Stack Exchange Network

Stack Exchange network consists of 175 Q&A communities including Stack Overflow, the largest, most trusted online community for developers to learn, share their knowledge, and build their careers.

Visit Stack Exchange

Questions tagged [genetics]

Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

-3
votes
0answers
14 views

DNA extraction by cell pellet

May I resuspend the cell pellet frozen in -80 freezer and take part of the pellet for DNA extraction?
0
votes
0answers
45 views

The Viceroy Evolution Paradox [duplicate]

The viceroy butterfly generates a toxin compound which make it distasteful to predators. Biologists agree that the viceroy must have developed this trait as a passive defence mechanism to prevent ...
2
votes
0answers
36 views

what is the difference between homozygous and heterozygous duplication?

In a genetic test result it's written homozygous duplication or heterozygous duplication Does it mean four copies of the ...
2
votes
0answers
23 views

The afflictions of Tarrare

Are there any conjectured mechanisms that cause Tarrare's extremely oversized stomach and abdominal cavity? Along with his superhuman appetite of course. Whether from a medical perspective or a ...
-2
votes
0answers
16 views

Does bincondylar/bigonial, bizygomatic and bitemporal breadth all come down to genetics? [duplicate]

Is the facial shape in an adult 100% the result of genes, based on these measurable areas? Because it seems at different times in life, some people report different breadth of their faces. For ...
2
votes
1answer
36 views

Interpretation of genetic results

Result of genetic testing indicated: c.341del, p.Thr114Lysfs*37. The c.341del probably means:deletion at the cDNA 341 nucleotide. Buy what does the second part:p.Thr114Lysfs*37 ?
16
votes
2answers
10k views

Solving Hardy Weinberg problems

I really fail to understand Hardy-Weinberg equilibrium and can't find an easy enough source of information. Can you help me to understand Hardy-Weinberg equilibrium? My goal is to be able to solve ...
6
votes
1answer
117 views

Evolution of Wheat

In the evolution of wheat, there are two instances of chromosomal doubling, when Emmer wheat Triticum turgidum was formed from Einkorn wheat, and when Triticum aestivum was formed from Emmer wheat. ...
8
votes
1answer
646 views

Genetic expression in interspecific hybrids

Referring to interspecific hybrids, I have the following two questions:- Quoting from wikipedia:- The offspring of an interspecific cross are very often sterile; thus, hybrid sterility prevents ...
-7
votes
0answers
32 views

#genetics #crossingover #crossword [on hold]

In some family, where mother has blood type Rh-, father was daltonist and has blood type Rh+, the healthy girl was born with blood type Rh-. Her grandmother, from the mother side has psoriasis, but ...
1
vote
0answers
19 views

Does the law of independent assortment apply to homologous chromosomes or alleles, or both?

My textbook is giving me two definitions 1st def: "random orientation of homologous chromosomes at the metaphase plate in meiosis 1." 2nd def: "alleles for one gene separate into gametes ...
-5
votes
0answers
33 views

Is there any targeted gene-therapy that can increase male sexual dimorphism/attractiveness?

Are there any means of targeted gene-therapy, such as TERT based gene therapy for reverse senescence, which can increase male sexual dimorphism in things like skeletal bone structure/prominence, ...
6
votes
2answers
101 views

Why is Turner syndrome a problem?

Turner syndrome is a chromosomal disorder where one of the X chromosomes is missing. For more details visit the Wikipedia page I don't understand why missing one X chromosome would be harmful. In ...
13
votes
1answer
297 views

Which is the reference 16S rRNA?

Recently, I've stumbled upon a fact, which hasn't bothered me for many years. The fact is that all universal 16S primers are written as "[FR][0-9]+" (in regex notation), that is they have a position ...
6
votes
2answers
4k views

Why do people with type O blood have anti-A and anti-B antibodies?

People with type O blood have anti-A and anti-B antibodies, even without receiving a transfusion. Why?
3
votes
1answer
72 views

Webtool to design guide RNA (gRNA) for use with CRISPR-AsCpf1?

My goals are to use a free webtool to: Identify guide RNAs (direct-repeat sequence followed by the targeting sequence) appropriate for use with AsCpf1 in order to target a specific segment of genomic ...
4
votes
0answers
300 views

Minor Allele Frequency (MAF) higher than 0.5?

