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Questions tagged [genetics]

Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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In marine DNA viral diversity studies, what would “paradigm of rampant mosaicism” refer to?

The recent paper in Cell Marine DNA Viral Macro- and Microdiversity from Pole to Pole describes the (huge) new Global Ocean Viromes 2.0 (GOV 2.0) dataset. In the Results and Discussion section, the ...
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Criteria for exchange of gene

I want to know what exactly determines whether this kind of recombination between two strands is allowed or not as it is said that after recombination the recipient may get new genes which logically ...
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If DNA methylation inactivates genes, does DNA demethylation activate them?

DNA demethylation can be passive or active. The passive process takes place in the absence of methylation of newly synthesized DNA strands by DNMT1 during several replication rounds – for example, ...
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What is the cause of “imbalanced” linkage disequilibrium?

With perfect linkage disequilibrium ($D' = 1, R^2 = 1$), you might have the following table of counts for the alleles: B b A 100 0 a 0 100 With "...
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How to find suitable qRTPCR reference gene for a inflammatory response experiment?

I have tried several housekeeping genes – Hprt, β-actin and GAPDH, to analyze the relative expression of a cytokine for measuring the inflammatory local response in mice ears. However, all ...
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How does the difference in the sequences of a dominant and a recessive allele of a gene help in the expression of the gene? [duplicate]

When an organism is heterozygous at a specific locus for a gene and carries one dominant and one recessive allele, the organism will express the dominant phenotype. These alleles vary in their ...
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Is brachydactyly due to mutation?

I have this so called "clubbed thumbs"also known as brachydactyly. It is of D-type. I searched for it on internet and found that it is a dominant inherited disease. But to my surprise,none of my ...
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Understanding genetic similarity in humans [duplicate]

I was reading "Blueprint" by Robert Plomin (online preview on webpage) and got stuck when I got to these two sentences in the prologue: "We are the same as every other human being for more than 99 ...
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Phenotypes caused by mutations in mitochondrial DNA?

Will mutations in mitochondrial DNA necessarily affect phenotypes? I have some cursory knowledge of serial endosymbiotic cell theory, and find it difficult to consider that the DNA of the former ...
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How do researchers define the region a lead SNP encompasses?

As I understand it, a lead SNP captures the variance for all unmeasured SNPs in a region due to it's low p-value and high linkage disequilibrium. However, in different papers the region size differs (...
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Is complete dominance actually a genotypic process?

An example often stated for codominance is blood groups, where both alleles version of the protein is expressed and can be found in the cell membrane. An example of incomplete dominance often given ...
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Are SNPs always in linkage disequilibrium with other SNPs

Is it possible to have a SNP that is not found is be non-randomly associating with any other SNP?
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Barr body Giemsa staining

Not all the female cheek cells show Barr Bodies when stained with Giemsa stain? Only 30 to 40% female cells show Barr Bodies. Why? Our Experiment: We washed mouth twice with listerine to reduce ...
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How to do a nucleic acid or genome and amino acid search [closed]

I have been looking to find a database where i can search for genome and amino acid search. Are there any open source databases available for the same.
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Can recessive alleles be expressed?

Say I have a disease that is autosomal recessive. If one was heterozygous for this trait, could the recessive gene still be expressed? I know sickle cell anemia has a heterozygous advantage so it ...
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Why are two forward and reverse priming sites depicted here? what do they do?

This question is in regard to the baculovirus expression system. (source: amsbio.com) Why do we need to generate primers for the polyhedrin promoter and the baculovirus? Primers are needed to ...
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Why do ladybugs have a different number of points on their backs

Everytime I see a ladybug I ask myself this question. Why does every ladybug have a different amount of points on its back? Is it because of its age? Or because of its genes? Is it inheritable?
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Why replication collapse but not stall leads to DNA break?

I have been looking into the concept of replication dynamics and was wondering why collapsing but not stalling leads to a DNA break.
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How does the colinearity of the HOX genes determine the body plan of an organism?

I was recently reading about colinearity in the HOX genes that give an organism its high-level body plan (where the order of the HOX genes on the chromosome follow the head-to-tail order of body ...
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Is DNA actually like source code repository?

So after reading articles like "People Use Just 8.2% of Their DNA" etc., and thinking a bit... I got this idea: What if DNA is actually like a software source code repository? You know, it has "...
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Why are some genes dominant over others? What is the mechanism behind it?

If I have a brown eye gene which encodes the protein that is responsible for the brown color and have a blue eye gene as well, what is the reason that my eye color is brown? How does one gene maintain ...
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What are primary reasons for the failure to localise/anchor sequences in genome assemblies?

My question concerns the incorporation of individual sequence reads into chromosomes during gene sequencing projects, especially those with larger genomes such as Drosophila melanogaster or Homo ...
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Are these cats calico?

