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The study of blood, the blood-forming organs, along with blood diseases and their treatment.

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How does vasodilation slow blood flow?

During inflammation, cytokines and histamine cause vasodilation to increase blood flow to the inflamed area. However, it is also said that vasodilation slows blood flow which facilitates the adhesion ...
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37 views

Realistic Application of CRISPR in Human Disorders

Human trials recently began to use the genome editing technology CRISPR to treat sickle cell anemia using edited stem cells. Sickle cell anemia is caused by a single DNA Mutation, and is also a ...
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3answers
8k views

Can a cancerous cell from outside cause cancer in a healthy person?

If a cancerous cell enters the body of a healthy person from someone else's blood or something, will that healthy person get cancer? In human beings.
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1answer
16 views

Why is there low hepcidin levels in hemochromatosis?

If hemochromatosis is iron overload and there is excess iron in the blood, why does the liver reduce hepcidin secretion (which increases the iron uptake) furthering the worsening of hemochromatosis?
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19 views

What's the difference between a lymphocyte and a plasma cell?

According to my understanding, lymphocytes is the broad terminology for both T lymphocytes as well as B lymphocytes, while plasma cells refers to mature B cells which produce antibodies. But then why ...
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2answers
27 views

Why is beta thalassemia major not lethal while alpha thalassemia with loss of all 4 genes lethal?

So why is beta thalassemia major with two B0 alleles not fatal in utero (despite the hemoglobin not having any B chains), while alpha thalassemia with deletion of all 4 genes encoding for the alpha ...
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0answers
9 views

What's the difference between beta thalassemia minor and beta thalassemia intermediate?

I mean beta thalassemia minor is caused by inserting one abnormal allele while beta thalassemia intermediate is when the person has at least one B+ allele. Is beta thalassemia intermedia a type of ...
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0answers
16 views

Why do I feel nauseous at the sight of blood, despite not being afraid of it?

Every time I ask google this question, all it spits at me is info on blood phobias ^-^; basically, I've always been hugely interested in morbid stuff, but I noticed that I always feel sick when ...
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1answer
112 views

How does a glucose molecule enter the cell from blood vessel?

The transporters in the plasma membrane of the cells promote the entry of glucose molecules from the extracellular matrix to the cytosol of the cell. Could someone explain how does the nutrient ...
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18 views

why is erythrocyte sedimentation rate higher in females?

erythocyte sedimentation rate should be independent of the sex. what is the reason behind this sex bias and why does it increase during pregnancy and how does age influence it.
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25 views

Long-term Vs Short-term hematopoietic stem cells

What is the conceptual difference between Long-term Hematopoietic stem cells (LT-HSCs) and Short-term (ST-HSCs)? Over the web I got into different definitions...does someone know the more accepted one?...
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21 views

How long does it take fluids to make their way into blood vessels, to dilute blood volume to full after major blood loss?

So if one has a significant haemorrhage, how long will it take say for blood test results (hemoglobin and iron etc concentrations) to be impacted to full extent?. I've heard it takes multiple hours, ...
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2answers
72 views

Is too much CO2 in the air toxic?

I know that if there is too much CO2 in the air we will have too much greenhouse effect. I would like to know if there is too much CO2 in the room, something like 3% while there is also more that ...
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1answer
38 views

Why should collected blood from patients be analyzed as soon as possible?

I'm looking for the possible factors influencing blood samples. What happens to the blood cells esp. WBCs/PBMCs after 8 hours of blood draw? For example, I know that granulocytes may cause oxidative ...
3
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1answer
44 views

What would the RBCs of someone heterozygous for sickle cell anemia look like?

Would half of the RBCs look normal, and the other half sickled? Or would all of the RBCs have slight deformation/sickling? Thanks!
3
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1answer
69 views

Is there a specific suffix for “with in a cell”? i.e. in a similar manner to how -aemia refers to within the blood

Words like hyperglycemia, hyponatremia, refer to the relative level of that component in the blood, not in the cell, is there a specific suffix for within the cell? I would like one word as an ...
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1answer
87 views

Why does applying pressure to a venipuncture site prevent haematoma?

