Questions tagged [human-genetics]

The scientific study of inheritance as it occurs specifically in human beings.

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Do all polygenic traits involve epistasis?

Consider the following statement All polygenic traits involve epistasis. I think its true because polygenic traits involve several genes interacting together to result in a certain phenotype and ...
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Commensalism with Virus bacteria [duplicate]

Why people die of infection from microorganism, when germs can keep breeding for longer if they dont kill host? Would not millions of years of evolution make germs evolve to not to kill human but feed ...
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Online phylogenetic tree of human lineages

I am looking for a source of information about the diversity of human lineages and their relationships. With a quick google search it is easy to find this type of tree A perfect online resource ...
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222 views

How to predict future generations from heritability

The heritability of human intelligence is estimated to be around 0.5. There are of course various estimates, some lower, some higher. But let's work with this value of 0.5 for the moment. I wanted ...
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Are MHC Proteins the Most Polymorphic Human Proteins Known?

There is a paragraph titled "MHC Proteins Are the Most Polymorphic Human Proteins Known" in the "Molecular Biology of the Cell" by Alberts et al. 6th ed. 2014. But someone has recently told me that ...
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How do we know Neanderthals DNA?

According to this article, a small amount of Neanderthal DNA was introduced into the modern human gene pool. How do biologists even know what the Neanderthals' DNA look like? The article doesn't ...
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Probability of number of boys and girls being born on a single day [closed]

I am new to genetics, I have the following question at hand : If four babies are born on a single day, what are the chances that $A>$ Number of boys and girls will be equal. $B>$ All $4$ will ...
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Do all tumors form the same way? [closed]

Do all tumors - both benign and malignant - form when proto-oncogenes and/or tumor suppressor genes experience mutations? Were all malignant tumors once benign?
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Are the human genes' promoters all known?

It seems to be a basic question, but I couldn't find a certain answer. The human genome is known for more than a decade, and is available through several data providers as the NCBI etc. For the genes'...
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How close genetically is the most human-like chimpanzee to the most chimp-like human?

I understand that: Chimpanzees are the closest species to humans genetically. Only 1%-6% of their genes are different. Within any species there is genetic diversity, i.e. no two individuals have the ...
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What´s the role or function of the homologous arms in a donor template in a knockout/knock edition via Crispr-cas9?

I have to make an exposition in my university about Crispr-cas9 edition and I have some questions about the method. In the knock out/knock in technique is used a plasmid containing the DNA that ...
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Are there any chromosomal/molecular difference in following human reproductive- traits? [closed]

Are there any chromosomal/molecular difference in 5 following human traits?Klinefelter-syndrome, Transgender, Bisexual, intersex, hermaphrodite. Are all 5 terms synonymous?
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how did we breed after the fusion ? and why can't we bread with chimps? [closed]

after the chromosome fusion happened to one of our ancestors, how did he breed ? if he was allowed to breed because the chromosomal differences were still not very big back then, why can donkey and ...
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Method to estimate age of a variant from genotype data

I will obtain array genotype data from approximately 60 related individuals who all share a rare pathogenic variant, which is at such a high frequency in the enlarged family due to a founder effect. ...
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Concept and analysis of Pedigree

Pedigree analysis is a process of establishing a virtually correct inheritance pattern of a genetic condition in a proband's family. I call it virtually correct because in many a cases we assume the ...
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1answer
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What's the determinant of the male-biased birth sex ratio in humans? [duplicate]

Will the baby be male or female? If it was a random biological switch then, with a huge sample number, the sex ratio at birth would be exactly 50-50. But it isn't; the ratio is about 51-49 in favour ...
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What is the probability of an XX female or XY male?

Homework question In genetics the chance of having a male or female is 50% for male and 50% for female. Using factorial method and Punnett Square prove or disprove the claim. My answer Using the ...
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Outbreeding depression in humans [duplicate]

Is there any evidence of outbreeding depression in human beings?
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Robertsonian translocation on the same chromosome

is there any big difference between Robert-son-i-an translocation between two 13 chromosomes comparing to a translocation between 13 and 14 chromosomes
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How Much DNA do Siblings whose Parents are First Cousins Share?

On average, two siblings generally share 50% of their genome. How much does this increase if the siblings' parents are first cousins?
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Is brachydactyly due to mutation?

I have this so called "clubbed thumbs"also known as brachydactyly. It is of D-type. I searched for it on internet and found that it is a dominant inherited disease. But to my surprise,none of my ...
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535 views

ExAC Browser: What does a “dubious variant annotation” mean? [closed]

I am studying a protein in the ExAC browser. However it is flagged with a "LoF flag". What exactly counts as a "dubious" variant in ExAC. I couldn't find any further information neither at the ...
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Why was the study of “Concordance of Monozygotic and Dizygotic twins for traits” designed in this way? [closed]

I am confused by the twin study 'Concordance of Monozygotic and Dizygotic twins for traits.' My questions arose from 3:17-4:17 of the video And this is the related data I have referred I have ...
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Hybridization of an Indo-Aryan ethnic group and a Tibeto-Burmese ethnic group

The state in which I reside houses these two distinct ethnic groups. Physical Traits of the Indo-Aryan group Height:Medium Eyes:does not posses epicanthic fold Nasal bones:is not flat and broad ...
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What percentage of a Neanderthal's DNA could be in a Denisovan?

