Questions tagged [human-genome]

The 23 chromosome pairs, made up of 3 billion base-pairs, 22 chromosomes of which are autosomal and one which is an allosome, or sex chromosome.

Filter by
Sorted by
Tagged with
0
votes
1answer
39 views

Why is the amount of protein variants in a human genome higher than gene variants?

Why does the human genome have more protein variants than gene variants? Is this because of PTMs?
2
votes
1answer
96 views

What advantages could there be for using the unseen variant chosen by He Jiankui instead of the naturally occurring CCR5-∆ 32 mutation?

Jennifer Doudna mentioned in https://youtu.be/9Yblg9wDHZA?t=2566 on 2019-02-21 that He Jiankui introduced an unseen variant of the CCR5 gene when gene editing the twin humans Lulu and Nana. What ...
4
votes
0answers
85 views

What percentage of the human genome hasn't been sequenced yet? If percentage estimates aren't precise, why is it difficult to estimate?

What percentage of the human genome hasn't been sequenced yet? I have read different estimates, e.g.: https://www.genome.gov/human-genome-project/Completion-FAQ (mirror): "In the April 2003 version, ...
1
vote
1answer
76 views

If some humans inherited 3% of Neanderthal DNA, why are we 99.9% same genome? [duplicate]

Many sources say that humans are 99.5 to 99.9 percent the same. Also some sources state that some humans have 3.4% Neanderthal DNA and some don't share those genes. Why is that?
0
votes
0answers
65 views

Why do genetic testing companies (FTDNA,AncestryDNA,23andme) express DNA shared in centimorgans (cM) instead of in number of base pairs or in percent?

Expressing DNA shared in number of base pairs or in percent of total genome would be so much simpler and easier to understand for the customers. .
0
votes
1answer
78 views

Are viruses ever manufactured directly from viral DNA embedded in the genome?

Some viruses can cause their genetic material to be pemanently stored in the human genome -- even getting passed on to offspring. Endogenous Retroviruses, for example are thought to make up between 5~...
1
vote
1answer
81 views

What's the longest intron in the human genome?

What's the longest intron in the human genome? Discarding isoforms were a long intron spans more than one exon, i.e. what's the longest distance between two exons without another exons in between.
1
vote
1answer
47 views

Balancing selection vs introgression?

Balancing selection can maintain polymorphisms in natural populations for extended periods of evolutionary time. However, in this paper, Dannemann et al. 2016 identify three archaic haplotypes in the ...
9
votes
2answers
153 views

What are the potential dangers (if any) facing the twin girls recently born in China with their CCR5 gene modified?

According to this Nature news article, a Chinese researcher claims to have made the world's first genome-edited baby using the popular CRISPR–Cas9 genome-editing tool. A gene called CCR5 was modified ...
-2
votes
1answer
77 views

Basic questions about human genome project [closed]

The "human genome" was sequenced by the Human Genome Project around 2000. But I don't understand what was done and what its significance is. Questions: Wasn't a single person's genome sequenced? I....
0
votes
1answer
115 views

Can a plasmid cause cancer? [closed]

Can a plasmid cause cancer? According to wikipedia, plasmids are normally present in bacteria They (plasmids) are normally present in bacteria , and sometimes in eukaryotic organisms such as yeast [...
1
vote
0answers
33 views

What percentage of a complete Denisovan genomes lives on in the union of the sets of overlapping pieces in extant humans

In studies like this one mapping out distributions around the world or the analysis described in this article (suggesting a contribution from a non-Denisovan but Denisovan-like unidentified hominin to ...
0
votes
0answers
70 views

How our body produce different T-cells?

I've heard in many documents said that : There are 25 million to a billion different T-cells in your body. Each cell has a unique T-cell receptor that can fit with only one kind of antigen - ...
4
votes
1answer
61 views

Is it safe to publish a person's genome? [closed]

I recently went through the process of having my genome analyzed by 23andme, and received my raw data. Its very interesting to me, and I want to share it with the world. Is it safe to publish the ...
1
vote
1answer
1k views

What is the relationship between DNA molecules and the chromosomes? [closed]

Regarding the human genome, if the DNA molecule is two continuous strands, with each gene occupying a segment in it, and there are 46 chromosomes each with some genes, where is the physical boundary ...
1
vote
1answer
41 views

HAR1 speedy mutation

From wiki: Human accelerated region 1 (HAR1) is a segment of the human genome found on the long arm of chromosome 20. It is a Human accelerated region. [..] These 49 regions represent parts of the ...
1
vote
3answers
331 views

If a DNA letter is one of A,T,C and G, and there are 3 billion base pairs, why don't we say that there are 6 billion letters in the genome?

