Questions tagged [genetics]

Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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37 views

What does (G+) (G++) in terms of male mutation rate and male-heterogametic XY-system?

What's the expression for $\alpha_m$ in case of male-heterogametic XY systems (G+)? Derive the corresponding $\alpha_m$ expression of for (sic) male-heterogametic XY systems (G++) I have absolutely ...
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101 views

Are microsatellites viable markers for GWAS?

I'm just reading some papers on genome-wide association studies and find that most of them use SNPs as a marker. I understand that they're the most polymorphic and thus the best for accurate ...
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52 views

Why does the definition of a "gene" require it to have a product?

In a textbook, I found the following (emphasis in the original): At this point, we can provide a molecular definition of a gene as a sequence of DNA that specifies production of a functional ...
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22 views

Does reversion of resistant strains to wild-type only occur when no more drug pressure is exerted

We always read that wild-type reversion of a resistant strain occurs when no more drug pressure is exerted. Could resistance reversion also occur under drug pressure, but from a drug other than the ...
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Does low gravity exposure to early stages of human fetus have potential to unloc unused genetic information from earlier stages of evolution?

The title seems quite self explanatory but let me elaborate. New mutations do take a very long time and many generations to occure in the genetic code. But our genetic code already holds all the ...
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Size constraints on CRISPR guide RNA

I had a quick questions on the size limitations of a CRISPR guide. More specifically on the shorter end. Can I make a guide that is say 7-10bp and still have an active complex? I transfect using an ...
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How does further hybridization affect fertility?

Numeruous scientific sites state that hybrids (like mules) are infertile. On the other hand, ligers are known to mate with both tigers and lions and still have viable offspring. So my question is: if ...
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49 views

Gene frequency — database/site

Is there any free database when one can check the gene frequency in a healthy population? For example I would like to check it for genes like BIN1, CLU or CR1. On the English Wikipedia I found a gene ...
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103 views

How it is possible that blood group shows that a person is not the son or daughter of their parents?

I see a family in which it has only one daughter. The blood group of the mother is AB positive and the father is B positive, but the blood group of the daughter is O negative. When she was young, ...
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Genes related to senses and their variation across animals

Animals often have very different numbers of active genes related to any sense. For instance, most fish or even aquatic mammals have very few olfactory receptor genes, whereas this is higher in ...
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104 views

What is the chance a given gene will end up in a given gamete?

Let us say a germ cell had a desired allele. This germ cell was replicated during interphase so that it had two of the desired allele. It then underwent meiosis. My question then is, what is the ...
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Time taken for species to become endemic [closed]

Is it known how long species take to become endemic? I know from examples such as Canada which have no endemics following the end of glaciation that the process must take at least 10 thousand years, ...
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48 views

Mendelian dominant trait involved with Hypodontia [closed]

If the absence of teeth is a dominant trait, then why is it not seen in generations? My teacher taught that absence of teeth is a mendelian dominant trait, but why don't we see this trait if it is ...
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mRNA Sequencing Basepair from Polyadenylation Site?

I was wondering how many basepairs are usually sequenced with mRNA/cDNA illumina methods from upstream of the polyedenlation site? Thanks.
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What exactly happens during the crossover [closed]

My knowledge of biology is rather limited, but I think I have a grasp of some basic concepts. For me (as a person close to math) a chromosome is a sequence of elements from the set {A,C,T,G} of some (...
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Phylogeny: Hybridization between different species sharing same genus?

I am doing a cross-breeding project with Capsicum chinense x Capsicum baccatum. I'm planning to breed them until 6-8 gen. My question: What will the completed breed be classified as? Would it be a ...
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Why are prokaryotic promoter sequences written 5' to 3', when transcription proceeds from 3' to 5'?

It seems that the promoter regions are written from the 5' to 3' direction. My lecture notes, for example, give the -35 and -10 promoter regions sequences like so: Wikipedia seems to agree, on their ...
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How do gain-of-function alleles help with problems caused by genetic redundancy?

Genetic redundancy masks the gene functions (eg it masks diverse functions of the tumor suppressor gene). I have read on the internet that gain of function alleles can solve a such problem caused by ...
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71 views

How does it make sense to speak of heritability of qualitative traits?

As far as I understand, heritability is defined as "proportion of variation of a phenotypical trait due to genetic variation between individuals in a population". I see the concept is being applied ...
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143 views

law of independent assortment [closed]

Self fetilization of F1 dihybrids, following independent assortment of alleles result in: ...
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275 views

What are the advantages of using interphase cells rather than metaphase cells for gene mapping purposes using FISH?

I have been told that interphase cells are better for gene mapping purposes than metaphase cells but don't know why.
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How can i confirm that the given pedigree chart is of an autosomal dominant trait?

This image is from the NCERT textbook. In diagram A, which represents an autosomal dominant trait, I found out that autosomal recessive inheritance also satisfies the pedigree. Yet, the NCERT text ...
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351 views

Inbreeding vs Mutations

Small populations of organisms may be exposed to the dangers of inbreeding. But if a small population manages to survive for many thousands or millions of years, would mutations eventually diversify ...
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genetic variance

A.Very very few traits have their variance explained only by the genetic variance, B. even fewer are explained only by variance at a single locus and C. yet even fewer have a locus that show a ...
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Autosomal genes expression occurs from both alleles simultaneously

Based on my understanding of Knobil and Neill's Physiology of Reproduction. For the vast majority of autosomal genes, expression occurs from both alleles simultaneously. In mammals, however, a small ...
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Can I use commercial DNA loading dye for my RNA samples without degrading them?

