Questions tagged [human-genetics]

The scientific study of inheritance as it occurs specifically in human beings.

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Measuring genetic distance: $F_{ST}$ vs. Nei's distance

As far as I'm aware, Nei's genetic distance is quite old compared to $F_{ST}$. However, I have recently read more papers that utilized Nei's genetic distance alongside with $F_{ST}$. As I'm not very ...
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Fst genetic distance: Autosomal vs. mtDNA

As far as I'm aware, mtDNA is only inherited from the mother. Hence, if I compute Fst from autosomal SNPs, then I'll get the actual genetic distance between two human populations. If I compute the ...
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Why are there sporadic lightly pigmented hairs in facial hair?

My body and scalp hair are entirely black. Until recently, I thought this was the case with my facial hair also, until I noticed a small handful of hairs that were anywhere from light brown to copper-...
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The concept of high genetic load of disease and non-random segregation of deleterious variants

I'm new in this field. I was reading Shakeel et al. (2018) and came across the below sentences The rate of emergence and distribution of deleterious variants in populations is important in ...
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Biological validation of computationally determined gene-gene interaction

How can a computationally determined three-way gene interaction be biologically validated? What kind of assays or tests must be performed using cell/tissue-based and/or mouse models to prove that the ...
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1answer
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HLA typing between siblings to identify a genetic disorder

If a patient suffering from a complex array of signs and symptoms for a disease and is having an 8/8 loci match with his sister who suffers no such symptoms can you conclude that the disease is an X-...
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240 views

True examples of common variation due to Mendelian Inheritance

Classic examples of mendelian inheritance are genetic diseases such as sickle-cell anemia, Tay-Sachs, cystic fibrosis, and xeroderma pigmentosa. For some of these diseases, it is believed that they ...
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Did the chromosomal fusion within humans affect phenotypical change compared to the separated chromosomes in the other apes?

I just read this article on the evolutionary divergence between humans and chimps, and how the most significant event was when the 24 number of chromosomes in chimps was reduced to 23 in humans due to ...
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Appropriateness of PCA to visualize clusters in genetic data

In many genetic studies, PCA is often utilized to examine genetic cluster in human populations. Rarely is the % variance reported for the components. With human data it's been my experience that the ...
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Query regarding KEGG KGML pathway files

With respect to the the Wnt pathway in KEGG, the KGML file of this pathway has description of each interaction between a pair of genes. These interactions are designated in the form: ...
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Around what time did dark skin disappear from Europe?

As Europeans gradually became lighter skinned, there would have been people that still had dark skin. Around what time period did Europeans become completely light skinned?
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With respect to which METRIC is my DNA 99% similar to any other person's DNA? [duplicate]

I clarified my question, by editing the title. Using the comments and links below, I have answered it myself: The answer to my question is: The similarity is between 98.4%-99.9%, depending on which ...
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What metric(s) is a good proxy for relatedness?

In attempting to seed a simulation, where an individual foregoes resources that go r to same-type individuals and (1-r) to all members (including same-type individuals). What commonly used metrics ...
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Is cruelty a human instinct? [closed]

I had started studying human behaviour and human instincts a few months ago, earlier the question was raised after seeing human behaviour with animals (his prey). Animals hunt their prey for eating, ...
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How is it known that Homo sapiens and Homo neanderthalensis interbred?

Many recent articles maintain that a small percentages of Neanderthal genes (up to 2%) are found in modern non-African people. (I believe that currently there is insufficient genetic material from ...
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Can you do DNA seq with Microarray? [closed]

Is it possible to do the entire DNA sequencing with Microarray or would you have to use Sanger or NGS methods for that?
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Does human behaviour that is caused by inheritance depend on the environment and lifestyle in general?

Different breeds of common domesticated animals such as horses and dogs clearly show different behaviour, instincts, social relationships and similar, due to their biological inheritance. Still they ...
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How many possible human genotypes are there that produce distinct phenotypes?

This and this Quora question ask how many unique human genotypes are possible. The answers take the combinatorial approach of raising the 4 possible base pairs to a power which is some appreciable ...
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What is the chemical mechanism by which PcP(c) is converted to PcP(Sc) in Fatal Familial Insomnia

I know the gene PRNP and it's location. There’s a mutation at codon 178 (asparagine found instead of normal aspartic acid) on the prion protein gene (also found in fCJD) and more uniquely there is a ...
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Is there evidence for higher human genetic diversity prior to the alleged Toba Catastrophe genetic bottleneck?

I've been reading on the Toba Catastrophe theory and that it supposedly caused a genetic bottleneck in humans some 70k years ago, which raised a question that I couldn't find an answer to by searching ...
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Storage DNA Condition

It is possible to store a digestion of cells with lysis buffer several days at -20 degrees and then proceed with the phenol chloroform isoamyl purification?
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How should I interpret for example AA result, when SNPedia only has CC/CT/TT listed? [closed]

I don't know how to properly formulate this question because I'm new to this, so please edit this if you can... For example when I would check SNPedia for rs gene, it would have listed CC/CT/TT genes,...
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109 views

Twins reproducing with each other ( just hypothetical)

If 2 twins (look exactly the same and also the genes which control their morphology, behaviour etc. are same and present at the same locus) produce an offspring , will their offspring be exact copy of ...
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How can I verify my true genetic relationship with my close relatives with simple physical traits?

