Questions tagged [human-genetics]

The scientific study of inheritance as it occurs specifically in human beings.

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17
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2answers
2k views

If a small population left one continent and sailed to another, would the genes of the population that left show relation to the original population?

This question has a specific context, a religious one, and so I'm not sure this is the right place to ask, but I can't think of a better place. I would like as objective and unbiased an answer as ...
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1answer
39 views

Can you calculate the coefficient of inbreeding (F) without a family history?

Apologies in advance, this question may be completely obvious. Say, I didn't have a family tree for two individuals. Could I calculate their coefficient of inbreeding? If not, is there a good proxy ...
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23 views

Preventing the transcription bubble from occurring in an individual gene

I'm trying to find a way to stop the transcription bubble from occurring over a individual gene in humans. I need the act of transcription to be inhibited, siRNA knock down of the transcript does not ...
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0answers
60 views

What is the methodogy used to determine the exact genetic flow from one area to another and the times in which it flowed?

For example, I take the instance of Central Asian migration into India. Say geneticists studied a) ancient bones in CA b) ancient bones in India c) living people in Central Asia d) living people in ...
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1answer
93 views

How many genes per 23 chromosomes in human genome? [closed]

It is estimated that humans have between 20,000 and 25,000 genes. Every person has two copies of each gene, one inherited from each parent. There are 46 chromosomes, half from the mother, half from ...
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1answer
57 views

What is the probability of having a son with blood type O? [closed]

So I was solving some biology questions, and this question left me confused. The response is supposed to be 22% according to the answers, but all the methods that I used did not lead me to it. I ...
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1answer
108 views

Is there any data on Neanderthal admixture in Western European Hunter Gatherers?

If there is any data, was the rate of admixture higher than today? Like WEHG brought the component in? Or was the amount maybe lower, like other groups like Early European Farmers or Yamnaya brought ...
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1answer
66 views

Does mitochondrial eve have to exist?

Suppose we took all living humans and found the set of their mothers, mothers' mothers, etc. and then traced down as far as possible. Is there a logical reason that this tree has to converge to one '...
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1answer
60 views

What is the criterion for genetic similarity among siblings and humans in general?

I just started reading Blueprint by Robert Plomin. He makes some well-known statements about genetic similarity which we all have read somewhere but I would like to know what the criteria for genetic ...
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1answer
142 views

Why is male balding so common in comparison to female balding?

I have heard that over 30% of men will be bald by 30, and that 60% will be bald by 50. However, I hardly ever see a bald woman unless it is a story about a cancer survivor or someone going through ...
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2answers
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Why is haemophilia unviable in later stages of life?

A sentence in my textbook is: The possibility of female being haemophilic is extremely rare because mother of such a female has to be at least carrier and the father should be haemophilic (unviable ...
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3answers
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Can a blood type O be born from AB and A parents?

I have a basic understanding of genetics, and I'm really puzzled by this. My grandma's blood type is A (I don't know if it's heterozygous or homozygous) and my grandpa is AB. Yet my mother is type O. ...
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1answer
28 views

Can a cell receive multiple copies of an insert when using different MOIs?

I want to transduce a cell line with virus that carries a specific insert. When using different Multiplicity of Infection (MOI), I expect to get different percentage of transduced cells, but is it ...
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3answers
152 views

In our 23 chromosome pairs, do the 2 members of the pair have distinct or virtually identical sequences?

I understand that we have 46 DNA molecules in the nucleus of our cells, arranged in 23 pairs: 22 autosomal and 1 sex chromosome pairs. I have read in different sources that the pairs contain nearly ...
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2answers
101 views

Why did the indigenous peoples of northern Asia and America not evolve the same physical characteristics as people of Nordic ancestry?

