Questions tagged [human-genetics]

The scientific study of inheritance as it occurs specifically in human beings.

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Inheritance of FEVR (Genetic Disease)

If a woman has FEVR and is affected by the disease, what are the chances of her passing the disease to future generations. I read somewhere from a credible source like NIH(I couldn't find the link ...
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Is there an established algorithm to produce a hash number from a person’s DNA?

It is often said that a person’s DNA uniquely identifies that person. Is there an established algorithm that can/could take values of a specific DNA sample to produce a digit string unique to its ...
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Does Telomere length shortening with age actually cause our cells to age and stop functioning properly?

The human telomere, a simple repeating sequence of six bases, TTAGGG located at the ends of chromosomes (Moyzis et al, 1988) protect them from degeneration, reconstruction, fusion, and loss. It is ...
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Complete human rDNA sequence

I've been trying to retrieve the complete human rDNA sequence (non-spacers and spacers), which should be about 43-kb in length using Biomart, NCBI, and rnacentral, but I have only been able to find ...
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Function of IGLL5 in the immunoglobulin lambda light chain locus

IGLL5 sits in the locus of the lambda light chain genes. GeneCards has this description: This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin ...
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In genomic imprinting, are single genes or entire chromosomes silenced?

My professor claims that: Only genes from one parent at a time are normally expressed, since either the parental or maternal allelle gets imprinted (that is to say silenced). Does this mean that ...
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Which genes are expressed from Barr bodies?

In someone with a typical female genotype, one x-chromosome is condensed into a Barr body. The majority of the genes in this chromosome are not expressed. Someone with Turner’s syndrome (one X ...
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Phenotype of a possible gene mutation

I have noticed multiple cases where patients had similar body characteristics : decreased ability to gain weight (slim) they are capable of sleep only 6 hours or less with normal functioning (...
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Using the law of independent assortment, why can't heterozygous parents make identical twins?

In a case where two parents are heterozygous, why can't any pairs of their children be identical twins? As the question asks, I tried to explain this using the law of independent assortment, which ...
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What is the latest consensus on the causes of sexuality?

In 2019, scientists concluded that there is no gay gene. Epigentic markers of homosexuality have been disproven. The Exotic becomes Erotic Theory is an ancient decrepit idea that holds no water. Yet, ...
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What is the probability for an offspring to inherit schizophrenia? [closed]

If an European male (i.e. white) is diagnosed with schizophrenia, but an European female (also white) 2-3 years younger than the male is healthy, what is the probability that their first child will: a)...
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Why is lower case used in front of a capitalized acronym (e.g. rDNA)? [closed]

Examples: rDNA, mRNA, tRNA. Why do we use small case for "r" in "rDNA", etc? Any particular reason?
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The village of Twins — Mystery behind and Scope

With the presence of more than 200 twins, Kodinhi , a village situated in Malappuram District in Kerala , India , is popularly known as the "Village of Twins".This phenomenon of large ...
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Method of determining base values of traits in isolated populations

Prelude: I came across a discussion about the correct formula for calculating the average IQ of offspring, which goes something like the following $$ 100 + \frac35 \left( \left(\text{father's IQ} + \...
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“The rhesus macaque is pretty much the closest thing we have to humans” — why?

Vincent Munster (researcher at Oxford) states (in the context of testing vaccines for COVID-19): The rhesus macaque is pretty much the closest thing we have to humans I thought chimpanzees and ...
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How does Humira work when injected into patients with rheumatoid arthritis?

OK, I have rheumatoid arthritis and I've been injecting Humira 2 times a month for the last 8 months. As far as I know rheumatoid arthritis is simply an immune system disorder which makes the immune ...
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Can two of a persons relatives who are unrelated to each other, one through each parent, match on the same chromosome segment?

Regarding the title, I would like to emphasize, assuming no recent endogamy. To be clear, let's say they're distant enough that any endogamy would be expected to be less than 5 continuous ...
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Do humans have enough biological differences to be grouped into races or subspecies?

After my online research on the subject, I learnt that, biologically speaking, many scientists believe that there is no such thing as a race. Homo sapiens as a species is only 200,000 years old, which ...
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Is it possible to fuse DNA from two sperms and can a baby be born from that? [closed]

If this is possible, then isn't there going to be a chance to have a YY child?
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Why do humans share over 99% of their genomes?

From Wikipedia The haploid human genome (23 chromosomes) is about 3 billion base pairs long and contains around 30,000 genes.[33] Since every base pair can be coded by 2 bits, this is about 750 ...
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What determines whether a trait brought out through sexual selection is transmitted only to offspring of the same sex or of both sexes?

First of all, let me apologize for my amateurishness. I have no background in biology. Please bear with me. My question relates to sexual selection, or specifically its most prominent manifestations: ...
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Can the effect of an allele on height be context-dependent?

Some data is available on the effect alleles have on height. For example Common DNA Variants Accurately Rank an Individual of Extreme Height However after browsing the literature I was not able to ...
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How many MAOA alleles are there?

The question is about the human gene MAOA. I've seen MAOA-H and MAOA-L mentioned in papers. The page https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000189221;r=X:43654907-43746824 ...
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How can you identify recessive mutations in a gene that has been disrupted by a chromosomal translocation?

I am reading a journal paper about a patient who has intellectual disability. The patient was found to have a balanced chromosomal translocation t(11;16)(q24.2;q24). This chromosomal translocation ...
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Are there any phenotypically visible examples of gene linkage in humans?

Are there any examples of two "visible" or "obvious" phenotypic traits in humans that are a priori unrelated, but which tend to be inherited together (i.e. their inheritance ...
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How often are diseases caused by more than a single mutation of a gene?