From what understand, when drawing blood, a phlebotomist puts pressure on the venipuncture site while withdrawing the needle to prevent a haematoma. I'd like clarification; How does this prevent a ...
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1answer
37 views

Turbulence in blood

Turbulence in blood flow is known to indicate diseased or obstructed arteries. Techniques to measure turbulence in blood flow are mostly based on turbulence kinetic energy measurments using MRI [e.g., ...
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52 views

Is it okay to donate blood after doing miRNA extractions?

I am planning to do miRNA extraction from the blood serum using Qiagen miRNeasy Serum/Plasma kit. As I am frequently participating in the whole blood donation (not for experiment; the process ...
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0answers
100 views

Found in blood sample - what is it? Hopefully not a nemotode-

After examining someone's blood - through microscope - I found these. There were some more that were not photographed. Could someone please inform me on what these are? Maybe abiotic material on the ...
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0answers
15 views

In Vivo and In Vitro Assays for Determining Self-Renewal Capabilities of of HSC and Progenitor Cells?

I am interested in understanding how we can determine the self-renewal capabilities of different cells on the hematopoietic hierarchy. For example, lets say I have a purified subset of MPP cells. How ...
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0answers
28 views

How does blood react to heat when inside the body

I was wondering: What are the possible dangers of being burned on the surface of the skin. Does it congeal (that's what my intuition tells me)? At which temperature would that happen? How heat-...
3
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1answer
37 views

How do drugs tests check so many substances?

There are about 170 drugs banned for sports and many other drugs that can be used in crimes. How can blood tests practically detect so many different substances? Do they divide the sample into 170 ...
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0answers
71 views

Location of ABO and Rh antigens

I read somewhere that in addition to red blood cells (RBCs), ABO antigens can be found in the other body tissues of the human. But Rh antigens located just on RBCs, in the other words, Rh polypeptides ...
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2answers
826 views

Why isn’t Haemoglobin a plasma protein, rather than being encompassed by the erythrocyte?

Erythrocytes (red blood cells) are a common feature of almost all vertebrates. What evolutionary advantage do they provide in containing haemoglobin, rather than it being just a plasma protein? In ...
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1answer
19 views

Mice that have been reconstituted with geneX-transduced cells

I read this article in the following: ... Mice that have been reconstituted with geneX-transduced cells Now, someone who is not familiar with animal sciences, what does this exactly mean? ...
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2answers
527 views

Why does Anti-A antibodies make type-A blood type clump?

A-type blood has B-antibodies; it also clumps anti-A antibodies are inserted. Why is that? The blood has no antibodies against the A-antibodies to make clump in this way.
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1answer
100 views

How might IV-saline cause kidney damage that seems to be less likely with “balanced fluids” IVs instead?

The ABC News article What's in the IV bag? Studies show safer option than saline includes: Saline — salt dissolved in water — has been the most widely used fluid in the U.S. for more than a century ...
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1answer
84 views

If women need more dietary iron than men, then do blood donors also?

My understanding that women's dietary iron requirements are slightly higher because I've heard the only way of losing iron from your body is by losing blood, and this happens in menstruation. This got ...
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0answers
12 views

What are these flower like cells in the photo attached?

I am a student of BSc. Zoology... I was doing a TC of RBC of my blood when I encountered these strange flower like cells. Are they lysed RBCs ? If so, why are they so geometric in shape ?
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193 views

Is carbon dioxide dissolved in plasma same as carbonic acid?

Carbon dioxide is transported through blood via 3 methods : 1. Dissolved in plasma 2. As bicarbonate ion 3.through RBCs. The carbondioxide when transported as bicarbonate ion i.e HCO3- and H+. What ...
2
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1answer
496 views

Sickle cell life span

How long do sickle red blood cells "live" before being broken down in phagocytosis? I had trouble doing a normal search as it brings up life span of those inflicted with the disease. Also, I have ...
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0answers
18 views

Do Marsupials have a standard classification system for their blood groups?

