Questions tagged [immunology]

The study of the immune system in organisms, primarily responsible for fighting infection.

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Cell-autonomous viral defense involving oxidative burst?

I'm looking for a mechanism by which a cell detects a virus (probably a retrovirus) within itself, then triggers an oxidative burst in response. This should all happen within the cell itself, ...
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What would happen if you swallowed a big lump of viruses ? Help in adding viruses to an evolutionary artificial life simulation [closed]

I'm working on an artificial life simulation and have been working on adding viruses to the ecosystem. I'm aware it's not going to be "realistic" in many ways, but I'm trying to get some ...
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What can cause white blood cell malformations in humans? Diseases, illnesses, medicines? [closed]

A recent blood test showed that my white blood cells were malformed. Never heard of that before.
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How do animals contain and dispose of bacterial endotoxins (lipopolysaccharides)?

Gram negative bacteria naturally release endotoxins which are lipopolysaccharide molecules. These molecules are toxic to many eukaryote cells, including macrophages. My question is how animal ...
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Why is there no herd immunity against common cold coronaviruses?

In discussions of herd immunity against SARS-CoV-2 the underlying assumption usually appears to be that the virus basically stops spreading once a sufficient percentage of the population has overcome ...
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RSV infection even after vaccination

why certain persons have RSV infection after vaccination
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Do person with strong immune system have less chance of surviving SARS-COV-2 attack?

In most of the cases dealing with SARS-COV-2 disease, the major mortality cause is due to cytokine storm in response to Corona-virus that also attack healthy organs causing multiple organ failure. ...
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Examining antibody - target interactions in PyMOL

I'm a student currently looking at antibody responses against a viral target protein of interest. I have my own, annotated PyMOL session of my protein and I also have .pdbs of crystallised antibody ...
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Can intracellular protein initiate strong immune response?

Some autoantibodies escape immune tolerance and can cause autoimmune disease. In order to cause harm to the tissues by these autoantibodies, do the antigen need to be extracellular or membrane bound, ...
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Can the innate immune system defeat a pathogen by itself? Fast enough that we don't develop antibodies, etc.?

Would we have any way of knowing if our innate immune system destroyed a pathogen without involving the adaptive? Could a symptomless person who tests positive for COVID-19 with the RNA test, e.g., ...
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Why are antibodies Y-shaped?

I generally know how antibodies work by binding to antigens, but what is the specific purpose to being Y-shaped, as opposed to any other shape? Does this aid their function? Thank you.
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How is minimum infectious dose defined?

I'm a bit confused by the concept of a minimum infectious dose (MID). It seems from what my research so far has turned up, that while any dose greater than 0 could potentially cause an infection, for ...
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Why do viruses cause different symptoms?

If the sole purpose of a virus is to hijack the nucleus of a cell to replicate, why do we have different symptoms for different viruses? I can think of the following comming into play: immune ...
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What is the protein composition of complete Freund's adjuvant?

The complete form of this adjuvant uses heat inactivated and dried mycobacteria. However, to rule out cross-reactivity with an antibody, I would like to know which proteins are left in the adjuvant. ...
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How do PARPs counteract coronaviruses?

I read that [SARS-CoV-2 has] a nonstructural protein called NSP3, a component of which blocks the host’s efforts to fight off the virus. In particular, this protein shuts down host enzymes called ...
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Is it still true that C. elegans has no known natural viruses?

I read in a 2009 review that While mammals and C. elegans each have a single Dicer that makes both miRNAs and siRNAs, Drosophila has two Dicers: Dcr-1 makes miRNAs, whereas Dcr-2 is specialized for ...
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Reasons why this protein is not suitable as an immunogen?

In a paper entitled "Progress and Prospects on Vaccine Development against SARS-CoV-2", the authors write the following in section 2.5: "Compared with S, N, and M protein, E protein is not suitable ...
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Which hormones, metabolites, or other molecules build up as the day progresses, other than melatonin and adenosine?

Melatonin and adenosine reach peak levels around midnight/bedtime. I was wondering what other molecules also buildup as the day progresses. Particularly molecules that affect the CNS and/or immune ...
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How antibodies are produced in our body against intracellular proteins of infectious bacteria?

When an infectious agent invades our body, then surface antigens of the infectious agent are detected by our immune system and B-cells get activated. However, we do have antibodies in our blood ...
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How come certain antibody lateral flow assays show positive results at different dilutions?

I acquired two antibody lateral flow assays that purported to have the same sensitivity. I acquired NP antibodies and tested against them to validate they were not fake. My testing protocol involved ...
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Why do antibody tests target different antibodies?

I've noticed in various COVID-19 lateral flow assays, they seem to target different antibodies (S1, S2, NP). What are the benefits or downsides of choosing different antibodies? I know that some have ...
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Markers of lung microvascular endothelial sub-populations and lung smooth muscles?

Can someone please help me with information where I can find a publication on the distribution of various markers on lung endothelial cell sub-populations and lung smooth muscle cells? Particularly ...
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Are B-cell-Ab selected according to their true efficiency towards viruses & infected cells?

Assume that (during the first week of Covid) the lymphoid organ produced two dozens of high affinity B-cell-antibodies for the same number of epitopes on the viral proteins (after numerous rounds of ...
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T-cell “exhaustion” in patients with Covid-19

Following up on my previously asked question, which asks how COVID infects T-cells in immune system. Here's a study that shows that recovered covid patients have "exausted t-cells". To quote: T ...
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Why is untreated trypanosomiasis invariably fatal in humans?

