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Questions tagged [human-genetics]

The scientific study of inheritance as it occurs specifically in human beings.

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What labs/companies provide comparative genomic analysis? [on hold]

I’m looking for labs/companies that provide comparative genomic analysis between two different species, AND do so for the “paying” public. I am looking to test a hypothesis regarding genetic ...
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X linked traits expression in females

We all know that females have an inactivated X chromosome (Most of its genes are inactivated). Consider a female who is a heterozygous carrier of an X linked abnormality, If the inactivated X was that ...
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Is hand size in humans 100% genetics or are there environmental factors/etc.?

And what genes are responsible for hand shape; finger width and length; palm breadth; etc.? I know it isn't always strongly correlated with height as I've seen males my same height who have notably ...
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DIYbio - CRISPR injection sites for targeting the ABCC11 gene [closed]

I've been researching into the biohacking world where people most notable Josiah Zayner and Tristan Roberts have used a CRISPR solution developed in their backyard for gene therapy. There is even a ...
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Would prehistoric humans have been considered negroid or australoid by modern standards? [closed]

What are your thoughts about this? For myself I think that the subject statement is rather obvious isn’t it, since Africans, & especially Australian Aboriginals, have the most archaic features &...
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Cell Division and the Role of the “RB” protein

How does the Retinoblastoma protein specifically inhibit DNA replication? Does anyone have a link (more information) on this "RB" protein? Supposedly, this "RB" protein inhibits (S-phase of cell ...
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For allele frequency determination, is it good to take samples from a college/school or a hospital or any other technique?

I am trying to determine allele frequency of a hla allele. Preliminary analysis shows the prevalence of the allele (homo or heterozygous both) is 3%. The allele is related to a disease (After exposure ...
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What is the distribution of gene polymorphism levels across human genes?

Of the approximately 19,000 human genes, about how many have one allele that occurs with appreciable frequency in the current human population, how many have two alleles, and so on? (By "appreciable ...
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How to identify whether something is in linkage disequilibrium?

If the following loci indicated the presence of an SNP in flu strains, is Locus 2 and Locus 3, which are located 10 bp apart in linkage disequilibrium? "When alleles and molecular markers are ...
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Polydactyly and its genetics

One of my friend was saying that her aunt (father's sibling sister) was having polydactyly but none of her cousins (her aunt has two daughters) is having it. What is the chance that my friend's ...
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Is it possible in modern biology to make any person's identical twin (or genetical clone) using his DNA?

I was told by a Biotech professor (who came in our college for a guest lecture) that Bio Technology has now become so advanced that if we want to make an identical twin (or Genetical DNA Twin) of a ...
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Height prediction based on genetics

My height, as predicted by my genetics, is 156 cm whereas my actual height is 172 cm. What could be the reasons for this substantial discrepancy? Does it just mean I had very good nutrition as a child?...
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what is the source of data in biological database like Genbank [closed]

What is the source of data in international biological data bases like Genbank and what is it meant for?
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Technical reason that specialized embryonic cells form

During the embryonic stage of human development, rapid cell division occurs and specialized cells form to build the various parts of the developing fetus. I'm curious: Why technically do specialized ...
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Degree of relatedness over assumed match in SNP poor region

First I want to give the disclaimer that I am not a biologist. I had my DNA tested and show as a match to a woman on parts of chromosome 1. However, parts of various chromosomes are not tested due to ...
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Gene frequency — database/site

Is there any free database when one can check the gene frequency in a healthy population? For example I would like to check it for genes like BIN1, CLU or CR1. On the English Wikipedia I found a gene ...
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How does the new discovery that mitochondrial dna is inherited from both parents change population genetics and other dates?

This new study seem to have pretty much proven that mtDNA is inherited from both parents. I assume that this would lead to most age estimates of ancient human ...
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Is it possible to deduce facts about a person's parents just by studying his/her genome?

As an example, suppose Anne had abusive parents. Is it theoretically possible to deduce this from her genome even if she didn't inherit this quality (of being an abusive parent)?
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Codons at for transcription vs translation [closed]

Why are start and stop codons present at translation level but not at transcription level? And how will I obtain a protein at transcription level? Thanks in advance
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Is it possible that there are two people in the world who belong to a different species? [duplicate]

There're over 7 billion people in the world and every one of them is different from everyone else. Is it possible that there are two people so different that they belong to different species (in the ...
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What type of genetic changes occurs when ovaries or uterus are removed from female body? [closed]

I saw so many women which have present dermoid cysts in their ovaries or uteruses. Doctors operate and mostly the ovaries and uterus can not be saved and the doctors remove the ovaries or uterus. ...
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Do we know which traits reside in which chromosome? If not, how about the next 10 years? [closed]

Assuming we develop a technology that allows us to make human gametes (sperm & eggs) combining chromosomes from different persons. Thus we take 1st chromosome from 1st person, 2nd chromosome from ...
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Are modern gene-editing techniques capable of creating genetically-superior versions of humans? [closed]

Can we alter the DNA in, say, a small-framed, low muscle mass male to those of elite bodybuilders? Can we alter the DNA sequence that stops balding and hair loss? How about the genes responsible for ...
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Relationship between inbreeding and sterility in humans

In general, inbred individuals tend to be at increased risk of sterility as shown in cows (Gonzales-Recio, 2007) or in leghorns (Nordskog and Cheng, 1988) for examples. I only have very quickly looked ...
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Are androgenic-anabolic steroids a form of gene editing?

Is taking AAS a form of gene-editing? Steroids alter genes in some way since they allow people to build more muscle than what's naturally possible -- so they sort of "break" natural genetics somehow. ...
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Hemoglobin question- how many alleles?

