Questions tagged [genetics]

Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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64 views

Are there traits exhibiting avoidance of the mean?

Sometimes if two organisms with an unusually large value of a continuous trait mate their offspring on average will not have a value as large as one might naively expect. Regression toward the mean is ...
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How strong can GC skew be?

How strong can GC skew be (in the positive or the negative direction)? What species is the current record holder?
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Can the effect of an allele on height be context-dependent?

Some data is available on the effect alleles have on height. For example Common DNA Variants Accurately Rank an Individual of Extreme Height However after browsing the literature I was not able to ...
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Relative abundance and action of 5p and 3p microRNAs

I am a beginner in genetic research and am currently conducting a project concerning microRNAs. Let's say we have miR-1-5p. If miR-1-5p is upregulated in a disease, will miR-1-3p always be ...
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Why do chromosome pairs have different shapes and sizes?

When I look at microscopic images of human chromosome pairs I see that they have different shapes and sizes. Is there a deeper biological reason for that? Is there some evolutionary pressure for them ...
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How do we know genes that are considered endogenous retroviruses are actually endogenous retroviruses and not just ordinary genes?

What makes these genes different as to be classed as an endogenous retrovirus? I've read the entirity of Wikipedia on retroviruses and didn't find the answer. I think it could be that these genes are ...
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Guide RNAs and SNPs for nanopore enrichment

In which part of the gRNA sequence is it most important to not get SNPs? I know the PAM site cannot have any SNPs but what about other ones? And secondly, are there any positions in the gRNA sequence ...
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How can we know which alleles are together on a chromosome?

This illustration says that if the two homozygotes pr+ pr+ vg+ vg+ and pr pr vg vg are crossed to produce a heterozygous offspring (pr+ pr vg+ vg), then: this cross gives us exactly what we need to ...
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What is the probability of having a son with blood type O? [closed]

So I was solving some biology questions, and this question left me confused. The response is supposed to be 22% according to the answers, but all the methods that I used did not lead me to it. I ...
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Can a strand not be synthesised in 5' -> 3' direction?

I've been solving some biology questions, and according to one of them ( I have the responses too) the following phrase is false: "Both strands are always synthesised in the 5' to 3' direction.&...
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Why is Somatic Cell Nuclear Transfer (SCNT) less effective for interspecies?

Somatic Cell Nuclear Transfer (SCNT), a process for replacing the nucleus of an egg cell with a nucleus containing genetic information of a different animal, seems to be very useful for cloning and ...
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Direction of translation/transcription

Perhaps it would not be wrong to say that "translation/transcription goes in the direction of 3' to 5'" or "in the direction of 5' to 3'";that's because these statements are ...
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Is there "stem" organelles in plant meristems?

Two cytoplasmic genomes exist in plant in addition to the nuclear one. As far as I understand, they divide more or less during the entire life of the plant along with cell proliferation/growth in ...
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Does parental conflict lead to genes combining important functions with functions only advantageous for one of the parents?

In a sitation of a mother-father conflict of interests, the mother might use epigenetics to turn off some genes only advantageous for the father's genes and not her own. I thought a logical father's ...
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How come the role of the Apis mellifera is determined by nutrition rather than chromosomes?

Prior to making my question I browsed on similiar question such as this one but it doesn't specifically addressed my doubt in the sense that it is related with a different species and on a concept not ...
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What are the effect of radioactivity on grey wolves in Chernobyl?

I am doing some research about the effects that radioactivity has and is having on grey wolves in Chernobyl and more particularly on their genetics, but maybe also looking at the populations in the ...
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3 primers to know if Homozygous, Heterozygous or WT

In this imaginary experiment, I am using T-DNA to make an insertional mutagenesis that will get randomly inserted into the DNA where it might get inserted within a gene, disrupting it. In order to get ...
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Questions regarding transformation in bacterial cells

First off, in transformation the donor DNA aligns itself with the complementary bases in the recipient DNA. Now a "perfect" alignment of the donor DNA ( Sorry if my terminologies are ...
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Inheritance of FEVR (Genetic Disease)

If a woman has FEVR and is affected by the disease, what are the chances of her passing the disease to future generations. I read somewhere from a credible source like NIH(I couldn't find the link ...
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what kind of dinucleotides can be considered important from a mutational point of view other than CpG islands?

CpG islands are regions with an high frequency of CpG (Cytosine-phosphate-Guanine) sites. The usual formal definition is that of a region with at least 200 bp, a GC percentage greater than 50% and an ...
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What degree of influence do SNPs have on activity of ligands at receptors?

I know that generally, evolution tends to evolve towards having some wiggle room in respect to effect of polymorphisms on binding of endogenous ligands, but with synthetic ligands, especially modern ...
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Determine similarity in percentages between species A and B, A and C, and B and C

The chart above is a graphic that shows the amino acid sequence differences between different organisms for a protein keratin. The question I am required to answer begins as, "Keratin is made up ...
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Estimate mutation rate in UVC treated cells

I am wondering how to get a coarse estimate of the number of mutation I obtain doing UVC treatment on eukaryotic cells (microalgae) starting from information such as the survival rate, genome size, ...
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Microarray experiment validation meaning

I have a quick question: what does microarray experiment validation mean ? I was reading a paper in which they say that the data of the experiment show that the 3 genes radB, dp1 and dp2 are co-...
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Empirical Measurements of Barr Body Ratio

'Both X-chromosomes in a female have an equal chance of becomes a Barr body in each cell.' Every source I can find on Barr bodies claims this and I can think of no reason for why it may be wrong. What ...
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The Proofreading Function of Coronavirus Polymerases

I have heard that the Coronavirus family have a proofreading and editing function in their polymerase enzymes which can recognize and excise mutations. This is obviously disastrous for the population ...
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How to build SEG in your personal environment?

