Questions tagged [human-genetics]

The scientific study of inheritance as it occurs specifically in human beings.

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someone find out the difference between meiosis and mitosis so she studied how red blood cells undergo cell division. Is her method appropriate? [closed]

someone find out the difference between meiosis and mitosis so she studied how red blood cells undergo cell division. Is her method appropriate? If not, what could she do to improve her experiment and ...
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48 views

Estimates of historical human population size

What are the estimates of minimum historical human population size, and how are they obtained from the current human genetic diversity? I seem to recall a Scientific American article from over 30 ...
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What new information does PheWAS add beyond GWAS?

I am trying to understand Phenome-Wide Association Study (PheWAS). If I understand correctly, PheWAS appears to be just the reverse of GWAS (finding gene-trait associations using traits instead of ...
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How do genes determine facial features?

What is known about the genes responsible for inherited facial features — the family resemblances that are so recognizable? Take for example a particular shape of nose: which gene or genes make it ...
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What would happen if we place denatured DNA in acidic medium?

DNA can be denatured at high temperatures or in alkaline solutions. But DNA can be annealed at low temperatures. I want to ask, could it be annealed in acidic medium?
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Monozygotic vs Dizygotic heteropaternal superfecundation

Update: I had a wrong assumption. After triple checking, I now see that how ordinary monozygotic twins arise is 1 sperm and 1 ovum and then later the zygote splits up. (1.1. and that that phil and ...
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How to find the origin of each Single Nucleotide Variants (SNV) in child when having variant call data for both parents?

I am working with a trio (Mom, Dad, Child). I have variant call data for all three. Now I want to know each SNV in the child comes from which parent? Is there any tool that could help me to achieve ...
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Why is Incontinentia Pigmenti lethal?

I recently read that the X-linked dominant disorder incontinentia pigmenti is lethal in males and homozygous females. Why is it so? Is there any other effect of this disorder on the body, other than ...
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DNA shared by octopuses and modern humans

What percentage of DNA do we share with octopuses? I tried looking it up but couldn't find the answer on the internet. Could someone enlighten me on the same? To make the question more specific, I am ...
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About genomic imprinting

In the context of genomic imprinting, how does a human cell "know" whether a chromosome is paternal or maternal(out of a homologous pair), in order to silence genes?
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Why the major gene model can be supported by finding de novo mutations in affected cases?

I found a sentence which I can't fully understand in a publication on the genetics of autism. The unified major gene model is supported by the significant increase in damaging de novo mutations ...
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Possibility a child could genetically be also the child of its grandparent

When two people have sex, it is my understanding their diploid set of chromosomes is randomly split in half to create two haploid sets which unify into the diploid chromosome set of the child. For ...
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“The rhesus macaque is pretty much the closest thing we have to humans” — why?

Vincent Munster (researcher at Oxford) states (in the context of testing vaccines for COVID-19): The rhesus macaque is pretty much the closest thing we have to humans I thought chimpanzees and ...
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Are there people blind to touch?

There are people who completely blind or deaf. Are there people who are completely blind to touch in a particular area or in the entirety of their body? If not, are there people in whom the ...
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RFLP Pedigree question

A relatively frequent, completely penetrant recessive disease variety of mutations in the gene. The gene has been recently cloned. Analysis of the region flanking the gene reveals that the population ...
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Does the rate of human evolution change over time?

Weakening the natural selection would increase the rate of evolution. This is because mutations aren't removed as efficiently – this increases their frequency. However, this is not the result of ...
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Genes associated with human female breast size

What are the genes associated with female breast size and natural variation thereof in human beings?
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What percent of mucle growth is possible without steroids consumption?

I am interested to know, if someone does bodybuilding exercises with good rest, enough protein, high presure workout, etc, but without consuming any steroids, how much of muscle gorwth is possible for ...
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Understanding ancestry testing mathematically

Forgive me if this question has been asked here before, because it is something which should be very easy to find, but I can't seem to find an answer no matter where I search. The question is simply ...
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1answer
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What is meant by translational repression by an upstream open reading frame?

The NCBI report on the human huntingtin gene contains the following statement: “This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene ...
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How exactly can a drug affecting squalene epoxidase affect the methylation cycle, necessitating the use of 5-MTHF?

I found a case report in which the authors say that Terbinafine might have possibly affected the methylation cycle in a patient, necessitating the prescription of 5-methylfolate to correct the ...
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Do haplotypes have a role to play in the aggression of a human?

there are a couple research papers that connect haplotypes and aggressiveness in canines. Our genes, for example the MAOA gene in the X-chromosome, have also been shown to affect aggression. But can ...
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How many different DNA of different species are there in the DNA of modern humans?

According to this DNA of extinct human species Aboriginal Australians, Pacific Islanders carry DNA of unknown human species, research analysis suggests and according to this Neanderthal ...
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centiMorgan distribution among human chromosomes

Using the rough estimate of 7,000 centiMorgans in a human... Is there an estimate that breaks down this total by chromosome (including the sex chromosomes)? E.g., in the human karyotype, do ...
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KRAS gene and K-Ras Mutations

This question pertains to the KRAS wikipedia page, and I just want to double check and clarify my own understanding of how this mutation works in cancer. It states: K-Ras protein acts like a switch ...
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Is there a measure of human genetic variation, where human genetic variation can differ more than 1%?

