Questions tagged [human-genetics]

The scientific study of inheritance as it occurs specifically in human beings.

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Monophyly, paraphyly and polyphyly in humans

A monophyletic group is a group or organisms that consists of all the descendants of a common ancestor. Three examples: 1. Rosales (an angiosperm order) (it includes roses, hemp, apples, pears, elms, ...
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What percent of mucle growth is possible without steroids consumption?

I am interested to know, if someone does bodybuilding exercises with good rest, enough protein, high presure workout, etc, but without consuming any steroids, how much of muscle gorwth is possible for ...
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Genes associated with human female breast size

What are the genes associated with female breast size and natural variation thereof in human beings?
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Is this formula describing the loss of unfixed genes from a population accurate?

In the 1954 science fiction novel Search the Sky by Frederick Pohl and Cyril M. Kornbluth, a formula is featured that "quantitatively describes the loss of unfixed genes from a population". $$L_T=L_0 ...
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How exactly can a drug affecting squalene epoxidase affect the methylation cycle, necessitating the use of 5-MTHF?

I found a case report in which the authors say that Terbinafine might have possibly affected the methylation cycle in a patient, necessitating the prescription of 5-methylfolate to correct the ...
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Understanding ancestry testing mathematically

Forgive me if this question has been asked here before, because it is something which should be very easy to find, but I can't seem to find an answer no matter where I search. The question is simply ...
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56 views

What is meant by translational repression by an upstream open reading frame?

The NCBI report on the human huntingtin gene contains the following statement: “This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene ...
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Do mitochondrial haplotypes affect our physical or mental characteristics?

There are some studies that haplotypes may affect our intelligence or physical features. But do mitochondrial haplotypes have even close to as big a role to play as our genes in determining some of ...
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Do haplotypes have a role to play in the aggression of a human?

there are a couple research papers that connect haplotypes and aggressiveness in canines. Our genes, for example the MAOA gene in the X-chromosome, have also been shown to affect aggression. But can ...
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How many different DNA of different species are there in the DNA of modern humans?

According to this DNA of extinct human species Aboriginal Australians, Pacific Islanders carry DNA of unknown human species, research analysis suggests and according to this Neanderthal ...
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How much DNA can differ among different humans today?

According to this article, Australian aborigines carry unknown DNA Australian Aboriginal people carry the DNA of an unknown human relative. This made me wonder, is it known how much DNA can differ ...
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Why was light eyes selected for while non-myopia was not? [closed]

Assumption: Blue/green/grey (light) eyes in europeans were developed to see better at night in dark forests. Assumption: Myopia (nearsightedness) is to a large extent genetic. Given that these ...
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Examples of environmentally influenced gene-expression in humans?

In discussions of the relevant importance of genetic and environmental influences on the development of the individual, it's often stated that the genetic and environmental influences interact. An ...
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centiMorgan distribution among human chromosomes

Using the rough estimate of 7,000 centiMorgans in a human... Is there an estimate that breaks down this total by chromosome (including the sex chromosomes)? E.g., in the human karyotype, do ...
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KRAS gene and K-Ras Mutations

This question pertains to the KRAS wikipedia page, and I just want to double check and clarify my own understanding of how this mutation works in cancer. It states: K-Ras protein acts like a ...
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Genetic variance for a behavioural trait among human populations

From this article from The Guardian: We instinctively assume that differences in behaviour that are in fact due to culture must be linked to – even caused by – characteristics of appearance. That ...
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Is there a measure of human genetic variation, where human genetic variation can differ more than 1%?

According to this Neardenthal genetics The proportion of Neanderthal-inherited genetic material is about 1 to 4 percent[12] [later refined to 1.5 to 2.1 percent[11]] and is found in all non-...
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Quantifying the Genetic Basis of Complex Diseases

In general, there are 2 types of diseases for which we understand "causality" very well: Infectious disease, where there is some etiological agent that causes the disease and Monogenic genetic ...
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What is a gene transcript, how is it different from an allele?

Within human genetics, My current understanding of a transcript for a particular gene is that it's the exact nucleotide sequence and position of a particular instance of said gene in some individual. ...
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Genetic diversity from meeting an isolated tribe?

Assume we make contact to a tribe we did not know existed. We understand the value of genetic diversity for our species. And as we had no contact for a long time, we can assume that the tribe adds to ...
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DNA described somewhere?

This is not purely biological question but how do the companies making DNA analysis know what your DNA means? Is there some database describing human DNA? I watched some documents about DNA, gene ...
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What is the probability of an offspring sharing identical HLA typing as one of their parents?

DISCLAIMER: I have yet to thoroughly study HLA 100% to the bone, and hence I won't know everything about it at the back of the hand. Recently I came across this information on a San Francisco ...
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What is the fundamental difference between human genome and other genomes that makes human a self-conscious living organism?

DNA is considered to be the blueprint from which any organism can be created. DNA carries the genetic information to construct a living body. DNA carries genes which represents the information that is ...
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Way to analyze the functional relevance of human mutation in vivo

In the literature I „found“ a pointmutation in the protein coding sequence of an enzyme subunit to be a risk factor for a certain disease. It is not known whether the mutation leads to loss or gain ...
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Genetically speaking, are dogs exactly similar to humans and chimps both?

Richard Dawkins mentions in his book The Greatest Show on Earth that dogs are exactly similar to both humans and chimps. Supposing that a cell contains the genetic similarity between 2 species, he ...
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How do different genes on human genome express themselves?

