Questions tagged [infectious-diseases]

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Could SARS-CoV-2 be hypothetically eradicated if every human being/animal on the planet simultaneously isolated themselves for 14 days? [closed]

I understand this is not at all a practical scenario; I'm just asking from a theoretical perspective. It seems to me that if SARS-CoV-2 needs reliable, periodic host-to-host transmission in order to ...
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How typhoid fever severe case's intestine perforation occur? (non trauma)

In typhoid severe case, intestinal perforation occurs. As stated here [4, 6]. Intestinal perforation is a serious complication of typhoid fever My question here is, how does the bacteria (Salmonella ...
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1answer
71 views

Fluctuations in disease burden of respiratory viruses (especially influenza/coronaviruses)

Compared to peaks in terms of disease burden (morbidity and mortality, or incidence of severely symptomatic cases and deaths caused by a viral strain within a population), is the relatively light ...
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1answer
228 views

Why did Rivers replace Koch's postulates?

In 1937, Rivers introduced a new set of postulates that were meant to replace those formulated by Koch. However, I couldn't find an article (or other scientific literature) that describes why Koch's ...
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Why do OX5034 GM mosquitos require the presence of tetracycline to survive? What does the drug do in this case?

I'm confused. Debug Fresno; why are the released mosquitos said to be sterile? from 2017 addresses male mosquitos released with a bacteria that will affect fertility of females after mating. They are ...
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1answer
101 views

Acquiring Covid-19 vaccination through kissing with viral vector vaccinated person

The mechanism of COVID-19 viral vector based vaccines (AstraZeneca - Vaxzevria, Johnsen, Sputnik V - Gam-COVID-Vac, Johnson & Johnson - Janssen, etc. ) is delivering the genetic information of the ...
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2answers
285 views

HPV. How do viruses persist outside the body?

The main route of transmission of human papillomavirus (HPV) is generally believed to be sexual. While fomites have been postulated for inexplicable infections, sexual health professionals regularly ...
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1answer
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Loss of taste and smell during a SARS-CoV-2 infection

In France the loss of taste and smell (la perte du goût et de l'odorat) is considered as one of the key symptoms of a SARS-CoV-2 infection (although googling shows that it is considered less ...
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Do partial (nighttime) curfews curb the spread of epidemics (and via which mechanisms)? [closed]

Do partial (e.g., nighttime) curfews curb the spread of epidemics? What is the (epidemiological) mechanism by which partial curfews curb the spread of epidemics? Is there evidence from past or present ...
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1answer
36 views

Minimum and maximum exposure to virus

Is it possible to say that there is a maximum exposure time for the virus so that even an exposure time beyond that - will leave us with the same chances of infection? If so, is there a way to ...
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COVID-19 infection data when partitioning to communities

Suppose we think of the disease in a certain country as follows. We have a set of "communities" $C_1,\dots,C_k$ in the country where $k$ is some small constant, say $10$. Each individual is ...
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Why do some vaccines lose their efficacy with time?

Why do some vaccines lose with time their efficacy? The two obvious examples that I have in mind are influenza and tetanus. The former case is clear, as influenza virus undergoes frequent gene ...
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1answer
88 views

What is the probability of virus undergoing a specific dangerous mutation? [closed]

Non-biologist here so apologies if the question is violating too many of the community standards for asking a question in the forum. What got me thinking was imagining how much more terrifying the ...
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1answer
38 views

In terms of Prions is there a possibility, that other proteins apart from PRPC could be misfolded [closed]

This is as from research PRPC seems to be the cause of all Prion related diseases. Thank you
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Is it possible for a prion to have a short incubation period ie 1 week or 1 month?

I know that all prions so far have long incubation periods but is there a possibility for one to have a short incubation period, is there any evidence that suggests this is possible. Thank you
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1answer
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How good are the hematologic parameters (e,g, IL6 or others) in predicting which patients will develop a severe COVID-19 disease?

