Questions tagged [genetics]

Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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Studying the epigenetic variability, can I use SNPs?

So, I'm trying to study the effects of epigenetic variability on the brain structure. Can I use SNPs associated with a gene's higher expression to compute the likelihood of that gene being expressed ...
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Bad Genes in Human Genome Project [on hold]

I know that we found 20,000 to 25000 genes in Human Genome Project. Now,my questions are- Are ALL THESE (20k) Genes expressed (or functioning) in our body? Is there any BAD GENE in these 20k genes ...
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Are all fusion genes somatic in origin or can fusion genes be germline?

Fusion genes should have an origin.These are essentially hybrid genes that are translocated in its entirety. Eg. BCR-ABL, EML4-ALK are known to be implicated in cancer pathogenesis. Do these ...
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What is “dissection-based microscopy” described here, and how can it give genetic information?

The Phys.org article 'DNA microscopy' offers entirely new way to image cells references the new Open Access paper in Cell DNA Microscopy: Optics-free Spatio-genetic Imaging by a Stand-Alone Chemical ...
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Epigenetic experiment(Improvement of Weismann mouse experiment) [on hold]

The first phase of the experiment is an improved version of the Wisman experiment, which is mainly used to identify the right and wrong of Wisman and its opponents. Experiment procedure Start ...
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Is there a lac operon like sequence in the eukaryotic genome?

A lac operon regulates the expression of the genes that encode for proteins that decomose lactose into its simpler monosaccharides. It is also known to be an inducible operon. Any similar sequence in ...
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What is Mendelian Segregation and how is it related to the Hardy-Weinberg equilibrium?

I can't find the exact definition of Mendelian segregation. In addition, I am wondering how it is related to the Hardy-Weinberg equilibrium?
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1answer
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Are chromosomal microdeletions passed on?

I've been looking around but can't find a clear answer: are chromosomal micro-deletions passed on (hereditary) or not?
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1answer
56 views

What does “PDPN+ cells” means?

Are they podoplanin positive cells (cells that tested positive for podoplanin)? "...though it has been shown that podoplanin (PDPN+) cells analogous to mouse FRCs are found in human secondary ...
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GULO only for mammals?

I am not a biology student, but just want to know if GULO gene are present only in mammals or all species possess it ? And is GULO gene active in human fetus?
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Rationale behind Most Recent Common Ancestor (MRCA)?

My main question is this - I heard Richard Dawkins say in a video that after 1000s of years, any given individual alive today will be either an ancestor to ALL of the humans (in that future time) or ...
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How to search for a DNA sequence in a genome on ENA (European Nucleotide Archive)?

I have to do a search for small DNA sequences in the genome of an organism in ENA. I have the accession number and project id. However, I can't download the whole genome because of the download size ...
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50 views

Is the lac operon repressed in the presence of both glucose and lactose?

In the presence of both sugars (glucose and lactose) will there be repression of the lac operon completely? I know that more glucose means less cAMP --> less CAP --> less positive regulation, and ...
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How can a child be blood type AB, if both of the parents are blood type A?

Basically, both of my parents are blood type A (both are confirmed and it's also certain both of them are my biological parents). I recently found out my blood type is AB. How is this possible? I ...
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30 views

What the “due to” means in the definition of heritability?

According to Wray and Visscher, heritability is formally defined as the proportion of phenotypic variation (VP) that is due to variation in genetic values (VG). My question is, what does “due to” ...
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2answers
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Advantages of pain sensation?

The hazards of congenital insensitivity to pain (CIP) are well-known. This question is about the obverse: what selective advantage, if any, does the normal sensation of pain confer? I'm thinking of ...
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Are gametes diploid or haploid?

Some sources say that gametes are haploid, some say that they are diploid. I'm confused.
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For eQTL analysis, is it ok to combine all the ethnic groups?

I am performing eQTL analysis, and wish to be answered for a quick question. In conducting eQTL analysis, biologically, is it fine to include subjects from all ethnic groups (to increase statistical ...
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3answers
287 views

What does the gene name “lexA” stand for?

It is an important gene expressed in E. coli that represses the SOS response and also the expression of lambda lytic phase genes. UV light and damage to DNA is responsible for its breakdown and hence ...
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1answer
405 views

Left and Right Handedness

Today I found out that the gene for being Left-handed is dominant while Right-handed is recessive. I personally am left handed and so is my father. My mothers father is also left handed and I was ...
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Number of DNA strands per chromosome

As I was reading Griffith's Introduction to genetic analysis this evidence was provided for single DNA makes single chromosome. Eventually geneticists demonstrated directly that certain chromosomes ...
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1answer
36 views

What species would this be?

A common way to define species can be found on Wikipedia: A species is often defined as the largest group of organisms in which any two individuals of the appropriate sexes or mating types can ...
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1answer
41 views

Gene frequency — database/site

Is there any free database when one can check the gene frequency in a healthy population? For example I would like to check it for genes like BIN1, CLU or CR1. On the English Wikipedia I found a gene ...
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How can I calculate Fst, Gst, and Nei diversity index?

I got different polymorphisms of Cucumber mosaic virus in different regions of its genome from different libraries of RNAseq. This virus have two coding regions which are 3A and CP regions. I have ...
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1answer
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skin colouration in thalassemia

Now when i was studying about thalassemia, I read that anaemia is its major characterstic. I can understand that fact. But it was also written that the skin gets pale. Wikipedia says that the skin ...
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2answers
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Meaning of letter “c” in description of mutation: “Homozygous c.195C>G; (p.Cys65Trp)”

In a table in a paper titled Cerebral folate deficiency: Analytical tests and differential diagnosis, there's the following description of a mutation in a patient: Homozygous c.195C>G; (p.Cys65Trp)...
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1answer
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Is it possible to change the DNA of all the cells of an adult human [closed]

The process of making and transferring changes is pretty straightforward relatively speaking in an embroyo. You change the DNA of one cell and all the cells now inherit this change. But let's say ...
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3answers
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Does recombination slow mutation accumulation in sexual populations? Is there any evidence?

