Questions tagged [genetics]

Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

Filter by
Sorted by
Tagged with
0
votes
0answers
15 views

Why doesnt the SARS-Cov-2 affect other animals?

Why doesnt the coronavirus affect animals like dogs and cows? I know that the SARS-CoV-2 is a zootonic virus i.e. it can affect both humans and other animals. I also know that the DNA composition and ...
0
votes
0answers
21 views

Clarifying distinction between genetic recombination , translocation. and transposition

Having thought about the distinciton between these terms I have come up with the following definitions, are these correct? Translocation describes the relocation of a chromosomal segment to a ...
-3
votes
1answer
37 views

Can Euchromatin convert into Heterochromatin?

I know that Heterochromatin can convert into Euchromatin but is the reverse possible? If yes, then How?
0
votes
1answer
25 views

what kind of dinucleotides can be considered important from a mutational point of view other than CpG islands?

CpG islands are regions with an high frequency of CpG (Cytosine-phosphate-Guanine) sites. The usual formal definition is that of a region with at least 200 bp, a GC percentage greater than 50% and an ...
0
votes
1answer
33 views

How does permanently modifying human DNA work? And how does it impact procreation?

So I read an article about a metabolic disease being treated with gene therapy, where they inserted corrective dna into the patient. https://www.independent.co.uk/news/science/dna-permanent-change-...
1
vote
0answers
67 views

if an SNP were edited using CRISPR What are the chances that, absent artificial selection, wild type alleles would reemerge?

I am researching a fatty acid amide hydrolase (FAAH) SNP RS324420 and FAAH out microdeletion that together lead to reduced pain sensitivity and reduced anxiety (Moreira et al 2008). The causative ...
-3
votes
0answers
35 views

Why is Cas9 considered an enzyme?

I've been doing some research into CRISPR-Cas9 - a fascinating topic. But I don't understand why Cas9 is considered to be an enzyme? From what I've researched, Cas9 is the molecule that cuts DNA. In ...
1
vote
0answers
13 views

Why are parents of contrasting genotypes involved for a reciprocal cross?

In a reciprocal cross, we try to determine whether a trait is sex-linked Or not... One thing I couldn't understand was that, why are parents of contrasting genotypes involved? Does that mean that at ...
-1
votes
0answers
33 views

How many genes are involved in mitochondrial metabolism and/or related to mitochondria in humans?

I have made a list of about 68 genes which are involved in mitochondrial biogenesis, bioenergetics and mitophagy, but I'm sure there are more. Can someone please help me with how many genes in humans ...
-2
votes
0answers
27 views

a) Diagram the relative content of the human genome. b) Explain the contribution of transposable elements to genome content and gene function? [closed]

a) Would the relative content of the genome only be DNA? Or does this include more such as RNA and proteins? b)From my understanding, transposable elements can change DNA sequences since they can jump ...
-1
votes
0answers
32 views

How does gene and genome relationship relate to genetic complexity?

From my understanding, gene and genome relationship would relate to genetic complexity because every species has a different genome and therefore the complexity ie. transcription, translation, ...
-3
votes
0answers
17 views

What are the major types of genetic variation? What is the relationship between recombination and variation?

Im not sure what the main major types would be for genetic variation.
4
votes
1answer
45 views

How can Chronic myeloid Leukaemic drugs reduce the production of the Philadelphia genotype?

How can Chronic Myeloid Leukaemic drugs (Tyrosine kinase inhibitors, e.g. imatinib, etc.) that act by inhibiting bind of ATP to the active site of the BCR-ABL1 protein actually reduce the prevalence ...
1
vote
0answers
36 views

What degree of influence do SNPs have on activity of ligands at receptors?

I know that generally, evolution tends to evolve towards having some wiggle room in respect to effect of polymorphisms on binding of endogenous ligands, but with synthetic ligands, especially modern ...
0
votes
1answer
22 views

Determine similarity in percentages between species A and B, A and C, and B and C

The chart above is a graphic that shows the amino acid sequence differences between different organisms for a protein keratin. The question I am required to answer begins as, "Keratin is made up ...
0
votes
1answer
60 views

How to identify an unknown species from a .fasta file containing its genome sequences

I am a Biochemist that is unfamiliar with bioinformatic tools and new to academia as a whole. I am currently using ILLUMINA PE DNA sequence data, which I trimmed (Trimmomatic), corrected (Rcorrector) ...
6
votes
1answer
143 views

What does Δcys mean after a gene name?