It is said that human genome contains over twenty five thousand genes, How many of these (can) express themselves as an external or internal trait in human beings (for e.g. like eye-colors, hair ...
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DNA Inheritance- Math vs. Biology

After doing some statistical analysis of the raw math involved in DNA contributions, I would like to understand the scale of the biological factors. I know that 99% of the human genome is identical ...
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Inheritance percentiles

I am aware that the average DNA contribution from each grandparent is 25%, while the possible range is 0%-50%. I found a source citing 18%-32% as the "normal" range but this was undefined. I assume ...
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Chromosome size without heterochromatin

Im doing different analysis of the human chromosomes and diffent loci, however when using different databases, the heterochromatin structures are not part of the human genomes. I know that ...
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Does the 1:1 sex ratio at birth apply to every human pregnancy or is it a statistical average?

Are there genetic factors that biase the sex ratio of offsprings for each person but average to 1:1 for the entire human population, or does the 1:1 ratio apply to every single fertile person?
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What is a Singleton Variant

I'm reading a paper that on a population genetics study where they sequence a number of genomes. The study states that 101 Singleton Variants per individual where found. What does Singleton mean?
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What could humans do to “see” what dogs smell?

We're able to see a lot of things using computers that we can't see normally: yellow-green, UV light, X-rays, etc. What do we have that harnesses the ability to "see" what dogs smell (e.g., harnessing ...
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Why do I have 95% of chimpanzee's DNA, and only 2% of Neanderthal's DNA? [duplicate]

Excuse me if it is a question with a simply answer, but I don't understand these discoveries, looking a discrepancy from my unknowledge of genetics: I have 95% of Chimapanzee's DNA, and, I have [...
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Why is the GULO pseudo gene expressed in humans?

The GULO pseudo gene is being expressed in humans according to Genecards. Why is this still taking place after tens of millions of years since then gene lost the capacity to encode for a functional ...
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Why has reproduction evolved as a choice? [closed]

From an evolutionary perspective, the purpose of an organism is to pass along its genes through reproduction. However, as humans we have a choice if we want to reproduce or not. The good feeling from ...
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Figure out which is the risk allele from SNP in GWAS article

I do neuroimaging research, and am interested in dabbling in genetics. I am trying to create an anxiety risk profile score from several SNPs shown to correlate with measures of anxiety in past GWAS ...
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Is it possible to breed neanderthals through selective breeding?

I've heard most non-subsaharan africans have neanderthal DNA with it being more prevalent in northern regions, that sometimes 1-4% of the DNA has neanderthal origins. Speaking strictly ...
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Difference Junk DNA and Pseudogenes [duplicate]

1-Are Pseudogenes and Junk DNA both Non-Coding DNA or they are different entity? How much Pseudogenes & Junk DNA do we have respectively? 2-I read that Non-Coding DNA has functions, my question ...
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Is brachydactyly due to mutation?

I have this so called "clubbed thumbs"also known as brachydactyly. It is of D-type. I searched for it on internet and found that it is a dominant inherited disease. But to my surprise,none of my ...
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Can different cell lines of same type symbolise samples from different patients in ChIP-seq?

Can I simulate different patients by using different cell lines of the same cell type and from the same tissue? Can I also study apoptosis in an immortalised cell line? I have a gene X (transcription ...
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Is it tautological that all living humans descended from a single male and single female human ancestor?

Many popular science articles cite high sequence conservation of mitochondrial DNA and the Y chromosome among living people as evidence that all humans are descended from a single male and single ...
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Are chromosomal microdeletions passed on?

I've been looking around but can't find a clear answer: are chromosomal micro-deletions passed on (hereditary) or not?
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Replacing, instead of repairing, DNA

I've been doing some light reading on DNA damage theory of aging. One of the main ideas from that theory that I got is that the accumulation of damage in our DNA is one of the biggest causes of why we ...
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Rationale behind Most Recent Common Ancestor (MRCA)?

My main question is this - I heard Richard Dawkins say in a video that after 1000s of years, any given individual alive today will be either an ancestor to ALL of the humans (in that future time) or ...
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Do humans have enough biological differences to be grouped into races or subspecies?

After my online research on the subject, I learnt that, biologically speaking, many scientists believe that there is no such thing as a race. Homo sapiens as a species is only 200,000 years old, which ...
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How to determine if two mutations in a gene are on the same or different alleles?

I would like to know, except a familial study, is there another way to determine if a mutation/variation is cis or trans (i.e. on the same or different alleles)? For example by sequencing technique or ...
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What the “due to” means in the definition of heritability?

According to Wray and Visscher, heritability is formally defined as the proportion of phenotypic variation (VP) that is due to variation in genetic values (VG). My question is, what does “due to” ...
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Why are (some) human men sexually attracted to female breasts?

Many human men are sexually attracted to female breasts. Is there an evolutionary reason for this?
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What physical differences can be observed due to the inactivation of the X-chromosome in female monozygotic twins?

I'm doing research on twins, specifically on how to identify monozygotic twins and dizygotic twins by their physical appearance alone. Since I assume that the X-chromosome plays some part in the ...
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Gene frequency — database/site

Is there any free database when one can check the gene frequency in a healthy population? For example I would like to check it for genes like BIN1, CLU or CR1. On the English Wikipedia I found a gene ...

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