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Questions tagged [human-genetics]

The scientific study of inheritance as it occurs specifically in human beings.

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Are there any completely, or 'true', Mendelian traits that do not display any polygeny at all?

Recently, I learned about polygenic traits and it got me wondering, are there any truly Mendelian traits where the trait displayed exists in a total binary? I have looked at some questions on the ...
gzkts's user avatar
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-2 votes
0 answers
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A politically incorrect interpretation of race [closed]

The following seems to be the establishment view: There is "no such thing as race" Genetic diversity is similar between groups of people Genetic diversity is enhanced by mixing genes ...
economics's user avatar
-1 votes
1 answer
74 views

How often do humans have two different genomes?

I read: Two eggs fertilized by two sperm coincided in a uterus and, instead of giving rise to two sisters, they fused to form a single person: Karen Keegan. When she was 52 years old, this woman from ...
Franck Dernoncourt's user avatar
0 votes
3 answers
104 views

Have there ever been "half-twins" who were halfway between siblings and twins?

Have there ever been two human siblings who were 75% or more genetically related?
BigMistake's user avatar
1 vote
0 answers
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How exactly are the eye color genes related?

How exactly are the gey (maybe aka EYCL1?), bey(2?) (aka EYCL3?), HERC2, and OCA2 genes related to each other? There are numerous sources that explain eye color in terms of OCA2's role in the creation ...
robertwb's user avatar
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2 votes
2 answers
203 views

If race doesn’t exist; why do humans look so different?

I was talking about a speculative new race of humans that could be created with genetic engineering and several people told me that race does not exist and is a social construct. I get what they are ...
Max's user avatar
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0 answers
47 views

How did the fusion of Chromosome 2 spawn a separate smarter species?

I’m familiar with the evidence that two primate chromosomes fused into human Chromosome 2, and I understand that primates with such a mutation could still breed with those without it. My question is, ...
Jerry Guern's user avatar
0 votes
2 answers
153 views

Different hominid species or simply mutated humans?

I am not a biologist, however, I am curious as to how do evolutionary biologists classify a newly discovered hominid fossil as a separate species. If simply the bone structures are a criteria to ...
Dr. user44690's user avatar
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What is the most accurate polygenic score for Alzheimer’s disease?

To date, which polygenic score (i.e. which study) has produced the largest effect size for Alzheimer’s prediction in out-of-sample validation?
BigMistake's user avatar
0 votes
1 answer
118 views

What is the exact definition of the term 'trait'?

A trait is a characteristic shown by an organism. For example a Tt plant would show the 'tallness' trait. It seems to me that, by analogy, sickle cell anaemia (SCA) carriers should show the 'normal' ...
Harjot Dhillon's user avatar
0 votes
1 answer
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Searching for reference regarding the impact of famine on a woman's grandchildren

I was once told that if a woman experiences a famine, her grandchildren will show epigenetic changes because the egg that the intervening mother came from also experienced the famine. In other words, ...
Azor Ahai -him-'s user avatar
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0 answers
84 views

Can someone with albinism have red hair with very pale skin and blue eyes?

I have heard of a type of albinism that occurs in races with darker skin that can give people red hair, but in the pictures I've seen, they usually have reddish-brown hair, a medium skin tone, and ...
Apollo's user avatar
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3 votes
1 answer
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Do endogenous retroviruses (ERV) have a high degree of heterogeneity among people?

Endogenous retroviruses (ERV) make up 5~8% of human genome. These ERV are ancient retroviruses which infected germ cells and therefore became parts of our genomes. However, unless the ERV can increase ...
哲煜黄's user avatar
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1 answer
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How does positional memory in fibroblast cells work?

I have a question regarding how positional memory in fibroblasts work, specifically, where the memory comes from/how its made. For example, the Salamander & other amphibians are able to regenerate ...
user105463's user avatar
0 votes
0 answers
36 views

Overlapping annotated regions among repetitive families of human genome

I am studying the repetitive elements in the human genome and I have come to know that some genomic locations are not uniquely described by a single repeat family. What's behind this uncertainty? Does ...
AVO's user avatar
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2 votes
0 answers
281 views

How pitch of a DNA Helix is 3.4 nm?

How pitch of a DNA Helix is 3.4 nm? In the image that I have attached, the numbers with prime represent the number of base pair and normal numbers represent the number of gap elements between two base ...
Peter swift's user avatar
0 votes
1 answer
189 views

Is heritability just slope?

Is broad-sense heritability just the slope of the line that passes through the coordinates: (1, The phenotypic correlation among monozygotic twins) (0.5, The phenotypic correlation among dizygotic ...
BigMistake's user avatar
1 vote
0 answers
39 views

Why do protanopes see yellow and not green?

