Stack Exchange Network

Stack Exchange network consists of 174 Q&A communities including Stack Overflow, the largest, most trusted online community for developers to learn, share their knowledge, and build their careers.

Visit Stack Exchange

Questions tagged [genetics]

Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

0
votes
0answers
25 views

Statistical Genetics - What information is required for haplotype phasing in a novel, admixed population?

Let's say there is a population that has never been sequenced before and has experienced varying levels of admixture from multiple sources at different times. There is ancient admixture and recent ...
3
votes
0answers
37 views

Measuring gene similarity in two bacteria models

I'm currently working with some computational models of bacteria. The bacterium I am considering is an Ecoli K-12 which has 139 genes. I have several models of the same bacterium with different ...
2
votes
0answers
78 views

With respect to which METRIC is my DNA 99% similar to any other person's DNA? [duplicate]

I clarified my question, by editing the title. Using the comments and links below, I have answered it myself: The answer to my question is: The similarity is between 98.4%-99.9%, depending on which ...
0
votes
1answer
332 views

Why are prokaryotic promoter sequences written 5' to 3', when transcription proceeds from 3' to 5'?

It seems that the promoter regions are written from the 5' to 3' direction. My lecture notes, for example, give the -35 and -10 promoter regions sequences like so: Wikipedia seems to agree, on their ...
0
votes
0answers
23 views

What metric(s) is a good proxy for relatedness?

In attempting to seed a simulation, where an individual foregoes resources that go r to same-type individuals and (1-r) to all members (including same-type individuals). What commonly used metrics ...
3
votes
1answer
58 views

What is the relatedness of sisters in a haplodiploid system if you mate virgin queens with 1 of their sons

So I'm having trouble wrapping my head around this. In haplodiploid insects, sisters are related by 75% on average due to all sharing 100% of dad's genetics and 1/2 of mom's. (males are produced from ...
3
votes
1answer
37 views

Why is gene finding in Eukaryotes such a difficult task? [closed]

Why is gene prediction in eukaryotes such a difficult task? Every gene starts with a codon and the non coding regions in between a coding region also has some specific base sequence(which are used by ...
0
votes
0answers
26 views

Is FST convertible into r?

Would a correct interpretation of Harpending's 2002 article (http://www.humanbiologicaldiversity.com/articles/Harpending,%20Henry.%20%22Kinship%20and%20Population%20Subdivision.%22%20Population%20and%...
5
votes
2answers
465 views

What is the difference between silent and synonymous mutations?

Several sources all caution that silent mutations and synonymous substitutions are not the same thing and should not be confused. But they seem to draw different actual distinctions between the terms: ...
1
vote
1answer
62 views

What is linkage?

If two genes are on the same chromosome, are they always “linked”? What if they are more than 50 cM apart? Then they would follow Mendalian pattern of inheritence. So are they still linked?
5
votes
1answer
117 views

How is it known that Homo sapiens and Homo neanderthalensis interbred?

Many recent articles maintain that a small percentages of Neanderthal genes (up to 2%) are found in modern non-African people. (I believe that currently there is insufficient genetic material from ...
0
votes
0answers
17 views

Is there a distinction between linkage phase and haplotype?

Linkage phase- combination of alleles that are coinherited Haplotype- combination of alleles an organism has at different loci. So could an informative meiosis be defined as a meiosis in which a ...
3
votes
2answers
92 views

Human ancestor reproduction after chromosome fusion

I read somewhere that human chromosome 2 is the result of 2 primate chromosomes fusing together somewhere along our evolutionary journey. This is why we have 23 chromosomes while other primates have ...
3
votes
2answers
218 views

Could two women have a child through artificial insemination/genetic engineering?