According to this Neardenthal genetics The proportion of Neanderthal-inherited genetic material is about 1 to 4 percent[12] [later refined to 1.5 to 2.1 percent[11]] and is found in all non-...
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Genetic variance for a behavioural trait among human populations

From this article from The Guardian: We instinctively assume that differences in behaviour that are in fact due to culture must be linked to – even caused by – characteristics of appearance. That ...
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Quantifying the Genetic Basis of Complex Diseases

In general, there are 2 types of diseases for which we understand "causality" very well: Infectious disease, where there is some etiological agent that causes the disease and Monogenic genetic ...
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DNA described somewhere?

This is not purely biological question but how do the companies making DNA analysis know what your DNA means? Is there some database describing human DNA? I watched some documents about DNA, gene ...
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What is the fundamental difference between human genome and other genomes that makes human a self-conscious living organism?

DNA is considered to be the blueprint from which any organism can be created. DNA carries the genetic information to construct a living body. DNA carries genes which represents the information that is ...
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DNA Inheritance- Math vs. Biology

After doing some statistical analysis of the raw math involved in DNA contributions, I would like to understand the scale of the biological factors. I know that 99% of the human genome is identical ...
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How do different genes on human genome express themselves?

It is said that human genome contains over twenty five thousand genes, How many of these (can) express themselves as an external or internal trait in human beings (for e.g. like eye-colors, hair ...
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Inheritance percentiles

I am aware that the average DNA contribution from each grandparent is 25%, while the possible range is 0%-50%. I found a source citing 18%-32% as the "normal" range but this was undefined. I assume ...
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Chromosome size without heterochromatin

Im doing different analysis of the human chromosomes and diffent loci, however when using different databases, the heterochromatin structures are not part of the human genomes. I know that ...
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Does the 1:1 sex ratio at birth apply to every human pregnancy or is it a statistical average?

Are there genetic factors that biase the sex ratio of offsprings for each person but average to 1:1 for the entire human population, or does the 1:1 ratio apply to every single fertile person?
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What is a Singleton Variant

I'm reading a paper that on a population genetics study where they sequence a number of genomes. The study states that 101 Singleton Variants per individual where found. What does Singleton mean?
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Why do I have 95% of chimpanzee's DNA, and only 2% of Neanderthal's DNA? [duplicate]

Excuse me if it is a question with a simply answer, but I don't understand these discoveries, looking a discrepancy from my unknowledge of genetics: I have 95% of Chimapanzee's DNA, and, I have [...
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What could humans do to “see” what dogs smell?

We're able to see a lot of things using computers that we can't see normally: yellow-green, UV light, X-rays, etc. What do we have that harnesses the ability to "see" what dogs smell (e.g., harnessing ...
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What is the probability of an offspring sharing identical HLA typing as one of their parents?

DISCLAIMER: I have yet to thoroughly study HLA 100% to the bone, and hence I won't know everything about it at the back of the hand. Recently I came across this information on a San Francisco ...
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62 views

Why is the GULO pseudo gene expressed in humans?

The GULO pseudo gene is being expressed in humans according to Genecards. Why is this still taking place after tens of millions of years since then gene lost the capacity to encode for a functional ...
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Examples of environmentally influenced gene-expression in humans?

In discussions of the relevant importance of genetic and environmental influences on the development of the individual, it's often stated that the genetic and environmental influences interact. An ...
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Figure out which is the risk allele from SNP in GWAS article

I do neuroimaging research, and am interested in dabbling in genetics. I am trying to create an anxiety risk profile score from several SNPs shown to correlate with measures of anxiety in past GWAS ...
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Why has reproduction evolved as a choice? [closed]

From an evolutionary perspective, the purpose of an organism is to pass along its genes through reproduction. However, as humans we have a choice if we want to reproduce or not. The good feeling from ...
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Is it possible to breed neanderthals through selective breeding?

I've heard most non-subsaharan africans have neanderthal DNA with it being more prevalent in northern regions, that sometimes 1-4% of the DNA has neanderthal origins. Speaking strictly ...
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Difference Junk DNA and Pseudogenes [duplicate]

1-Are Pseudogenes and Junk DNA both Non-Coding DNA or they are different entity? How much Pseudogenes & Junk DNA do we have respectively? 2-I read that Non-Coding DNA has functions, my question ...
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Can different cell lines of same type symbolise samples from different patients in ChIP-seq?

Can I simulate different patients by using different cell lines of the same cell type and from the same tissue? Can I also study apoptosis in an immortalised cell line? I have a gene X (transcription ...
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Is it tautological that all living humans descended from a single male and single female human ancestor?

Many popular science articles cite high sequence conservation of mitochondrial DNA and the Y chromosome among living people as evidence that all humans are descended from a single male and single ...
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Are chromosomal microdeletions passed on?

I've been looking around but can't find a clear answer: are chromosomal micro-deletions passed on (hereditary) or not?
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Replacing, instead of repairing, DNA

I've been doing some light reading on DNA damage theory of aging. One of the main ideas from that theory that I got is that the accumulation of damage in our DNA is one of the biggest causes of why we ...
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How to determine if two mutations in a gene are on the same or different alleles?

I would like to know, except a familial study, is there another way to determine if a mutation/variation is cis or trans (i.e. on the same or different alleles)? For example by sequencing technique or ...

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