Clinical implications of the hematologic profile of COVID-19 patients including cytokine storm, coagulation profile and thrombophilic complications are starting to be recognized. Hypercoagulability ...
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SARS-COV-2 detectability versus viability

This week (#47 of 2020) two meta-reviews were published in the Lancet. Ct values and infectivity of SARS-CoV-2 on surfaces, a brief review published on 19 November in The Lancet Infectious Diseases, ...
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1answer
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Why do diseases in the tap water of developing countries affect people from developed countries more?

My siblings and I went abroad to a country that doesn't have drinkable tap water, but we did not know this at the time as the people who lived there used to drink it all the time with no issues. One ...
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Reason for partially double-stranded DNA of Hepatitis B virus

According to my school biology textbook and also Wikipedia, hepatitis B is the only Hepatitis virus to possess partially double-stranded DNA. I found an image from here What is the reason for the ...
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1answer
81 views

COVID-19 deaths by year of birth?

Are there (global, country, etc.) data of COVID-19 deaths (or hospitalization) by year of birth? I was able to found them only by "age group", the meaning of this being usually an interval ...
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1answer
95 views

Did most pandemics originate from Asia/China?

This question may be on the borderline of well-posed-ness. Let me ask it. Then please tell me if or where it can be improved. Is it statistically true that the majority of the pandemics or epidemics ...
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1answer
53 views

Why are diseases generally specific to a particular species

"Zoonosis" is the process of transmitting a disease from an infected animal to a human. This suggests that animal-to-human transmission is not common. HIV is believed to have first spread to humans ...
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How to model social structure in SIR models

I refer to J.H. Jones' Notes on R0. More details in this question at Mathematics SE: How does the reproduction number depend on characteristics of the physical contact graph of a population? The ...
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2answers
162 views

The role of duration of infectiousness in SIR models

I refer to J.H. Jones' Notes on R0. The basic SIR model - as described in Jones' Notes - considers three factors that make up the reproduction number: $\tau$ = the transmissibility (i.e., ...
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1answer
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Do we know if dogs are asymptomatic transmiters of sars-cov-2?

Dogs do not use mask when going for a walk nor they observe the security distance. On the contrary, they frequently join their noses, and put their noses where other dogs had put them before or had ...
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Because we don't live as closely to livestock, are we at a greater or lesser risk of plagues?

Give recent events, some people have called for the 'wet markets' in China to be shut down, (for many reasons) but largely because it is likely the source of the recent plague outbreak, due to the ...
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1answer
339 views

How is the carrying capacity of a logistic growth model calculated?

I am reading a book in epidemiology where the carrying capacity for a standard logistic growth rate is given by K = (b - delta) / gamma where: ...
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How antibodies are produced in our body against intracellular proteins of infectious bacteria?

When an infectious agent invades our body, then surface antigens of the infectious agent are detected by our immune system and B-cells get activated. However, we do have antibodies in our blood ...
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2answers
107 views

Why does the SARS-CoV2 virus not remain infectious forever? Or does it?

Given that the majority of biologists do not currently consider viruses to be alive, a virus can never die. It can, however, get destroyed by long exposures to soapy water, alcohol, and apparently ...
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1answer
102 views

Can swarming locusts act as a vector for any human pathogens?

What human pathogens can the locusts currently swarming in Africa act as a vector for? E.g. can the locust swarm 'become a reservoir for' SARS-CoV-2? Measles? Ebola?
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1answer
57 views

Are specific primers or detectors, or both, used in COVID-19 tests?

I am trying to learn about the rRT-PCR testing procedure used to test for COVID-19, but I am slightly confused on one point. Are highly specific primers used with a non-specific detector, or are ...
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1answer
62 views

How likely is to develop an infection from a single virion entering a single cell? [closed]

Is there any research (including mathematical or computational modelling) regarding how likely it is to infect an organism starting from a single virion entering a single cell? I am interested in any ...
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143 views

Can an infectious diseases come from a plant?

Coronavirus, HIV, 1918 Flu, etc. They all come from animals. Do any infectious diseases (in humans) come from plants? More specifically, are there viruses that infect plants that can mutate to infect ...
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1answer
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Do we know of any "species ending bugs"?