I was wondering if I have to use special RNA loading dye or can I run RNA samples with regular loading dye that is used for DNA?
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Is there any way to tell if a gene is functional for an individual with only a reference sequence and the individual's sequence of the gene?

I have gene sequence of a ton of individuals within a subspecies from cdna and the ncbi IDed sequence as well. Is there any way to tell using just the sequence that the gene for an individual is non-...
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147 views

In what does Genetic clustering and Cline sharpness differ?

They are both ways to measure divergence in species but I'm not understanding in what exactly the differ if both use hybrid zones and gene frequencies in the study.
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402 views

What kind of factors determine how someone looks according to their race or ethnicity?

From what I read, race is considered the biology, the physical traits inherited by ancestry. Ethnicity and nationality have to do with social construct and cultural identity. This is almost the same ...
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543 views

What percentage of twins has the same gender

If 30% of all twins are identical twins, what percentage of twins has the same gender? I thought: all identical twins have the same gender so it’s at least 30%. And of the non-identical twins it’s ...
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4k views

Pedigree Probability, Autosomal Recessive Trait

So, I thought I understood how to calculate the probability for a pedigree, until I came across this answer in my textbook. The question is: what is the probability the offspring of IV1 x IV2 will ...
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Trying to extract DNA with an incomplete kit

I'm wanting to run a DNA extraction on soil and root samples using a 96-well plate kit. My problem is that someone has gone through the kit and taken the Sealing Tape. This tape it used to seal the ...
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78 views

What is the probability that there are no substitution between an ancestor and a modern individual?

What is the probability that there are no differences if you compare the DNA of the ancient sample to a single DNA sequence from a modern individual? Assuming the individual was diploid and lived T ...
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Question about phylogenies and DNA sequencing

I'm reading this web page which talks about phylogenies and DNA sequencing: https://bioinf.comav.upv.es/courses/biotech3/theory/phylogeny.html A certain sentence says, "If we consider dolphins and ...
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Bottleneck effect

Is it true that animals that faced a severe bottleneck will have genetic deficiency for a long time? Does it mean they will all look the same for a long time?
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539 views

What's the difference between germ line and germ cells?

I'm currently reading some introductory chapters about genetics (in Campbell's book, chapter 13) and I realized that I don't really understand what is the difference between the germ line and the germ ...
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I'm trying to unserstand Yamanaka's iPS cells paper

Can someone please explain to me what is the beta-geo cassette and why is it used? I understand that it was inserted in the Fbx15 gene, and this gene is present in ES cells, and I believe this ...
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Are drug-gene interactions predictable? [closed]

I have been reading about drug-gene interactions and pharmacogenetic tests. I haven't been able to find many resources that define the process of testing for possible drug-gene interactions without ...
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8k views

What is a set of chromosome and what is a pair of chromosome [closed]

What is the definition of set of chromosomes? Does it differ from pair of chromosomes?
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40 views

Can we detect the origin of a 1000 year old dead body after grave excavation?

I recently read an article saying DNA analysis has shown some of the people buried in Viking graves in Scandinavia originated from places like Persia and it is talking about something around 1000 ...
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823 views

Genotype result of double fertilization

So, clearly, the endosperm would be a fusion of the polar nuclei and one male gamete. Does this mean that each male gamete would have a T allele on it? I can't seem to figure out a way to predict ...
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122 views

Selective breeding and Mutagenesis

I am writing an argumentative essay in which I claim that GMOs are safe. I know, it is not proved, but for the sake of my course I want to prove it. The counterargument that my professor said to me is ...
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347 views

Dominance and recessive relationship of alleles [closed]

You can find easily in textbooks that definitions for dominant and recessive alleles as follows: Dominant allele: produces working protein and shows its effects in hybrid state. Recessive allele: ...
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69 views

Horse female bias [closed]

I don't know if it's a more general fact, but in most stables I visited, I have observed that there were more mares than stallions or geldings. Typically in a group of ~7 horses I'd notice one or two ...
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99 views

How much of my ancestry comes from each grandparent?

Three of my grandparents were Eastern European, back at least several generations. I recently discovered that I am less than 25% Eastern European, the rest being Western European and other. How likely ...
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57 views

Is it feasible to grow edible crops for lawns?

Is it possible to grow some type of plant that functions well as a lawn (e.g. is somewhat grass like), but that is humanly edible? Would anything that currently exists fit this role? For example ...
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101 views

Genetic Recombination and Mutation

Can genetic recombination yield mutation depending on the new DNA that is incorporated into the genome? I would say yes because when something foreign comes in, the genome is bound to not function ...
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721 views

Calculating chromosome number in meiosis: Why is the crossbreed between a fox and a dog (dox) sterile?

Given the following example/question (originally found here): I worked out the haploid number of the dox to be 29 and the diploid number of the dox to be 58. 58 is an even number, so surely 29 ...
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258 views

DNA centrifugation in water

If I have bacteria diluted in water and I centrifuge at max speed for 15-30 min, it is possible that I break the walls so the DNA can scape and I do not get any DNA pellet? or should I get it as a ...
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Do I need primers if ordering from a DNA synthesis provider

Do I need to design / synthesize primers for PCR if I am ordering from a DNA synthesis company and they are providing free cloning into my preferred vector backbone? Any good reason to order primers ...

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