A DNA letter is either one of A,T,C or G. Human genome is supposed to have 3 billion base pairs coming from each parent. But these are pairs - a combination of A-T or C-G. So, doesn't that make the ...
0
votes
1answer
181 views

haplotype data for 1000 Genomes

I need to get haplotype data for HapMap or 1000 Genomes for CEU, MKK, TSI, CHB and JPT for ± 1 Mb at LCT gene. I'm quite new in the area. Actually I don't know the meaning of "± 1 Mb". From which ...
2
votes
2answers
287 views

What does chrUn mean in the output from a Bowtie run on human sequences?

After having performed an alignment using bowtie2 and GRCh38 as a reference sequence, I got inusual matches on chrUn. Here a small part of the SAM file: ...
4
votes
1answer
4k views

Are SNPs and alleles the same thing?

It seems to be quite difficult to find an answer to this. Are SNPs the same thing as alleles?
2
votes
0answers
281 views

What is Genome Folding?

Why does genome folding have such great interest? For protein folding I could say that's important because protein's functionality closely depends on its folded state, since it affects its ...
2
votes
1answer
106 views

What sequences are between adjacent genes?

The human genome has a lot of non-coding regions, which include regulatory elements, repetitive DNA, and introns. Suppose there are two adjacent genes on a chromosome, and their positions on the ...
4
votes
3answers
2k views

SNPs in the Human Genome

I have read online that they have found around 10 million SNPs in the human genome [1]. I was wondering how many SNPs there are in a single person on average, I could not find any well-found evidence ...
10
votes
2answers
1k views

Why does human chromosome 19 have the second highest number of protein-coding genes?

While chromosome 19 only is the 19th largest autosomal chromosome, it contains 1440 protein-coding genes, and thus has the second highest number of protein-coding genes of any human chromosome. For ...
2
votes
1answer
1k views

How Much DNA do Siblings whose Parents are First Cousins Share?

On average, two siblings generally share 50% of their genome. How much does this increase if the siblings' parents are first cousins?
2
votes
1answer
113 views

Dnase data for GRCh38

This question below turned to be completely faulty. I don't have to do anything with DNase data for GRCh38. I asked it because of the file count difference between hg38 and hg37, which I thought to be ...
2
votes
1answer
122 views

How two genomes adopt when cell goes to recipient's body from donor's body?

We often give blood to another following the blood giving compatibility chart. Heart transplant and similar transplants also brings one's cell to another's body. My curiosity is, when a cell goes to ...
0
votes
2answers
456 views

What physical traits are derived from the Neanderthal DNA in human DNA?

Some researches had found that Human DNA has a bit of Neanderthal DNA. So they suggested there would have been crossing between Homo sapiens and Neanderthals. Now the Neanderthal looked a bit ...
2
votes
1answer
190 views

Does GC content determine codon bias or does codon bias determine GC content

I was wondering if someone knows the answer to this quenstion, because I can't find a clear answer, maybe there isn't a clear answer :). question Which of these two is right? or maybe both influence ...
0
votes
1answer
81 views

No. of genes in chromosomes. phenotype

Why do cells need all the genes of all the 22 pairs (excluding the 2 X- or Y-chromosomes) of autosomes in every somatic cell, when each and every cell which is specialised for its function does not ...
1
vote
1answer
80 views

What's the difference between CREs and DHSs?

I would like to know what's the difference between cis-regulating elements and DNase I–hypersensitive sites, in order to produce a meaningful segregation of non coding elements affecting gene ...
6
votes
1answer
987 views

In percentage, how much is the human genome (DNA) similar to the mouse genome?