Are we aware of a "bug" (virus, bacterium, prion, ...) that has completely exterminated an entire species? Either through direct observation or maybe some form of archeological evidence? If not, are ...
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1answer
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Are there any documented instances of coronaviruses being directly transmitted from bats to humans?

Many human coronaviruses have ancestral host origins in species of bat. However, all instances I am aware of identified other animals as intermediary vectors: SARS-CoV: Human ← Palm Civet / Raccoon ← ...
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1answer
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What is the formula to calculate $R_0$ (basic reproduction number)?

What is the mathematical formula for $R_0$ and what does each variable represent? I have tried searching this to no avail.
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1answer
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Is COVID-19 more deadly than swine flu?

I have a question about the novel coronavirus and swine flu. How do the death rates compare between the two diseases? How do the transmissions and rate of transmission compare? Was a vaccine ...
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1answer
181 views

What differentiates diseases like Covid-19 and Polio from the common cold

Why are vaccines required for our body's immune system to destroy viruses that cause the likes of Covid-19 or Polio, while viruses that cause the common-cold are self-limiting (go away on their own)? ...
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Is a nightly curfew an effective intervention strategy for limiting the spread of an infectious disease? [closed]

The governing bodies of several geographic areas hit by disease outbreaks will sometimes impose a nightly curfew on their citizens, restricting or limiting the ability of their citizens from going ...
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1answer
667 views

Difference between aerosol and droplet transmission for airborne diseases

I've been doing some pandemic reading and can't find why there is a distinction between transmission by aerosols and by droplets. Some articles give a size cutoff of 5 microns; how is that important? ...
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Examples of healthy lifelong asymptomatic carrier of a severe infectious disease?

I am curious, is there any known disease/infection that is very severe normally (patient suffers greatly and die easily without medical treatment), but ends up having little to no effect on the lives ...
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1answer
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Why do gram-negative bacteria attack the digestive system more than gram-positive ones?

I was researching for a biology project on the subject of contagious infections of the digestive system (mainly the intestines) and almost all of the bacteria that came up (E.coli, Shigella, Cholera, ...
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From a hosts point of view, which comes first, effect of toxins on pathways or identification of toxins by immune system?

From a pure biology perspective, when a pathogen (gram-negative bacteria) affects a host by secreting toxins, what comes first, the effect of the toxin on the pathways or identification of the toxin ...
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How was 2019-nCoV (Wuhan coronavirus) identified so quickly?

It seems that from the first few cases to identifying 2019-nCoV as a new disease happened very quickly. How were they able to identify this as a new disease and not an outbreak of a previously known ...
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Is there a Zipf law in epidemiology?

Are there cases where Zipf Law appears in epidemiology? I ranked provinces of China by their coronavirus confirmed cases (2020-01-30 14:29): 4586, 428, 311, 278, 277, 200, 165, 162, 145, 142, 129,...
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1answer
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How can a disease be transmissible animal-to-human but not human-to-human? [duplicate]

I have heard some debate about whether or not the Wuhan virus can be transmitted human-to-human, but this doesn't make sense to me. Why wouldn't it be able to? Are there diseases that can only be ...
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1answer
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Where can I find disease diagnosis datasets?

For an epidemiological study, I'm looking for datasets for any kind of vector-borne disease (i.e. West Nile Virus, Malaria, etc.), or any parasites that are dependent on intermediate hosts (i.e. ...
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1answer
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Is PrEP used for anything other than HIV?

In the field of HIV prevention, PrEP is an abbreviation of pre-exposure prophylaxis. This is a very generic term. Are any diseases other than HIV prevented using a similar approach? Do they use the ...
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Is slow growth a virulence factor?

Many slow-growth pathogens (e.g. Mycobacterium tuberculosis, lentivirus, Rhabdovirus, Leptospira spp) are difficult to treat. In addition, a review of 61 pathogens found that slower growing ...
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Why is synthesis of tetanospasmin advantageous to C. tetani?

The tetanospasmin is a neurotoxin synthesised by some strains of C. tetani. It is the factor causing tetanus, but what is its role for the bacteria itself? I do not believe the main objective of C. ...