Questions tagged [genetics]

Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

Filter by
Sorted by
Tagged with
0 votes
1 answer
19 views

How frequently does recombination occur, and how long are the recombinated fragments?

I understand the mechanics of recombination, but am struggling with the 'scale'. When two homologous chromosomes pair, roughly how many recombination events occur on average? I understand there will ...
user265902's user avatar
0 votes
0 answers
31 views

Change in gene frequency in generation due to genetic drift?

I was wondering if the reason was other than genetic drift. But I could not find an explanation. Here is the question: Consider an isolated, randomly mating population consisting of 100 individuals (...
statm's user avatar
  • 1
2 votes
1 answer
85 views

Can a person have different sex at cellular level?

I mean like every cell has a sex chromosome.So does a male with XY chromosomes has all the cells in all the organs inside his body of XY chromosomes only? And vice versa.....
PAWAN's user avatar
  • 29
-4 votes
0 answers
214 views

Is there evidence of an evolutionary strategy similar to human autism in mammals during the Pleistocene? [closed]

Edit trying to reopen this now that I am bored at work I hoppe it is a bit more clear now. You can comment what you want if you are interested in reopenning this too. As a geologist, I enjoy creating ...
Universal_learner's user avatar
-1 votes
0 answers
45 views

Relationship between TADs and supergenes

I need to investigate the architecture of supergenes. If someone is familiar with the topic (TADs and supergenes) could you please send me some links to articles covering this topic? Already did ...
Caterina's user avatar
  • 109
0 votes
0 answers
20 views

Do multiple alleles undergo crossover?

For a reference, point 3 of this article: https://www.biologydiscussion.com/genetics/multiple-alleles/multiple-alleles-meaning-characteristics-and-examples-genes/35452 According to google Bard and ...
abhijaat's user avatar
0 votes
2 answers
84 views

How many base codes are in DNA? Two or four?

We know there are four bases found in a DNA: adenine (A), cytosine (C), guanine (G), and thymine (T). We also know that A always pairs with T and G always pairs with C. Can we say that the DNA is ...
Mehdi Abbassi's user avatar
0 votes
0 answers
18 views

What is the most accurate polygenic score for Alzheimer’s disease?

To date, which polygenic score (i.e. which study) has produced the largest effect size for Alzheimer’s prediction in out-of-sample validation?
BigMistake's user avatar
1 vote
1 answer
61 views

Are there two different senses of the word 'heritability' in use?

Target Height as Predicted by Parental Heights in a Population-Based Study states: The heritability value was taken as the regression coefficient between final height and midparental height Is this ...
Mohan's user avatar
  • 111
0 votes
0 answers
10 views

Why do many plasmids for Flp-mediated Flip-Excision only flanked by one FRT site on each side and not two non-homologous?

I'm trying to build some molecular gene switches into a model, and want to use both Cre and Flp. I understand how to invert gene segments with Cre, double floxing (e.g. with loxP and lox2272, like in ...
immunoLogical's user avatar
1 vote
1 answer
130 views

Could the inability of adult mammals to digest lactose be partially explained by the loss of lactose-metabolizing bacteria from the microbiome?

BACKGROUND: 1. Lactase persistence Lactase persistence is the continued activity of the lactase enzyme in adulthood, allowing the digestion of lactose in milk. According to Wikipedia, only a small ...
J..y B..y's user avatar
  • 192
0 votes
0 answers
19 views

Ames Assay Confusion: Aren't the odds of spontaneous revertants too low to be able to accurately test the mutagenicity of certain compounds?

I am a student conducting a test with the Ames Assay. This assay uses a strain of bacteria that has a mutation in an amino acid synthesizing operon, which doesn't allow it to synthesize its protein. ...
Kyotiq's user avatar
  • 1
0 votes
1 answer
68 views

What does the term 'trait' really mean?

A trait is a characteristic shown by an organism. For example a Tt plant would show the 'tallness' trait. In same way sickle cell anemia carriers should show a 'normal' trait, but I found on various ...
Harjot Dhillon's user avatar
0 votes
0 answers
33 views

Can someone with albinism have red hair with very pale skin and blue eyes?

I have heard of a type of albinism that occurs in races with darker skin that can give people red hair, but in the pictures I've seen, they usually have reddish-brown hair, a medium skin tone, and ...
Apollo's user avatar
  • 1
0 votes
0 answers
28 views

Can hybrids from closely related species with similar chromosomes reproduce?