I am reading a paper and I have come across the following statement: "Plasmids encoding full-length NCAM140 and NCAM140Δcys, intracellular domain of NCAM140, and the NCAM140ID729–750 fragment ...
1
vote
0answers
18 views

What does it mean for a protein to be dominant-negative?

I am reading this journal paper, which investigates the interaction of the NCAM protein and the Pak1 protein. In this paper I have come across the term "dominant-negative Pak1" and "...
3
votes
1answer
77 views

Probability of all alleles represented in a sample

I'm trying to wrap my head around some formulas presented in the 1992 paper from Chakraborty Sample Size Requirements for Addressing the Population Genetic Issues of Forensic Use of DNA Typing, but I ...
-1
votes
0answers
21 views

The parasites in kingdom Monera and their evolution

The kingdom Monera was first to be on this planet In this kingdom we have the Eubacteria in which certain organisms have an ability to infect humans, plants and other organisms {parasitic in nature} ...
0
votes
0answers
18 views

Estimate mutation rate in UVC treated cells

I am wondering how to get a coarse estimate of the number of mutation I obtain doing UVC treatment on eukaryotic cells (microalgae) starting from information such as the survival rate, genome size, ...
4
votes
1answer
103 views

Quantifying Gene Expression

I have found that many studies use the mRNA concentration as a “proxy” for protein activity because there should be correlation between mRNA levels and proteins expression levels. How is protein ...
0
votes
0answers
22 views

Microarray experiment validation meaning

I have a quick question: what does microarray experiment validation mean ? I was reading a paper in which they say that the data of the experiment show that the 3 genes radB, dp1 and dp2 are co-...
0
votes
2answers
44 views

Meaning of 5’–3’ in relation to ORFs

I was reading a paper in the journal Molecular Basis of Disease, which stated: The ORFs are arranged as replicase, and protease and major S, E, M, and N proteins which follows a typical 5’—3’ order ...
0
votes
1answer
24 views

Do we come to know which allele is dominant by seeing family genration tree only?

I know that a Gene has Alleles (variation) and one is Dominant over Other i.e the Other Recessive. Then I got a Thought that How can we tell whether an Allele is Dominant or Recessive...... and I came ...
-1
votes
1answer
42 views

Genes are linearly arranged on the chromosome [closed]

Could someone please explain the meaning of the statement given by TH Morgan: "genes are linearly arranged on chromosomes" Since according to my knowledge there are noncoding parts in ...
1
vote
0answers
21 views

Can alleles have cyclic dominance?

Do the relationships between alleles always form a hierarchy? Ignoring partial and codominance, can alleles have a cyclic relationship? For example, is there anything that exists analogous to the ...
3
votes
0answers
30 views

Why do I get cytosine to guanine/adenine transitions in bisulphite treated sequences?

I got my sequencing results (bisulphite treated and non treated sequences of same species Allium cepa) and now I have to do analysis in Cymate online tool. I prepared all sequences as it is written in ...
4
votes
1answer
76 views

Who discovered DNase?

I was recently studying genetics in which DNase had a crucial role in proving DNA to be the genetic material and I tried to find who discovered DNase (like the discoverer of DNA) but in vain. Who ...
1
vote
1answer
39 views

What's the role of SNP (Single Nucleotide Polymorphism) in a disease when there is no gene associated to that SNP

I am quite new to the field of GWAS (genome-wide association studies), and I'm combining GWAS results and single cell analysis on type-1 diabetes (T1D), to see the role of cell specificity on the ...
2
votes
2answers
30 views

Are Oct4 and Oct3 the same protein?

Are the transcription factors Oct4 and Oct3, who are encoded by the POU5F1 gene, actually the same protein, or alternative spliced products from said gene?
0
votes
1answer
64 views

At what point during an organism’s lifespan do mutations occur?

I’m a software developer and I’m implementing something called a Genetic Algorithm. I would like some input on when during an organism’s lifespan mutations occur. Genes mutate throughout the lifetime ...
0
votes
1answer
61 views

Recombination Data Set

So I was looking over some genetics question and came across this data set. In Fruit fly Drosophila melanogaster, there is a dominant gene b+ for grey body color and another dominant gene c+ for ...
0
votes
0answers
25 views

What does an allele frequency of 0 mean in gnomAD v3?