Many genetic diseases are caused by mutations in a gene and often, it is a single nucleotide polymorphism (SNP) that has dramatic consequences (e.g. the E6V hemoglobin mutation in sickle cell disease)....
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Difference between heritability on the scale of liability versus the scale of observation

I was reading a paper on disease heritability ("Estimating Missing Heritability for Disease from Genome-wide Association Studies") and it struck me that I don't have a great understanding of ...
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Prader-Willi Syndrome and Angelman Syndrome?

On the website http://www.whatisepigenetics.com/fundamentals/2/ it states that the imprint disorders Prader-Willi syndrome and Angelman syndrome, display an abnormal phenotype as a result of the ...
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Why do chromosome pairs have different shapes and sizes?

When I look at microscopic images of human chromosome pairs I see that they have different shapes and sizes. Is there a deeper biological reason for that? Is there some evolutionary pressure for them ...
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Are there any congenital anomalies that cause a lack of epicanthic folds in a child who would normally have them?

Wikipedia lists several medical conditions associated with epicanthic folds. Mount Sinai says that epicanthic folds in a baby who would not be expected to have them is a diagnostic tool that indicates ...
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From an evolutionary standpoint, why don’t couples attempt to have as many kids as possible?

Many couples have 4 or 5 kids, but it is unusual for a couple to have 10 or 15. Shouldn’t humans have evolved to want as many kids as possible to maximize the chances that their genes are passed down?
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Is there any way siblings could be related more than 3/4th siblings, but less than full siblings?

I couldn’t find anything on Wikipedia. 3/4th siblings are 37.5% related while full siblings are 50% related. Is there anything in between?
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What are the additional considerations for primer design in ancient DNA?

I'm familiar with the principles of primer design and have previously designed primers for use in modern DNA. However, in my current project I am working with ancient DNA (nuclear gene) and need to ...
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Can one mouse gene have multiple human orthologs?

I was trying to map a mouse gene: Arfgap1 to it's human ortholog. Uniprot shows there are two human orthologs of this gene: https://www.uniprot.org/uniprot/?query=yourlist:...
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If a small population left one continent and sailed to another, would the genes of the population that left show relation to the original population?

This question has a specific context, a religious one, and so I'm not sure this is the right place to ask, but I can't think of a better place. I would like as objective and unbiased an answer as ...
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What's the process for determining whether a GC -> AT conversion in bisulfite sequencing is due to degradation?

I'm working on an ancient DNA project (humans) examining the methylation patterns for a single nuclear gene on chromosome 5. I understand the protocols of bisulfite sequencing, and in general how the ...
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Can chain-linked genetic segment data be used to reliably assign unknown relatives to either the donor's mother or father?

I am analyzing DNA matching segment data, and I am trying to broadly group all DNA matches by my donor's parents. Based on documented evidence, I can confidently identify "Person 'B'" as a ...
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Y Chromosome in Ovary Cancer Data

I have been analyzing TCGA Ovary Cancer data. In Somatic Mutation data, there is data of mutations in all the chromosomes (1-22 and X), but amazingly, I have found one (just one) row of Y Chromosome ...
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Can you calculate the coefficient of inbreeding (F) without a family history?

Apologies in advance, this question may be completely obvious. Say, I didn't have a family tree for two individuals. Could I calculate their coefficient of inbreeding? If not, is there a good proxy ...
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why didn't natives of south america evolve darker skin?

I understand that darker skin tone is caused by melanin which helps to protect against the extra UV radiation that comes from more direct sunlight. It evolved in Africa before we migrated away from ...
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Preventing the transcription bubble from occurring in an individual gene

I'm trying to find a way to stop the transcription bubble from occurring over a individual gene in humans. I need the act of transcription to be inhibited, siRNA knock down of the transcript does not ...
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What is the methodogy used to determine the exact genetic flow from one area to another and the times in which it flowed?

For example, I take the instance of Central Asian migration into India. Say geneticists studied a) ancient bones in CA b) ancient bones in India c) living people in Central Asia d) living people in ...
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How many genes per 23 chromosomes in human genome? [closed]

It is estimated that humans have between 20,000 and 25,000 genes. Every person has two copies of each gene, one inherited from each parent. There are 46 chromosomes, half from the mother, half from ...
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Veritasium video about mosquitoes

In the recent veritasium video about mosquitoes , the host says that the researchers used identical female twins and fraternal female twins to understand the effect of genes on attractiveness to ...
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What is the probability of having a son with blood type O? [closed]

So I was solving some biology questions, and this question left me confused. The response is supposed to be 22% according to the answers, but all the methods that I used did not lead me to it. I ...
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Is there any data on Neanderthal admixture in Western European Hunter Gatherers?

If there is any data, was the rate of admixture higher than today? Like WEHG brought the component in? Or was the amount maybe lower, like other groups like Early European Farmers or Yamnaya brought ...
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Does mitochondrial eve have to exist?

Suppose we took all living humans and found the set of their mothers, mothers' mothers, etc. and then traced down as far as possible. Is there a logical reason that this tree has to converge to one '...
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What is the criterion for genetic similarity among siblings and humans in general?

I just started reading Blueprint by Robert Plomin. He makes some well-known statements about genetic similarity which we all have read somewhere but I would like to know what the criteria for genetic ...
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Inheritance percentiles

I am aware that the average DNA contribution from each grandparent is 25%, while the possible range is 0%-50%. I found a source citing 18%-32% as the "normal" range but this was undefined. I assume ...
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Why is male balding so common in comparison to female balding?

I have heard that over 30% of men will be bald by 30, and that 60% will be bald by 50. However, I hardly ever see a bald woman unless it is a story about a cancer survivor or someone going through ...

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