...
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Research on chicken that cannot feel pain

In was having a conversation about the ethics of vegetarianism, and if it is right to cause pain to other animals. It is then that I stumbled upon the question, that if, just the way chicken and many ...
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Why does polyploidy occur during failure of cytokinesis and not during failure of karyokinesis?

Polyploidy is increase by a whole set of chormosomes, Cytokinesis is the process of splitting the cell cytoplasm and polyploidy is the splitting of the nuclear mass. Now I ask why polyploidy occurs ...
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Will a less favorable allele's frequency go to 0?

For example, a pond is dark in color. There are two alleles. The dark color allele is dominant over the light color one. Let's assume that the relative fitness of both the homozygous dominant and ...
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Monophyly, paraphyly and polyphyly in humans

A monophyletic group is a group or organisms that consists of all the descendants of a common ancestor. Three examples: 1. Rosales (an angiosperm order) (it includes roses, hemp, apples, pears, elms, ...
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How does the age of a parent affect the chances of occurrence of certain genetically transmitted diseases?

Do genetically transmitted age-related diseases (like hypertension, arthritis etc.)have the probability of occurring at an earlier(younger) age in the offspring if they are born at a later age to ...
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What are an internal and external exons?

I read the book: Essential Genetics and Genomics It has a table summarizing the properties of the "typical" human gene: It has a gene feature Size of internal exon,...
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What is enrichment score?

I was studying a paper and in that paper, there was mention of Enrichment score. Can someone please explain to me what is enrichment score. More score is good or bad. Here is the text from the paper. ...
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How quickly does recombination shuffle chromosomes?

For each pair of homologous chromosomes, one was inherited from the father and one from the mother. If there were no recombination in meiosis, one could then say that one of the chromosomes was ...
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Understanding ancestry testing mathematically

Forgive me if this question has been asked here before, because it is something which should be very easy to find, but I can't seem to find an answer no matter where I search. The question is simply ...
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Are there “old” neuron types in the neocortex?

"Old" may mean a neuron type that appeared early in the tree of life, and it may mean – going together – that it comes early in the lineage tree of neuronal cells, rooted in the fertilized ...
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Do mitochondrial haplotypes affect our physical or mental characteristics?

There are some studies that haplotypes may affect our intelligence or physical features. But do mitochondrial haplotypes have even close to as big a role to play as our genes in determining some of ...
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Is genetic equivalence a universal truism or are there exceptions?

Someone who I have been discussing scientific topics for some time came around to the notion that, on a biological level, the seed of a plant is not the same organism as the mature stage of the plant. ...
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What is the developmental and health outcome of an XY individual with an SRY addition on their X chromosome?

I know that "XX male" syndrome occurs through various means, including the addition of an SRY gene in one of the X chromosomes. The developmental and health outcomes of such individuals can be ...
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Why is inbreeding depression universal?

I've seen variations of the statement "inbreeding depression is universal" ad nauseam, but I can't seem to find an explanation as to why it is considered universal. Could somebody clarify or point me ...
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Do haplotypes have a role to play in the aggression of a human?

there are a couple research papers that connect haplotypes and aggressiveness in canines. Our genes, for example the MAOA gene in the X-chromosome, have also been shown to affect aggression. But can ...
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Why don't retroviruses kill more?

A retrovirus produces thousands of copies in days. If there are 10e12 cells in the body then it will infect all in four days. It would kill all animals in a few days after that. Why don't ...
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How does an antisense RNA molecule restore protein function in CF patients?

I am researching a treatment for cystic fibrosis (CF) called Eluforsen and I am trying to understand the mechanism by which an RNA molecule can restore proper protein function. In many research ...
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Breeder's equation and equivalent expressions for narrow-sense heritability

I am trying to model the phenotype of a trait as $X = G + E$, where $G$ and $E$ are the genetic and environmental effects. (I'll ignore the distinction between broad-sense and narrow-sense ...
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What is the charge of (bacterial) ribosome?

Ribosomes are negatively charged and thus electrostaticaly repelled from DNA. However, I could not find a good reference that would allow me to estimate the magnitude of negative charge on a ribosome. ...
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Expected $\mu$ and $\sigma^2$ for a phenotypic trait, given heritability h and known parental phenotypic measures?

Say a measurable phenotypic trait has mean $\mu =0$, variance $\sigma^2 = 1$, and heritability $h$, meaning that h*100% of the variation in the population is caused by genetic variation and (1-h)*100% ...
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What is the probability that a gamete will only contain father's chromosomes

As it is depicted in most textbooks, cross-over does not occur between the two "outer" sister chromatids. By independent assortment during Meiosis I, there is 1/2^23 chance that all father's ...
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Could Cyanobacteria farms help dilute pollutants in the atmosphere

If I understand correctly, roughly ~2.8 billion years ago cyanobacteria started pumping large amounts of oxygen into the atmosphere. Using modern industrial processes could this be emulated by ...
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Does natural selection still increase biological complexity?

I recently read The Selfish Gene by Richard Dawkins, which I found very interesting. In one of the last chapters, he gives multiple possible explanations to the question "Why did natural selection ...
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Hardy–Weinberg equilibrium for SNPs

I have a SNP stats file structure, which contains all information about genotypes and imputed SNP/INDEL imputation qualities, allele frequencies and minor allele assignment. ...
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125 views

How many generations are required for a specific neutral mutation to reach fixation?

