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Questions tagged [histamine]

Histamine is a neurotransmitter that plays a key role in allergenic responses, sleep, alertness, cognition and gastric acid synthesis and secretion. It binds primarily to the four types of histamine receptors, H1 (responsible for alertness, cognition, allergenic responses), H2 (responsible for gastric acid synthesis and excretion), H3 (which serves as the histamine autoreceptor) and H4 which seems to play a role in immune function.

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Why does histamine cause bronchoconstriction?

What purpose does histamine-caused constriction serve in lungs during allergies and such, since it's vasodilator in other parts of body. Wouldn't it be more practical to vasodilate lungs so that white ...
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Why don't allergies cause fever?

Allergy To my understanding, an allergy is a hypersensitivity of the immune system causing a substance in the environment to be identified as pathogenic by the immune system while it is not ...
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Long-term effects of antihistamines on mind and CNS [closed]

Can maybe someone share knowledge or guesses on the following questions: Does the prolonged use of antihistamines cause long-term effects on mind or CNS? Are there any known evidences of their ...
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What are mast cell membranes made out of?

What are mast cell membranes made out of? What would weaken or strengthen them? Web searches bring up a lot of information about mast cells but very little on the membrane. And the Wikipedia page ...
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What's the Mechanism of Paradoxical Excitatory Effects with Sedating Antihistamines? [closed]

I've been reading the British National Formulary 65 (BNF-65) and it mentioned that in some, especially at higher dosages, sedating (first-generation) antihistamines, can produce paradoxical excitatory ...
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How do Opioids Stimulate a Histamine Release?

Histamine is a neurotransmitter that also has peripheral functions such as the regulation of gastric acid secretions, allergic responses, etc. I know that opioids stimulate a release of histamine but ...