If left untreated, African trypanosomiasis will invariably kill the patient. The human immune system is unable to clear the infection. I am aware of a few other infectious diseases with this property ...
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Is it possible for virus infected cells to continue to present a self-antigen on the MHC1?

Forgive my ignorance, as I'm new to immunology, however it seems like there would be some amount of positive selective pressure for viruses to develop the ability to continue to present the host's ...
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Why doesn't infection with Clostridium Tetani immunize you?

What Immunity to COVID-19 Really Means - Scientific American It is less clear what those antibody tests mean for real life, however, because immunity functions on a continuum. With some pathogens, ...
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What determines if a small protein / large peptide is immunogenic?

I'm wondering if there is some threshold in size or a specific structural property that determines if a small protein or large peptide would cause an immune reaction. Context: there are a number of ...
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How to prepare bacterin using formalin(formaldehyde)

I am finding how much formalin I have to use to make bacterins for vaccine experiments. I searched for it in google but I can't find about specific procedures like the concentration of formalin and ...
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Making new antibodies

Is there a model of how the B-cell-antibody pool in the lymphoid organ evolves during the first two weeks of infection by a new virus ? With a model I mean something like this At first we have $10^...
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Why hasnt been developed yet a COVID-19 vaccine? [duplicate]

I'm a complete noob when it comes to biology, but as far as I remember from my biology class, a vaccine is just a the viruses itself but in small amounts so that the immune system creates memory cells....
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What are the difficulties/challenges against developing a coronavirus vaccine?

Multiple groups of scientists are trying to develop a coronavirus vaccine but they are not yet being fruitful. What challenges or difficulties are there in the process that slowing down and/or causing ...
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How does the immune system distinguish between a TH1 and a TH2 response?

Hello and thanks for taking the time to read my post. I know that naive T-Cells (T0) can be induced to become mature T-Helper cells (TH1 or TH2) by induction with either IL2 or IL4. IL2+ TH0 -> TH1 ...
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If every person between 15-60 had an immune system equal to the healthiest people, would this affect the spread of coronavirus? [closed]

Has anyone calculated the speed or breadth of the spread of something like coronavirus (or any cold, flu, airborne pathogen) based on how well the population can master the virus with their immune ...
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How are antibodies specific for a disease detected in the blood if everybody produces a different antibody for the same antigen?

To break the title down into parts: There exist serology tests that detect the amount of an antibody (Ab) against a specific pathogen/antigen. Every human produces their own Ab for a specific ...
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How are B cells activated

I am currently an A-level biology student — what I understand is: B cells can either be independent of T cells or dependent on T cells for activation. The ones which are dependent on T cells ...
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Why do only some viruses cause a fever?

A fever is supposed to be one of the body's defense mechanisms against a virus. Raising body temperature can kill some viruses. So why isn't this response seen for all viruses, but just a few?
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If the covid-19 appeared once, could it reappear anytime?

Governments are imposing confinement measures on their populations, trusting that if there is no more transmission the virus will die out. But since this coronavirus appeared a first time, what could ...
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What differentiates diseases like Covid-19 and Polio from the common cold

Why are vaccines required for our body's immune system to destroy viruses that cause the likes of Covid-19 or Polio, while viruses that cause the common-cold are self-limiting (go away on their own)? ...
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Is it red blood cells or white blood cells that fight infection?

This article has me very confused; https://www.dailymail.co.uk/science...-blood-likely-catch-coronavirus.html#comments It's implying that red blood cells (ABO blood groups only affect the surface of ...
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Is Covid-19 likely to mutate into a deadlier form?

When the Spanish influenza hit in 1918, it struck in two waves. The first wave was typical for a flu virus, targetting mainly elderly people, but the second wave was far deadlier and killed far more ...
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Is COVID-19 claimed to get less deadly over time? If so, why?

From a TV news report of a press conference from (I think) the German Robert Koch Institute, I remember hearing an expert declare that he was expecting COVID-19 to get less deadly over time. ...
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How could the genocide of native Americans have happened? [closed]

According to work from Broden et al. (2015), the variation in the human immune system is largely driven by non-heritable influences. If there is little heritibility how can the genocide of native ...
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sperm reaction of virus infected

we know when a human body cell infected by a virus , create interferon 1 to call other cells that surrounded it , but red blood cells couldn't do this because they loose their nuclear and other ...
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Is it possible for an immune host to be reinfected and show symptom before swift recovery?

For example, let's say the pathogen is a virus, and the host was infected once but recovered purely on its own and thus retained a highly effective adapted immunity. However, if we IV inject the the ...
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What is holding the immune system back to not attack human body cells?

There are plenty of loose proteins or other macromolecules free floating everywhere. Why wouldn't they be seized and presented to T cell to trigger an immune response? Does each of these molecules ...
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How are lipid-coated mRNA-based vaccines transported into cells for expression?

In CNN's video Scientist says Coronavirus vaccine could be ready by 2021 after about 00:25 'Robin Shattock, the Head of Mucosal Infection and Immunity at Imperial ...
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Immunity to one's own microbiome

It seems that a human bite can be very dangerous, because of the myriads of bacterial species found in saliva. This leads to several questions that, perhaps, may have the same single answer. But, I'...
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Provisional vaccine for fast spreeding new viruses?

Developing a standard vaccine for coronavirus will take at least a few months - what might be too late: However, its sequence is already known, and is nearly identical - suggesting a recent single ...
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Why do vaccines sometimes induce a fever? [closed]

How does a vaccine cause an immune response such as fever? Why do only some people experience these reactions? Why might those reactions change upon subsequent doses of the same or similar vaccines?

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