Questions tagged [inflammation]
The inflammation tag has no usage guidance.
24 questions
1
vote
1
answer
105
views
Why do damaged joints or ligaments experience inflammation? Why do physiotherapists try to stop inflammation as part of the healing process?
I have had the repeated experience of going to physiotherapists with injuries to ligaments or joints and they all expressly aim to reduce inflammation.
I don’t understand this. Our mammalian (and ...
- 190
1
vote
0
answers
39
views
COX enzyme inhibitors
The use of aspirin inhibits COX-1 and hence the production of TXA2. This would prevent the aggregation of platelets. However, inhibition of COX-1 should also inhibit the production of PGI2 which is an ...
- 115
1
vote
0
answers
27
views
Chronic-stress of predation risk in vertebrate prey
Prey must be vigilant when their predators are around.
Predators may affect mortality (and morbidity, i.e. loss of quality of life) through these mechanisms:
Direct attacks, including injuries ...
- 1,276
1
vote
0
answers
25
views
Is there a link between SASP and fibrosis?
1/ Fibrosis: Fibrosis is the formation of excessive fibrous connective tissue in an organ or tissue during a reparative process.
2/ SASP: SASP is the accumulation of molecules and senescent cells in ...
- 263
1
vote
1
answer
54
views
How does slowed action potential propagation in the optic nerve cause blurred vision?
Multiple sclerosis is accompanied by optic neuritis, and there is demyelination of the optic nerve, causing the action potential to be propagated more slowly along axons. But how does this lead to ...
- 52.6k
3
votes
1
answer
160
views
How did sulfasalazine become a disease-modifying treatment for rheumatoid arthritis?
Sulfasalazine has been around for about fifty years, starting as an antibiotic. More recently it is used as a disease-modifying anti-rheumatic drug (DMARD, see also arthritis.org). While biologics (...
- 5,570
1
vote
1
answer
177
views
How did the "serendipitous rediscovery" of Sulfasalazine as an antirheumatic agent after 30 years happen?
This excellent answer describes the history of the ~50 year old drug Sulfasalazine, and it's worthwhile to take a moment and read through the answer now.
Roughly speaking the drug is an antibiotic ...
- 5,570
1
vote
0
answers
34
views
How does excessive acute inflammation damage tissue (eg, in sepsis or cytokine release syndrome)?
While inflammation is necessary to recruit immune cells to sites of infection in order to clear the etiological agent of disease, excessive inflammation has often been implicated in many of the poor ...
- 11
0
votes
2
answers
726
views
Loss of function in inflammation
The Wikipedia-article about Inflammation says
The five classical signs of inflammation are heat, pain, redness, swelling, and loss of function (Latin calor, dolor, rubor, tumor, and functio laesa).
...
- 7,680
1
vote
0
answers
30
views
What is the difference between cytokine and chemokine?
I often see these terms being used in inflammation, and I'd like to know, are they synonymous with each other or do they mean different things? Also could someone provide an example of each?
5
votes
1
answer
162
views
Are new blood vessels able to deliver oxygen to hypoxic tissue before the establishment of blood circulation?
Sprouting angiogenesis - the growth of new blood vessels from a preexisting vasculature - can be triggered by cells in hypoxia in order to re-stablish the oxygen and nutrients supply to the tissue.
...
CommunityBot
- 1
6
votes
3
answers
313
views
Why doesn't surgical steel cause inflammation?
It seems some very specific alloys like implant surgical steel and titanium don't cause inflammation in the human body, but when I asked my doctor about it, they simply said "it just has some chemical ...
CommunityBot
- 1
-1
votes
1
answer
74
views
Why hasn't there been a serious effort to develop an anti-inflammatory that blocks the responsible genes? [closed]
After numerous years of reading about how to disable inflammation and related treatments, it appears that the common existing approaches are fundamentally wrong.
The most popular over-the-counter ...
- 4,401
1
vote
0
answers
71
views
In the event of an abrasion, do mast cells cause vasodilation or vascular constriction?
Or both? I am unsure as to what mast cells will do in the event of a wound either on the epidermis or the epithelial. I know they secrete factors that mediate vascular constriction / dilation, but I ...
- 11
0
votes
1
answer
109
views
Can inhibition of lymphocytes migration be a direct cause of chronic inflammation?
Here is the original slide:
I am thinking about the "cord factor" sentence in a more general case.
Assume you inhibit Leucocytes migration.
How does this lead to accumulation of macrophages in the ...
- 52.7k
1
vote
2
answers
114
views
From what stage can you speak of an inflammation?
Imagine you hit your foot at a table leg and it hurts a while or you got a tiny graze. Those injuries aren't an infection but could these things still be called an inflammation?
Is it necessary that ...
- 8,798
1
vote
0
answers
65
views
Can oral bacteria be targeted by white blood cells?
Today I was told from a dentist that a leukocyte is much larger than a bad bacterium. So a leukocyte cannot remove bad bacteria when they hide in very places like the space between the gums and teeth ...
- 2,603
1
vote
1
answer
101
views
How many NOD like receptors in Human?
This is pretty specific question maybe. Anybody have an estimate? For Toll Like Receptors there are something like 10...
http://www.jbc.org/content/276/4/2551.long
I'm only finding NOD1 and NOD2 => ...
- 28.3k
1
vote
1
answer
146
views
How does a blunt force stimulate histamine to develop early stages of inflammation?
I know that viruses and sharp forces can stimulate mast cells by cut or by a virus infecting them and then release histamine. How can blunt force do this and cause inflammation? It doesn't have the ...
- 7,147
0
votes
1
answer
41
views
How many systemic reactions in inflammation?
I have this sentence in my notes
Inflammation consists of two local reactions and one systemic reactions.
which is difficult for me to accept.
Two local reactions are vascular and cellular.
I ...
CommunityBot
- 1
1
vote
1
answer
301
views
What are the purposes of granulocytes in acute inflammation?
I heard the phrase
Neutrophilic leucocytes are kings in the acute inflammation.
Neutrophils are granulocytes, while leucocytes are not granulocytes.
I think this statement refers to the fact that ...
- 5,169
1
vote
1
answer
148
views
Which inflammatory response with Cytomegalovirus infection?
I am thinking about inflammation process with Cytomegalovirus infection.
I first thought it is about chronic inflammation, but then changed my mind because of virus infection.
I think cytokines must ...
- 52.7k
1
vote
1
answer
153
views
How host defends against S. pneumoniae capsule?
The host response involves at least phagocytosis and probably localised acute inflammatory response at least after the colonisation.
I am thinking how the host can defend against pneumolysin which ...
- 52.7k
0
votes
1
answer
79
views
Is Rheumatic fever more Chronic than acute?
It follows from the complication of S.pyogenes' pharyngitis.
I am thinking how the inflammatory response behaves: acute or chronic or something between.
I think chronic disease is better description ...
- 5,700