Questions tagged [human-genetics]

The scientific study of inheritance as it occurs specifically in human beings.

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What determines whether a trait brought out through sexual selection is transmitted only to offspring of the same sex or of both sexes?

First of all, let me apologize for my amateurishness. I have no background in biology. Please bear with me. My question relates to sexual selection, or specifically its most prominent manifestations: ...
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Can the effect of an allele on height be context-dependent?

Some data is available on the effect alleles have on height. For example Common DNA Variants Accurately Rank an Individual of Extreme Height However after browsing the literature I was not able to ...
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Why do humans share over 99% of their genomes?

From Wikipedia The haploid human genome (23 chromosomes) is about 3 billion base pairs long and contains around 30,000 genes.[33] Since every base pair can be coded by 2 bits, this is about 750 ...
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Is it possible to fuse DNA from two sperms and can a baby be born from that? [closed]

If this is possible, then isn't there going to be a chance to have a YY child?
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recessive autosomal diseases that exhibits in all generations

Is there any rare types of diseases which are recessive autosomal but somehow exhibit in all generations of a family pedigree? I mean, there should be such a category (because my professor asked the ...
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How many MAOA alleles are there?

The question is about the human gene MAOA. I've seen MAOA-H and MAOA-L mentioned in papers. The page https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000189221;r=X:43654907-43746824 ...
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How can you identify recessive mutations in a gene that has been disrupted by a chromosomal translocation?

I am reading a journal paper about a patient who has intellectual disability. The patient was found to have a balanced chromosomal translocation t(11;16)(q24.2;q24). This chromosomal translocation ...
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Are there any phenotypically visible examples of gene linkage in humans?

Are there any examples of two "visible" or "obvious" phenotypic traits in humans that are a priori unrelated, but which tend to be inherited together (i.e. their inheritance ...
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How often are diseases caused by more than a single mutation of a gene?

Many genetic diseases are caused by mutations in a gene and often, it is a single nucleotide polymorphism (SNP) that has dramatic consequences (e.g. the E6V hemoglobin mutation in sickle cell disease)....
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Difference between heritability on the scale of liability versus the scale of observation

I was reading a paper on disease heritability ("Estimating Missing Heritability for Disease from Genome-wide Association Studies") and it struck me that I don't have a great understanding of ...
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Why do chromosome pairs have different shapes and sizes?

When I look at microscopic images of human chromosome pairs I see that they have different shapes and sizes. Is there a deeper biological reason for that? Is there some evolutionary pressure for them ...
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Are there any congenital anomalies that cause a lack of epicanthic folds in a child who would normally have them?

Wikipedia lists several medical conditions associated with epicanthic folds. Mount Sinai says that epicanthic folds in a baby who would not be expected to have them is a diagnostic tool that indicates ...
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From an evolutionary standpoint, why don’t couples attempt to have as many kids as possible?

Many couples have 4 or 5 kids, but it is unusual for a couple to have 10 or 15. Shouldn’t humans have evolved to want as many kids as possible to maximize the chances that their genes are passed down?
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Is there any way siblings could be related more than 3/4th siblings, but less than full siblings?

I couldn’t find anything on Wikipedia. 3/4th siblings are 37.5% related while full siblings are 50% related. Is there anything in between?
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Can one mouse gene have multiple human orthologs?

I was trying to map a mouse gene: Arfgap1 to it's human ortholog. Uniprot shows there are two human orthologs of this gene: https://www.uniprot.org/uniprot/?query=yourlist:...
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What are the additional considerations for primer design in ancient DNA?

I'm familiar with the principles of primer design and have previously designed primers for use in modern DNA. However, in my current project I am working with ancient DNA (nuclear gene) and need to ...
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What's the process for determining whether a GC -> AT conversion in bisulfite sequencing is due to degradation?

I'm working on an ancient DNA project (humans) examining the methylation patterns for a single nuclear gene on chromosome 5. I understand the protocols of bisulfite sequencing, and in general how the ...
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Can chain-linked genetic segment data be used to reliably assign unknown relatives to either the donor's mother or father?

I am analyzing DNA matching segment data, and I am trying to broadly group all DNA matches by my donor's parents. Based on documented evidence, I can confidently identify "Person 'B'" as a ...
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If a small population left one continent and sailed to another, would the genes of the population that left show relation to the original population?

This question has a specific context, a religious one, and so I'm not sure this is the right place to ask, but I can't think of a better place. I would like as objective and unbiased an answer as ...
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Can you calculate the coefficient of inbreeding (F) without a family history?

Apologies in advance, this question may be completely obvious. Say, I didn't have a family tree for two individuals. Could I calculate their coefficient of inbreeding? If not, is there a good proxy ...
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Preventing the transcription bubble from occurring in an individual gene

I'm trying to find a way to stop the transcription bubble from occurring over a individual gene in humans. I need the act of transcription to be inhibited, siRNA knock down of the transcript does not ...
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What is the methodogy used to determine the exact genetic flow from one area to another and the times in which it flowed?

For example, I take the instance of Central Asian migration into India. Say geneticists studied a) ancient bones in CA b) ancient bones in India c) living people in Central Asia d) living people in ...
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How many genes per 23 chromosomes in human genome? [closed]

It is estimated that humans have between 20,000 and 25,000 genes. Every person has two copies of each gene, one inherited from each parent. There are 46 chromosomes, half from the mother, half from ...
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What is the probability of having a son with blood type O? [closed]

So I was solving some biology questions, and this question left me confused. The response is supposed to be 22% according to the answers, but all the methods that I used did not lead me to it. I ...
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Is there any data on Neanderthal admixture in Western European Hunter Gatherers?

