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Questions tagged [human-genetics]

The scientific study of inheritance as it occurs specifically in human beings.

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16 views

Genetic diversity from meeting an isolated tribe?

Assume we make contact to a tribe we did not know existed. We understand the value of genetic diversity for our species. And as we had no contact for a long time, we can assume that the tribe adds to ...
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2answers
59 views

DNA described somewhere?

This is not purely biological question but how do the companies making DNA analysis know what your DNA means? Is there some database describing human DNA? I watched some documents about DNA, gene ...
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5answers
110 views

What is the fundamental difference between human genome and other genomes that makes human a self-conscious living organism?

DNA is considered to be the blueprint from which any organism can be created. DNA carries the genetic information to construct a living body. DNA carries genes which represents the information that is ...
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26 views

Way to analyze the functional relevance of human mutation in vivo

In the literature I „found“ a pointmutation in the protein coding sequence of an enzyme subunit to be a risk factor for a certain disease. It is not known whether the mutation leads to loss or gain ...
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1answer
53 views

DNA Inheritance- Math vs. Biology

After doing some statistical analysis of the raw math involved in DNA contributions, I would like to understand the scale of the biological factors. I know that 99% of the human genome is identical ...
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1answer
52 views

How do different genes on human genome express themselves?

It is said that human genome contains over twenty five thousand genes, How many of these (can) express themselves as an external or internal trait in human beings (for e.g. like eye-colors, hair ...
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17 views

How much DNA can differ among different humans today?

According to this article, Australian aborigines carry unknown DNA Australian Aboriginal people carry the DNA of an unknown human relative. This made me wonder, is it known how much DNA can differ ...
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52 views

Inheritance percentiles

I am aware that the average DNA contribution from each grandparent is 25%, while the possible range is 0%-50%. I found a source citing 18%-32% as the "normal" range but this was undefined. I assume ...
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1answer
27 views

Chromosome size without heterochromatin

Im doing different analysis of the human chromosomes and diffent loci, however when using different databases, the heterochromatin structures are not part of the human genomes. I know that ...
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1answer
38 views

What are the genetic basis for further classification of human beings? [closed]

According to anthropology, human race further gets divided in Caucasians, Mongoloids, Aboriginals, Eskimos, Red Indidians and Negro's. How far, is this classification, though maybe anthropologically ...
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1answer
64 views

Does the 1:1 sex ratio at birth apply to every human pregnancy or is it a statistical average?

Are there genetic factors that biase the sex ratio of offsprings for each person but average to 1:1 for the entire human population, or does the 1:1 ratio apply to every single fertile person?
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47 views

What is a Singleton Variant

I'm reading a paper that on a population genetics study where they sequence a number of genomes. The study states that 101 Singleton Variants per individual where found. What does Singleton mean?
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42 views

Why do I have 95% of chimpanzee's DNA, and only 2% of Neanderthal's DNA? [duplicate]

Excuse me if it is a question with a simply answer, but I don't understand these discoveries, looking a discrepancy from my unknowledge of genetics: I have 95% of Chimapanzee's DNA, and, I have [...
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105 views

What could humans do to “see” what dogs smell?

We're able to see a lot of things using computers that we can't see normally: yellow-green, UV light, X-rays, etc. What do we have that harnesses the ability to "see" what dogs smell (e.g., harnessing ...
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1answer
45 views

What is the probability of an offspring sharing identical HLA typing as one of their parents?

DISCLAIMER: I have yet to thoroughly study HLA 100% to the bone, and hence I won't know everything about it at the back of the hand. Recently I came across this information on a San Francisco ...
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1answer
31 views

Why is the GULO pseudo gene expressed in humans?

The GULO pseudo gene is being expressed in humans according to Genecards. Why is this still taking place after tens of millions of years since then gene lost the capacity to encode for a functional ...
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77 views

Examples of environmentally influenced gene-expression in humans?

