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Questions tagged [histone-deacetylase]

Histone deacetylase (HDAC) is a family of enzymes that play key roles in gene expression.

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Perform CHIP-qPCR to detect Myc

I use Panobinostat (HDAC inhibitor) to treat the GBM cells. I saw Myc protein level go down but not mRNA level. Panobinostat is known to inhibit HDAC1 and HDAC2. HDAC2 gene belongs to the histone ...
Trang's user avatar
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Can one talk about deacetylation of a promoter rather than associated histone?

I am confused on a detail in a paper I am reading and am not sure whether I am misunderstanding the wording or misunderstanding the concept. I am including the whole abstract of this paper for ...
mshum's user avatar
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What class of histone deacetylase (HDAC) inhibitor is sodium valproate (VPA)?

VPA is a known HDAC inhibitor. But I cannot find what class it is. What class is it? And is there any method of finding an answer better than floundering with Google?
P i's user avatar
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What does effect would Sulforaphane have on Kennedy's Disease?

Sulforaphane is a isothiocyanate found in cruciferous vegetables including broccoli and cauliflower. Its 2D structure is as follows: It's been found to serve as a histone deacetylase 6 (HDAC6) ...
Josh Pinto's user avatar
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