I'm trying to implement SEG (Wootton & Federhen,1993) in my MATLAB and Python environment. From this oriinal article I cannot figure out what I need to build my script. Are there any related ...
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Why is the 5′ end of DNA a monophosphate?

According to my textbook: While the 5′ end of a DNA strand is typically a monophosphate, the 5′ end of an RNA molecule is typically a triphosphate. Source: Biology: How Life Works, 3rd Edition How ...
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Pre-Mendelian genetics

In the 18th century, Joseph Gottlieb Kölreuter concluded from his plant experiments that in some hybrid generations the characteristics of grandmother generation, grandfather species and F1 generation ...
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my way of solving the biology question

Pure-breeding tall and pure-breeding short pea plants in the P generation were crossed as shown below. Based on the diagram below, one can assume that a)short plant height is the dominant trait. b)...
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About genomic imprinting

In the context of genomic imprinting, how does a human cell "know" whether a chromosome is paternal or maternal(out of a homologous pair), in order to silence genes?
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Modeling the production of mRNA

I have the following example of how an equation for the production of mRNA in a particular organism could look like: Consider the following equation for the production of mRNA for a gene Y. Gene Y ...
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Research on chicken that cannot feel pain

In was having a conversation about the ethics of vegetarianism, and if it is right to cause pain to other animals. It is then that I stumbled upon the question, that if, just the way chicken and many ...
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Will a less favorable allele's frequency go to 0?

For example, a pond is dark in color. There are two alleles. The dark color allele is dominant over the light color one. Let's assume that the relative fitness of both the homozygous dominant and ...
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What is the probability that a gamete will only contain father's chromosomes

As it is depicted in most textbooks, cross-over does not occur between the two "outer" sister chromatids. By independent assortment during Meiosis I, there is 1/2^23 chance that all father's ...
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Could Cyanobacteria farms help dilute pollutants in the atmosphere

If I understand correctly, roughly ~2.8 billion years ago cyanobacteria started pumping large amounts of oxygen into the atmosphere. Using modern industrial processes could this be emulated by ...
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Can men with Klinefelter syndrome produce chromosomally normal sperm?

Individuals with Klinefelter syndrome are XXY. Even though sperm counts are low some individuals can generate enough to be used in IVF and have offspring. Does this mean that when sperm are formed, ...
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Why do individuals vary in the number of SNPs for a given gene ( e.g. FOXO3A )?

Individual #1, sequenced by 23andMe and then inputed into Promethease for SNP data has the following SNP output: 1) rs1935949(C;T) 2) rs2802292(G;T) 3) rs13217795(C;T) 4) rs13220810(C;T) 5) rs2764264(...
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Genes where both a disabling mutation and copy number amplification cause different genetic diseases

I'm trying to make a list of such genes, because they must be tightly regulated. MeCP2 is one - it causes Rett Syndrome with a disabling mutation, but causes MeCP2 duplication syndrome if its copy ...
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Which sample type is more proper for whole genome sequencing in AML patients? Peripheral blood or bone marrow?

I intend to perform whole genome sequencing in AML patients in order to find genomic abnormalities, particularly translocation and gene fusions. However, I am not sure whether it is better to obtain ...
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Analysis of post transplantation lineage tags

I'm having some trouble understanding some bits of a study, mostly about the Sleeping Beauty system and TARIS model, from this paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408613/ I ...
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Study on Introns?

I am curious whether there has been a study done on the effects of removing introns. Specifically, what happens if you genetically edit a eukaryote genome to no longer contain introns? Or maybe just a ...
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Brain evolution in the age of the caesarian

I have just been reading an account of the evolution of human intelligence in Matthew Syed’s recent book on diversity, called “Rebel Minds”. He is not the originator of this idea, but he suggests ...
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How much DNA (or genes) do homo-sapiens and ursus arctos (brown bear) share?

How much DNA (or genes) do homo-sapiens and ursus arctos (brown bear) share? There are articles online that indicate that humans share xxx% of DNA with Chimpanzees, bananas, and other assorted ...
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Is there any evidence that genes which are associated with physically adjacent structures are located near each other within the genome?

I am not sure if there are individual genes for, say, fingers and if so, would such genes be near the genes that affect hand growth? If not "near" in the Euclidean sense, could there be a different ...
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What causes cellular differentiation?

Each cell in our body contains identical dna. And, yet some cells become liver cells, some become brain cells etc. How this happens , when all of them has same dna? Is it because of epigenetic control ...
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Easy Hardy Weinberg Equilibrium [duplicate]

Hi My friend and I get 2 different answers to this question. I would like to know how to calculate the value of q. My friend says that 500/1500=q because there are 500 recessive alleles in the ...
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Number of DNA strands per chromosome

As I was reading Griffith's Introduction to genetic analysis this evidence was provided for single DNA makes single chromosome. Eventually geneticists demonstrated directly that certain chromosomes ...
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Why can't a genetically sound human stay alive for an indefinite amount of time given all the ideal conditions? [duplicate]

I have read that even if we can control our food and lifestyle and keep things as ideal as possible, there are other factors beyond our control like effects from neutrinos passing through our body ...
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What's the difference between reaction norms and phenotypic plasticity?

I'm trying to understand better these two concepts, but I cannot see a clear difference yet. Reaction norm: "set of phenotypes that can be produced by an individual genotype when exposed to different ...

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