Calico cats are cats that have 3 fur colors and are always female or males two X chromosomes. I've seen many cats that will have 2 fur colors (one of them is usually white) and another, third, color ...
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Absorbance anomaly

The standard concentration for absorbance of 1 for ssDNA is 33 ug/ml, while for RNA it is 40 ug/ml. I can't find the reason for the difference in this value for these two macro-molecules. My professor ...
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Genetic expression in interspecific hybrids

Referring to interspecific hybrids, I have the following two questions:- Quoting from wikipedia:- The offspring of an interspecific cross are very often sterile; thus, hybrid sterility prevents ...
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Intein Splicing

Currently I am trying to read and understand this paper on intein splicing. https://sci-hub.tw/https://www.ncbi.nlm.nih.gov/pubmed/22001202 However, I'm a little confused with Figure 4. Why do the ...
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Control of protein by DNA sequence with respect to RNA polymerase

I want to know how can a particular base sequence like the TATA box in the -10 region of a gene is able to regulate a protein's function like RNA polymerase? What kind of interaction really occurs?Is ...
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How close genetically is the most human-like chimpanzee to the most chimp-like human?

I understand that: Chimpanzees are the closest species to humans genetically. Only 1%-6% of their genes are different. Within any species there is genetic diversity, i.e. no two individuals have the ...
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In what does Genetic clustering and Cline sharpness differ?

They are both ways to measure divergence in species but I'm not understanding in what exactly the differ if both use hybrid zones and gene frequencies in the study.
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number of chromatids seen in karyotype

The karyotype is performed on a cell whose cycle has been stopped in metaphase or pro metaphase, using colchicine or by other means. In the textbooks I read that during the S phase each of the 46 ...
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What is the gene for height?

Height doesn't seem to be linked to sex, which is surprising. I have seen ways to predict children's height and it involves taking the average of both parents height. Upon my search, I did not find ...
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Genes & Map Units

Two genes of a flower, one controlling blue (B) versus white (b) petals and the other controlling round (R) versus oval (r) stamens, are linked and are 10 map units apart. You cross a homozygous blue ...
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Webtool to design guide RNA (gRNA) for use with CRISPR-AsCpf1?

My goals are to use a free webtool to: Identify guide RNAs (direct-repeat sequence followed by the targeting sequence) appropriate for use with AsCpf1 in order to target a specific segment of genomic ...
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How to download different kinds of data from NCBI eutils?

I have been researching NCBI eutils and wish to get some 'big data' from it. I know that I can construct queries to query one of (I think) 8 databases, like this: ...
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What's the benefit of the average human body temperature?

Why would the body choose a resting temperature of 36.1c to 37.2c? It seems a very inefficient mechanism of survival considering the typical ambient temperatures on Earth. If there is a benefit to ...
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Have humans finished evolving?

I thought that massive changes among organisms are over long periods of time. This is caused by, to my knowledge: Evolutionary pressure Natural/artificial selection Mutations Genetic drift Will ...
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Maximum recombination frequency [duplicate]

During the process of crossing over, Why is the maximum possible recombination frequency between two genes equal to 50% and not more than that?
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The space of all human DNAs [closed]

This is both a math and biology question but I think it makes more sense for a biologist to answer it. My question is: what can be said, if anything, about the space of all possible human DNAs (for a ...
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What's the difference between shotgun sequencing and clone based sequencing?

In a lecture during my undergraduate degree we were introduced to the race to complete the human genome. Celera were competing with Sanger and collaborators to sequence the human genome. Celera ...
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What is the difference between silent and synonymous mutations?

Several sources all caution that silent mutations and synonymous substitutions are not the same thing and should not be confused. But they seem to draw different actual distinctions between the terms: ...
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Why can't this be 1st meiotic division non-disjunction as well?

The child has gotten 2 "sick" chromosomes from his dad and 1 healthy from his mom, leaving it with trisomy 13. I can see how this can happen in the second meiotic division of the father but I can ...
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Is Chargaff's rule really applicable?

Chargaff's rules states that DNA from any cell of all organisms should have a 1:1 ratio (base Pair Rule) of pyrimidine and purine bases and, more specifically, that the amount of guanine is equal to ...
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Did cats evolve from monkeys ? or vice versa?

Did cats evolve from monkeys? or vice versa? How similar are the genes of cats and monkeys? What is the proof that they are related or that they are not related? Most monkeys climb in trees and ...
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Is Wikipedia a good source of taxonomy? [duplicate]

I have been quite interested in biology lately,and I would like to know whether it is a good choice to look up taxonomic information there.
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What is the smallest number of amino acids required for life?

Is there any hypothesis on the minimum number of amino acids required for life?
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Genetic linkage greater than 50 centimorgans

Classically, the linkage between two loci can be measured in centimorgans (cM), which represents the percent chance that these two loci will recombine an odd number of times (generating a recombinant ...
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Possible combinations in the Meiosis' Telophase 1

As you might already know Meiosis is the process in eukaryotic, sexually-reproducing animals that reduces the number of chromosomes in a cell before reproduction $^{[1]}$ One of the reasons why ...
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Why does size decrease across the sequence of human chromosomes?

The following graph shows a decrease in the number of base pairs per chromosome across the sequential set of human chromosomes: Is this because chromosomes were originally numbered by their size on ...
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How can the number of genes increase through evolution?

I am aware of the basics of evolutionary theory, however I don't understand how mutations can add genes over time. Am I correct in thinking that creatures within the same species who mutate to have ...
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What is the instructional language of DNA?

DNA carries most of the genetic instructions used in the development, functioning and reproduction of all known living organisms and many viruses (Wikipedia). Is it already know how ATCG's sequences ...