In population genetics, the term “time to fixation” is defined as the time it takes for a specific mutation to appear in a population, plus the time required for this mutation to spread throughout ...
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What are the disadvantages of myelin

The myelination of axons has plenty of advantages. It increases signal speed in axons, and thereby reduces reaction times. This is, of course, very good for the survival of the animal in question. ...
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More efficient method of calculation genotype or phenotype ratios rather than doing a trihybrid punnett square or forked-line method?

Is there any other more efficient method of predicting ratios of offspring phenotypes or genotypes than doing a trihybrid Punnett square or forked-line diagram? Or are those two methods really the ...
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How to calculate percentage of DNA that ancestors contributed?

In David Reich's book "Who we are and how we got here" there is a graph explaining that more we go back in our ancestors generations, the least we have chances to have any DNA inherited from one of ...
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Can men with Klinefelter syndrome produce chromosomally normal sperm?

Individuals with Klinefelter syndrome are XXY. Even though sperm counts are low some individuals can generate enough to be used in IVF and have offspring. Does this mean that when sperm are formed, ...
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Why do individuals vary in the number of SNPs for a given gene ( e.g. FOXO3A )?

Individual #1, sequenced by 23andMe and then inputed into Promethease for SNP data has the following SNP output: 1) rs1935949(C;T) 2) rs2802292(G;T) 3) rs13217795(C;T) 4) rs13220810(C;T) 5) rs2764264(...
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lifespan of Nautilus compared to other cephalopods

Most cephalopods live uncharacteristically short lifes compared to other creatures of their size and intelligence. The octopuses with the longest lifespan for example, the giant pacific octopus, only ...
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Evolution of hunting behavior of parasitoid wasps

Wasps in the genus Pepsis lay their eggs in a specific region on a species of tarantula and their larvae eat the tarantula organs in a specific sequence to keep it alive as long as possible. How ...
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What are the implications/predictions of the selfish gene theory?

Are there any testable predictions or implications of the selfish gene theory? Or it is just interesting interpretation of the observations/experimental data? If this theory is not falsifiable and ...
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Genes where both a disabling mutation and copy number amplification cause different genetic diseases

I'm trying to make a list of such genes, because they must be tightly regulated. MeCP2 is one - it causes Rett Syndrome with a disabling mutation, but causes MeCP2 duplication syndrome if its copy ...
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What is indirect vs direction selection of genes?

As the title suggests, what is the direct and indirect selection of genes. Couldn't find a straightforward answer. Is it the same as direct and indirect fitness?
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Which sample type is more proper for whole genome sequencing in AML patients? Peripheral blood or bone marrow?

I intend to perform whole genome sequencing in AML patients in order to find genomic abnormalities, particularly translocation and gene fusions. However, I am not sure whether it is better to obtain ...
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Frameshift Mutation

With regards to LMNA frameshift mutations further downstream in the tail region, specifically (p.Arg455Gln fs*5) which has yet to be found/recorded in any medical literature...Does anyone have any ...
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Can Huntington's Disease be homozygous dominant?

Can Huntington's Disease be homozygous dominant? I am not sure whether the individual who is homozygous dominant for Huntington's Disease will survive into adulthood, or die when they are infants or ...
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How do mutations of viruses lead to drug resistance?

For instance, after starting zidovudine monotherapy against HIV, resistance develops against the drug because of a point mutation in the RNA transcriptase enzyme to which the drug binds. So how does ...
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Gene APOA2 SNP rs5082 alleles are A or G, but papers describe it with CC and TT?

rs5082 is a SNP in the APOA2 gene. It is associated with obesity and heart disease risk. According to this article the alleles can be A or G https://www.ncbi.nlm.nih.gov/snp/rs5082#frequency_tab Why ...
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Quantifying the Genetic Basis of Complex Diseases

In general, there are 2 types of diseases for which we understand "causality" very well: Infectious disease, where there is some etiological agent that causes the disease and Monogenic genetic ...
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PCR markers for C57B6

Do you know any primers that can be used to genotype mice and check if they are still C57B6? I'm concerned about genetic drift in my colony. I bought a breeding pair 3 years ago and expanded. I wanna ...
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Parthenogenesis vs. Fertilization. Is a polar body different from an egg?

In Parthenogenesis that happens by automixis "the replication of an egg by meiosis and the transformation of the haploid egg to a diploid cell occur by fusion with a polar body." =https://www....
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Effect of myelination on inteligence in cephalopods

Cephalopods are known for their unique intelligence compared to other invertebrates. The number of neurons of cephalopods is of the order $5*10^8$, similar to dogs. Humans have about $10^{11}$ ...
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ELI5 what is true breeding?

In "Variation under Domestication", Darwin makes several references to the concept of true breeding: They believe that every race which breeds true, let the distinctive characters be ever so slight,...
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Analysis of post transplantation lineage tags

I'm having some trouble understanding some bits of a study, mostly about the Sleeping Beauty system and TARIS model, from this paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408613/ I ...

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