Why can protanopes see yellow but not green when the relative absorbance of these two colour waves by the m cone can be identical?
sasha times's user avatar
1 vote
0 answers
30 views

Identification of cells containing the gene of interest at a double strand break instead of undergoing recombination

If I tried to knock in a gene for example KANMX and want to swap it with say some gene "x", but, since, there can be double strand break in the DNA and KANMX may get inserted within the ds ...
Adaintyflower's user avatar
1 vote
1 answer
76 views

What is the sequence similarity between humans and chimps in the noncoding genome?

I've seen some papers discuss extensively how human and chimp genomes compare in many of their features, eg Suntsova & Buzdin 2020, but I have not been able to find a paper that specifically ...
arara's user avatar
  • 706
1 vote
2 answers
383 views

What colour skin would the child of someone with albinism have?

My question is assuming the baby doesn't have albinism. If the mother has albinism and her family all has dark skin and the father doesn't have albinism and has light skin, would the baby just get the ...
Val's user avatar
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5 votes
2 answers
389 views

When is the sex of a human not determined by their chromosomes?

This might sound like a silly question, but what chromosomes determine whether a human is born a boy or a girl? I ask this because I got https://embryo.asu.edu/pages/sex-determination-humans when ...
Gili's user avatar
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4 votes
2 answers
227 views

What motivates an organism to reproduce? [closed]

What is the biological factor (gene or something else in case of humans) which motivates an organism to reproduce? By reproducing the evolutionary success of an organism increases. But why would an ...
Tarun Gupta's user avatar
0 votes
0 answers
44 views

What is my original skin tone i.e. my genetic skin tone with minimal/ subtle sun tan?

When I was younger (about 2-3 year old) I had a lighter skin color and now I have a darker skin color ( currently 19 years old ). Now as a teen I have became conscious about my skin issues ( including ...
Tushar's user avatar
  • 101
0 votes
2 answers
116 views

Can gene mutations cause Down's syndrome in humans?

I am working on an A levels questions: Which of the following statements about gene mutation is incorrect? A. It can occur in both somatic and sex cells B. It can cause Down's syndrome in humans C. ...
green onion's user avatar
2 votes
1 answer
60 views

Correlation between polygenic scores and reproductive success

I was looking through this article in the journal Behavior Genetics. The researchers has investigated 400 000 people in the UK Biobank and calculated polygenic scores for 33 traits. Then they ...
Agerhell's user avatar
  • 590
2 votes
0 answers
62 views

What is the heredity model of the following heredity tree?

I have the following heredity tree: and I need to decide which heredity model it fits the most, with the least number of assumptions, from the following models: autosome dominant autosome recessive ...
Ilya.K.'s user avatar
  • 139
2 votes
1 answer
224 views

Are all genes capable of being switched on or off?

Are all genes capable of being switched on or off or only some genes? Are there some genes that permanently do not have the functionality that enables them to be switched on or off? Everything I have ...
NetCentric's user avatar
2 votes
0 answers
29 views

How I can find the list of transcription factor proteins involved in transcription of a specific gene?

I want to get the list of transcription factor proteins involved in the transcription of the human SIRT1 gene. How can I access that?
Mehad's user avatar
  • 29
0 votes
0 answers
36 views

How do genetic variants of a gene moderate an association, leading to counterintuitive result?

I have run moderation analysis to study the interaction between SNP (dominant model) of a gene (A) with DNA methylation on cognition measures. For this, I have calculated the mean DNA methylation ...
Mehad's user avatar
  • 29
1 vote
3 answers
124 views

How can you diagnose albinism in a naturally light-colored person? [closed]

Not all albinos have white hair. There is a type of albinism where the affected person has light yellow hair and the skin color can be the same as a normal North European person. How can you diagnose ...
Icecre4m's user avatar
1 vote
1 answer
85 views

Do the quantum mechanical properties of the particles that make up DNA affect mutations in the genome?

Do quantum mechanical properties of particles, such as uncertainty, probability, tunneling, and so on, affect mutations in the genome?
Арман Гаспарян's user avatar
7 votes
1 answer
117 views

How can I find/simulate mixed-ancestry DNA data?

