Questions tagged [medicinal-chemistry]

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Why is half dose of Oxford's vaccine of covid more effective than full dose?

I recently read in a newspaper that the half dose of the Oxford's vaccine is 90% effective while the full dose is only 62% effective. Why is this the case ?
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Is it advised to calculate QED parameters for salts?

QED (quantitative estimation of drug-likeness) is a score which helps you to predict if a small molecule is desirable as an orally absorbed drug, described in the Quantifying the chemical beauty of ...
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What exactly causes SSRIs, SNRIs, and tricyclics to induce akathisia?

Such as too high neurotransmitter levels (serotonin/dopamine/other) or the method of drug delivery or some other reason? Please keep in mind I know very little about this subject, I apologize for the ...
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What is the proper way to dispose of a medicinal substance?

Is there a protocol or a set of guidelines to safely dispose off a batch of expired drugs (as a manufacturer)? I guess the process may vary for different drugs. My specific question regarding the safe ...
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Sulforaphane vs. Hyperthermic conditioning (sauna use) which would induce a greater heat shock response in the human body?

I’m curious to know which would induce a greater upregulation of heat shock proteins, consuming sulforaphane or putting the body through heat stress such as using the sauna. Sulforaphane reference- ...
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Why is plasma glucose concentration not double that of whole blood?

It is known that the concentration of plasma glucose is 12% higher than that of whole blood. But since 45-50% of whole blood is red blood cells, shouldn't the plasma glucose be almost double — since ...