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Questions tagged [hematology]

The study of blood, the blood-forming organs, along with blood diseases and their treatment.

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Free diving physiological changes

When training for free diving, there are several physiological and psychological changes that enable this activity, however one of the changes that I do not understand is increased resistance to blood ...
Evamentality's user avatar
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Other than the major histocompatibility complexes, what is the difference between professional and non-professional antigen presenting cells?

Can both professional and nonprofessional APCs activate helper T-cells? Or is that only macrophages and B-cells? Do cytotoxic T-cells only make non-professional APCs go into apoptosis?
kuns 's user avatar
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1 answer
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Why is mean systemic filling pressure used to calculate pressure differential for venous return?

I'm really struggling to understand venous return curves and their relationship to mean systemic filling pressure. I understand mean systemic pressure is the pressure that would be measured throughout ...
Haeler's user avatar
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Covalent modification of Pyruvate Kinase in RBCs

Human body has 4 isozymes of PK and I am particularly interested in the RBC isozyme. It is capable of being covalently modified through phosphorylation catalysed by Protein Kinase A which is in turn ...
Vibhav Agarwal's user avatar
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Can we improve the hemocompatibility of VAD by growing a single layer of endothelial cells on the surface?

Maglev centrifugal pumps have been used in the latest ventricular assist devices (VAD) and several experimental total artificial hearts (TAH). Compared to previous generation pumps, maglev pumps don’t ...
哲煜黄's user avatar
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2 votes
2 answers
183 views

Do afterload and stroke volume form part of a negative feedback loop in blood pressure regulation?

Blood pressure is the product of cardiac output and total peripheral resistance: $\text{BP} = \text{CO} \times \text{TPR}$ Since cardiac output is the product of heart rate and stroke volume, we have: ...
Quin's user avatar
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1 vote
0 answers
66 views

Iron absorption and oxidative stress

Fe2+ is more bioavailable than Fe3+, so it's absorbed more quickly. I read that, for this reason, Fe2+ doesn't give enough time to the organism to bind it to a protein then it stays longer in a ...
Helix's user avatar
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Is there any bloodstream chemical composition software simulator?

Let's say I'd like to know how certain substance affects bloodstream levels of certain drug during a period of time. Is there any simulation software available publicly to run such kind of simulation?
Ya Y's user avatar
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1 answer
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What are the priorities of blood group that a person with AB group can recieve?

Suppose a person has a blood group of AB. I read somewhere that it is best to transfuse blood of type AB into that person, as opposed to groups A, B, or O. If AB is not available, however, it might be ...
Harshit Raj's user avatar
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2k views

Converting microequivalents per liter to mg for sodium?

I read that a normal blood sodium level is between 135 and 145 milliequivalents per liter (mEq/L). Hyponatremia occurs when the sodium in your blood falls below 135 mEq/L. How do I convert mEq/L to a ...
Nick's user avatar
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4 votes
1 answer
406 views

Why does the luminal test need hydrogen peroxide?

In the chemiluminescent reaction of Luminol in an aqueous solution, the luminol needs to react with molecular oxygen to produce a photon of blue light. In the technique, the hemoglobin of blood ...
Evamentality's user avatar
4 votes
1 answer
84 views

How to reduce PPi concentration in blood samples by PPase

I have some samples of whole blood that are a little bit expensive and I want to significantly reduce the concentration of PPi in the samples by causing a reaction. I don't have any experience in ...
Mikkel Rev's user avatar
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39 views

Anticoagulation of black beans extract

How many ml of lithium heparin do I need to use on 2 ml blood to prevent coagulation for over 15 minutes? I am comparing it to the 4 different dosages of black turtle bean extract that has polyphenols ...
Tenshi's user avatar
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80 views

Does your blood stop moving in between heart beats?

Does blood stop moving in between heart beats or does it move continuously?
Akshay Chugh's user avatar
0 votes
2 answers
323 views

How many cells does a single blood cell generally visit in its lifespan?

Taking the point of view of a single RBC travelling through blood vessels, approximately how many cells will it affect throughout its lifetime? As blood tends to provide O2 as a whole, I am taking &...
Imran Q's user avatar
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How do the anti-D antibodies help prevent Hemolytic Disease of the Newborn? And why do they not act like the maternal antibodies?

I understand that this question has been asked a few times in the past, but the answers there didn't really explain to me why the Anti-D antibodies we introduce are able to prevent the hemolysis of ...
anon's user avatar
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-4 votes
1 answer
371 views

What exactly does my body do with oxygen? Why do I need it? [closed]

I know that my body and brain need oxygen in order to survive. If I stop breathing, my lungs (and blood) can't distribute oxygen to my body anymore, and I could get brain damage and die. What exactly ...
deserdoo's user avatar
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1 answer
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Is Haemoglobin a positively charged Sol?