Mullers Ratchet is the process by which asexual organisms would accumulate mutations without bound. It is claimed that sexual organisms would slow this mutation accumulation through recombination. Is ...
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Mechanism behind Philadelphia chromosome translocation?

I was reading up on causative factors of leukemia on medicinenet and I came across the following statement: ...an exchange between chromosomes 9 and 22 leads to what is known as the Philadelphia ...
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1answer
47 views

Balancing selection vs introgression?

Balancing selection can maintain polymorphisms in natural populations for extended periods of evolutionary time. However, in this paper, Dannemann et al. 2016 identify three archaic haplotypes in the ...
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1answer
69 views

If some humans inherited 3% of Neanderthal DNA, why are we 99.9% same genome? [duplicate]

Many sources say that humans are 99.5 to 99.9 percent the same. Also some sources state that some humans have 3.4% Neanderthal DNA and some don't share those genes. Why is that?
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632 views

Are all genes transcribed in differentiated cells?

My textbook tells me that it’s specific transcription factors that allow for a different set of genes to be expressed in different cells (differential gene expression). My book gives the example of ...
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Why can't a genetically sound human stay alive for an indefinite amount of time given all the ideal conditions? [duplicate]

I have read that even if we can control our food and lifestyle and keep things as ideal as possible, there are other factors beyond our control like effects from neutrinos passing through our body ...
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29 views

How are haplotype blocks different from genes?

According to Cardon et al. 2003, a haplotype block is A discrete chromosome region of high linkage disequilibrium and low haplotype diversity. It is expected that all pairs of polymorphisms ...
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1answer
34 views

Do human genes get affected by irregular sleep and other factors

I'm new here so please go easy on me. Do our genes-the ones that carry our appearance, intelligence and other traits get destroyed or lost due to irregular sleep, excessive body heat, smoking, ...
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Why is the strength of genetic drift inversely proportional to the population size?

I saw a concept on the Internet that says "the strength of genetic drift is inversely proportional to the population size". I don't know why they are inversely proportional? Can somebody explain? ...
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1answer
77 views

Fertilization of the human egg- where does our centrosome come from?

Is there a centrosome in a human egg cell? Is the reason why the egg cell remains paused before meiosis 2 because there isn't a centrosome, and it only divides when the sperm fertilizes it thus it can ...
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Recombination due to crossover, outcome?

Garden peas normally have 7 pairs of chromosomes (n=7, 2n=14). Please calculate how many different types of gametes can be produced through the meiotic process if no crossover happens. If cross-over ...
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Is it possible to Clone a Dinosaur with a full strand of their DNA? [duplicate]

If you have a full strand of Dinosaur DNA would it be possible to make it living and hatch a dinosaur? Or would it be a failure? Could you use a bird or alligator, for replacein
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1answer
40 views

x-linked recessive inheritance and correlation for males

I was inspired by a discussion in this thread. Wikipedia lists a number of disorders linked to recessive genes on the x-chromosome. One typical example is red-green color blindness. Now wikipedia says ...
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How do crossbreeding with Neanderthals affect the genetic difference between ethnic groups?

I do not know exactly how much Neanderhtal/Denisova DNA non-subsaharan peoples carry around today, but I have heard figures of less than two percent in Europe, up to three percent in East Asia and ...
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1answer
56 views

Where can I find DNA decryption research? [closed]

What is the name of the science that studies the mathematics of DNA? Where can I learn about maths, statistics, types of code, numbers, patterns and graphs for genes and information found in DNA?
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what are best methods for mrsa screening in hospital?

methods for screening MRSA are based on PCR (mecA detection) and MRSA latex test and culture. I need to know sensitive, specific and cost-effective methods for diagnosis MRSA infection on one work day ...
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2answers
35 views

What's the difference between reaction norms and phenotypic plasticity?

I'm trying to understand better these two concepts, but I cannot see a clear difference yet. Reaction norm: "set of phenotypes that can be produced by an individual genotype when exposed to different ...
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How does a neutral allele change relative to a nearby allele under selection?

Suppose I'm looking at a gene being selected against (A) that's decreasing at a rate ($\Delta$P). If there's a nearby allele that is neutral (B) am I correct to assume that B will decrease with A at a ...
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1answer
2k views

Are left-handed people more likely to be colorblind?

My friend, uncle, and I are left handed and also suffer from Protan colorblindness. Is it more likely for left-handed people to be colorblind? Disclaimer: I was originally Right handed and due to a ...
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2answers
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Is there natural occurrence of induced pluripotency / expression of Yamanaka factors and what is the evolutionary explanation of that?

Is there natural biological processes in which the full (full reprogramming into pluripotent state) or partial (partial reprogramming, stopped before point-of-no-return, preserving the functional ...
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1answer
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Can Females Songbirds Have Male Plumage?

Male birds are colorful for courtship displays, females are dull for camouflage. But, is written in a website somewhere that sometimes, when females birds are sterile, they grow male plumage due to ...
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is it possible for a son to inherit an allele on a Y chromosome?

Obviously, the only way for one to be male is to inherit the Y chromosome, but are there alleles on the y chromosomes? Or is it just automatically the recessive trait without an allele.
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N value in a GWAS?

Just like the title says. I am reading about a GWAS but I don't know much about them. I understood most of it but I couldn't figure out what the "n" value was.