This is something I just thought of while looking up stuff about matriarchies. I recall a comic series I heard of once, I think it was called 'Y, the last man'. In that story, all males (besides the ...
4
votes
3answers
161 views

Knockout and knockdown of gene

Out of curiosity, I got this question whether knocking out (deletion) of a gene on one side and knocking down (RNAi) of the same gene on the other side will affect the cell in a similar manner or not. ...
0
votes
0answers
56 views

Assignment help: Transcription and translation

I was almost sure I had the right approach to this assignment until I got a variation of answer. Please help to evaluate my approach. An E. coli promoter has the following consensus sequence (Figure ...
1
vote
2answers
247 views

Chromosomal pair possible in metaphase - I

There is this question which was asked in my exam. A diploid cell contain 6 chromosomes. How many possible random arrangement of homologous chromosomes could occur during metaphase-I? (consider ...
34
votes
6answers
12k views

Biological siblings possible with <9 months age difference?

I'm currently in the middle of writing a story, and one of the story elements threw up a question for me. In this story, there are two siblings, who are only one or two months apart in age. As they ...
0
votes
0answers
11 views

Pompe Disease/ GSD II karyotype

Does anyone know of a karyotype of the DNA of someone with Pompe Disease? It would appear because of the rarity of Pompe Disease that there aren't any/very many karyotypes of a person with it although ...
-1
votes
1answer
71 views

Why are worker ants not clones of the queen?

Currently worker ants of most species share only three quarters of their genetic code. It seems like worker ant clones would be better, as it would remove all genetic conflict of interest between them....
0
votes
1answer
40 views

How do gain-of-function alleles help with problems caused by genetic redundancy?

Genetic redundancy masks the gene functions (eg it masks diverse functions of the tumor suppressor gene). I have read on the internet that gain of function alleles can solve a such problem caused by ...
0
votes
2answers
54 views

How does it make sense to speak of heritability of qualitative traits?

As far as I understand, heritability is defined as "proportion of variation of a phenotypical trait due to genetic variation between individuals in a population". I see the concept is being applied ...
1
vote
1answer
30 views

DNA Sequencing - Sanger termination method: What effects will more ddNTPs in solution have on the resolution on agarose gel via electrophoresis?

Say instead of a small amount of ddNTPs, you add a significant percent of ddNTPs to dNTPs. I was thinking this would reduce the resolution for larger fragments due to more ddNTPs terminating ...
1
vote
3answers
120 views

is it possible that there is no gene at a locus?

"the location of a certain gene on a chromosome " is the definition I know for locus. ı just read that a gene is not necessarily present on a locus. how would that be possible?
0
votes
0answers
14 views

Mutation on Plants - SSLP Mapping

If you are inspecting a mutation on a plant, how to calculate the number of sample plants you would need to determine what BAC in the plant has the mutation?
-3
votes
2answers
56 views

Genetic disease elimination: Possible?

This is a question having to do with my generation ship story but more specifically, genetics, and even more specifically, genetic disease. Here are the conditions as far as people with or without ...
6
votes
1answer
369 views

Why do living things go belly up as they die? [closed]

I have seen birds, lizards, frogs, fish, etc in various places on their back dead. May be insecticides cause them to flip over but I do not believe every upside down creature died by poison as stated ...
1
vote
1answer
409 views

How many possible human genotypes are there that produce distinct phenotypes?

This and this Quora question ask how many unique human genotypes are possible. The answers take the combinatorial approach of raising the 4 possible base pairs to a power which is some appreciable ...
-4
votes
1answer
125 views

Can 2 people give rise to billions? Adam and Eve 2.0 [closed]

With with the advancement of GMOs the idea of giving rise to humans from 2 people is possible making questions like this invalid? How many people are required to maintain genetic diversity? With ...
2
votes
2answers
48 views

Does anyone know if there is a term to describe the following process?

I'm actually currently studying physics but this came up in my textbook (taken from Giancoli 7th edition section 16-10): The random (thermal) velocities of molecules in a cell affect cloning. When a ...
0
votes
1answer
92 views

epigenetic vs. environmental factors

I'm trying to understand the difference between epigenetic and environmental factors. For example, if gene A increases the risk of lung cancer by 50% and smoking increases the risk by another 75% when ...
0
votes
1answer
26 views

What are some features that do not make an individual better than others without this feature? [closed]

If a mutation occurs so that this allele gives a noticeable feature that is present in this individual but absent in every other individual and this feature is of no benefit or detriment to the ...
0
votes
0answers
36 views

Yeast transformation: is it necessary to remove template plasmid from PCR?

