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Questions tagged [immunology]

The study of the immune system in organisms, primarily responsible for fighting infection.

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Is autoimmune disease associated with self-reactive B cells?

I'm a bit of an amateur, so excuse what may be a very naive question, but I somewhat understand how B cells that are self-reactive (bind to endogenous epitopes) are selected out during development. I ...
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How are primary monoclonal antibodies for screening mutant cells made, physically?

I'm working with a fairly common protein expressed in a large numbers of organisms, let's say a keratin-associated beta-protein. I'm trying to develop a process which requires primary-secondary ...
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Can MHC class I be used for presenting peptides of extracellular origin by non-professional APCs?

Wikipedia says that: "The antigens presented by MHC class II are derived from extracellular proteins (not cytosolic as in MHC class I)." So does this mean that MHC class I cannot be used for ...
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Which cells are prefered by the HIV virus to establish an infection?

We always read that HIV infects CD4 cells, macrophages, and dendritic cells. However, is it a common event for HIV to infect non-immune cells within a host? If not, why? And also if not, why are ...
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If a bacterium had a protein on its surface that humans also have, would it cause an autoimmune disease?

Suppose that a bacterium happened to have a protein on its surface. This protein can also be found in the human body. If this bacterium were to then infect a human with an otherwise normal immune ...
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Does eosinophil-derived neurotoxin attack the helminth nervous system?

I had always assumed that EDN's purpose was to attack the nervous systems of helminths and similar multicellular parasitic organisms, given the function of eosinophils. The enzyme was named due to its ...
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Question on compatibility of blood groups [duplicate]

How come a person with blood group O can donate to a person with blood group AB? Since there are A and B antibodies in the O blood group blood surely this would cause agglutination in the blood of the ...
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Do memory B cells communicate?

How do memory cells(B-cells) encounter pathogens? This question talks about how most of the memory B cells reside in the spleen and that upon a reinfection, produce antibodies which then circulate ...
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Will new proteins incorporating new amino acids trigger an immune response?

This article reported that scientists have succeeded in adding two new bases to the quartet of A, C, G and T, resulting in non-canonical amino acid. Additionally, the bacteria in which this was done ...
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Why proximal muscle weakness is seen earlier than distal muscle weakness in Dermatomyositis?

It is said that in dermatomyositis(DM) , proximal muscle weakness is seen earlier than distal muscle weakness. It is also said that , DM is due to damage to small blood vessels contributing to muscle ...
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Could bone marrow transplants be used to prevent tissue rejection of trans-species organs?

So the immune system doesn't calibrate (for want of a better euphemism) to recognize it's own cells until fairly well along in fetal development & the major components of the immune system (...
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Antigen molecular mimicry

Let us consider a situation in which the body is attacked by a microbe, and the microbe is captured by the immune system for recognition of surface antigens. The surface antigen recognized mimics one ...
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Why is there such a large evening rise of temperature and night sweats in certain diseases like TB, lymphoma etc?

I've heard that it's got to do something with the levels of cortisol which usually dampens the effects of IL-1, but when it's night time the cortisol levels are usually low so IL-1 response is ...
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Fever vs Inflammation

What's the difference between inflammation and fever? And why is fever called an inflammatory response? Does the word inflammation have both a general and a specific meaning?
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Why doesn't our immune system react to infused antibodies produced in a horse?

Calmette tried injecting horses with snake venom and then taking out the serum which has produced antibodies against the venom and injecting in the snake-bitten human. Shouldn't our immune system ...
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Why does the HLA show a high degree of polymorphism?

I know how the HLA undergoes high degree of polymorphism (random genetic rearrangements), but I have not understood why it undergoes rearrangements. What is the advantage offered when HLA shows a high ...
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What is the benefit of reducing inflammation when producing antibodies?

We just learned in lecture that IL-10 promotes the formation of plasma cells over memory cells. Which seemed strange to me as IL-10 also reduces inflammation, and I figure you would want inflammation ...
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Can people with AIDS/HIV be vaccinated?

If there is no immune system,it seems like vaccines wouldn't do much since there is no adaptive immune system to develop antibodies and memory cells. But can people with AIDS/HIV still be vaccinated? ...
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How do opportunistic infections affect an immunocompromised or AIDS patient?

I mean, everyone knows that AIDS patients don't die of the HIV infection, rather the opportunistic infections. But if HIV only affects T lymphocytes, and destroys them, then that means only cell ...
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What's the difference between a lymphocyte and a plasma cell?

According to my understanding, lymphocytes is the broad terminology for both T lymphocytes as well as B lymphocytes, while plasma cells refers to mature B cells which produce antibodies. But then why ...
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Common english name for tissues which are separated from the blood by blood-tissue barriers

Which general term is used to denote such organs/tissues as: brain, testis, thymus etc., which are separated from the blood by blood-tissue barriers?
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What do phagocytes secrete? [closed]

What do phagocytes release after interacting with a pathogen? I know that this is a broad topic but I only need a general and concise answer.😊
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White blood cells after dealing with an infection

I just have a quick question. If there was an infection of a tissue within the body, white blood cells would leave the capillaries around the tissue and enter the tissues to help cure the infection. ...
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Cross-species infections

I’ve heard that HIV developed from SIV, etc. I’ve also heard that most species (including most monkeys) can’t get a common cold like humans. So then what causes infections to be able to travel ...
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T-Cell Motility: does motility require direction specific actin polymerization?