If there is any data, was the rate of admixture higher than today? Like WEHG brought the component in? Or was the amount maybe lower, like other groups like Early European Farmers or Yamnaya brought ...
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Does mitochondrial eve have to exist?

Suppose we took all living humans and found the set of their mothers, mothers' mothers, etc. and then traced down as far as possible. Is there a logical reason that this tree has to converge to one '...
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What is the criterion for genetic similarity among siblings and humans in general?

I just started reading Blueprint by Robert Plomin. He makes some well-known statements about genetic similarity which we all have read somewhere but I would like to know what the criteria for genetic ...
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Why is male balding so common in comparison to female balding?

I have heard that over 30% of men will be bald by 30, and that 60% will be bald by 50. However, I hardly ever see a bald woman unless it is a story about a cancer survivor or someone going through ...
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Why is haemophilia unviable in later stages of life?

A sentence in my textbook is: The possibility of female being haemophilic is extremely rare because mother of such a female has to be at least carrier and the father should be haemophilic (unviable ...
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Can a blood type O be born from AB and A parents?

I have a basic understanding of genetics, and I'm really puzzled by this. My grandma's blood type is A (I don't know if it's heterozygous or homozygous) and my grandpa is AB. Yet my mother is type O. ...
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Can a cell receive multiple copies of an insert when using different MOIs?

I want to transduce a cell line with virus that carries a specific insert. When using different Multiplicity of Infection (MOI), I expect to get different percentage of transduced cells, but is it ...
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In our 23 chromosome pairs, do the 2 members of the pair have distinct or virtually identical sequences?

I understand that we have 46 DNA molecules in the nucleus of our cells, arranged in 23 pairs: 22 autosomal and 1 sex chromosome pairs. I have read in different sources that the pairs contain nearly ...
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Why did the indigenous peoples of northern Asia and America not evolve the same physical characteristics as people of Nordic ancestry?

I was watching DW's documentary on the Arctic the other day, and I was struck by how the indigenous peoples of the far north seemed - visually speaking - to fit into two categories. On the one hand, ...
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Could two different pairs of humans generate the same child

What I mean is this. Take male A, female A, male B, female B. Is it possible for the pair of male A x female A generate a child that is genetically identical to a child from the possible children from ...
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Inheritance of FEVR (Genetic Disease)

If a woman has FEVR and is affected by the disease, what are the chances of her passing the disease to future generations. I read somewhere from a credible source like NIH(I couldn't find the link ...
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Genome-wide association study (GWAS) search engine?

I am not a biologist and came across the term genome-wide association study or 'GWAS' for the first time today. Now I would like to see if there is a GWAS on the particular condition I am interested ...
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Can one derive COVID-19 risk from a cheap consumer genetic test like 23andme?

Studies have found genes associated with a significantly higher risk of severe COVID-19, some of them claiming it to be 1.6 times the general risk. They mention genes at markers such as rs35044562, ...
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Hybridization capture: Array-capture vs. in solution

If I wanted to utilize hybridization capture for capturing certain genomic regions, I could do it by utilizing complementary probes immobilized on an array or to use the probes in solution and then ...
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Estimates of historical human population size

What are the estimates of minimum historical human population size, and how are they obtained from the current human genetic diversity? I seem to recall a Scientific American article from over 30 ...
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How do genes determine facial features?

What is known about the genes responsible for inherited facial features — the family resemblances that are so recognizable? Take for example a particular shape of nose: which gene or genes make it ...
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What would happen if we place denatured DNA in acidic medium?

DNA can be denatured at high temperatures or in alkaline solutions. But DNA can be annealed at low temperatures. I want to ask, could it be annealed in acidic medium?
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Monozygotic vs Dizygotic heteropaternal superfecundation

Update: I had a wrong assumption. After triple checking, I now see that how ordinary monozygotic twins arise is 1 sperm and 1 ovum and then later the zygote splits up. (1.1. and that that phil and ...
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How to find the origin of each Single Nucleotide Variants (SNV) in child when having variant call data for both parents?

I am working with a trio (Mom, Dad, Child). I have variant call data for all three. Now I want to know each SNV in the child comes from which parent? Is there any tool that could help me to achieve ...
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DNA shared by octopuses and modern humans

What percentage of DNA do we share with octopuses? I tried looking it up but couldn't find the answer on the internet. Could someone enlighten me on the same? To make the question more specific, I am ...
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About genomic imprinting

In the context of genomic imprinting, how does a human cell "know" whether a chromosome is paternal or maternal(out of a homologous pair), in order to silence genes?
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Why the major gene model can be supported by finding de novo mutations in affected cases?

I found a sentence which I can't fully understand in a publication on the genetics of autism. The unified major gene model is supported by the significant increase in damaging de novo mutations ...
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Possibility a child could genetically be also the child of its grandparent

When two people have sex, it is my understanding their diploid set of chromosomes is randomly split in half to create two haploid sets which unify into the diploid chromosome set of the child. For ...
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"The rhesus macaque is pretty much the closest thing we have to humans" -- why?

Vincent Munster (researcher at Oxford) states (in the context of testing vaccines for COVID-19): The rhesus macaque is pretty much the closest thing we have to humans I thought chimpanzees and ...
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Are there people blind to touch?

There are people who completely blind or deaf. Are there people who are completely blind to touch in a particular area or in the entirety of their body? If not, are there people in whom the ...
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RFLP Pedigree question

A relatively frequent, completely penetrant recessive disease variety of mutations in the gene. The gene has been recently cloned. Analysis of the region flanking the gene reveals that the population ...

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