I've seen a limited amount of animal blood groups listed...like dogs, cats, horses, etc. But what blood types do marsupials have? To clarify, what I want to know is if the species has a ...
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1answer
165 views

Why is blood collected at crime scenes? [closed]

I have read that mature red blood cells (MRBs)do not have DNA. So I am curious why crime scene technicians collect blood. Is it to collect and amplify segments of white blood cells?
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57 views

Why does deep venous thrombosis occurs mostly in lower limbs?

Why does deep vein thrombosis occur mainly in the lower limbs? And why even in the deep veins? Thrombus can occur anywhere (i.e., they may be in superficial veins) then why is the name deep vein ...
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0answers
40 views

What happens to neutrophils in whole blood stored for transfusion?

The lifetime of neutrophils is normally quite short, 3-5 days in vivo (link). On the other hand, whole blood can be stored for a fairly long time, up to 35 days (link). What happens to neutrophils ...
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1answer
224 views

Veins collapse when empty

Veins collapse when empty. That's because they have thin and almost inelastic walls. What has inelasticity and thinness of the walls to do with the collapsing of the veins?
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1answer
2k views

Does donating blood lower testosterone levels? [closed]

I'm a guy and I decided to donate blood because of persuasion. My testicles feel weak afterwards specifically. I mean they feel like they're compensating -- assuming that makes sense. Is this because ...
2
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1answer
120 views

What are null cells?

My histology textbook says the following: The pluripotential hemopoietic stemm cell (which resembles a lymphocyte) is a member of the null cell population of lymphocytes. It then goes on to add: ...
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0answers
143 views

Why do erythrocytes have no MHC1 but platelets do?

Red blood cells do not have a considerable number of MHC1 through their membranes, and that's explained by them not having a nucleus. But why do platelets have MHC1s if they have no nucleus either? I ...
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1answer
55 views

Blood Group Notation

In a textbook, I encountered a notation used when writing blood groups down, which was "I" with the blood group type as a superscript. I was curious as to why the letter "I" is used in this notation ...
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0answers
2k views

Why women have high Erythrocyte sedimentation rate? [closed]

Why ESR (Erythrocyte sedimentation rate) 1. higher in women 2. increases with age 3. increases in pregnancy, infection, malignancies what I thought so far : since women are menstruating so there ...
0
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1answer
97 views

Meaning of red blood cell volume expansion

In the scientific papers about EPO I read RBC volume (mL) expansion. What is it? The volume of a single cell or the volume expansion (=that is the increase of the number of cells) caused by the EPO? ...
7
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2answers
3k views

Is there a purpose for nucleated red blood cells in reptile, avian and fish blood?

I have read, and read, and read documents on this subject but still have no conclusions. Everything I have read explains why mammals don't have a nucleus (to make more room for the haemoglobin and ...
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0answers
25 views

What's the difference in roles of GATA-2 and BMI-1 in guiding Hematopietic cells?

I've discovered that hematopoietic cells become lineage-positive (Lin+) and go down the path of becoming lymphoblasts and myeloblasts, and that both BMI-1 and GATA-2 are transcription factors that ...
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2answers
359 views

Where does the extra blood in arterial circulation when exercising come from? [closed]

When exercising more blood is in our arterial circulation. Where did this blood come from and how did it get there ?
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1answer
309 views

Why is the pressure pulse bigger after exercise?

Right after exercise, is the amplitude of the pulse smaller or bigger than resting period? And why is that ?
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2answers
610 views

what is the word origin of myelo- as in myelofibrosis or myeloma?

what is the word origin of myelo- as in myelofibrosis or myeloma? I know that these are plasma cancers originating in the bone marrow.
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1answer
207 views

What is “multiple” myeloma?

Multiple myeloma, commonly referred to as myeloma, is a cancer of the plasma cells found in the bone marrow.(source) Is there any significance in calling myeloma as "MULTIPLE" myeloma?
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2answers
355 views

What's the smallest animal with hemoglobin running in its veins?

What's the smallest known animal with hemoglobin running in its veins? Here I mean an animal that on its own is able to produce the hemoglobin that is running in its veins. For that reason this ...