Question I don't know if it is ethical to ask a question like that, but I would like to know every simple physical trait that I can observe on me, my parents and my siblings which are regulated by a ...
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1answer
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Genetic modifications in humans to prevent disease [closed]

I was reading an article about "designer babies", which was about how before birth the DNA can be modified so to achieve certain features. Can a technique such as this also be used to prevent diseases,...
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Veritasium video about mosquitoes

In the recent veritasium video about mosquitoes , the host says that the researchers used identical female twins and fraternal female twins to understand the effect of genes on attractiveness to ...
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Understanding the genotype written in terms of two genes

I have some doubt in understanding the following genotypes: HCV-Tg/AID(+/+), HCV-Tg/AID(-/-) and HCV-Tg/AID(+/-), where HCV-Tg stands for "Hepatitis C Virus (HCV) core proteins" and AID for the gene "...
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310 views

Check on 23andme what type of CYP2D6 substrate metabolizer I am

CYP2D6 is responsible for the metabolism and elimination of approximately 25% of clinically used drugs. Which SNPs do I need to check on 23andme in order to determine if I'm a poor or ultrarapid ...
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201 views

Complete human rDNA sequence

I've been trying to retrieve the complete human rDNA sequence (non-spacers and spacers), which should be about 43-kb in length using Biomart, NCBI, and rnacentral, but I have only been able to find ...
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139 views

Pseudoautosomal regions of the X chromosome showing heterozgyosity

I've always had questions for myself about sex differentiation, mostly on account of an unusual history & puberty. I won't go into details, but needless to say it was unique. My question is... I ...
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Mechanism behind Philadelphia chromosome translocation?

I was reading up on causative factors of leukemia on medicinenet and I came across the following statement: ...an exchange between chromosomes 9 and 22 leads to what is known as the Philadelphia ...
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1answer
142 views

Subtracting shared DNA with half-sibling

I want to note that I am not a biologist. I've been on a nearly 20-year search for the identity of the parents of my 4th great grandfather (not an easy task.) I'm using ancestry.com DNA, GEDmatch, and ...
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Can telegony happen in humans like in Telostylinus angusticollis?

Is it possible for a human male to transmit features of his phenotype via non-genetic semen-borne factors to his mate's subsequent offspring sired by another male? As it happens in flies (Crean et al.,...
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Genetics… Translocation

Can a Translocation of chromosomal parts occur between an autosome and an allosome? If it occurs in between allosomes,what could be the effect of Robertsonian Translocation between an X and a Y ...
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Question on the concept of mitochondrial Eve [closed]

My question is about the very definition of this common ancestor. Why shouldn't be the mother of mitocondrial Eve the real Eva m (and so on to grand grand ...mother)? All I know on the subject comes ...
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Do DNA footprints vanish in generations?

Consider humans (or really any creature with sufficiently complex set of genes). If person $A_0$ has an offspring, say $A_1$, we can without a doubt find markers in $A_1$ that we can definitely say ...
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“50% of the variance in antisocial phenotypes is the result of genetic factors” means what?

How can i understand the following sentence: Overall, the conclusions reached by these studies have been highly consistent in showing that approximately 50% of the variance in antisocial phenotypes ...
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144 views

Is it possible to use virus for genetic modification of embryos during the fetus stage

I know this probably sounds rather hypothetical and not very feasible but I would very like an answer telling why it is possible or not possible and why. With the advancement of crispr and other dna ...
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Are genes known or at least conjectured to evolve cyclically ?

I observed recently that some people born the same year in not too distant areas (say, in the same country whose size is not too big, like France) share similar phenotypical features, for example they ...
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Are drug-gene interactions predictable? [closed]

I have been reading about drug-gene interactions and pharmacogenetic tests. I haven't been able to find many resources that define the process of testing for possible drug-gene interactions without ...
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125 views

What is the likelihood of a single human gene to the same gene from the other human?

The human genome comprises 3,234.83 Megabases and contains ~ 19,000 genes. It has been estimated that the genomes of humans are 99.9% identical. How likely is it that any single gene might vary from ...
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Name of human language related gene

I'd like to know the name of a gene with the following description of effects: Humans having two copies of this gene with a certain mutation aren't able to acquire human language, but otherwise their ...
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Human genetic diversity in Africa in comparison with the rest of the world

Background The claim ... Most of the genetic diversity in humans is in Africa ... is quite common. On Biology.SE, it is easy to find posts that make this claim. Consider for example: Do humans ...
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476 views

What is the structural/chemical difference leading to different shapes in facial/head/pubic hair?

Different hairs have different shapes, thicknesses, properties. What exactly is different between these types of hairs? a previous post implies that the root of the differing length (pun intended) ...
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954 views

Phenotype-Genotype for multi-hybrid crosses

It's generally easy to figure out genotype and phenotype frequencies using a Punnett square for monohybrid and Dihybrid crosses. But what about situations involving 5 or 6 traits? Is there a simpler ...
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DNA Analysis (AncestryDNA)

A recent1 AncestryDNA commercial highlights a customer who discovered that she was 26% Native American. Credit: ancestry.com/dna You can see the full commercial here. My question is, how can this ...
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Online resource for downloading gene variant data?

I have a long list of gene variations. For example, Here are 4 of them: CBL Q249E TERT H412Y SF3B1 R625H EGFR L747_T751delinsP The first term identifies the gene, the second identifies the ...
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Is genetic purging based on random shuffling of the genes of an individual or is it more intentional way of removing deleterious recessive alleles?

Inbreeding depression may be reduced by selection against deleterious alleles, which eliminates, or purges, them from the population. I have two questions: Is genetic purging based on random ...
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Is most of the human genome functionless “junk DNA”?

In January 2012, David Icke published a book (ISBN: 9780955997334) entitled “Remember where you are and where you come from” in which he challenged what he claimed to be the view of mainstream science ...
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How much variation in mutation rate in there in the human genome?

In humans, the average mutation rate is estimated to be around $2.5 \cdot 10^{-8}$ (Nachman and Crowell, 2000). Of course this mutation varies from sequence to sequence. Can you please give some ...

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