Some guy argued with me against evolution theory, and he claimed that human and mice share 98% just like human and chimpanzee. I've tried to search online for a simple and accurate answer, but I ...
0
votes
1answer
51 views

Where can I find a file listing the genetic differences in humans?

I don't know much about genetics. For an arts project I'm looking for a human genome. I read that: Only about 0.1% of the genome is different among individuals, which equates to about 3 million ...
2
votes
1answer
5k views

Why are the genomes of Humans 99.5% the same?

Human's DNA sequence is said to be roughly 99.5% equal. As far as I understand, this means that if I walked up to you and compared our DNA, the sequence of base pairs would be 99.5% the same. My ...
1
vote
0answers
82 views

Insertion of synthetic DNA sequence

If I have some synthetic DNA sequence (<=20 bp long), is there a way for me to reliably insert this sequence next to some n-bp motif? I'd like for this to be possible in humans. If so, are there ...
0
votes
1answer
211 views

why dna polymerase 3 requires a primer for replication [duplicate]

Why DNA polymerase 3 needs a primer to star replication.And whats happens when there is no AUG sequence on entire DNA.
1
vote
0answers
46 views

Will someone with a double mutation in the allosomes be normal?

Normally a female human has an X allosome from her father and an X allosome form her mother. What if an double mutation happened, which causes that someone has two X allosomes form her mother and no ...
8
votes
3answers
8k views

What is the strand specificity of a reference genome?

It's a simple question but I've come across many people who have this question, is the reference genome Positive of Negative strand? Indeed, I've had heated arguments over the same issue. So here's ...
0
votes
1answer
84 views

Similarity between the human genome and archea genome in deep sea hydrothermal vents?

I'm trying to find some reference that shows what percentage of the human genome is similar to some organism from the domain Archea that lives near or on deep sea hydrothermal vents. Can someone ...
2
votes
1answer
144 views

Markers for human genetic mapping

For human genetic mapping several different types of markers are used: RFLPs (Restriction Fragment Length Polymorphisms) VNTRs (Variable Number of Tandem Repeats) such as mini- and microsatellites ...
15
votes
3answers
2k views

Why reference genome is a reference?

I have heard that a reference genome such as humans is generated by randomly choosing samples from a group of donors. But why do we call the DNA sequence generated as a reference? Why should we ...
6
votes
2answers
216 views

How would you effect bulk DNA gene therapy for a human?

Let's imagine that we understood DNA programming and our genome very well and realized that there were some significant flaws (we die, we need sleep, etc.) And let's imagine that we understand how to ...
2
votes
0answers
104 views

Are the Chromosomes organized in any meaningful way? [closed]

So my major is in pharmacy but both my master and my (currently in progress) doctoral degree are both in theoretical chemistry. My thesis is about quantum chemistry and proteins, but it has a certain ...
8
votes
1answer
1k views

Number of transcription factor genes in the human genome

What is the number of the transcription factor genes present in the human genome? Does this value differ compared to Mus musculus, Drosophila melanogaster, Arabidopsis thaliana, C. elegans and S. ...
0
votes
2answers
251 views

Chromatids in metaphase?

Please see the following picture: In my book, the author claims that these chromosomes are in metaphase (a metaphase stopped by cholchicin). I don't understand why they don't have two chromatids...A ...
6
votes
2answers
1k views

Is there a known minimal stretch of DNA that can distinguish any two people in the world?

I imagine this could be used as a universal Identifier.
4
votes
0answers
166 views

Is there a more updated version of the book “Genome?” [closed]

I read the book Genome by Matt Ridley for my AP biology course. I found it fascinating, although it seems another book must have been written on the topic since 1999. Anything you can recommend?
6
votes
2answers
176 views

Turning publicly available genome data into proteins

I'm a computer scientist who is starting to dabble with biology. My eventual goal is to model different kinds of cells with a computer program. As of right now, I'm just trying to take some smaller ...
5
votes
3answers
7k views

How many recombination events are there per generation in humans?

I'm looking for a reference that tells me how many recombenation events occur in humans from one generation to the next. Assuming that the human genome is a 3.3 GigaBases long DNA sequence, how many ...
5
votes
3answers
1k views

How do you merge SNP data with a reference genome?

My Data I have a 23andMe file listing SNPs in the form: ...