There is a single nucleotide variant: 18-47394-G-A (GRCh38) with an allele count and allele frequency of 0. As I understand it, this means that there are no alleles in the population with this variant,...
0
votes
0answers
12 views

What new information does PheWAS add beyond GWAS?

I am trying to understand Phenome-Wide Association Study (PheWAS). If I understand correctly, PheWAS appears to be just the reverse of GWAS (finding gene-trait associations using traits instead of ...
0
votes
0answers
12 views

Do single oligo sgRNAs for CRISPR require a modified CAS9?

I am attempting to use CRISPR to insert a tag into a gene. The way we have done this in the past is to use separate crRNA (with a sequence to interact with the tracr) and the universal Tracr sequence ...
0
votes
0answers
17 views

Empirical Measurements of Barr Body Ratio

'Both X-chromosomes in a female have an equal chance of becomes a Barr body in each cell.' Every source I can find on Barr bodies claims this and I can think of no reason for why it may be wrong. What ...
-4
votes
2answers
80 views

Could DNA replication fail in the far future? [closed]

Assuming that all environmental conditions on Earth remain the same in distant future, the tendency of nature to increase entropy would cause the chemistry and the mechanism of DNA replication to ...
1
vote
3answers
49 views

Role of epigenetics in evolution and transmission of defects caused by drugs

In a documentary, they were saying that epigenetics changes caused by the environment in an individual can be transferred to the following generations. I have some questions on that: How many ...
0
votes
0answers
28 views

The Proofreading Function of Coronavirus Polymerases

I have heard that the Coronavirus family have a proofreading and editing function in their polymerase enzymes which can recognize and excise mutations. This is obviously disastrous for the population ...
-4
votes
2answers
57 views

Alleles and Ploidy [closed]

I was recently studying inheritance and variation and came across a sentence: A diploid organism can show only two alleles How is this possible?
0
votes
1answer
64 views

How do genes determine facial features?

What is known about the genes responsible for inherited facial features — the family resemblances that are so recognizable? Take for example a particular shape of nose: which gene or genes make it ...
0
votes
1answer
44 views

Are probabilities of mutations symmetric?

For the premise of this quiestion let's assume that there is an allele A and an allele B. The allele A has a probability P to mutate into the allele B in the given timeframe. Is it also true that the ...
3
votes
1answer
69 views

Why are Chromosome Territories important?

Chromosomes occupy discrete regions of the nucleus, referred to as 'Chromosome Territories'. This spatial organization is emerging as a crucial aspect of gene regulation and genome stability in health ...
-1
votes
2answers
80 views

Do identical twins have the same metabolism rate at birth?

Will monozygotic twins defecate at the same time if fed at the same time during the first weeks of life? They should have the same genetics (and epigenetics) since they are monozygotic and the same ...
3
votes
1answer
70 views

Rigorous definition of the kinship coefficient and proof of a recursion thereof

I am reading Section 5.2, Kinship and Inbreeding Coefficients, of Kenneth Lange, Mathematical and Statistical Methods for Genetic Analysis. There the kinship coefficient $\Phi_{i,j}$ is defined for ...
-1
votes
1answer
57 views

Genotypes without Recombination

When given that the parent generation's genotypes are linked traits, how do you determine the genotypes of the F1 generation when no recombination has occurred. For example, given the parents BbNn ...
-6
votes
1answer
43 views

Can the self correction mechanisms in cells imply that the DNA code to a degree is self modifying

There is an argument that proteins coded by 20 amino acids via the DNA program has so few successful protein formation that a search never can reach the complexity of it via natural selection and ...
1
vote
1answer
68 views

Evolution: Can the genotype frequencies change, but the allele frequencies remain constant?

If a population isn't evolving because it's in Hardy-Weinberg (HW) equilibrium, then I know that both genotype and allele frequencies must stay constant. My question is, can evolution still not occur ...
0
votes
0answers
22 views

How to build SEG in your personal environment?

I'm trying to implement SEG (Wootton & Federhen,1993) in my MATLAB and Python environment. From this oriinal article I cannot figure out what I need to build my script. Are there any related ...

1
2 3 4 5
44