I have a set of data in PLINK format (*.bed, *.bim and *.fam files). There are around 2000 individuals in my dataset. I used PLINK to calculate allele frequencies in the population: ...
-1
votes
1answer
71 views

Is evolution theory falsifiable by whether mutations result in a loss or gain of genetic information? [closed]

If I understand the theory correctly, evolution revolves around the process of adaptation of a being to its environment which results in the increment of survival and reproduction chances for that ...
3
votes
1answer
105 views

What is mRNA expression level?

I cannot find a clear explanation of what is mRNA expression level, and how to measure it. I would appreciate if someone explained it or gave a reference.
0
votes
1answer
48 views

How do biologists discover information from fossils? [closed]

I have a query about the study of fossils (palaeontology). Let me know about the study of fossils. How do biologist discover "DNA" information from dead and old fossils such as a dinosaur? (answer ...
0
votes
1answer
62 views

Can I train my non-dominant hand and make it dominant?

Are our dominant limbs decided on birth or is there some way in which I can train my non-dominant hand and make it as coordinated as my dominant?
0
votes
0answers
17 views

What are the issues with excessive tandem repeats in replication?

Why is it that tandem repeats like CAGCAGCAG cause primer-template misalignment and diseases like Huntingtons disease? By my understanding, too many such repeats can cause strands to form hairpins and ...
0
votes
1answer
34 views

Do all gene mutations in pathogens lead to more harmful consequences for humans?

It seems that the concern we always hear is that bacteria and viruses mutate to dodge our treatments either through random mutations or survival of the fittest. Do harmful living things ever mutate to ...
0
votes
1answer
21 views

What does Ercc1-/- / DAT-Cre+ mean?

I really need to know what Ercc1-/- / DAT-Cre+ mean. I think the 1st part means that the mice don't have the Ercc1 gene (knockout). But what about DAT-Cre+? This question arised from reading the ...
0
votes
1answer
29 views

How are mitochondrial diseases like MERRF inherited?

I am doing a project on the disorder MERRF in Mitochondrial DNA. I have to make a pedigree and explain how it is transferred on from generation to generation. I know that it is inherited maternally, ...
2
votes
1answer
87 views

What makes an E.coli an E.coli, genotype or phenotype?

According to this paper, among 61 strains of E. coli they studied only 6% of the genes are common in all. Which means that the overwhelming majority of the genes are not shared. And wikipedia ...
6
votes
1answer
108 views

Are all genetic disorders inherited?

I know that genetic diseases such as cystic fibrosis are often passed down through generations and are therefore classified as genetic disorders, but if a mutation occurs spontaneously, which for ...
1
vote
1answer
38 views

Why not self pollination for finding the genotype instead of test cross?

Test cross can tell us what's the genotype of a plant is. But we can know that even by self pollinating the plant. For example, If a garden pea plant has the genotype TT, then self pollinating them ...
0
votes
2answers
93 views

How much of my ancestry comes from each grandparent?

Three of my grandparents were Eastern European, back at least several generations. I recently discovered that I am less than 25% Eastern European, the rest being Western European and other. How likely ...
2
votes
0answers
28 views

What are the different types of SNPs?

When I search for this online I get answers such as substitutions, deletions, insertions etc. But I mean in the sense that I have been reading different terms infront of the word SNP such as: lead SNP,...
1
vote
2answers
413 views

Chromosomal pair possible in metaphase - I

There is this question which was asked in my exam. A diploid cell contain 6 chromosomes. How many possible random arrangement of homologous chromosomes could occur during metaphase-I? (consider ...
0
votes
1answer
43 views

How can inbreeding be used for selecting mutations?

I understand that inbreeding, after a number of generations of crossing genetically related individuals eventually yields homozygotes, however I can't seem to understand how it can be used for ...
0
votes
1answer
34 views

Have there been new discoveries concerning the perception of taste for the last 10 years? [closed]

What are the last discoveries concerning the perception of taste for the last 10 years? We discovered the 5th flavour: umami. Also the 6th and 7th: oleogustus and starchy. Anything else? Maybe in ...
1
vote
1answer
115 views

What's the exact meaning of and how to derive the coefficient of the path from sire to offspring?