Some collaborators and I are building an ancestral inference tool, and we're having trouble obtaining reliable ground-truth data for samples of mixed ancestry. All the ground-truth DNA datasets we're ...
Jeff's user avatar
  • 73
0 votes
1 answer
159 views

Nondisjunction of chromosomes

Why is it that nondisjunction of chromosomes usually happen in the egg, followed by in the sperm, followed by in the embryo? Why isn’t there also a chance that it occur in any cell cycle at any point? ...
chris winchell's user avatar
2 votes
1 answer
102 views

Question about manifestation of an X linked disease (homework help)

I am doing some practice exams and came across this question. Perhaps the answer is a lot simpler than my reasoning, but after discussing it with others, I still disagree why the answer is clearly and ...
I have many questions's user avatar
0 votes
1 answer
115 views

Skin tone of a new born just after birth

I have a question. My skin tone is light but the photographs of me as a baby show that when i was just born, i was having an even lighter skin colour for about two years or probably more. As for now ...
Ruchi's user avatar
  • 141
0 votes
1 answer
107 views

Is there an established algorithm to produce a hash number from a person’s DNA?

It is often said that a person’s DNA uniquely identifies that person. Is there an established algorithm that can/could take values of a specific DNA sample to produce a digit string unique to its ...
Tristan Fabrini's user avatar
6 votes
3 answers
215 views

Does Telomere length shortening with age actually cause our cells to age and stop functioning properly?

The human telomere, a simple repeating sequence of six bases, TTAGGG located at the ends of chromosomes (Moyzis et al, 1988) protect them from degeneration, reconstruction, fusion, and loss. It is ...
schizoid_man's user avatar
1 vote
0 answers
29 views

Phenotype of a possible gene mutation

I have noticed multiple cases where patients had similar body characteristics : decreased ability to gain weight (slim) they are capable of sleep only 6 hours or less with normal functioning (...
mohamed's user avatar
  • 320
0 votes
0 answers
406 views

Using the law of independent assortment, why can't heterozygous parents make identical twins?

In a case where two parents are heterozygous, why can't any pairs of their children be identical twins? As the question asks, I tried to explain this using the law of independent assortment, which ...
John Liu's user avatar
  • 109
1 vote
2 answers
238 views

What is the latest consensus on the causes of sexuality?

In 2019, scientists concluded that there is no gay gene. Epigentic markers of homosexuality have been disproven. The Exotic becomes Erotic Theory is an ancient decrepit idea that holds no water. Yet, ...
Aaron's user avatar
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-4 votes
1 answer
68 views

What is the probability for an offspring to inherit schizophrenia? [closed]

If an European male (i.e. white) is diagnosed with schizophrenia, but an European female (also white) 2-3 years younger than the male is healthy, what is the probability that their first child will: a)...
mercury0114's user avatar
9 votes
0 answers
303 views

The village of Twins — Mystery behind and Scope

With the presence of more than 200 twins, Kodinhi , a village situated in Malappuram District in Kerala , India , is popularly known as the "Village of Twins".This phenomenon of large ...
Asmi's user avatar
  • 123
1 vote
1 answer
114 views

Method of determining base values of traits in isolated populations

Prelude: I came across a discussion about the correct formula for calculating the average IQ of offspring, which goes something like the following $$ 100 + \frac35 \left( \left(\text{father's IQ} + \...
Maximilian's user avatar
3 votes
0 answers
64 views

What determines whether a trait brought out through sexual selection is transmitted only to offspring of the same sex or of both sexes?

First of all, let me apologize for my amateurishness. I have no background in biology. Please bear with me. My question relates to sexual selection, or specifically its most prominent manifestations: ...
user3724492's user avatar
0 votes
1 answer
111 views

Can the effect of an allele on height be context-dependent?

Some data is available on the effect alleles have on height. For example Common DNA Variants Accurately Rank an Individual of Extreme Height However after browsing the literature I was not able to ...
SKG's user avatar
  • 45
1 vote
1 answer
253 views

Why do humans share over 99% of their genomes?

From Wikipedia The haploid human genome (23 chromosomes) is about 3 billion base pairs long and contains around 30,000 genes.[33] Since every base pair can be coded by 2 bits, this is about 750 ...
SKG's user avatar
  • 45
1 vote
3 answers
370 views

Is it possible to fuse DNA from two sperms and can a baby be born from that? [closed]

If this is possible, then isn't there going to be a chance to have a YY child?
Aranya's user avatar
  • 19
2 votes
1 answer
55 views

How many MAOA alleles are there?

The question is about the human gene MAOA. I've seen MAOA-H and MAOA-L mentioned in papers. The page https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000189221;r=X:43654907-43746824 ...
pans's user avatar
  • 121
0 votes
2 answers
43 views

How can you identify recessive mutations in a gene that has been disrupted by a chromosomal translocation?

I am reading a journal paper about a patient who has intellectual disability. The patient was found to have a balanced chromosomal translocation t(11;16)(q24.2;q24). This chromosomal translocation ...
ceno980's user avatar
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