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Questions tagged [intracellular-transport]

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Endocytic pathway: Macropinocytosis

So I'm trying to understand this phrase: Unlike other endocytic pathways, macropinocytosis is acutely induced by growth factors From the following paper The 4 endocytic pathways I know of are ...
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When are neuropeptides loaded into vesicles?

It is well known that small neurotransmitters like monoamines (dopamine, serotonin, etc), acetylcholine, glutamate, etc are loaded into vesicles at the axon terminal. Stated differently, synaptic ...
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Lysosomal Storage Disease

In my biochemistry class today we did a problem detailing two lysosomal storage diseases. In the first scenario, a cell line for I-cell disease can synthesize lysosomal hydrolases that are perfectly ...
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Can an importin without any cargo pass through the NPC?

Can an importin (nuclear import receptor) without any cargo pass through the Nuclear Pore Complex (NPC)? If it can, wouldn't it be a waste of energy to have the 'unloaded' importin enter the nucleus ...
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How do cells relocate transmembrane proteins from one side of the cell to the other? Is it possible?

Is there a process by which cells can relocate proteins residing on the cell membrane in areas of low demand to that of a high demand location somewhere else in on the cell? What's that process called?...
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Why is GTP, rather than ATP, used in nuclear transport?

Why is GTP used for nuclear transport and not ATP, given that ATP hydrolysis is used to drive most cellular energonic reactions?
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COPI/COPII proteins and kinesins/dyneins

I am considering the transport of protein from ER to Golgi, and have read that this involves the COPII protein coat. I have also read that this is a form of anterograde transport, and elsewhere that ...
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Why do large neurotransmitters travel faster down the axon?

I understand that with large neurotransmitters, like neuropeptides, the precursor neurotransmitter and the enzymes are produced in the soma and quickly travel down the axon to be modified in the axon ...
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Retrograde/anterorade transport; kinesin/dynein; COP1/COP2; Endoplasmic reticulum/Golgi

I am getting slightly confused with all of the terms above and was wondering if someone could see if I have got this right: I think transport from the ER to Golgi is almost always from the plus end ...
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What are internal and external osmotic pressures when referring to a cell?

I've seen the term used but cannot find a clear answer: What are internal and external osmotic pressures when referring to a cell?
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Transport mechanism in absorption of monosaccharides in small intestine

In the cell membrane of the intestinal cells, there is a mobile carrier protein called Sodium Dependent Glucose Transporter(SGLT1).It transports glucose and galactose to inside the cell using energy....
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Moss Transportation System

In my biology textbook, it says that mosses are avasculer and do not have xylem like spermatophytes. So by what means do mosses transport nutrients ?
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Determining and Differentiating specific ATPases

In respects to this certain ATPase transporter. What do i look for in respects to determining what specific kind it is out of: F-ATPases V-ATPases A-ATPases P-ATPases E-ATPases Im assuming that ...
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In the endomembrane system, after a protein leaves the rough ER, where does it go?

It can either go to the smooth ER then to the Golgi or it can go directly to the Golgi, right? Also, the smooth ER gets all of its material to synthesize things from the rough ER, right? Sorry, I ...
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Water potential in plants?

The concept of water potential in plants tries (and succeeds) to explain various movement and transports in plants. I have learnt that it can be though of being composed of various components like the ...
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How do axon terminals report to the soma?

It is important to bear in mind that the distance between a neuron's axon terminal and its soma can be extensive, up to about 1m in the human body. The fastest transport along the axon is 400mm/day (...
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Could silicon oil block Na+ ion channels in the membrane of an axon and prevent Na+ influx?

Could silicon oil block Na+ ion channels in the membrane of an axon and prevent Na+ influx? I have been wondering if Na+ influx could have been a diluting factor in anterograde fills. If so, could ...
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Why isn't there any repulsive force between Na+ and K+ disrupting thier roles in transmembrane voltage/ action potentials

Pretty self explanatory question. I have a basic grasp on the "How" and "Why" of Reversal/Action Potential in and between neurons, but this question lingers.
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How are synaptic vesicles brought to the synapse?

I'm reading about how synaptobrevin is used to identify synaptic vesicles for tethering near the synaptic cleft. Since neurons have a synapse and dendrites, I'd like to know how exactly the vesicles ...