According to Wright's Coefficients of Inbreeding and Relationship, the coefficient of the path from sire to offspring is given as $p_{o \cdot s}=\frac{1}{2}\frac{\sqrt{1+F_s}}{\sqrt{1+F_o}}$ But ...
0
votes
1answer
69 views

Can environmental pressures affect genes in one generation? [duplicate]

Environmental pressures are the catalyst of evolution. Pushing a species to adapt to changes therein. My question is can these mechanisms cause significant adaptation over one generation(parent-> ...
-1
votes
1answer
43 views

What impedes the understanding of genotype/phenotype relationship without statistics? [closed]

Most genetic research tries to establish a relationship between a certain genotype and certain phenotype. To me this is like trying to understand a system as a black box, where you try to establish ...
1
vote
0answers
14 views

What genes in a plant determine whether a stem is erect or climbing?

I was randomly reading this Wiki article on Jasmine and this question crossed my mind after reading the following lines: Jasmine can be either deciduous (leaves falling in autumn) or evergreen (...
1
vote
1answer
76 views

What exactly does the phrase “chimerical sharing” mean in this abstract?

The Gizmodo article Australian Siblings Are Semi-Identical Twins, Some of the Rarest Humans Ever links to the new paper in NEJM Molecular Support for Heterogonesis Resulting in Sesquizygotic Twinning ...
0
votes
3answers
50 views

why and how multi allele gets reported during variant calling in vcf?

This might be a very basic question for many here. With the basic understanding of inheritance, eventhough there is a possibility of multiple genotypes due to multi alleles, the resulting genotype can ...
2
votes
2answers
1k views

Advantages of pain sensation?

The hazards of congenital insensitivity to pain (CIP) are well-known. This question is about the obverse: what selective advantage, if any, does the normal sensation of pain confer? I'm thinking of ...
11
votes
1answer
4k views

Did the eugenics program in Nazi Germany have a measurable effect? [closed]

Did the killing or sterilisation of people considered as living a "life unworthy of life" in Nazi Germany have any measurable effect on the "average health" of Germany? Is there any statistical ...
5
votes
2answers
200 views

Is most of the human genome functionless “junk DNA”?

In January 2012, David Icke published a book (ISBN: 9780955997334) entitled “Remember where you are and where you come from” in which he challenged what he claimed to be the view of mainstream science ...
0
votes
1answer
54 views

Inheritance of partly genetic conditions

Suppose Anne has a condition like OCD, that has a significant genetic component. Neither of Anne's parents have OCD, though. Does this mean that each of Anne's OCD genes were carried by at least one ...
5
votes
2answers
69 views

How do transgenic transformations cause off-target phenotypes?

I read that transgene insertions can cause off-target mutations that result in a phenotype being overly ascribed to the transgene, e.g. the increase of lifespan being ascribed to Sir2 overexpression (...
3
votes
0answers
170 views

Regulation of LBD33 genes Arabidopsis. If LBD 33 gene is up-regulated by auxin then why does expression decrease when increasing auxin concentration?

I have a question regarding the regulation of lateral boundary domain genes in Arabidopsis (specifically LBD33). I am an undergraduate student trying to understand the results of a lab where I measure ...
1
vote
1answer
2k views

Heterochromatin v Euchromatin. Which is more abundant?

So I was just reading that whether heterochromatin or euchromatin is more abundant in a particular human cell depends on how active that cell is. But considering that most of the 25,000 or so genes in ...
13
votes
6answers
11k views

Difference between genetic engineering and synthetic biology

I've recently seen the term synthetic biology being used to describe research involving genetic modification of organisms. What is the difference between synthetic biology and genetic engineering? Is ...
0
votes
1answer
35 views

What does (G+) (G++) in terms of male mutation rate and male-heterogametic XY-system?

What's the expression for $\alpha_m$ in case of male-heterogametic XY systems (G+)? Derive the corresponding $\alpha_m$ expression of for (sic) male-heterogametic XY systems (G++) I have ...
2
votes
1answer
292 views

Genetics independent assortment?

As indicated in this question, what do you think is is the best explanation for the observed progeny, is it because distance between genes affects recombination frequency? My main concern is question ...
0
votes
1answer
29 views

X linked traits expression in females

We all know that females have an inactivated X chromosome (Most of its genes are inactivated). Consider a female who is a heterozygous carrier of an X linked abnormality, If the inactivated X was that ...