Let's say the plant Triticum monococcum which has 2 sets of 7 chromosomes when diploid and 1 set of 7 chromosomes when haploid has the genome AA. When interbred with a different species that has the ...
Woo Luke's user avatar
2 votes
1 answer
116 views

Why is the codon size three, rather than four? [duplicate]

The genetic code consists of triplets, each of which (apart from the stop codons) yields an amino acid when the mRNA is translated. But why did triplets evolve, rather than a longer or shorter codon ...
Mathew's user avatar
  • 29
0 votes
0 answers
16 views

Databases medicine and therapy - animal & human studies, technology readiness level

I am looking for some universal databases that would offer information about drugs and therapies currently in development. The area of interest is mostly cell and gene therapy. I am looking for ...
menshiki's user avatar
0 votes
1 answer
43 views

Inheritance of child behavior based on daily life experiences of the parent

Our brain is a large network of neurons connected with each other.Our daily experiences change how our neurons are connected.Some experiences create better connections between two neurons A and B and ...
Cerise's user avatar
  • 101
1 vote
1 answer
43 views

How to disambiguate between chromosome and chromosome pair?

Our genetic information is stored in 23 pairs of chromosomes that vary widely in size and shape. Chromosome 1 is the largest and is over three times bigger than chromosome 22. Source: https://www.ncbi....
vaughan's user avatar
  • 111
0 votes
0 answers
69 views

Calculating pitch of B-DNA

From this question (How pitch of a DNA Helix is 3.4 nm?), I've learnt that for counting the number of axial rise for 10 base pairs in 1 helical turn to measure the pitch of B-DNA, we have to include ...
Apogee Point's user avatar
0 votes
1 answer
41 views

How does positional memory in fibroblast cells work?

I have a question regarding how positional memory in fibroblasts work, specifically, where the memory comes from/how its made. For example, the Salamander & other amphibians are able to regenerate ...
user105463's user avatar
1 vote
1 answer
41 views

What exactly is "Whole-genome sequencing"?

Newbie question: For few years I have seen news like “Whole-genome sequencing” is now under $1000 etc. I believed that this means all the base pairs of all chromatids in a single cell are identified ...
Aelian's user avatar
  • 113
0 votes
1 answer
99 views

What do alleles look like visually on linear DNA strands?

I've seen many textbook images of alleles on homologous chromosomes with the gene loci identified but how could this be visualised on linear DNA sequences with the bases written out? Is it that you ...
mydearestpotato's user avatar
0 votes
1 answer
23 views

What is a good expression vector for Salmonella enterica subsp. enterica serovar typhimurium

I am interested in expressing custom proteins in a Salmonella strain, however I am facing difficulties in finding the appropriate expression vector for it. It seems that most of the resources provide ...
John Appleseed's user avatar
2 votes
1 answer
93 views

Considering Two Genes, Are There Only Two Possible Outcomes for the Four Gametes Produced After Meiosis, Regardless of Independent Assortment?

Is it true that for a single meiotic event when considering only two genes, there are only two possible genetic outcomes among the four gametes produced, regardless of whether the two genes are found ...
Simon's user avatar
  • 137
0 votes
0 answers
37 views

Mitochondrial diseases inheritance

I've read information about mito genes inheritance but some parts are still obscure for me. Here is the context: Mother has a son that is affected by some mitochondrial disease and a healthy daughter. ...
Euler-Maskerony's user avatar
1 vote
1 answer
33 views

ddT-tailed TA cloning, and the fate of a double nicked plasmid in E. coli

In an undergraduate lab class on TA cloning, it was explained that ddNTPs are used as the substrate for terminal transferase when making the T overhangs of the vector. I was told this was to ensure ...
jettosutorimu's user avatar
0 votes
1 answer
57 views

Why is There a Necessity for Two Rounds of Cell Division and Four Daughter Cells in Meiosis

Why does meiosis involve two rounds of cell division instead of stopping after meiosis I, where each daughter cell would have one chromosome randomly selected from each pair of homologous chromosomes? ...
Simon's user avatar
  • 137
1 vote
0 answers
148 views

How pitch of a DNA Helix is 3.4 nm?

How pitch of a DNA Helix is 3.4 nm? In the image that I have attached, the numbers with prime represent the number of base pair and normal numbers represent the number of gap elements between two base ...
Peter swift's user avatar
0 votes
0 answers
34 views

Is it possible for a non-self antigen to NOT be recognized by the body?

The amazing diversity of antigens that the body can recognize (by virtue of T and B cells that express receptors complementary to them) is truly fascinating. The explanation mooted for this is the ...
A-big-neutron's user avatar
0 votes
1 answer
146 views

Is heritability just slope?

Is broad-sense heritability just the slope of the line that passes through the coordinates: (1, The phenotypic correlation among monozygotic twins) (0.5, The phenotypic correlation among dizygotic ...
BigMistake's user avatar
2 votes
3 answers
217 views

What is the exact definition of a "gene"?

(In this question, I'm only considering the molecular-biology notion of a gene, not the older Mendelian notion.) Wikipedia defines a "gene" as "a sequence of nucleotides in DNA that is ...
tparker's user avatar
  • 717
0 votes
0 answers
42 views

How long does it take for a gene to be switched on or off through the process of epigenetic expression?

