Questions tagged [genetics]

Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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What is the number of autosmes in the normal female? [closed]

The autosomes is the first the 22 chromosomes in human and female karyotype,the ovum represents female gamete in sex cell,but I dont know how to reach to this answer ?
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How likely is a lack of DNA match with a distant relative?

How likely is a lack of DNA match with a distant relative? I have recently gotten interested in ancestry research and have had a DNA analysis performed by a prominent commercial provider. I've been ...
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Best book to read to understand human Genetics for a beginner?

I'm just a person who's interested in human genetics, genetic diseases and the human genome. I have some idea of genetics and humanity as a whole but it is not my profession. Just a hope
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2answers
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Can almost all plant derivatives be produced with genetic engineering using fungi/bacteria?

I saw a Thought Emporium video where they produced spider silk by genetically modifying yeast. I have also read about companies making vanillin (vanilla flavour) using this technique. I am now curious ...
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Broadly, what are some considerations for doing a psychological study with a genetics component?

I am a Ph.D. student in a brand new lab that focuses on biological mechanisms relevant to psychotherapeutic processes. I come from a psychology/biology background (undergraduate level) and I have an ...
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Impact of Terminator Efficiency in Genetic Constructs

I was looking at the iGEM Bioregistry of Terminator parts which offer varying degrees of termination efficiency. I am wondering why studies into combinatorial synthesis of genetic circuits for ...
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What is the life of cell-free genetic circuits?

Can genetic circuits be tested in a cell-free environment? What would be their life if we keep them at room temperature? The circuits which are composed of DNA-based components are commonly referred ...
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1answer
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Why is DNA replication not 100% accurate

I've been reading about DNA mismatch repair (MMR) and how this process improves DNA fidelity. However, I was wondering, what is stopping MMR from correcting all mistakes in the daughter DNA with 100% ...
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1answer
126 views

Why is male balding so common in comparison to female balding?

I have heard that over 30% of men will be bald by 30, and that 60% will be bald by 50. However, I hardly ever see a bald woman unless it is a story about a cancer survivor or someone going through ...
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2answers
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Why is haemophilia unviable in later stages of life?

A sentence in my textbook is: The possibility of female being haemophilic is extremely rare because mother of such a female has to be at least carrier and the father should be haemophilic (unviable ...
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What if target DNA doesn’t have restriction sites

All the examples on DNA cloning I have encountered have assumed that the target gene and vector both have compatible restriction sites at just the right locations (probably for ease of explanation). ...
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How would you use readthrough as part of a genetic circuit design?

Traditionally, in synthetic biology, researchers tried to avoid some transcription phenomena (like roadblocking of tandem promoters or readthrough of weak terminators) since they are not in line with ...
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Does parental conflict lead to genes combining important functions with functions only advantageous for one of the parents?

In a sitation of a mother-father conflict of interests, the mother might use epigenetics to turn off some genes only advantageous for the father's genes and not her own. I thought a logical father's ...
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What can you learn about someone's mother and father by examining their DNA?

Disclaimer: I ask this question from the position of having paid absolutely no attention throughout school/highschool science classes. I am incredibly ignorant, but I don't know how to find the answer ...
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How come the role of the Apis mellifera is determined by nutrition rather than chromosomes?

Prior to making my question I browsed on similiar question such as this one but it doesn't specifically addressed my doubt in the sense that it is related with a different species and on a concept not ...
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Can a trait be too successful? Wouldn't overwhelmingly successful traits limit variability, which is one of the requirements of NS? [closed]

Can a trait be too successful? Wouldn't an overwhelmingly successful trait soon limit the gene pool, and if so, how would the process of natural selection react to that? If an individual is born ...
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Why are almost all inborn errors of metabolism autosomal recessive? [closed]

Technically, the only inborn error of metabolism I know that is autosomal dominant is acute intermittent porphyria. Also, the only inborn of metabolism I know that is X-linked recessive is Lesch-Nyhan ...
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How do gene locations change during crossing over events?

Suppose you have two variants from the same species, which have slightly different chromosomes I's to each other. Genes may be in slightly different positions on the chromosome, and the lengths of the ...
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1answer
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How long would you expect a designed plasmid to remain in a population of E. coli after transformation?

When transforming E. coli with a genetically-modified plasmid, how quickly/often is this plasmid "lost" because of mutation, or horizontal-transfer, or "dilution" over reproduction ...
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Are genetic crosses between asexual organisms possible?

To my knowledge (Please correct me if I am wrong), genetic basis is the key in defining species. When we encounter an unknown species, we can sequence it's genome and compare the genome with other ...
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Statistician confused about exact SNP data type

I'm from a statistical (not biological) background, and I'm very confused about what exactly is the "data" associated with a SNP. Below, I'll explain things as best I can--please correct me ...
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Can a cell receive multiple copies of an insert when using different MOIs?

I want to transduce a cell line with virus that carries a specific insert. When using different Multiplicity of Infection (MOI), I expect to get different percentage of transduced cells, but is it ...
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Are there any animals whose genome haven't been sequenced yet? [closed]

I referred to a few websites and it seems like almost every animal's genome has been sequenced. However, are there any animals that haven't yet been sequenced? If so, can you provide the list here or ...
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Confusion about how to compute probabilities for linked genes

I am confused about how to compute probabilities for linked genes. The problem that I am solving is this: P generation: AAbbddEEff X aaBBDDeeFF. If A and B are 40 centimorgan apart, what is the ...
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DNA mutations in humans are generally bad, but why to they make viruses stronger?