My book NCERT(Class 12, Surface chemistry) claims that hemoglobin is a positively charged sol. The cytosolic pH in human cells is around 7.4, but fluctuates through the cell cycle according to this ...
Samardeep singh's user avatar
1 vote
1 answer
62 views

Why are basophils and eosinophils considered granulocytes?

I have read that granulocytes are a type of leukocytes that have granules (hence the name) visible by microscopy. But then there is something called a granulocyte/monocyte progenitor cell, which I ...
Ibby's user avatar
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469 views

Why is heparin contraindicated in patients with severe uncontrolled hypertension?

Heparin is a parenteral anti coagulant- prevents clot formation by inhibiting factors 2 a and 10 a mainly. Now, patients with severe uncontrolled hypertension- have persistent bp of more than 140/90. ...
Kavya Chandrasekaran's user avatar
2 votes
0 answers
49 views

Vitamin B12 deficiency Megaloblastic anemic

I have two doubts regarding Megaloblastic anemia which shakes my mind (1) first is- I know that vitamin B12 is required for thymidine synthesis which is further required for DNA synthesis and so if ...
Rahul Dhillon's user avatar
2 votes
0 answers
42 views

How does the negative charge on endothelium prevent blood coagulation?

I was reading about the factors that keep the blood inside the body in fluid state and came across a line in my book which states that, "Smoothness of the endothelium, its negative charge and its ...
Mrinal Gautam's user avatar
0 votes
1 answer
466 views

What is the time frame for coagulation of blood cells & the resulting separation of the cells and platelets from the plasma in a dead body?

I have had this subject come up repeatedly in the context of a discussion about death and how it affects the body. I found this statement, which is typical of the common understanding among non-...
RevRunD's user avatar
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1 vote
1 answer
178 views

Why is only the donor's antigen seen during a blood transfusion?

I am a high school student and I am a little confused that why only donor's antigen matters during blood transfusion? for e.g if the donor's blood is O- so it means that it will antibodies against all ...
Arun Bhardwaj's user avatar
1 vote
0 answers
156 views

What is the water content of avian blood?

I'm doing a work about heavy metal contamination in seabirds. I have found that the toxic threshold for Cu in blood is 1,15 μg/g wet weight. That number refers to an average between some seabirds. I ...
Ifer's user avatar
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1 vote
0 answers
38 views

What is the relationship between the oxygen affinity of hemoglobin and the maximal oxygen uptake (VO₂ max) of the human body?

I was curious about whether any of the numerous documented human hemoglobin variants conferred a quantifiable athletic advantage but the only thing I've found of any relevance is the relative oxygen ...
小奥利奥's user avatar
1 vote
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48 views

Why don’t bone marrow donations harm the donor in the long term?

I have googled about this, and the most I can really find is that donating bone marrow/blood stem cells is not harmful in the long run, but I want to know why and how much is really known about this. ...
asterac's user avatar
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1 vote
1 answer
66 views

Why are cells in blood smears undetectable after absorbing moisture?

I'm a student learning how to prepare blood films and today I was curious about something, so I performed an experiment. After preparing a thin blood smear and drying it (no staining), I took a look ...
RedDynamite's user avatar
5 votes
0 answers
145 views

What are these structures in blood from a nosebleed?

I decided to look at some blood from a nosebleed (not mine) under the microscope and took some pictures of the results. There many large orange structures interspersed within the blood cells and I'm ...
VatsofGoo's user avatar
-4 votes
1 answer
143 views

Can a person survive without platlets in the bloodstream? [closed]

Can a person survive without platlets or thrombocytes in the bloodstream, if I guarentee that the person is isolated and won't injure? Any help will be appreciated. Thank you!
Abhigyan Kumar's user avatar
-1 votes
1 answer
65 views

Does alcohol really helps to get substances get faster into the bloodstream? [closed]

I saw the video where Arnold Schwarzenegger cooks some protein cocktail and adds Austrian Schnapps to the mix, saying that it's to make everything get faster to the blood. Is it true or some kind of a ...
R S's user avatar
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-4 votes
1 answer
54 views

is blood anaerobic? [closed]

I was wondering if anyone knows whether there is free molecular oxygen in the blood? My reasoning would be that oxygen is too reactive to be left alone in the blood, that's why it is transported in a ...
raygozag's user avatar
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-5 votes
1 answer
57 views

Uranium based blood [closed]

Here's a hypothetical planet with complex, sapient life and a very weak magnetic field. Could they have Uranium-based blood, much as our blood is based on iron and crab's is based on copper? ...
Robert Goddard-Wright's user avatar
3 votes
1 answer
157 views

How long does foreign DNA stay intact in human blood?