T-cells have been shown to migrate inside concentration gradients - both in the direction of the source or away. Even under shallow gradients, t-cells move. I argue that, to be able to move in a ...
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Why do the host cells containing iC3b fragment not undergo phagocytosis?

As far as I understand, in complement system C3b gets deposited on pathogen surface but it can also be deposited on host cells. Host cells have some negative regulatory system such as membrane ...
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Allergy desensitization: what is the mechanism? Could it happen with other immune responses? [closed]

Allergy is a type of immune response against an otherwise harmless substance. If I understand it well, the aim of allergy immunotherapy is not to stimulate an immune response like the immunotherapy ...
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Infant immunization

I know that polio vaccine consists of small dose of polio virus itself, which activates body's immunity against the disease. An infant is given a no of vaccines including chickenpox, tetanus, ...
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Is it logical for someone to be allergic to the water molecule, but be perfectly fine with drinking milk since it's only 87% water molecules? [closed]

Recently this article got into the tabloids. The comments were disabled very quickly. Strange. The authos says she has Aquagenic Urticaria but it is a skin condition not an allergy, and hence wouldn'...
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Why do neutrophils need to die after pathogen phagocytosis?

From referenced article below, neutrophils need to be removed because its granule contents and oxygen metabolites (used for killing phagocytosed pathogen) are harmful to the surrounding tissue. Thus, ...
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Are cloned spieces significantly more vulnereble to deseases than sexually reproducing species?

I would like to be able to compare the risk for species to go extinct implied by their reproduction mechanism in the very short term. Imagine we choose some species A that can reproduce both sexually ...
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1answer
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Why reaginic antibodies are absent in these types of syphilis?

According to Textbook of Microbiology and Immunology 2e, Subhash Chandra Parija, pg.no; 375 These(reaginic) antibodies do not appear in early primary syphilis, latent acquired syphilis of long ...
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Purpose of Fc Region

Could someone explain to me the role played by the Fc region of an antibody as well as the purpose of isotype switching? According to Wikipedia, it's to allow the antibody to be usable by different Fc ...
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Why exactly does the immune system weaken with age?

Why does the immune system become weaker with age in humans and in some other mammals? Let's try to be more specific than just "everything degrades with age."
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Could the Immune Gene HLA-B27 be gentically altered, snipped, switched off, replaced, edited within the body

Could the Immune Gene HLA-B27 be genetically altered, snipped, switched off, replaced, edited within the body.? Thousands upon thousands suffer immune disease as do I from this highly implicated gene....
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B cell clones and affinity maturation

As B-cells undergo affinity maturation, their BCR sequences change. Are they still considered to be part of the same clone? I couldn't find a clear answer in response to this very similar question: ...
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Animals as organ donors and organ's life expectancy

Recent attempts to find reliable organ donors was using genetically-engineered (GE) pigs as heart donors. The pig's DNA is altered so that its tissues will appear identical to the patient's tissue and ...
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Exactly what biochemical factors control the intensity of an allergic reaction?

I think have a functional understanding of how an allergic reaction (Type I Hyper Sensitivity) occurs: basically the allergen causes production of antibodies that attach to mast cells and basophils. ...
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Europeans succumbing to diseases they introduced to native Americans

I am reading a non-fiction account of Spanish first contact with native Americans. The Spaniards were shipwrecked, undernourished, malnourished, and dehydrated upon their arrival. Over 75% of them ...
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Why aren't all infections immune-system resistant?

It's been less than a century since the widespread use of antibotics started, and already we're seeing bacteria that have evolved immunities to the antibotics we use. On the other hand, we've been ...
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Why there are no RBCs in lymphatic vessels?

I know the following. Leukocytes (white blood cells) are made in the bone marrow, and naive leukocytes go to the blood vessels. So, leukocytes mainly exist in blood vessels. Endothelial cells ...
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Why do alpha-gal allergies only occur after a tick bite if alpha-gal is already present in red meat?

I just read an NPR article about allergies to red meat being caused by tick bites. That stood out to me because I thought allergies are triggered by an initial exposure to some allergen. In this case, ...
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Can immunity to diseases vary by populations?

A common explanation for the massive population decreases of isolated societies upon contact with Europeans during the Age of Discovery is that the natives lacked immunity to newly introduced diseases....
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B -Cell activation by helper T cell

When Dendritic cell travels to nearby lymph node with antigen presented on MHC II molecule, the helper T-cell residing there gets activated. But what happens to B- cell residing there? Does it get ...
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Maternal immunity without prenatal vaccination?

It is recognized that antibodies from the mother provide a level of protection to infants. This is why mothers are often advised to get vaccinated when they're pregnant. However, does the vaccine have ...
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Immune System - B-cell receptors

How do the B-cells, which are a part of our body, develop antibodies against antigens of outside world (outside of our body), which they don't even know about? Is it just a random match?
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Isolation of Intact Granules from Mast Cells

How to isolate intact granules from mast cells without using sucrose and percoll?
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how can I get stronger staining for my lymph node sections

I am using the same protocol and same antibodies that the literature says but still I cannot get good staining for my lymph node sections, I tried to change the fixation method and I am using now ...
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If an antiserum was raised in a buffalo by injecting it with monkey red blood cells, what would be the full name for this antiserum?

Im confused, i've attempted this & what i got is buffalo anti-monkey red blood cell antiserum. I'm not sure if this answer is right
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Regarding Passive Aritficial Immunity: Why does the concentration of the foreign antibodies decrease over time?

So, like suggested in question, I am extremely confused about this one concept. That whether or not the injection of foreign antibodies ( passive artificial immunity ) triggers an immune response. ...