I understand that in our lifetime, our experiences affect the expression of our genes. Some get switched on, while others switched off. Our experiences, diet, lifestyle etc. determines this expression ...
Ihatecontrolfreaks's user avatar
0 votes
0 answers
20 views

Trying to find information about intraspecific allelic expression divergence in recombinant individuals due to changes in the cis regulatory regions

I am trying to find any research articles or resources that focus on differences in expression levels at the allelic level due to changes in cis regulatory regions in recombinant individuals. For ...
Joss's user avatar
  • 1
2 votes
0 answers
37 views

What portion of the human genome is dedicated to the developement of the fetus?

I was thinking about how we don't know the function of a large portion of DNA and I thought maybe it's because it's only used during the development of the fetus
Shannon T's user avatar
  • 129
0 votes
1 answer
133 views

Arguments against incest

Incest is forbidden in most countries because if there is a genetic disease in the family the child of a incestuous relationship will be at least holder of the gene of that disease. But lets say the ...
Volpina's user avatar
  • 111
0 votes
1 answer
30 views

Calculation for underlying genetic value of a phenotype given parents genetic values

What is the most accurate way to calculate a child's genetic predisposition to a phenotype, given both parents' genotypic predispositions? Assume trait X is 50% heritable and controlled by an ...
BigMistake's user avatar
0 votes
2 answers
95 views

Are mutation rates normally distributed? If not, what are they?

On average, there are 64 mutations per generation in the human genome. Is this constant, or can we expect variation in the number of mutations?
Shannon T's user avatar
  • 129
2 votes
2 answers
88 views

Preservation of citrus fruit

A decade ago [1] the possibility of using Cas9 systems to impart desirable properties to oranges seemed within reach [1]. Antifungals like Imazalil can increase shelf life of citrus but are known to ...
daniel's user avatar
  • 2,799
0 votes
2 answers
104 views

What really is an allele?

My textbook says: genes which code for a pair of contrasting traits are known as alleles. Then that means T and t are alleles. Further, it says: Mendel also proposed that in a true breeding, tall ...
Charles's user avatar
0 votes
0 answers
17 views

Are there any genetically modified GMO squash with a vine growth habit which grow back from the root?

When I cut Scottish thistles with scissors, the thistle grows back from the tap root. When I accidentally step on squash vines, the squash vine dies. I was wondering if genetics research has produced ...
Samuel Muldoon's user avatar
0 votes
1 answer
74 views

How random is genetic recombination?

Two parents can have a very large number of different potential offsprings, and it's common knowledge that the daughter chromosomes in meiosis are produced randomly, i.e. in crossover, the exact spots ...
Alex L's user avatar
  • 131
0 votes
0 answers
39 views

What actually causes temporal isolation

Temporal isolation is caused when members of the same species are available to reproduce at the same time. How is such a phenomenon even possible, is it caused by mutations which lead to a certain ...
Malhar Kookada's user avatar
0 votes
2 answers
62 views

Is it possible for two fraternal twins to be completely different at the genetic level?

Given that the 46 chromosomes split evenly during meiosis, if the even pairs of the male gametes match with an even pair of the female gametes, the offsprings in theory should be carrying chromosomes ...
RobotMan's user avatar
0 votes
1 answer
77 views

How do we know that the DNA we share with other species (especially primates) isn't fully the result of transposable elements?

I recently read a couple studies that concluded the 25% of genetic similarity between cows and reptiles is actually primarily due to TEs (transposable elements) rather than common ancestry. Here's the ...
Mihir Dhawan's user avatar
2 votes
0 answers
95 views

How is melatonin production related to proteins produced by clock genes?

I am a high school student learning about feedback mechanisms. My teacher gave an example of how proteins produced by clock genes are related to melatonin production. However, I'm confused about the ...
Authentic Melody's user avatar
0 votes
1 answer
36 views

Can We Determine the Cell Types Ab initio?

Is it possible to find all cell types in the human body and their respective transcriptomes by analyzing the human genome (and doing no physical experiment)? If such a thing is possible in principle, ...
Vegetable New Man's user avatar
0 votes
0 answers
36 views

What are the chances that parents and siblings are also carriers when a child is a carrier for autosomal recessive disorder like sickle cell disease?

I understand the inheritance pattern from parents to children for autosomal recessive disorders. Here, I am trying to calculate two probabilities when child is a carrier Probability of parents being ...
Allani Pavan's user avatar
1 vote
0 answers
38 views

How similar are polyembryonic plant siblings to each other?

I successfully germinated all the seeds I found in a Yuzu fruit. From about half of the seeds there are 2 little plants growing, like in the picture. I understand this is due to the occurence of ...
chlaus's user avatar
  • 13
1 vote
1 answer
81 views

Why would GREML in GCTA treat SNP effects as random effects?

I've read many papers, but none of them gave clear answer to my question. For example, https://www.nature.com/articles/s41576-019-0137-z#Sec5 The univariate GREML approach can model multiple random ...
John Smith's user avatar

1
2 3 4 5
50