I'm frequently transforming budding yeast with PCR fragments. Normally, after PCR I digest with DpnI to remove the template plasmid. DpnI is a restriction enzyme which cuts methylated DNA, i.e. the ...
1
vote
0answers
14 views

Chromosomally different D. melanogaster sperm

I know that D. melanogaster have 4 pairs of chromosomes and crossing over is absent in males. Denoting autosomes as Ai,j where i is chromosome no. and j are homologues (1 and 2) I am solving the total ...
1
vote
1answer
74 views

Why replication collapse but not stall leads to DNA break?

I have been looking into the concept of replication dynamics and was wondering why collapsing but not stalling leads to a DNA break.
0
votes
0answers
36 views

is it possible to create eggs from male skin cells?

According to this article, Eggs from skin cells? There is a technique called "in vitro gametogenesis", which they say could allow any type of cell to be reprogrammed into a sperm or egg. The ...
0
votes
1answer
42 views

Understanding Genetic Dynamics of Specific Problem

The following questions comes from International Biology Olympiad 2014, theoretical part B. It states: Earlier research suggested that the red flower pigment of plant species was the result of a ...
0
votes
1answer
79 views

law of independent assortment [closed]

Self fetilization of F1 dihybrids, following independent assortment of alleles result in: ...
34
votes
1answer
4k views

How could a species be engineered to go extinct?

Non-biology background here. I read this very interesting article: https://www.wired.com/story/crispr-eradicate-invasive-species/ However I am having a hard time wrapping my head around something: ...
-1
votes
1answer
25 views

Assessing carrier Risk

susan has been found to be a carrier of Tay Sachs. what is the risk that her maternal aunt is also a carrier if we don't know her parents status?
-1
votes
1answer
65 views

Is there any mechanism that prevents DNA of an eaten entity's cell from affecting that of own?

When we eat food I heard that our digestive enzymes disassemble the DNA of the eaten cells so that the DNA cannot affect us. Then, is there any mechanism (that prevents the eaten cell's DNA from ...
1
vote
1answer
406 views

Why can't Turner Syndrome occur in males?

In Turner Syndrome, one X chromosome is missing, meaning that the resulting egg or sperm has 22 chromosomes (without pair) and the 23rd chromosome is missing. If this develops in an egg, and a normal ...
3
votes
2answers
38 views

What is the heritability of brain gyrification?

Brains of mammals with a folded neocortex do not have identical patterns of folding in the same species. Do two genetically identical individuals of a species have the same pattern of brain ...
1
vote
0answers
65 views

How can census population size be smaller than the effective population size in some species? is that possible?

The only way I can think this could happen is through a recent population bottleneck. Can it be possible though ?
10
votes
5answers
3k views

How does DNA still work after recombination?

If you take two computer programs and randomly swapped pieces from each of them. The result is not going to work. It will just be garbage. If you take two novels and randomly swapped chapters the ...
0
votes
1answer
94 views

What are the advantages of using interphase cells rather than metaphase cells for gene mapping purposes using FISH?

I have been told that interphase cells are better for gene mapping purposes than metaphase cells but don't know why.
1
vote
0answers
40 views

A reliable source of Cas9?

I live in Egypt, and I do want to perform CRISPR-Cas9 genome modification, but there are no reliable sources of Cas9. I can order some Cas9 online from the US, but not much. So... my question is, is ...
0
votes
0answers
9 views

Can agouti signalling peptide inhibit MC1 and MC5 production in the body?

I read a comment on reddit where someone said that its impossible to use ASIP to inhibit those two. And that it will be difficult for the peptide to reach MC1 and MC5, and that the chances of it ...
0
votes
0answers
15 views

Looking for neuronal gene expression database

I am looking to see if there is a database that contains gene expression profiles differences of differentially stimulated neurons.
-1
votes
1answer
36 views

How should I interpret for example AA result, when SNPedia only has CC/CT/TT listed? [closed]

I don't know how to properly formulate this question because I'm new to this, so please edit this if you can... For example when I would check SNPedia for rs gene, it would have listed CC/CT/TT genes,...