How aggressively is foreign DNA in blood targeted and degraded by the human body? I am asking because we have a metagenomics project where we want to detect parasite DNA in the human blood. The ...
Michael's user avatar
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2 votes
1 answer
38 views

How good are the hematologic parameters (e,g, IL6 or others) in predicting which patients will develop a severe COVID-19 disease?

Clinical implications of the hematologic profile of COVID-19 patients including cytokine storm, coagulation profile and thrombophilic complications are starting to be recognized. Hypercoagulability ...
Octo's user avatar
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1 vote
0 answers
54 views

How do injected purified anti-D antibodies prevent the natural production of antibodies in order to prevent Hemolytic Disease of the Newborn?

Treatments involving Anti-D antibodies are given to pregnant women carrying Rh+ fetuses when the mother has an Rh- blood type in order to prevent Hemolytic Disease of the Newborn during the 2nd ...
JulianS's user avatar
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2 votes
0 answers
25 views

Blood serum transfusions - could vaccines against the anti-A/anti-B etc. antibodies be derived, at least in theory?

People with the AB-positive blood type have all three of the A, B and RhD antigens present on their red blood cells, and no antibodies to these in their blood serum (aka blood plasma.) This means that ...
Astrid_Redfern's user avatar
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0 answers
33 views

What is the mechanism of aspirin as an anticoagulant? [duplicate]

I understand that aspirin prevents blood clots from forming by interfering with the clotting action. I want to know at which stage aspirin interferes with clot forming and what really happens in the ...
Roshelle Perera's user avatar
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0 answers
47 views

CML (Chronic Myeloid Leukemia) and blast cell percentage

I'm trying to understand the oncogenesis of CML. I have a question about CFC cells and blast cells. Are those the same? I know that in the chronic phase of CML there is a blast percentage of 1-10% of ...
Mario Pérez's user avatar
2 votes
0 answers
37 views

If you add type A blood to type B blood, is there a visible reaction?

I read that the original discovery of blood types was because they combined random blood samples togethers and noticed a reaction. I was wondering if this was a visible reaction? Or is anti-A or anti-...
olnog's user avatar
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1 vote
1 answer
17k views

Why is the blood thick in Wet Cupping / Hijama

I have just witnessed the wet cupping procedure being performed and have questions regarding the blood that is seen in the cups. I understand there are no studies that show cupping is an effective ...
James's user avatar
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2 votes
0 answers
69 views

How many hematopeietic stem cells (in percentage) does the bone marrow contains?

I've found out that the body marrow of an adult weights about 5% of it's total weight. How much (%) of the bone marrow consists of hematopeietic stem cells and how much consists of other non-...
NumLock's user avatar
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0 votes
0 answers
278 views

How far up a limb can a severed artery retract?

This is about the application of tourniquets. I was taught a hand width above wound, but recently I read severd arteries can in some cases retract higher than that which would then bleed into the arm. ...
Maritn Ge's user avatar
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1 vote
2 answers
848 views

What is the mass of a single erythrocyte?

I really have been searching through internet on different languages, but can’t find any article that answers on the question what is the single erythrocyte mass. I don’t know, I think it’s pretty ...
bcubeu26dncs's user avatar
3 votes
0 answers
652 views

What is blood pH for different animals?

So we all know that humans average blood pH is 7.4. But is it the same for the animals? I need examples of animals with the same blood pH as humans and the ones with different blood pH. I guess dogs ...
Jane's user avatar
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1 vote
1 answer
40 views

How does the choice of blood draw site influence the possible specificity of a serological test?

The news has reported that a new serological test for the presence of anti-SARS-CoV-2 antibodies has received an emergency use authorization from the FDA, and notably has a higher specificity than ...
nanofarad's user avatar
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1 vote
0 answers
51 views

Edema and hydrostatic pressure

I'm currently studying Robbins basic pathology, and I'm confused about a specific statement: It states in the book that when hydrostatic pressure is low due to a lack of albumin synthesis, it leads ...
Kudo Anastasia's user avatar
1 vote
1 answer
158 views

What causes the localization of myoglobin in turkey to regions of muscle tissue?

I've read that myoglobin localization is responsible for the darker colour of leg muscles in turkeys. Why does this localization occur in terms of any of cell biology, molecular biology, or ...
Galen's user avatar
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1 vote
2 answers
61 views

Can erythrocytes Function without plasma?

my title is not very specific. So i will proceed to clarify it. I am trying to make sure that the only blood cells in a sample are Erytocytes, since i want to evaluate their metabolism, I am aware ...
RockishWood's user avatar
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0 answers
39 views

Is there any situation where bloodletting should be paired with transfusion?

Clearly, bloodletting only has benefits in a couple of rare instances —— for example promoting blood flow into reattached tissues1. But could it (or, should it) realistically be used along with ...
Galaxy's user avatar
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