I was watching DW's documentary on the Arctic the other day, and I was struck by how the indigenous peoples of the far north seemed - visually speaking - to fit into two categories. On the one hand, ...
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1answer
66 views

Could two different pairs of humans generate the same child

What I mean is this. Take male A, female A, male B, female B. Is it possible for the pair of male A x female A generate a child that is genetically identical to a child from the possible children from ...
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1answer
44 views

Inheritance of FEVR (Genetic Disease)

If a woman has FEVR and is affected by the disease, what are the chances of her passing the disease to future generations. I read somewhere from a credible source like NIH(I couldn't find the link ...
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0answers
29 views

Genome-wide association study (GWAS) search engine?

I am not a biologist and came across the term genome-wide association study or 'GWAS' for the first time today. Now I would like to see if there is a GWAS on the particular condition I am interested ...
0
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1answer
85 views

Can one derive COVID-19 risk from a cheap consumer genetic test like 23andme?

Studies have found genes associated with a significantly higher risk of severe COVID-19, some of them claiming it to be 1.6 times the general risk. They mention genes at markers such as rs35044562, ...
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0answers
9 views

Hybridization capture: Array-capture vs. in solution

If I wanted to utilize hybridization capture for capturing certain genomic regions, I could do it by utilizing complementary probes immobilized on an array or to use the probes in solution and then ...
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1answer
56 views

Estimates of historical human population size

What are the estimates of minimum historical human population size, and how are they obtained from the current human genetic diversity? I seem to recall a Scientific American article from over 30 ...
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14 views

What new information does PheWAS add beyond GWAS?

I am trying to understand Phenome-Wide Association Study (PheWAS). If I understand correctly, PheWAS appears to be just the reverse of GWAS (finding gene-trait associations using traits instead of ...
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1answer
77 views

How do genes determine facial features?

What is known about the genes responsible for inherited facial features — the family resemblances that are so recognizable? Take for example a particular shape of nose: which gene or genes make it ...
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1answer
49 views

What would happen if we place denatured DNA in acidic medium?

DNA can be denatured at high temperatures or in alkaline solutions. But DNA can be annealed at low temperatures. I want to ask, could it be annealed in acidic medium?
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1answer
44 views

Monozygotic vs Dizygotic heteropaternal superfecundation

Update: I had a wrong assumption. After triple checking, I now see that how ordinary monozygotic twins arise is 1 sperm and 1 ovum and then later the zygote splits up. (1.1. and that that phil and ...
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1answer
32 views

How to find the origin of each Single Nucleotide Variants (SNV) in child when having variant call data for both parents?

I am working with a trio (Mom, Dad, Child). I have variant call data for all three. Now I want to know each SNV in the child comes from which parent? Is there any tool that could help me to achieve ...
5
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1answer
88 views

DNA shared by octopuses and modern humans

What percentage of DNA do we share with octopuses? I tried looking it up but couldn't find the answer on the internet. Could someone enlighten me on the same? To make the question more specific, I am ...
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0answers
23 views

About genomic imprinting

In the context of genomic imprinting, how does a human cell "know" whether a chromosome is paternal or maternal(out of a homologous pair), in order to silence genes?
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1answer
29 views

Why the major gene model can be supported by finding de novo mutations in affected cases?

I found a sentence which I can't fully understand in a publication on the genetics of autism. The unified major gene model is supported by the significant increase in damaging de novo mutations ...
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2answers
62 views

Possibility a child could genetically be also the child of its grandparent

When two people have sex, it is my understanding their diploid set of chromosomes is randomly split in half to create two haploid sets which unify into the diploid chromosome set of the child. For ...
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1answer
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“The rhesus macaque is pretty much the closest thing we have to humans” — why?

Vincent Munster (researcher at Oxford) states (in the context of testing vaccines for COVID-19): The rhesus macaque is pretty much the closest thing we have to humans I thought chimpanzees and ...
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1answer
136 views

Are there people blind to touch?