So I know that Hemoglobin is made of 2 alpha and 2 beta subunits. The alpha consists of 2 genes on chromosome 16, and the beta of 1 gene on chromosome 11. So why does Hemoglobin only have 4 alleles? ...
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Does the deletion of Chromosome 20 cause immunity against prion disease?

I was reading recently about prion disease and it caught my attention that a normal prion protein is coded n chromosome 20, therefore, in order for an infectious prion protein to attack, there must be ...
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Why is the mechanism of inheritance for this disease autosomal dominant?

An unrelated couple has a daughter and a son with the same rare condition. Neither parent has any obvious signs of the condition, but the father's mother (paternal grandmother) and her brother have ...
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Why did scientists think humans had 100,000 genes (before the Human Genome Project)?

One of the major results of the Human Genome Project (HGP) was that humans have far fewer separate genes than previously thought. From a 2004 article about the HGP: Francis S. Collins, director of ...
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What does “novel, predicted deleterious, within autozygome” mean in genetics?

I am a medical student and just got involved with a genetic lab and research. I read a lot phrases like: "Although no mutations have been reported in this gene, we think this variant is interesting ...
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What is meant by “50% related to sibling” versus “95% related to chimpanzee”?

Obviously I am more related to my sister than to a chimpanzee, so what do these different percentages actually refer to? Here is my preliminary research: https://genetics.thetech.org/ask-a-...
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Very frequent multiple births in humans

18th century Feodor Vassilyev is said to have had children by two wives, each of whom only ever had twins, triplets or quadruplets. His first wife has 16 sets of twins, 7 of triplets and 4 of quads; ...
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Can people be bred for tameness in a similar way to Russian foxes?

Russian foxes were selectively bred for tameness. https://en.wikipedia.org/wiki/Domesticated_red_fox Can a similar process happen to humans, under the right conditions - say extreme political ...
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Bipolar disorder genetics

My understanding is that bipolar disorder is polygenic. 1) Does one need to have all the genes for bipolar disorder in order to have the disease? 2) Is it possible for a person to have all the genes ...
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Can supplements affect DNA? (Could 10,000% Methylcobalamin affect MTHFR genotype)

Originally titled "Could B12 supplementation affect dna test results for B12 need?" - B12 just seems like a good example question to frame the more general question of "Can supplements affect DNA?" I ...
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Reason behind using DNA primer in PCR techcnique while RNA primer use in replication in vivo? [closed]

I have went through Lehinger ( biochemistry book) and cooper ( cell Biology) but i didn't find my answer. plese help me
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Measuring genetic distance: $F_{ST}$ vs. Nei's distance

As far as I'm aware, Nei's genetic distance is quite old compared to $F_{ST}$. However, I have recently read more papers that utilized Nei's genetic distance alongside with $F_{ST}$. As I'm not very ...
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Fst genetic distance: Autosomal vs. mtDNA

As far as I'm aware, mtDNA is only inherited from the mother. Hence, if I compute Fst from autosomal SNPs, then I'll get the actual genetic distance between two human populations. If I compute the ...
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Why are there sporadic lightly pigmented hairs in facial hair?

My body and scalp hair are entirely black. Until recently, I thought this was the case with my facial hair also, until I noticed a small handful of hairs that were anywhere from light brown to copper-...
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The concept of high genetic load of disease and non-random segregation of deleterious variants

I'm new in this field. I was reading Shakeel et al. (2018) and came across the below sentences The rate of emergence and distribution of deleterious variants in populations is important in ...
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Biological validation of computationally determined gene-gene interaction

How can a computationally determined three-way gene interaction be biologically validated? What kind of assays or tests must be performed using cell/tissue-based and/or mouse models to prove that the ...
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1answer
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HLA typing between siblings to identify a genetic disorder

If a patient suffering from a complex array of signs and symptoms for a disease and is having an 8/8 loci match with his sister who suffers no such symptoms can you conclude that the disease is an X-...
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True examples of common variation due to Mendelian Inheritance

Classic examples of mendelian inheritance are genetic diseases such as sickle-cell anemia, Tay-Sachs, cystic fibrosis, and xeroderma pigmentosa. For some of these diseases, it is believed that they ...
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Did the chromosomal fusion within humans affect phenotypical change compared to the separated chromosomes in the other apes?

I just read this article on the evolutionary divergence between humans and chimps, and how the most significant event was when the 24 number of chromosomes in chimps was reduced to 23 in humans due to ...
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Which has greater autosomal genetic diversity: East or West Eurasian?

Let's define the two population groups as such: West Eurasian: Northern European, Southern European, Middle Easterner (e.g. Levantine people, Iranian people). Does not include the following mixed ...
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Appropriateness of PCA to visualize clusters in genetic data

In many genetic studies, PCA is often utilized to examine genetic cluster in human populations. Rarely is the % variance reported for the components. With human data it's been my experience that the ...
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Is Rh factor an evidence for human evolution from primates?

The Rhesus Factor is an important blood antigen that is found on Rhesus macaque and human being. So is this an evidence for human evolution from monkeys. ???
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Location of gene on chromosome

Recently i got to know about how location of gene is shown on chromosome for example-CFTR gene's location is designated as 7q31.2 Which means that it is present on 7th chromosome on the long arm(q), ...
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Query regarding KEGG KGML pathway files

With respect to the the Wnt pathway in KEGG, the KGML file of this pathway has description of each interaction between a pair of genes. These interactions are designated in the form: ...
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primer blast for BSP methylation

How can I blast my BSP(Bisulfite sequencing) primers? I designed in this way that C nucleotide converted to T and my primers just sit on the converted DNA! I blast it with Bisearch but I don't know ...