In discussions of the relevant importance of genetic and environmental influences on the development of the individual, it's often stated that the genetic and environmental influences interact. An ...
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21 views

Figure out which is the risk allele from SNP in GWAS article

I do neuroimaging research, and am interested in dabbling in genetics. I am trying to create an anxiety risk profile score from several SNPs shown to correlate with measures of anxiety in past GWAS ...
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1answer
72 views

Why has reproduction evolved as a choice? [closed]

From an evolutionary perspective, the purpose of an organism is to pass along its genes through reproduction. However, as humans we have a choice if we want to reproduce or not. The good feeling from ...
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2answers
3k views

Is it possible to breed neanderthals through selective breeding?

I've heard most non-subsaharan africans have neanderthal DNA with it being more prevalent in northern regions, that sometimes 1-4% of the DNA has neanderthal origins. Speaking strictly ...
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1answer
46 views

Difference Junk DNA and Pseudogenes [duplicate]

1-Are Pseudogenes and Junk DNA both Non-Coding DNA or they are different entity? How much Pseudogenes & Junk DNA do we have respectively? 2-I read that Non-Coding DNA has functions, my question ...
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26 views

Can different cell lines of same type symbolise samples from different patients in ChIP-seq?

Can I simulate different patients by using different cell lines of the same cell type and from the same tissue? Can I also study apoptosis in an immortalised cell line? I have a gene X (transcription ...
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52 views

Is it tautological that all living humans descended from a single male and single female human ancestor?

Many popular science articles cite high sequence conservation of mitochondrial DNA and the Y chromosome among living people as evidence that all humans are descended from a single male and single ...
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1answer
32 views

Are chromosomal microdeletions passed on?

I've been looking around but can't find a clear answer: are chromosomal micro-deletions passed on (hereditary) or not?
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1answer
125 views

Replacing, instead of repairing, DNA

I've been doing some light reading on DNA damage theory of aging. One of the main ideas from that theory that I got is that the accumulation of damage in our DNA is one of the biggest causes of why we ...
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1answer
38 views

How to determine if two mutations in a gene are on the same or different alleles?

I would like to know, except a familial study, is there another way to determine if a mutation/variation is cis or trans (i.e. on the same or different alleles)? For example by sequencing technique or ...
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What the “due to” means in the definition of heritability?

According to Wray and Visscher, heritability is formally defined as the proportion of phenotypic variation (VP) that is due to variation in genetic values (VG). My question is, what does “due to” ...
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26 views

What physical differences can be observed due to the inactivation of the X-chromosome in female monozygotic twins?

I'm doing research on twins, specifically on how to identify monozygotic twins and dizygotic twins by their physical appearance alone. Since I assume that the X-chromosome plays some part in the ...
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2answers
230 views

Why are (some) human men sexually attracted to female breasts?

Many human men are sexually attracted to female breasts. Is there an evolutionary reason for this?
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1answer
83 views

Is it possible to change the DNA of all the cells of an adult human [closed]

The process of making and transferring changes is pretty straightforward relatively speaking in an embroyo. You change the DNA of one cell and all the cells now inherit this change. But let's say ...
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1answer
80 views

If some humans inherited 3% of Neanderthal DNA, why are we 99.9% same genome? [duplicate]

Many sources say that humans are 99.5 to 99.9 percent the same. Also some sources state that some humans have 3.4% Neanderthal DNA and some don't share those genes. Why is that?
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27 views

Why can't a genetically sound human stay alive for an indefinite amount of time given all the ideal conditions? [duplicate]

I have read that even if we can control our food and lifestyle and keep things as ideal as possible, there are other factors beyond our control like effects from neutrinos passing through our body ...
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1answer
41 views

Do human genes get affected by irregular sleep and other factors

I'm new here so please go easy on me. Do our genes-the ones that carry our appearance, intelligence and other traits get destroyed or lost due to irregular sleep, excessive body heat, smoking, ...
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2answers
121 views

Rationale behind Most Recent Common Ancestor (MRCA)?