There are people who completely blind or deaf. Are there people who are completely blind to touch in a particular area or in the entirety of their body? If not, are there people in whom the ...
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1answer
48 views

RFLP Pedigree question

A relatively frequent, completely penetrant recessive disease variety of mutations in the gene. The gene has been recently cloned. Analysis of the region flanking the gene reveals that the population ...
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1answer
91 views

Genes associated with human female breast size

What are the genes associated with female breast size and natural variation thereof in human beings?
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2answers
131 views

Understanding ancestry testing mathematically

Forgive me if this question has been asked here before, because it is something which should be very easy to find, but I can't seem to find an answer no matter where I search. The question is simply ...
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1answer
74 views

What is meant by translational repression by an upstream open reading frame?

The NCBI report on the human huntingtin gene contains the following statement: “This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene ...
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1answer
25 views

How exactly can a drug affecting squalene epoxidase affect the methylation cycle, necessitating the use of 5-MTHF?

I found a case report in which the authors say that Terbinafine might have possibly affected the methylation cycle in a patient, necessitating the prescription of 5-methylfolate to correct the ...
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1answer
55 views

centiMorgan distribution among human chromosomes

Using the rough estimate of 7,000 centiMorgans in a human... Is there an estimate that breaks down this total by chromosome (including the sex chromosomes)? E.g., in the human karyotype, do ...
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1answer
54 views

KRAS gene and K-Ras Mutations

This question pertains to the KRAS wikipedia page, and I just want to double check and clarify my own understanding of how this mutation works in cancer. It states: K-Ras protein acts like a switch ...
2
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1answer
108 views

Is there a measure of human genetic variation, where human genetic variation can differ more than 1%?

According to this Neardenthal genetics The proportion of Neanderthal-inherited genetic material is about 1 to 4 percent[12] [later refined to 1.5 to 2.1 percent[11]] and is found in all non-...
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0answers
114 views

Genetic variance for a behavioural trait among human populations

From this article from The Guardian: We instinctively assume that differences in behaviour that are in fact due to culture must be linked to – even caused by – characteristics of appearance. That ...
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1answer
43 views

Quantifying the Genetic Basis of Complex Diseases

In general, there are 2 types of diseases for which we understand "causality" very well: Infectious disease, where there is some etiological agent that causes the disease and Monogenic genetic ...
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2answers
105 views

DNA described somewhere?

This is not purely biological question but how do the companies making DNA analysis know what your DNA means? Is there some database describing human DNA? I watched some documents about DNA, gene ...
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5answers
168 views

What is the fundamental difference between human genome and other genomes that makes human a self-conscious living organism?

DNA is considered to be the blueprint from which any organism can be created. DNA carries the genetic information to construct a living body. DNA carries genes which represents the information that is ...
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1answer
68 views

DNA Inheritance- Math vs. Biology

After doing some statistical analysis of the raw math involved in DNA contributions, I would like to understand the scale of the biological factors. I know that 99% of the human genome is identical ...
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1answer
60 views

How do different genes on human genome express themselves?

It is said that human genome contains over twenty five thousand genes, How many of these (can) express themselves as an external or internal trait in human beings (for e.g. like eye-colors, hair ...
5
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1answer
101 views

Inheritance percentiles

I am aware that the average DNA contribution from each grandparent is 25%, while the possible range is 0%-50%. I found a source citing 18%-32% as the "normal" range but this was undefined. I assume ...
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1answer
33 views

Chromosome size without heterochromatin

Im doing different analysis of the human chromosomes and diffent loci, however when using different databases, the heterochromatin structures are not part of the human genomes. I know that ...
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1answer
75 views

Does the 1:1 sex ratio at birth apply to every human pregnancy or is it a statistical average?

Are there genetic factors that biase the sex ratio of offsprings for each person but average to 1:1 for the entire human population, or does the 1:1 ratio apply to every single fertile person?
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1answer
464 views

What is a Singleton Variant

I'm reading a paper that on a population genetics study where they sequence a number of genomes. The study states that 101 Singleton Variants per individual where found. What does Singleton mean?

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