My questions arose from an online course video at 3:11-19 The professor mentioned that the Neanderthals were inbred with their cousins breeding together but the Denisovans were very diverse , with 70%...
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How do heredity and regression to the mean work with respect to intelligence?

I am trying to understand the heredity of intelligence between generations in general, and how regression to the mean works in detail in particular. The answer I'm looking for should preferably answer ...
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Perplexing by the way of estimating the shared or different genes between humans and chimps

We share 98.5% genes with chimps (it means we have 98.5% same DNA sequeces ),so there is about one percent difference .It means we can approximately differ from them by one base pair every hundred ...
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How valid is the theory of human's chimp-pig origin? [closed]

Edit: I have also asked the question on skeptics.stackexchange.com and it has been answered there. Here is the link. There is a person called Dr. Eugene McCarthy who has a theory that the origin of ...
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How likely is it that a person's progeny has an inheritable disorder based on this pedigree?

Case study: A person (let's just call him "John") had 3 aunts that died back in the 1950's in early childhood due to an unknown form of neuromuscular disorder. One died at birth, one at 2 years and ...
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668 views

What are silent carrier traits? [closed]

I couldn't find a definition but I have come to know the following from google search: People who are carriers of a thalassemia gene show no thalassemia symptoms and might not know they're carriers....
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What are sex linked traits?

Which of the two definitions of sex-linked trait is correct? Traits controlled by genes present on the non-homologous region of sex chromosomes are called sex-...
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Links between Genetics and Personality Types

This topic was visited briefly in the thread, Genetic Effects on Personality, but I was surprised not to find more on it. (Is there a taboo I don't know about? What's the ethical stance on this ...
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autosomal recessive population numbers

This question is background research for a science fiction / fantasy novel, my knowledge of genetic is very basic. It seems obvious to me that for genetic disorders that are autosomal recessive, if ...
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135 views

How do harsh conditions cause an increase in the male birth ratio?

I've heard that in harsh conditions more human baby boys are born than girls because a bigger ratio of them will die before reproductive age. But in which aspects of the random gene combination while ...
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What is the difference between a human being, a Homo sapiens, and a Neanderthal?

I know that the Neanderthals were part of the genus Homo. How do they relate to other members of the genus, such as Homo sapiens?
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How big advantage had a trait have to bring to evolve in the human evolution? [closed]

Yes, I've heard that we have evolved from the common ancestor with primates as intesively, as the chimpanzees. Sometimes I read about some enormously complex traits, evolutionary psychologists think ...
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Infer gene frequency within a species over time

I was reading Karlsson et al. (2014) and I came into this: A selected variant that increases rapidly in frequency in the past ~250,000 years can be detected as an unusual reduction in genetic ...
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Runs of homozygosity - degree of inbreeding and disease associations

Been reading recently about methods to determine how inbred a particular person is by measuring their "runs of homozygosity." Loosly, these are defined as regions of the genome (typically >1Mb) where ...
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1answer
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Data on Gene Position in Human Genome

I am trying to get some data on gene position in the human genome and I need some help What I tried I downloaded ...
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1answer
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Data on Recombination rate and Gene Positions in Humans

I am looking for estimates of per base pair recombination rate in humans and indication on gene positions. The goal is to be a able to plot recombination rate in the y-axis and position (in bp) along ...
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When sperm and egg mix, are the genes rearranged? [closed]

I remember once my high school teacher said when the sperm fertilizes the egg the genes are mixed very randomly, is that true?
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Are males taller than females in humans?

Is there any scientific evidence that in humans males are taller than females? And if so, what is the reason that they are taller (please include genes or hormones that accounts for human growth and ...
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Molecules, Targets and Isoforms

I have a question. Given a molecule A and two isoforms of a gene X, Y, and the knowledge that A targets X. Can I infere from this anything about whether A targets Y? As a motivation think about ...
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Unwanted E. coli product in plasmid product

Using a TOPO XL Cloning kit, our lab took some amplified human DNA, inserted it into the vector, and attempted to clone it in E. coli. However, upon sequencing the purified plasmid product, the ...
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Is it common to have multiple recessive traits in humans?

I just started thinking about my phenotype and realized I got multiple recessive traits. I have attached ear lobes, my blood type is O-, I got green eyes (I think eye color in polygenic but still ...
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Why is down syndrome more common than other trisomies? [duplicate]

Why is Down syndrome more common than say trisomy 18? Is chromosome 21 easier to replicate? Or is it because those babies are more viable?
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Irradiation positive effect on humans?

In research paper Euphytica 135: 187–204, 2004 it is written that: 434 mutant varieties of rice have been released with improved characters such as semi-dwarf height, early maturity, improved ...
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What is positive and negative supercoiling?

Is the following correct? Positive supercoiling = the coiling of DNA helix (B-DNA) on itself during intesified coiling of the two DNA stands in right handed direction negative supercoiling = the ...
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Basic Genotyping

As a disclaimer, I'm from a computer science / statistics background, working on some bioinformatics problems. I've got some genotyping data (VCF from Exome Sequencing), and I'm struggling to get my ...
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What causes the range of severity of neurological deficits in Down's syndrome?

It's known that the severity of symptoms caused by a trisomy 21 varies from individual to individual. Part of the explanation for this range of severity is the finding that 94% of Down's syndrome ...

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