When I read about DNA mutations in humans, the mutations are generally bad. When I read about mutations in viruses such as the recent emerging strains of COVID-19, however, it seems to be good for the ...
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What are the effect of radioactivity on grey wolves in Chernobyl?

I am doing some research about the effects that radioactivity has and is having on grey wolves in Chernobyl and more particularly on their genetics, but maybe also looking at the populations in the ...
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When is it better for a gene to cause a biased sex ratio?

Because genes are selfish and want to maximise their transmission from generation to generation, if they can distort a population's sex ratio, isn't it always in their interest to cause a biased sex ...
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Using punnett squares to express sex/gene linkage and recombination frequency

I have been using punnett squares to visualize mating experiments. I am looking at a pairing which is known to have a crossover event occur. I know from empirically collected data the recombination ...
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Why didn't Escobar's hippos introduced in a single event die out due to inbreeding

Today I read a BBC Report about how Pablo Escobar had once imported 4 hippos (1 male, 3 female) into his estate in Colombia for his private zoo. After his downfall, while other species were shipped ...
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Is the number of nucleoli in a nucleus fixed?

A nucleus can have multiple nucleoli. But are there any constraints on the number of nucleoli in a nucleus? Can cells of individuals of different species have a different number of nucleoli? Can ...
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Explanation of “differential transcript usage” (DTU)

This paper describes differential transcript usage as Differential transcript usage (DTU) is a special case of alternative splicing in which a gene’s relative transcript abundance (RTA) profile, the ...
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exercise of gene linkage in genetics

Could you help me solve this problem: AAbbCC is crossed with aaBBcc and the offspring re-crossed with aabbcc. Considering that A and B are linked and their distance is 12 mapping units, while the gene ...
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1answer
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Get “DNA” of one parent based on its children [closed]

I'm no biology expert so bear with me, but I've been given a task to estimate alleles of an animal based on the animal's children and the children's other parents. I've looked up Mendel's laws but I'm ...
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Why are adenoviral vector vaccines safe in terms of insertion mutagenesis due to genome integration and E4 region's proteins effects?

Disclaimer: I'm neither a genetics professional nor an anti-vax fanatic, I just tried to compare COVID-19 vaccine types currently available on the market and got some questions that I'd like to answer ...
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1answer
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The Perfect Predator? [closed]

I’m not a biology major or even studying it in any way so I apologize if this makes no sense. I’m curious, if say the Jurassic Park team came up to you and asked you to genetically engineer the ...
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3 primers to know if Homozygous, Heterozygous or WT

In this imaginary experiment, I am using T-DNA to make an insertional mutagenesis that will get randomly inserted into the DNA where it might get inserted within a gene, disrupting it. In order to get ...
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1answer
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Why is the number of cells virtually a constant?

Going back to highschool, I learnt about mitosis: in order to renew their cells, eucaryots' cells divide themselves into two copies. But my course didn't cover what moderate the replication. By ...
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Cystic Fibrosis Genetic Risk Determination

Let's say Jane has Cystic Fibrosis and we know her brother doesn't. What are the chances of her brother's future child having CF? (The chances of Cystic Fibrosis in the general population can be taken ...
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1answer
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gene mutation occurs on two strands of DNA or just one strand?

Suppose we have one strand with 3'-AAA-5' and the other strand is 5'-TTT-3'. So when point mutation occurs, does it happen to two strands at the same time? e.g. 3'-AAA-5' becomes 3'-AGA-5' and 5'-TTT-...
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Standard notation for crossings (female, male)

Is there any standard for the notation of a crossing (hybrid) which tells me which part is the mother and which is the father? Example StrainA: egg cell ...
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How could I make my fish gold?

I'm doing research on how the pigmentation of fish. I want to know how could you change it with the help of genetic modification. I have some Silver Dollar fish (Metynnis argenteus) and I want to make ...
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Questions regarding transformation in bacterial cells

First off, in transformation the donor DNA aligns itself with the complementary bases in the recipient DNA. Now a "perfect" alignment of the donor DNA ( Sorry if my terminologies are ...
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Inheritance of FEVR (Genetic Disease)

If a woman has FEVR and is affected by the disease, what are the chances of her passing the disease to future generations. I read somewhere from a credible source like NIH(I couldn't find the link ...
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1answer
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Can Taq polymerase be stored with PCR primers?

I don't think it's possible for TAQ to be stored with the primers, but I'm not sure. This storage wouldn't be long-term (a few days, or a week at most). Thoughts?
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Why does the DNA of Bacillus subtilis not contain DNA families of 20-37 members?

I am reading the book "Molecular biology of the Cell, 6th edition" and in chapter one page 18 the following figure is included I am presuming this figure represents all genes within the ...
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What is neutral theory of evolution?

The question is not about the very basics, but more about where the line separating the neutral theory from the rest of population genetics lies. One often reads/hears claims that "the findings ...
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Should I consider one or two DNA chains to find how many nucleotides are in a gene?

I am trying to solve an exercise. How many nucleotides does a gene contain if information about 287 amino acids is encoded in it? What is the molecular mass and length of this gene? AFAIK, I have to ...
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Why does this study about genetic likelihood of COVID hospitalization not associate risk to base pairs?

In the study "Genetic mechanisms of critical illness in Covid-19", (free to download) the authors share their findings on which genomes seem to be associated with an increased likelihood of ...
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Can one derive COVID-19 risk from a cheap consumer genetic test like 23andme?

Studies have found genes associated with a significantly higher risk of severe COVID-19, some of them claiming it to be 1.6 times the general risk. They mention genes at markers such as rs35044562, ...

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