My main question is this - I heard Richard Dawkins say in a video that after 1000s of years, any given individual alive today will be either an ancestor to ALL of the humans (in that future time) or ...
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1answer
44 views

skin colouration in thalassemia

Now when i was studying about thalassemia, I read that anaemia is its major characterstic. I can understand that fact. But it was also written that the skin gets pale. Wikipedia says that the skin ...
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1answer
25 views

Repopullation after a mass extinction [duplicate]

Is it possible to restart the whole human species with less than 10 individual. let say that the whole human species was wipe out of the surface of the earth by a catastrophe only 8 different couple ...
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65 views

Why do genetic testing companies (FTDNA,AncestryDNA,23andme) express DNA shared in centimorgans (cM) instead of in number of base pairs or in percent?

Expressing DNA shared in number of base pairs or in percent of total genome would be so much simpler and easier to understand for the customers. .
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106 views

what is the difference between homozygous and heterozygous duplication?

In a genetic test result it's written homozygous duplication or heterozygous duplication Does it mean four copies of the ...
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1answer
88 views

Can I train my non-dominant hand and make it dominant?

Are our dominant limbs decided on birth or is there some way in which I can train my non-dominant hand and make it as coordinated as my dominant?
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1answer
140 views

Are all genetic disorders inherited?

I know that genetic diseases such as cystic fibrosis are often passed down through generations and are therefore classified as genetic disorders, but if a mutation occurs spontaneously, which for ...
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1answer
45 views

What labs/companies provide comparative genomic analysis? [closed]

I’m looking for labs/companies that provide comparative genomic analysis between two different species, AND do so for the “paying” public. I am looking to test a hypothesis regarding genetic ...
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1answer
34 views

X linked traits expression in females

We all know that females have an inactivated X chromosome (Most of its genes are inactivated). Consider a female who is a heterozygous carrier of an X linked abnormality, If the inactivated X was that ...
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2answers
125 views

DIYbio - CRISPR injection sites for targeting the ABCC11 gene [closed]

I've been researching into the biohacking world where people most notable Josiah Zayner and Tristan Roberts have used a CRISPR solution developed in their backyard for gene therapy. There is even a ...
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2answers
139 views

Would prehistoric humans have been considered negroid or australoid by modern standards? [closed]

What are your thoughts about this? For myself I think that the subject statement is rather obvious isn’t it, since Africans, & especially Australian Aboriginals, have the most archaic features &...
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1answer
30 views

For allele frequency determination, is it good to take samples from a college/school or a hospital or any other technique?

I am trying to determine allele frequency of a hla allele. Preliminary analysis shows the prevalence of the allele (homo or heterozygous both) is 3%. The allele is related to a disease (After exposure ...
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25 views

What is the distribution of gene polymorphism levels across human genes?

Of the approximately 19,000 human genes, about how many have one allele that occurs with appreciable frequency in the current human population, how many have two alleles, and so on? (By "appreciable ...
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1answer
35 views

How to identify whether something is in linkage disequilibrium?

If the following loci indicated the presence of an SNP in flu strains, is Locus 2 and Locus 3, which are located 10 bp apart in linkage disequilibrium? "When alleles and molecular markers are ...
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1answer
66 views

Polydactyly and its genetics

One of my friend was saying that her aunt (father's sibling sister) was having polydactyly but none of her cousins (her aunt has two daughters) is having it. What is the chance that my friend's ...
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2answers
119 views

Is it possible in modern biology to make any person's identical twin (or genetical clone) using his DNA?

I was told by a Biotech professor (who came in our college for a guest lecture) that Bio Technology has now become so advanced that if we want to make an identical twin (or Genetical DNA Twin) of a ...
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1answer
32 views

Height prediction based on genetics

My height, as predicted by my genetics, is 156 cm whereas my actual height is 172 cm. What could be the reasons for this substantial discrepancy? Does it just mean I had very good nutrition as a child?...